Abstract：
BACKGROUND:Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT. METHODS:We recruited 178 patients with uncomplicated nondiabetic HT in this study. Baseline glucose, insulin, lipid profiles, and central aortic pressure indexes obtained using applanation tonometry were measured at the beginning of the study. Patients were followed for new-onset DM. RESULTS:After a mean follow-up period of 31 ± 12 months, 22 patients (12.4%) developed new-onset DM. In multivariate regression analyses adjusted for age, sex, and mean blood pressure (BP) in model 1, we found that central systolic BP (CSBP; hazard ratio 1.24, 95% CI 1.10-1.41, P < 0.001), and augmentation index (AIx) corrected at heart rate 75/min (AIx(75); hazard ratio 1.58, 95% CI 1.11-1.58, P < 0.05) were independent predictors for new-onset DM. After adjustment for age, sex, mean BP, glucose concentration, and β-blocker use in model 2, we found that CSBP (hazard ratio 1.36, 95% CI 1.19-1.55, P < 0.001) and AIx(75) (hazard ratio 1.71, 95% CI 1.16-2.52, P < 0.01) were independent predictors for new-onset DM. CONCLUSIONS:CSBP and AIx(75) were independent factors for future DM in essential hypertensive patients. Increased central pressure indexes were associated with risk of DM in essential hypertension.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Chen JY,Chou CH,Lee YL,Tsai WC,Lin CC,Huang YY,Chen JHdoi
10.1038/ajh.2010.145subject
Has Abstractpub_date
2010-10-01 00:00:00pages
1069-73issue
10eissn
0895-7061issn
1941-7225pii
ajh2010145journal_volume
23pub_type
杂志文章abstract：BACKGROUND:Morning blood pressure (BP) surge seems to be a risk factor for cardiovascular events. Although physical activity after arising significantly affects morning BP surge, it has remained unclear whether morning BP surge after controlling for physical activity (morning BP reactivity) is associated with target or...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.06.015
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:This study analyzed whether hypertension induced by N(omega)-nitro-l-arginine methyl ester (L-NAME) is associated with dysregulation of the main antioxidant enzymes (superoxide dismutase [SOD], catalase, glutathione peroxidase [GPX], and glutathione reductase [GR]) and whether chronic administration of tempo...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.12.022
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. However, the association between serum vitamin D and blood pressure in pregnant women has been scarcely evaluated, particularly in women with a high risk of developing hypertensive disorders of pregnancy. We sought ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu043
更新日期：2014-10-01 00:00:00
abstract：:The principal aim of the present study was to determine the relationship of ambulatory blood pressure (BP) to urinary electrolyte excretion in normotensives. Twenty-five young adults underwent ambulatory BP and heart rate monitoring while collecting urine over 24 h. The correlations of 24 h urine sodium excretion and ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/6.6.480
更新日期：1993-06-01 00:00:00
abstract：BACKGROUND:In experimental renovascular hypertension, aldosterone has been implicated in myocardial remodeling and fibrosis, but it is uncertain whether excess aldosterone effects left ventricular structure and function in hypertensive patients. METHODS:Hypertensive patients from the Cardiovascular Center of the New Y...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1016/s0895-7061(01)02331-7
更新日期：2002-04-01 00:00:00
abstract：:This study was designed to analyze the cardiac effects of aging and of hypertension in patients with essential hypertension and with or without left ventricular hypertrophy (LVH). Thirty-one patients <55 years old and 66 patients >64 years old with essential hypertension were divided according to the presence or absen...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(97)00500-1
更新日期：1998-04-01 00:00:00
abstract：BACKGROUND:Progression of atherosclerosis with increased arterial stiffness is associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Compliance index (CI) derived from digital volume pulse (DVP), measuring the relationship between volume and pressure changes in ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.266
更新日期：2011-05-01 00:00:00
abstract：:The influence of increased lability of blood pressure on the development of aortic atherosclerosis was examined. Because sinoaortic denervation (SAD) produced increased lability of blood pressure without blood pressure elevation, the development of atheromatous plaque was examined in SAD rats. These rats were fed a hi...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/7.5.453
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:The aim of our study was to investigate the control of hypertension (HT) in treated children using ambulatory blood pressure (BP) monitoring (ABPM). METHODS:We retrospectively reviewed all ABPM studies in our center. Controlled HT was defined as systolic and diastolic BP index (patients' BP divided by the 9...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2011.218
更新日期：2012-03-01 00:00:00
abstract：BACKGROUND:Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, mode...
