Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelial Function in African American Hemodialysis Patients.

Abstract:

BACKGROUND:Matrix Gla protein (MGP) is a vascular calcification inhibitor dependent upon vitamin K for activation. Evidence suggests that elevated plasma inactive MGP levels (desphospho-uncarboxylated MGP, dp-ucMGP; indicating poorer vascular vitamin K status) are associated with greater cardiovascular disease (CVD) risk. Despite African Americans experiencing highest rates of kidney failure and CVD events, relationships between dp-ucMGP and CVD risk markers have not been examined in this population. We investigated vascular vitamin K status (via plasma dp-ucMGP) between African American hemodialysis (HD) patients and healthy controls, and the associations of dp-ucMGP with arterial stiffness and endothelial function in HD patients only. METHODS:In 37 African American HD patients and 37 age- and race-matched controls, plasma dp-ucMGP was measured by enzyme immunoassay as a marker of vascular vitamin K status. Carotid-femoral pulse wave velocity (PWV; arterial stiffness measurement) and brachial artery flow-mediated dilation (FMD; endothelial function measurement) were assessed by applanation tonometry and ultrasound, respectively, in HD patients only. RESULTS:Mean dp-ucMGP levels were 5.6 times higher in HD patients vs. controls (2,139 ± 1,102 vs. 382 ± 181 pmol/l, P < 0.01). Multiple linear regression, adjusting for age, sex, dialysis vintage, diabetes mellitus, CVD history, body mass index, and blood pressure, revealed that dp-ucMGP was independently related to PWV (standardized β = 0.49) and FMD (standardized β = -0.53) (both P < 0.01). CONCLUSIONS:Our data suggest that the higher plasma dp-ucMGP concentrations found in African American HD patients may be associated with greater arterial stiffness and endothelial dysfunction.

journal_name

Am J Hypertens

authors

Fain ME,Kapuku GK,Paulson WD,Williams CF,Raed A,Dong Y,Knapen MHJ,Vermeer C,Pollock NK

doi

10.1093/ajh/hpy049

subject

Has Abstract

pub_date

2018-05-07 00:00:00

pages

735-741

issue

6

eissn

0895-7061

issn

1941-7225

pii

4964022

journal_volume

31

pub_type

杂志文章
  • Impairment of flow-dependent coronary dilation in hypertensive patients. Demonstration by cold pressor test induced flow velocity increase.

    abstract::In normal coronary arteries, increased flow velocity induces endothelium-dependent dilation, and dilation in response to sympathetic stimulation evoked by the cold pressor test is partly due to increased flow velocity. In arterial hypertension, angiographically normal coronary arteries were constricted by acetylcholin...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00028-n

    authors: Nitenberg A,Antony I,Aptecar E,Arnoult F,Lerebours G

    更新日期:1995-05-01 00:00:00

  • Left ventricular hypertrophy and angiotensin II antagonists.

    abstract::Left ventricular hypertrophy in patients with hypertension is an important condition. It is associated with significant mortality and carries increased risk for developing nonfatal cardiovascular complications, including coronary heart disease. The pathogenesis of left ventricular hypertrophy is linked to activation o...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(00)01257-7

    authors: Dahlöf B

    更新日期:2001-02-01 00:00:00

  • Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients.

    abstract::To evaluate the clinical importance of serum hepatocyte growth factor (HGF) concentration, we designed two clinical investigations. The first study analyzed the correlation between serum HGF concentration and clinical arterial stiffness or the vasodilator response to reactive hyperemia in hypertensive patients. The se...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)02274-4

    authors: Komai N,Ohishi M,Morishita R,Moriguchi A,Kaibe M,Matsumoto K,Rakugi H,Higaki J,Ogihara T

    更新日期:2002-06-01 00:00:00

  • Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR.

    abstract:BACKGROUND:Ryanodine receptor (RyR) dysfunction in skeletal muscle (RyR1) leads to malignant hyperthermia, and in cardiac muscle (RyR2) triggers cardiac arrhythmias. We hypothesized that RyR dysfunction in vascular smooth muscle could increase vascular resistance and hypertension, and may contribute to increased atrial...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa021

    authors: Lee JS,Greco L,Migirov A,Li Y,Gerdes AM,Zhang Y

    更新日期:2020-04-29 00:00:00

  • Captopril renography. Early observations and diagnostic criteria.

    abstract::This article describes the methods and the interpretation of captopril renography. The essentials of the methods are the discontinuation of diuretics, the refraining from solid foods before administration of 25 mg captopril, hydration to induce diuresis, the performing of 1-min sequential images, data acquisition with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/4.12.678s

    authors: Oei HY

    更新日期:1991-12-01 00:00:00

  • Increase of calmodulin activator in hypertension. Modulation by dietary sodium and calcium.

