Relationship of plasma renin with a prothrombotic state in hypertension: relevance for organ damage.


BACKGROUND:Components of the renin-angiotensin-aldosterone system (RAAS) and a prothrombotic state are predictors of cardiovascular events in hypertensive patients. A relationship between the RAAS and the coagulation/fibrinolytic systems has been demonstrated, but its clinical relevance in hypertension is unclear. We investigated the relationships of the RAAS and the hemostatic system with hypertensive organ damage. METHODS:Plasma components of the RAAS and parameters that directly assess the activation of coagulation and fibrinolysis were measured in 247 essential hypertensive patients in whom the extent of organ damage had been characterized at the cardiac, renal, and vascular level. RESULTS:Positive association with increasing plasma renin activity (PRA) was demonstrated for plasma fibrinogen, D-dimer, and plasminogen activator inhibitor-1 (PAI-1) levels. PRA was directly correlated with plasma aldosterone, fibrinogen, d-dimer, and PAI-1. The relationship of PRA with fibrinogen and PAI-1 remained significant after correction for age, gender, duration of hypertension, and smoking status. Plasma aldosterone levels were directly correlated with fibrinogen, D-dimer, and PAI-1, whereas plasma angiotensin-converting enzyme was not related with any of the coagulation parameters. Elevated PRA, aldosterone, fibrinogen, D-dimer, prothrombin fragment 1+2, and PAI-1 levels were associated with clinical and/or instrumental evidence of hypertension-related cardiac and renal damage. Both fibrinogen and PAI-1 were independent predictors of the presence of organ damage and their inclusion in a multivariate model eliminated PRA and aldosterone as independent predictors. CONCLUSIONS:A strong and independent association exists between renin, aldosterone, and markers of a prothrombotic state in essential hypertension. This relationship might contribute to the development of hypertensive organ damage.


Am J Hypertens


Sechi LA,Novello M,Colussi G,Di Fabio A,Chiuch A,Nadalini E,Casanova-Borca A,Uzzau A,Catena C




Has Abstract


2008-12-01 00:00:00














  • Functional Status and Antihypertensive Therapy in Older Adults: A New Perspective on Old Data.

    abstract:BACKGROUND:Functional status may be useful for identifying older adults who benefit from lower blood pressure. We examined whether functional status modifies the effect of antihypertensive treatment among older adults. METHODS:Post hoc analyses of the Systolic Hypertension in the Elderly Program (SHEP), a randomized t...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Charlesworth CJ,Peralta CA,Odden MC

    更新日期:2016-06-01 00:00:00

  • Impact of Uric Acid on Hypertension Occurrence and Target Organ Damage: Insights From the STANISLAS Cohort With a 20-Year Follow-up.

    abstract:BACKGROUND:Recent studies have shown that hyperuricemia may be associated with incident hypertension (HTN). We examined whether serum uric acid (SUA) is a predictor of HTN and target organ damage (TOD) 20 years later in initially healthy middle-aged individuals. METHODS:Participants from the Suivi Temporaire Annuel No...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kanbay M,Girerd N,Machu JL,Bozec E,Duarte K,Boivin JM,Wagner S,Ferreira JP,Zannad F,Rossignol P

    更新日期:2020-09-10 00:00:00

  • Plasma insulin levels do not change during atrial natriuretic factor infusion in human essential hypertensives.

    abstract::In order to evaluate the effects of atrial natriuretic factor (ANF) infusion on plasma insulin (IRI) in hypertension, 32 essential hypertensives (aged 40 to 62 years) were studied. After 1 week of pharmacologic washout under normal sodium intake (120 mEq of Na+/day), patients were randomly assigned to receive either A...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ferri C,De Mattia G,Piccoli A,Carlomagno A,Luparini RL,Germanò G,Giarrizzo C,Torregrossa G,Santucci A,Balsano F

    更新日期:1991-11-01 00:00:00

  • Plasma viscosity in isolated systolic hypertension: the role of pulse pressure.

    abstract::Atherosclerosis is increasingly recognized as an inflammatory vascular disease, and high blood pressure (BP) has been suggested to exert a proinflammatory action. Whether plasma viscosity (PV), a major determinant of blood flow in microcirculation and a marker of systemic inflammation and cardiovascular risk, is incre...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ciuffetti G,Schillaci G,Lombardini R,Pirro M,Vaudo G,Mannarino E