journal_title：American journal of hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1093/ajh/hpx123
更新日期：2017-11-06 00:00:00
abstract：:Angiotensin-converting enzyme inhibitors (ACEIs), introduced in clinical practice in 1980, are a relatively new class of drugs. They have been useful in the treatment of hypertension, where they are effective monotherapy in 40% to 50% of the patients and in combination therapy in up to 90%. They are also useful in the...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/2.1.57
更新日期：1989-01-01 00:00:00
abstract：:Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 with normal blood pressure, 14 with untreated hypertension, nine treated with a thiazide diuretic only, and eight treated with combined diuretic ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/2.6.419
更新日期：1989-06-01 00:00:00
abstract：BACKGROUND:Osteopontin (Opn) is highly upregulated in many different animal models of renal disease, where it is suspected to participate in progression of the disease. In some models, angiotensin II (Ang II) seems to induce the elevated Opn production. Therefore, we examined the regulation of Opn in two-kidney, one-cl...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(02)03266-1
更新日期：2003-03-01 00:00:00
abstract：BACKGROUND:Endothelial dysfunction and arterial stiffening are commonly observed in type 2 diabetes. These abnormalities might be secondary to increased plasma concentrations of homocysteine. We sought to determine whether oral folic acid supplementation, by lowering homocysteine levels, enhanced endothelial function a...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.amjhyper.2004.08.036
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:Aldosterone acts to restrain the extracellular potassium (K+) concentration. Blacks have on average lower plasma aldosterone concentrations (PACs) than Whites. Whether this ethnic difference is associated with similar changes in the concentration of K+ is unclear. METHODS:Subjects were Blacks and Whites fro...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpx006
更新日期：2017-05-01 00:00:00
abstract：:Since young SHR excrete less urinary kallikrein than WKY, active and total kallikrein (A and T Kall, respectively) was measured (amidolytic assay) in the renal cortex of both strains. Neither at birth nor at age 4 weeks did renal T Kall differ between SHR and WKY. Renal A Kall was significantly lower in newborn SHR an...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/1.3.53s
更新日期：1988-07-01 00:00:00
abstract：:The aim of this study was to evaluate the delayed effects of an angiotensin converting enzyme (ACE) inhibitor on blood pressure and on structural and functional alterations in mesenteric small resistance arteries of spontaneously hypertensive rats (SHR). The ACE inhibitor fosinopril (25 mg/kg/day) was administered acc...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(97)00166-0
更新日期：1997-09-01 00:00:00
abstract：:The purpose of this study was to determine whether antihypertensive therapy with the angiotensin converting enzyme inhibitor lisinopril would alter cell Na+ transport kinetics, metabolic parameters associated with insulin resistance, or both in young adults with mild hypertension. Sixteen young adults (mean age 29 +/-...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)00018-K
更新日期：1995-05-01 00:00:00
abstract：BACKGROUND:The efficacy and safety of angiotensin receptor blockers (ARBs) in the older population is unclear. OBJECTIVES:To determine the efficacy and safety of ARBs in older patients. METHODS:Randomized trials that compared ARBs to control and reported clinical outcomes in patients with a mean age of 65 years or ol...
journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析,评审
doi：10.1093/ajh/hpu209
更新日期：2015-05-01 00:00:00
abstract：:Angiotensin II (Ang II) and transforming growth factor-beta (TGF-beta) modulate cell growth and metabolism. Our objective was to evaluate the effect of Ang II on the characteristics and expression of TGF-beta receptors on vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats. The addition of TGF-beta1 elicited a ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(99)00152-1
更新日期：2000-02-01 00:00:00
abstract：BACKGROUND:There is growing evidence that residential environment is associated with hypertension. Recently, interest has also turned toward examining the possible influence of remoteness on hypertension. The aim of this study is to explore the effect of remoteness, the shortest path between the subject location and th...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2012.36
更新日期：2012-07-01 00:00:00
abstract：:Angiotensin II (Ang II) plays important roles in the development of cardiovascular diseases including hypertension, renal diseases, cardiac hypertrophy, congestive heart failure, and ischemic heart disease. Angiotensin II exerts classic hemodynamic and renal effects, but it is also a local biologically active mediator...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/j.amjhyper.2005.05.005
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:Aging is a major risk factor for the development of arterial stiffness and vascular disease, and it is related to the upregulation of matrix metalloproteinase-2 (MMP-2) in the aorta of rats and nonhuman primates. This study aimed to determine whether MMP activity in the human vasculature changes with aging. ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.11.011
更新日期：2005-04-01 00:00:00
abstract：:In order to evaluate the effects of atrial natriuretic factor (ANF) infusion on plasma insulin (IRI) in hypertension, 32 essential hypertensives (aged 40 to 62 years) were studied. After 1 week of pharmacologic washout under normal sodium intake (120 mEq of Na+/day), patients were randomly assigned to receive either A...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/ajh/4.11.880
更新日期：1991-11-01 00:00:00
abstract：BACKGROUND:Matrix Gla protein (MGP) is a vascular calcification inhibitor dependent upon vitamin K for activation. Evidence suggests that elevated plasma inactive MGP levels (desphospho-uncarboxylated MGP, dp-ucMGP; indicating poorer vascular vitamin K status) are associated with greater cardiovascular disease (CVD) ri...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpy049
更新日期：2018-05-07 00:00:00
abstract：BACKGROUND:Central systolic blood pressure (SBP) can be estimated by an oscillometric method developed from a pulse volume plethysmography (PVP) device. The present study applied this novel method to a noninvasive blood pressure monitor (NBPM). METHODS:We enrolled 50 patients (37 men, age range 30-84 years) referred f...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2011.259
更新日期：2012-05-01 00:00:00
abstract：:In this study we have compared Ca2+ efflux in cultured aortic smooth muscle cells derived from male, 10-week-old spontaneously hypertensive and Wistar-Kyoto rats. The role of Ca(2+)-dependent protein kinase C and Ca2+ uptake in the regulation of the Ca2+ pump and Na(+)-Ca2+ exchange mediated Ca2+ efflux were investiga...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)00226-X
更新日期：1995-10-01 00:00:00
abstract：BACKGROUND:Apelin is an adipokine directly associated with adiposity, insulin resistance, and decreased blood pressure. Urinary 8-isoprostane is a marker of chronic oxidative endothelial stress. Visfatin, an adipokine that acts by binding and activating the insulin receptor, has been associated with hypertension. As se...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpw007
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:We postulated that acute hypoxemia increases susceptibility to orthostatic hypotension by increasing the sensitivity of cardiovascular baroreceptors. METHODS:Hemodynamics were measured noninvasively in 17 healthy, normotensive subjects while being subjected to decreasing venous return by exposure to lower b...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2006.02.005
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:Large artery stiffness is increased in diabetes mellitus and causes an excessive pulsatile load to the heart and to the microvasculature. The identification of pathways related to arterial stiffness may provide novel therapeutic targets to ameliorate arterial stiffness in diabetes. Matrix Gla-Protein (MGP) i...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1093/ajh/hpw146
更新日期：2017-02-01 00:00:00