    abstract::The aim of this study was to investigate the effects of dietary calcium and sodium on blood pressure (BP) in normotensive rats (Wistar, WKY), spontaneously hypertensive rats (SHR) and Dahl rats and on calmodulin (CaM) activator, a newly-discovered hydrophobic compound that increases CaM activity in SHR and spontaneous...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.8.210

    authors: Chang E,Kunes J,Hamet P,Tremblay J

    更新日期:1990-08-01 00:00:00

  • New-Onset Resistant Hypertension in a Newly Diagnosed Prostate Cancer Patient.

    abstract:BACKGROUND:New onset resistant hypertension in a previously stable patient with chronic hypertension should lead to consideration of secondary causes. Electrolyte abnormalities are useful clues for identifying some common causes, especially mineralocorticoid excess. CASE PRESENTATION:We report the case of a 69-year-ol...

    journal_title:American journal of hypertension

    pub_type:

    doi:10.1093/ajh/hpz125

    authors: Klomjit N,Rowan DJ,Kattah AG,Bancos I,Taler SJ

    更新日期:2019-11-15 00:00:00

  • Prevalence of Self-Reported Hypertension in Deaf Adults Who Use American Sign Language.

    abstract:BACKGROUND:In the United States, roughly one-third of adults have hypertension; another third have prehypertension. The prevalence of hypertension in deaf American Sign Language (ASL) users is unknown. We address this gap through a descriptive study for the prevalence of hypertension in the American Deaf community and ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpy111

    authors: Simons AN,Moreland CJ,Kushalnagar P

    更新日期:2018-10-15 00:00:00

  • Interaction of 1,25-dihydroxyvitamin D and plasma renin activity in high renin essential hypertension.

    abstract::Renin secretion by the kidney is inhibited by an increase in free intracellular calcium concentration. This increase in free intracellular calcium content may be augmented by serum 1,25-dihydroxyvitamin D. In 10 subjects with high renin hypertension, an increase in dietary sodium intake resulted in an increase in urin...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ajh/3.12.903

    authors: Burgess ED,Hawkins RG,Watanabe M

    更新日期:1990-12-01 00:00:00

  • Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension.

    abstract:BACKGROUND:The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and en...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)02967-9

    authors: Galderisi M,Caso P,Cicala S,De Simone L,Barbieri M,Vitale G,de Divitiis O,Paolisso G

    更新日期:2002-09-01 00:00:00

  • Endothelin-1-like immunoreactivity in a new rodent model of spontaneous hypertension.

    abstract::The purpose of this study was to determine plasma and tissue endothelin-1 (ET-1)-like immunoreactivity in a new rodent model of spontaneous hypertension. Plasma and tissues were procured from pentobarbital-anesthetized 16- to 18-week-old male hamsters with spontaneous hypertension and genetically/age-matched normotens...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00047-8

    authors: Gulati A,Artwohl JE,Kumar A,Gao XP,Rubinstein I

    更新日期:1998-07-01 00:00:00

  • Circadian variation of arterial pressure wave reflections.

    abstract:BACKGROUND:Various factors are implicated in the circadian pattern of cardiovascular vulnerability. The exact mechanisms involved in the peak incidence of cardiovascular events occurring during the early morning hours after awaking are not completely known. The purpose of our study was to investigate the circadian vari...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2005.09.020

    authors: Papaioannou TG,Karatzis EN,Papamichael CM,Karatzi KN,Zakopoulos NA,Lekakis JP,Mavrikakis M,Stefanadis C

    更新日期:2006-03-01 00:00:00

  • Pulsatile hemodynamics and clinical outcomes in acute heart failure.

    abstract:BACKGROUND:The role of pulsatile hemodynamics in the management of patients with acute heart failure syndrome (AHFS) remains to be elucidated. We investigated the changes of the pulsatile hemodynamics along the hospital course of AHFS in relation to short-term outcomes. METHODS:A total of 80 AHFS patients (73.2 ± 14.1...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.26

    authors: Sung SH,Yu WC,Cheng HM,Chuang SY,Wang KL,Huang CM,Chen CH

    更新日期:2011-07-01 00:00:00

  • Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women.

    abstract::The results of our previous studies suggested that endothelin-1 (ET-1) might be contributory to the impaired uteroplacental blood flow seen in preeclampsia. The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/7.7.50s

    authors: Kublickiene KR,Wolff K,Kublickas M,Lindblom B,Lunell NO,Nisell H

    更新日期:1994-07-01 00:00:00

  • Polymorphisms of Leptin (G2548A) and Leptin Receptor (Q223R and K109R) Genes and Blood Pressure During Pregnancy and the Postpartum Period: A Cohort.

