Association of arterial stiffness indexes, determined from digital volume pulse measurement and cardiovascular risk factors in chronic kidney disease.


BACKGROUND:Progression of atherosclerosis with increased arterial stiffness is associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Compliance index (CI) derived from digital volume pulse (DVP), measuring the relationship between volume and pressure changes in fingertip, can evaluate the local arterial stiffness. The purpose of this study was to measure the stiffness of different arteries and determine the relationships of CI-DVP with clinical characteristics and renal function in CKD patients. METHODS:This cross-sectional pilot study included 186 CKD and 46 healthy subjects. Evaluation of different arterial stiffness was performed by DVP using dual-channel photoplethysmography and measured as CI (CI-DVP) and pulse wave velocity (PWV)-DVP. RESULTS:CKD patients had lower CI-DVP and higher PWV-DVP than that in the healthy group. There was a trend of stepwise decrease in CI-DVP and increase in PWV-DVP related to the advance of CKD from early to late stage. Decrease of CI-DVP was associated with the increase in number of cardiovascular risk factors. Multivariate linear regression analysis revealed that CI-DVP (B = 4.59, P < 0.01) was independently associated with estimated glomerular filtration rate (eGFR). Male gender, eGFR, and systolic blood pressure (BP) were independent determinants for CI-DVP (B = -0.25, P = 0.01; B = 0.007, P = 0.03; and B = -0.03, P < 0.0001; whole model R(2) = 0.28, P < 0.0001). CONCLUSIONS:Our data demonstrate a significant association between CI-DVP, a new surrogate marker of arterial stiffness different from PWV, and renal function and cardiovascular risk factors in CKD patients.


Am J Hypertens


Wang MC,Wu AB,Cheng MF,Chen JY,Ho CS,Tsai WC




Has Abstract


2011-05-01 00:00:00














  • Chemerin as a Driver of Hypertension: A Consideration.

    abstract::The protein chemerin (tazarotene-induced gene, TIG2; RARRES2) is a relatively new adipokine. Many studies support that circulating chemerin levels associate strongly and positively with body mass index, visceral fat, and blood pressure. Here, we focus on the specific relationship of chemerin and blood pressure with th...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ferland DJ,Mullick AE,Watts SW

    更新日期:2020-11-03 00:00:00

  • The Captopril Prevention Project (CAPPP): description and status.

    abstract::The Captopril Prevention Project (CAPPP) is an ongoing prospective intervention study in 10,800 hypertensive patients in Sweden and Finland. Patients are randomized to treatment with either conventional antihypertensive therapy, ie, diuretics or beta-blockers, or the angiotensin-converting enzyme inhibitor captopril. ...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Hansson L

    更新日期:1994-09-01 00:00:00

  • Worldwide trends and shortcomings in the treatment of hypertension.

    abstract::Despite advances in the availability and quality of antihypertensive medications and the institution of national programs to educate people about the seriousness of hypertension, much remains to be done. The percentages of people who are aware of their disease, are being treated for it, and are achieving adequate cont...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Julius S

    更新日期:2000-05-01 00:00:00

  • Clofibrate acutely reverses saline-induced endothelial dysfunction: role of calcium-activated potassium channels.

    abstract:BACKGROUND:Endothelium-dependent vascular relaxation is impaired in various disease states including hypertension. METHODS:We investigated whether a single bolus dose of clofibrate could rapidly reverse saline-induced endothelial dysfunction, in vivo, in salt-loaded Sprague-Dawley (S-D) rats. S-D rats, 5 weeks of age,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sankaralingam S,Desai KM,Wilson TW

    更新日期:2006-11-01 00:00:00

  • Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.

    abstract:BACKGROUND:Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats. METHO...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hye Khan MA,Neckář J,Haines J,Imig JD

    更新日期:2014-08-01 00:00:00

  • Left ventricular mass is better correlated with arising blood pressure than with office or occasional blood pressure.

    abstract::The peak incidence of cardiovascular complications in the morning points to a possible role of the abrupt increase in blood pressure on arising. However, there is as yet no firm evidence linking the extent of the elevation in blood pressure on arising and the risk of cardiovascular complications. We sought a correlati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gosse P,Ansoborlo P,Lemetayer P,Clementy J

    更新日期:1997-05-01 00:00:00

  • Ambulatory blood pressure after acute exercise in older men with essential hypertension.

