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Prognostic value of left ventricular concentric remodeling in uncomplicated mild hypertension.

Abstract：

BACKGROUND:The prognostic value of left ventricular (LV) concentric remodeling in essential hypertension, and particularly in uncomplicated mild hypertension, is not yet completely clear. We investigated cardiovascular outcome in uncomplicated mild hypertensive patients with normal LV geometry and LV concentric remodeling. METHODS:The occurrence of fatal and nonfatal cardiovascular events was evaluated in 1088 uncomplicated mild hypertensive patients, 751 with normal LV geometry (LV mass index <125 g/m(2) in men and <110 g/m(2) in women and relative wall thickness <0.45) and 337 with LV concentric remodeling (LV mass index <125 g/m(2) in men and <110 g/m(2) in women and relative wall thickness >/=0.45). RESULTS:During follow-up (4.74 +/- 2.4 years, range 0.5 to 9.7 years) the event rates per 100 patient-years in subjects with normal LV geometry and LV concentric remodeling were 0.69 and 1.87, respectively. After adjustment for other covariates, Cox regression analysis showed that LV concentric remodeling (LV concentric remodeling versus normal LV geometry, RR 1.78, 95% CI 1.02 to 3.1, P < .05) was an independent predictor of cardiovascular events. CONCLUSION:In a population with uncomplicated mild hypertension, patients with LV concentric remodeling have a worse prognosis than those with normal LV geometry.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Pierdomenico SD,Lapenna D,Bucci A,Manente BM,Cuccurullo F,Mezzetti A

doi

10.1016/j.amjhyper.2004.06.016

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

1035-9

issue

11 Pt 1

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(04)00877-5

journal_volume

17

pub_type

杂志文章

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