    abstract:BACKGROUND:The genetic component related to blood pressure (BP) changes during pregnancy is still not elucidated. Thus, the aim of the study was to evaluate the association between leptin and leptin receptor polymorphisms and systolic (SBP) and diastolic BP (DBP) variation during pregnancy and the postpartum period. M...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpw147

    authors: Farias DR,Franco-Sena AB,Rebelo F,Salles GF,Struchiner CJ,Martins MC,Kac G

    更新日期:2017-02-01 00:00:00

  • Opposite effects of cell growth factors and cicletanine sulfate on the sodium-independent [Cl-/HCO3-] exchange in cultured vascular smooth muscle.

    abstract::Cicletanine sulfate was tested on bicarbonate-dependent pHi changes in cultured vascular smooth muscle (A10 line). Cicletanine sulfate exhibited double reactivity with regard to the cell alkalinization induced by bicarbonate uptake. The analysis of 11 concentration-response curves revealed a high reactivity component ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/6.8.674

    authors: Fanous K,Nazaret C,Senn N,Decoopman-Morin E,Allard M,Garay RP

    更新日期:1993-08-01 00:00:00

  • Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis.

    abstract:BACKGROUND:Previous autopsy studies suggested that a reduced nephron number is associated with increased risk of hypertension and chronic kidney disease. However, the significance of the nephron number estimated from a renal biopsy in patients with hypertensive nephrosclerosis (HNS) has not yet been elucidated. METHOD...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu267

    authors: Haruhara K,Tsuboi N,Kanzaki G,Koike K,Suyama M,Shimizu A,Miyazaki Y,Kawamura T,Ogura M,Yokoo T

    更新日期:2015-09-01 00:00:00

  • Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension.

    abstract:BACKGROUND:Hypertensive disorders of pregnancy, including preeclampsia (PE), affect approximately 7-10% of pregnancies in the US. Clinical and experimental studies strongly suggest that the maternal immune system plays a role in the development of these disorders; however, few therapeutic options exist aside from deliv...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2009.125

    authors: Tinsley JH,Chiasson VL,South S,Mahajan A,Mitchell BM

    更新日期:2009-10-01 00:00:00

  • Different effects of antihypertensive agents on cardiac and vascular hypertrophy in the transgenic rat line TGR(mRen2)27.

    abstract::The hypertensive transgenic rat model TGR(mRen2)27 has been used to investigate the development of cardiac and vascular hypertrophy in response to two different drug regimes. Cardiac hypertrophy was shown to be related to age and gender with the copy number of mouse renin transgenes having an additive effect. A simila...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00021-7

    authors: Brosnan MJ,Devlin AM,Clark JS,Mullins JJ,Dominiczak AF

    更新日期:1999-07-01 00:00:00

  • Twenty-four-hour blood pressure control with isradipine in mild essential hypertension.

    abstract::The hypotensive effect of isradipine was assessed in 26 male patients, aged 40 to 64 years, with hypertension. After withdrawal of previous antihypertensive treatment and a four-week placebo period, patients were randomized into a double-blind active-treatment period of eight weeks to receive either placebo or 1.25 to...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ajh/4.2.161s

    authors: Viskoper JR,Laszt A,Faraggi D

    更新日期:1991-02-01 00:00:00

  • Association Between Chronic or Acute Use of Antihypertensive Class of Medications and Falls in Older Adults. A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Evaluating effect of acute or chronic use of antihypertensives on risk of falls in older adults. METHODS:Data sources: Systematic search of primary research articles in CINAHL, Cochrane, EBM, EMBASE, and MEDLINE databases from January 1 2007 to June 1 2017. Study selection: Research studies of cohort, case-...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpx189

    authors: Kahlaee HR,Latt MD,Schneider CR

    更新日期:2018-03-10 00:00:00

  • Pressor and bradycardic effects of centrally administered relaxin in conscious rats.

    abstract::The current study tested the hypothesis that centrally administered relaxin elevates arterial pressure in conscious rats and that this hypertensive effect is mediated, at least in part, by central or peripheral vasopressin. Injection of human relaxin (0.068 or 0.34 microgram in 200 nL artificial cerebrospinal fluid) i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(94)00208-s

    authors: Yang RH,Bunting S,Wyss JM,Berecek KH,Zhang L,Jin H

    更新日期:1995-04-01 00:00:00

  • Noninvasive detection of vascular dysfunction in alcoholic patients.