    abstract::We sought to determine whether reductions in blood pressure in hypertensives after acute exercise persist for more than the 2 to 3 h found in controlled laboratory settings. Subjects (n = 11) were obese (32 +/- 4% body fat), sedentary (VO2max 27 +/- 4 mL/kg/min) 60 +/- 6-year-old men with stage 1 or 2 essential hypert...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Taylor-Tolbert NS,Dengel DR,Brown MD,McCole SD,Pratley RE,Ferrell RE,Hagberg JM

    更新日期:2000-01-01 00:00:00

  • Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension.

    abstract:BACKGROUND:Hypertensive disorders of pregnancy, including preeclampsia (PE), affect approximately 7-10% of pregnancies in the US. Clinical and experimental studies strongly suggest that the maternal immune system plays a role in the development of these disorders; however, few therapeutic options exist aside from deliv...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tinsley JH,Chiasson VL,South S,Mahajan A,Mitchell BM

    更新日期:2009-10-01 00:00:00

  • Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans.

    abstract::Leptin may be a link in the relationship of obesity with hypertension. We evaluated associations of leptin with blood pressure (BP) in 54 normotensive and 114 hypertensive African American individuals. Plasma leptin was higher (P <.03) in hypertensive women than in normotensive women, although body mass index did not ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: El-Gharbawy AH,Kotchen JM,Grim CE,Kaldunski M,Hoffmann RG,Pausova Z,Hamet P,Kotchen TA

    更新日期:2002-11-01 00:00:00

  • Central serotonergic mechanisms in hypertension.

    abstract::Serotonin-containing neurons in the central nervous system are grouped into a number of discrete and distinctive collections with cell bodies in the brainstem and projections passing to many regions of the brain and spinal cord. Evidence is presented that activation of one projection of serotonin-containing neurons fr...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Chalmers JP,Pilowsky PM,Minson JB,Kapoor V,Mills E,West MJ

    更新日期:1988-01-01 00:00:00

  • Adjusting adiposity and body weight measurements for height alters the relationship with blood pressure in children.

    abstract:BACKGROUND:Adiposity measures are associated with increased pediatric blood pressure (BP). However, this correlation can be confounded by the relationship of both variables to height. We evaluated whether adiposity and anthropometric measures were associated with pediatric BP before and after adjusting each value for h...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Willig AL,Casazza K,Dulin-Keita A,Franklin FA,Amaya M,Fernandez JR

    更新日期:2010-08-01 00:00:00

  • Improvement in metabolic risk factors for coronary heart disease associated with cilazapril treatment.

    abstract::Patients with hypertension tend to be glucose intolerant, hyperinsulinemic, and dyslipedemic. Since all of these changes increase risk of coronary heart disease (CHD), it is important to know what effect antihypertensive treatment has on these variables. The current open-labelled, uncontrolled study was initiated in o...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Shieh SM,Sheu WH,Shen DD,Fuh MM,Jeng CY,Jeng JR,Chen YD,Reaven GM

    更新日期:1992-08-01 00:00:00

  • Atrial Dilatation Development in Hypertensive Treated Patients: The Campania-Salute Network.

    abstract:BACKGROUND:Left atrial (LA) dilatation is associated with unfavorable outcome in hypertension. However, there are few data on clinical, demographic, and echocardiographic findings correlated with LA dilatation development. METHODS:From the Campania-Salute Network registry, we identified 5,375 hypertensive patients (52...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Losi MA,Izzo R,Canciello G,Giamundo A,Manzi MV,Strisciuglio T,Stabile E,De Luca N,de Simone G,Trimarco B

    更新日期:2016-09-01 00:00:00

  • Genetic susceptibility of the donor kidney contributes to the development of renal damage after syngeneic transplantation.

    abstract::Solitary kidneys, especially in rats, appear vulnerable to develop functional and structural damage. However, differences in susceptibility exist between strains. It is not clear whether this is intrinsic to the kidney or due to environmental factors. Therefore, the aim of the present study was to investigate possible...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kouwenhoven EA,van Dokkum RP,Marquet RL,Heemann UW,de Bruin RW,IJzermans JN,Provoost AP

    更新日期:1999-06-01 00:00:00

  • Different Angiotensin-converting enzyme inhibitors and the associations with overall and cause-specific mortalities in patients with hypertension.

