Abstract:
BACKGROUND:Matrix Gla protein (MGP) is a vascular calcification inhibitor dependent upon vitamin K for activation. Evidence suggests that elevated plasma inactive MGP levels (desphospho-uncarboxylated MGP, dp-ucMGP; indicating poorer vascular vitamin K status) are associated with greater cardiovascular disease (CVD) risk. Despite African Americans experiencing highest rates of kidney failure and CVD events, relationships between dp-ucMGP and CVD risk markers have not been examined in this population. We investigated vascular vitamin K status (via plasma dp-ucMGP) between African American hemodialysis (HD) patients and healthy controls, and the associations of dp-ucMGP with arterial stiffness and endothelial function in HD patients only. METHODS:In 37 African American HD patients and 37 age- and race-matched controls, plasma dp-ucMGP was measured by enzyme immunoassay as a marker of vascular vitamin K status. Carotid-femoral pulse wave velocity (PWV; arterial stiffness measurement) and brachial artery flow-mediated dilation (FMD; endothelial function measurement) were assessed by applanation tonometry and ultrasound, respectively, in HD patients only. RESULTS:Mean dp-ucMGP levels were 5.6 times higher in HD patients vs. controls (2,139 ± 1,102 vs. 382 ± 181 pmol/l, P < 0.01). Multiple linear regression, adjusting for age, sex, dialysis vintage, diabetes mellitus, CVD history, body mass index, and blood pressure, revealed that dp-ucMGP was independently related to PWV (standardized β = 0.49) and FMD (standardized β = -0.53) (both P < 0.01). CONCLUSIONS:Our data suggest that the higher plasma dp-ucMGP concentrations found in African American HD patients may be associated with greater arterial stiffness and endothelial dysfunction.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Fain ME,Kapuku GK,Paulson WD,Williams CF,Raed A,Dong Y,Knapen MHJ,Vermeer C,Pollock NKdoi
10.1093/ajh/hpy049subject
Has Abstractpub_date
2018-05-07 00:00:00pages
735-741issue
6eissn
0895-7061issn
1941-7225pii
4964022journal_volume
31pub_type
杂志文章abstract::In normal coronary arteries, increased flow velocity induces endothelium-dependent dilation, and dilation in response to sympathetic stimulation evoked by the cold pressor test is partly due to increased flow velocity. In arterial hypertension, angiographically normal coronary arteries were constricted by acetylcholin...
journal_title:American journal of hypertension
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doi:10.1016/0895-7061(95)00028-n
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/4.12.678s
更新日期:1991-12-01 00:00:00
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1990-12-01 00:00:00
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
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更新日期:1994-07-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:American journal of hypertension
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doi:10.1093/ajh/6.8.674
更新日期:1993-08-01 00:00:00
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journal_title:American journal of hypertension
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doi:10.1093/ajh/hpu267
更新日期:2015-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1038/ajh.2009.125
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
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更新日期:1991-07-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/0895-7061(96)00199-9
更新日期:1996-11-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/2.2.111
更新日期:1989-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/4.1.56s
更新日期:1991-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:1997-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1016/s0895-7061(97)00109-x
更新日期:1997-08-01 00:00:00
abstract:BACKGROUND:Pregnancy-induced hypertension (PIH) is associated with chronic hypertension (HTN) and cardiovascular complications. We investigated the factors that predict the development of chronic HTN in women with PIH. METHODS:The study population comprised 108 women with PIH and 87 healthy age-matched women control s...
journal_title:American journal of hypertension
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更新日期:2016-01-01 00:00:00