    abstract::Vasodilation is impaired in various conditions, such as hypercholesterolemia and tobacco use. We evaluated brachial artery flow-mediated vasodilation (FMD) after blood pressure (BP) cuff occlusion using high-resolution B-mode ultrasound in 20 alcoholics, without any coexisting conditions such as smoking, hypertension,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00173-3

    authors: Maiorano G,Bartolomucci F,Contursi V,Minenna FS,Di Mise R,Palasciano A,Allegrini B,Amoruso M,Kozàkovà M

    更新日期:1999-02-01 00:00:00

  • Normal serum levels of calcitonin gene-related peptide (CGRP) in mild to moderate essential hypertension.

    abstract::Calcitonin gene-related peptide (CGRP), a highly potent vasodilator, is expressed from the calcitonin-gene and has been localized to nerve fibers of the cardiovascular system, suggesting involvement in the physiologic regulation of vascular tone. In this investigation serum concentrations of CGRP were measured in pati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/4.7.565

    authors: Schifter S,Krusell LR,Sehested J

    更新日期:1991-07-01 00:00:00

  • Comparison of target organ damage in renovascular and essential hypertension.

    abstract::In many reports, the prevalence of target organ damage in renovascular hypertension (RVH) appears to be higher than in essential hypertension (EH). Since in most studies the renal artery stenosis is part of a diffuse atherosclerotic disease, it is not known whether these complications are due to RVH itself or to the v...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(96)00199-9

    authors: Losito A,Fagugli RM,Zampi I,Parente B,de Rango P,Giordano G,Cao P

    更新日期:1996-11-01 00:00:00

  • Cytosolic Ca2+ regulation attenuates ANP-induced cGMP response in vascular smooth muscle cells of the SHR.

    abstract::Cultured vascular smooth muscle cells (VSMCs) of the spontaneously hypertensive rat (SHR) show a higher density (Bmax) of ANP receptors and a blunted cyclic (c) GMP response to the hormone. To explore the idea that a higher cytosolic free Ca2+ (Cai2+) may be responsible for a blunted cGMP response to ANP, we examined ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.2.111

    authors: Nakamura M,Nakamura A,Hatori N,Fine BP,Aviv A

    更新日期:1989-02-01 00:00:00

  • Angiotensin converting enzyme inhibitors suppress the vascular renin-angiotensin system of spontaneously hypertensive rats.

    abstract::The effects of angiotensin converting enzyme (ACE) inhibitors on the release of angiotensin II (Ang II) from isolated mesenteric arteries of spontaneously hypertensive rats (SHRs) were examined. Delapril, enalapril, and captopril suppressed Ang II release in a dose-dependent manner. After oral treatment with delapril ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.1.56s

    authors: Higashimori K,Nakamaru M,Tabuchi Y,Nagano M,Mikami H,Ogihara T,Inagami T

    更新日期:1991-01-01 00:00:00

  • Lack of difference in oxalate-dependent Ca2+ uptake by membrane homogenate of African-American and white subjects.

    abstract::In order to further characterize previously described racial differences in intracellular Ca2+ homeostasis, the activity of sarcoplasmic-endoplasmic reticulum Ca2+-ATPase was measured in cultured skin fibroblasts from normotensive African-Americans and whites. Cells originated from apparently healthy, normotensive Afr...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(96)00415-3

    authors: Yang XY,Aviv A,Hopp L

    更新日期:1997-04-01 00:00:00

  • Renal depressor mechanisms of physical training in patients with essential hypertension.

    abstract::To clarify characteristics of the patients in whom exercise training lowers blood pressure and to elucidate the mechanisms by which exercise training lowers blood pressure, we evaluated 24-h blood pressure, glomerular filtration rate (GFR), renal blood flow (RBF), filtration fraction (FF), plasma renin activity (PRA),...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0895-7061(97)00109-x

    authors: Kohno K,Matsuoka H,Takenaka K,Miyake Y,Nomura G,Imaizumi T

    更新日期:1997-08-01 00:00:00

  • Factors That Predict the Development of Hypertension in Women With Pregnancy-Induced Hypertension.

    abstract:BACKGROUND:Pregnancy-induced hypertension (PIH) is associated with chronic hypertension (HTN) and cardiovascular complications. We investigated the factors that predict the development of chronic HTN in women with PIH. METHODS:The study population comprised 108 women with PIH and 87 healthy age-matched women control s...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpv073

    authors: Shopen N,Schiff E,Koren-Morag N,Grossman E

    更新日期:2016-01-01 00:00:00