    abstract:BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors have been widely used in the treatment of hypertension, but the comparative effectiveness in reducing mortality among different drugs is seldom reported. METHODS:We identified hypertensive patients who started captopril, enalapril, lisinopril, fosinopril, perin...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Chang CH,Lin JW,Caffrey JL,Wu LC,Lai MS

    更新日期:2015-06-01 00:00:00

  • Endothelial dysfunction in resistance arteries is related to high blood pressure and circulating low density lipoproteins in previously treated hypertension.

    abstract:BACKGROUND:Peripheral endothelial dysfunction has been demonstrated in hypertension. However, its relationship to blood pressure (BP) load, vascular structure, and metabolic disturbances in patients with long-standing, previously treated hypertension is unclear. METHODS:A total of 41 patients with stage I to III essen...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Olsen MH,Wachtell K,Aalkjaer C,Devereux RB,Dige-Petersen H,Ibsen H

    更新日期:2001-09-01 00:00:00

  • Prevalence, awareness, treatment, and risk factors associated with hypertension in the Iranian population: the national survey of risk factors for noncommunicable diseases of Iran.

    abstract:BACKGROUND:The prevalence of hypertension in the Middle East is not well defined. We examined the prevalence, awareness, treatment, and control of hypertension in Iran. METHODS:The Survey of Risk Factors of Noncommunicable Diseases was conducted in 2005 and contains a representative sample of the Iranian adult populat...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Esteghamati A,Abbasi M,Alikhani S,Gouya MM,Delavari A,Shishehbor MH,Forouzanfar M,Hodjatzadeh A,Ramezani RD

    更新日期:2008-06-01 00:00:00

  • Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.

    abstract::In essential hypertension (EHT) the presence of a metabolic syndrome increases the risk of cardiovascular disease. A cell membrane abnormality is implicated but its role in cardiovascular disease is unclear. Neutrophil accumulation, which occurs by beta2-integrin (CD11b/CD18) expression, followed by release of proinfl...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Fardon NJ,Wilkinson R,Thomas TH

    更新日期:2001-09-01 00:00:00

  • Impact of blood pressure variability on cardiac and cerebrovascular complications in hypertension.

    abstract:BACKGROUND:The independent prognostic value of daytime and night-time blood pressure (BP) variability estimated by noninvasive 24-h BP monitoring is unclear. METHODS:We followed 2649 initially untreated subjects with essential hypertension for up to 16 years (mean, 6). Variability of BP was estimated by the standard d...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Verdecchia P,Angeli F,Gattobigio R,Rapicetta C,Reboldi G

    更新日期:2007-02-01 00:00:00

  • Glucocorticoid sensitivity of circulating monocytes in essential hypertension.

    abstract:BACKGROUND:Essential hypertension ranks among the strongest cardiovascular risk factors. Cytokine production by monocytes plays a key role in atherosclerosis development and acute coronary syndromes. We investigated whether stimulated monocyte cytokine release and its inhibition by glucocorticoids would differ between ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Wirtz PH,von Känel R,Frey K,Ehlert U,Fischer JE

    更新日期:2004-06-01 00:00:00

  • New-Onset Resistant Hypertension in a Newly Diagnosed Prostate Cancer Patient.

    abstract:BACKGROUND:New onset resistant hypertension in a previously stable patient with chronic hypertension should lead to consideration of secondary causes. Electrolyte abnormalities are useful clues for identifying some common causes, especially mineralocorticoid excess. CASE PRESENTATION:We report the case of a 69-year-ol...

    journal_title:American journal of hypertension



    authors: Klomjit N,Rowan DJ,Kattah AG,Bancos I,Taler SJ

    更新日期:2019-11-15 00:00:00

  • Prenatal Exposure to LPS Alters The Intrarenal RAS in Offspring, Which Is Ameliorated by Adipose Tissue-Derived Mesenchymal Stem Cells.

    abstract:BACKGROUND:Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cell...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ding XF,Sun M,Guan FX,Guo LN,Zhang YY,Wan YD,Zhang XJ,Yu YW,Ma SS,Yao HM,Yao R,Zhang RF,Sun TW,Kan QC

    更新日期:2017-11-06 00:00:00

  • Effects of low-sodium diet vs. high-sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride (Cochrane Review).

    abstract:BACKGROUND:The question of whether reduced sodium intake is effective as a health prophylaxis initiative is unsolved. The purpose was to estimate the effects of low-sodium vs. high-sodium intake on blood pressure (BP), renin, aldosterone, catecholamines, and lipids. METHODS:Studies randomizing persons to low-sodium an...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,meta分析,评审


    authors: Graudal NA,Hubeck-Graudal T,Jürgens G

    更新日期:2012-01-01 00:00:00

  • Are there meaningful differences in blood pressure control with current antihypertensive agents?

    abstract::Hypertension is a major risk factor for cardiovascular disease, and small reductions in blood pressure can have a substantial impact on outcome. Effective control of hypertension per se is important in reducing morbidity and mortality, but there is growing evidence that the class of drug used in treatment may affect p...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Oparil S

    更新日期:2002-01-01 00:00:00

  • Endothelin gene variants and aortic and cardiac structure in never-treated hypertensives.

    abstract:BACKGROUND:The polymorphism of several candidate genes has been studied in relation to essential hypertension and cardiovascular complications. Target organ damage in essential hypertension is a complex disorder influenced by multiple genetic and environmental factors. The possible contribution of endothelin gene varia...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lajemi M,Gautier S,Poirier O,Baguet JP,Mimran A,Gosse P,Hanon O,Labat C,Cambien F,Benetos A

    更新日期:2001-08-01 00:00:00

  • An additive effect of endothelial nitric oxide synthase gene polymorphisms contributes to the severity of atherosclerosis in patients on dialysis.

    abstract:BACKGROUND:Reduced synthesis of nitric oxide (NO) is considered a major proatherogenic mechanism in patients with end-stage renal disease (ESRD), but genetic factors impinging on this mechanism have been little studied in this population. METHODS:We tested the relationship between carotid intima-media thickness (IMT) ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Spoto B,Benedetto FA,Testa A,Tripepi G,Mallamaci F,Maas R,Boeger RH,Zoccali C

    更新日期:2007-07-01 00:00:00

  • Cardioprotective Effects of Paricalcitol Alone and in Combination With FGF23 Receptor Inhibition in Chronic Renal Failure: Experimental and Clinical Studies.

    abstract:BACKGROUND:In uremic animals, vitamin D receptor (VDR) agonists like paricalcitol (Pc) attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans with chronic kidney disease. Elevated fibroblast growth factor 23 (FGF23) levels cause cardiac hypertrophy with activation of the myocardia...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Czaya B,Seeherunvong W,Singh S,Yanucil C,Ruiz P,Quiroz Y,Grabner A,Katsoufis C,Swaminathan S,Abitbol C,Rodriguez-Iturbe B,Faul C,Freundlich M

    更新日期:2019-01-01 00:00:00

  • Pediatric Liddle Syndrome Caused by a Novel SCNN1G Variant in a Chinese Family and Characterized by Early-Onset Hypertension.

    abstract:BACKGROUND:Liddle syndrome (LS), an autosomal dominant disorder, is a common monogenic hypertension in pediatrics. In this study, we reported a novel SCNN1G variant in a Chinese family with pediatric LS, and conduct a systematic review of epithelial sodium channel (ENaC)-gene-positive LS cases to conclude the clinical ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Fan P,Pan XC,Zhang D,Yang KQ,Zhang Y,Tian T,Luo F,Ma WJ,Liu YX,Wang LP,Zhang HM,Song L,Cai J,Zhou XL

    更新日期:2020-07-18 00:00:00

  • Estimated healthcare savings associated with adequate dairy food intake.

    abstract::Medical literature that has coalesced during the past two to three decades has identified adequate intake of nutrients from dairy foods as a common factor in the reduction of the disease burden of several common medical conditions. These include obesity, hypertension, type 2 diabetes, osteoporosis, kidney stones, cert...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: McCarron DA,Heaney RP

    更新日期:2004-01-01 00:00:00

  • Pharmacodynamics of clonidine therapy in pregnancy: a heterogeneous maternal response impacts fetal growth.

    abstract:BACKGROUND:Clonidine, a centrally acting antihypertensive agent, has been used successfully in pregnancy. We sought to describe the pharmacodynamic effects of clonidine in pregnancy and the associated impact on fetal growth. METHODS:A retrospective cohort study was performed. Maternal hemodynamics were measured before...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Rothberger S,Carr D,Brateng D,Hebert M,Easterling TR

    更新日期:2010-11-01 00:00:00