    更新日期:2005-07-01 00:00:00

  • Ambulatory blood pressure after acute exercise in older men with essential hypertension.

    abstract::We sought to determine whether reductions in blood pressure in hypertensives after acute exercise persist for more than the 2 to 3 h found in controlled laboratory settings. Subjects (n = 11) were obese (32 +/- 4% body fat), sedentary (VO2max 27 +/- 4 mL/kg/min) 60 +/- 6-year-old men with stage 1 or 2 essential hypert...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Taylor-Tolbert NS,Dengel DR,Brown MD,McCole SD,Pratley RE,Ferrell RE,Hagberg JM

    更新日期:2000-01-01 00:00:00

  • High Home Blood Pressure Variability Associates With Exaggerated Blood Pressure Response to Cold Stress.

    abstract:BACKGROUND:Exaggerated sympathetic cardiovascular (CV) reactivity to stress associates with elevated risk for clinical and preclinical end points of CV disease. It would be useful to identify these individuals, preferably from feasible measurements commonly used in health care. Our study examined the association betwee...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hintsala HE,Kiviniemi AM,Antikainen R,Mäntysaari M,Jokelainen J,Hassi J,Tulppo MP,Herzig KH,Keinänen-Kiukaanniemi S,Rintamäki H,Jaakkola JJK,Ikäheimo TM

    更新日期:2019-05-09 00:00:00

  • Prenatal Exposure to LPS Alters The Intrarenal RAS in Offspring, Which Is Ameliorated by Adipose Tissue-Derived Mesenchymal Stem Cells.

    abstract:BACKGROUND:Prenatal lipopolysaccharide (LPS) exposure causes hypertension in rat offspring through an unknown mechanism. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) in hypertension induced by prenatal LPS exposure and also explored whether adipose tissue-derived mesenchymal stem cell...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ding XF,Sun M,Guan FX,Guo LN,Zhang YY,Wan YD,Zhang XJ,Yu YW,Ma SS,Yao HM,Yao R,Zhang RF,Sun TW,Kan QC

    更新日期:2017-11-06 00:00:00

  • Increased arterial stiffness in pre-eclamptic pregnancy at term and early and late postpartum: a combined echocardiographic and tonometric study.

    abstract:BACKGROUND:Pre-eclampsia (PE) is characterized by hypertension and proteinuria, and complicates from 3%-10% of all pregnancies. The hemodynamic pathophysiology of the heart and systemic arteries in pre-eclamptic patients has not been well described. We therefore performed a comprehensive comparison of the systemic arte...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Estensen ME,Remme EW,Grindheim G,Smiseth OA,Segers P,Henriksen T,Aakhus S

    更新日期:2013-04-01 00:00:00

  • Estimated healthcare savings associated with adequate dairy food intake.

    abstract::Medical literature that has coalesced during the past two to three decades has identified adequate intake of nutrients from dairy foods as a common factor in the reduction of the disease burden of several common medical conditions. These include obesity, hypertension, type 2 diabetes, osteoporosis, kidney stones, cert...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: McCarron DA,Heaney RP

    更新日期:2004-01-01 00:00:00

  • Increased human urotensin II levels are correlated with carotid atherosclerosis in essential hypertension.

    abstract:BACKGROUND:Circulating blood levels of human urotensin II (U-II), the most potent vasoconstrictor peptide identified to date, are increased in patients with essential hypertension. Our previous studies showed that U-II accelerates human macrophage foam cell formation and vascular smooth muscle cell proliferation, sugge...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Suguro T,Watanabe T,Ban Y,Kodate S,Misaki A,Hirano T,Miyazaki A,Adachi M

    更新日期:2007-02-01 00:00:00

  • Left ventricular hypertrophy and clinical outcomes in hypertensive patients.

    abstract::The prevalence of left ventricular hypertrophy (LVH) rises with severity of hypertension (HT), age, and obesity. Its prevalence ranges from 20% in mildly hypertensive patients to almost 100% in those with severe or complicated HT. However, the diagnosis of LVH is not straightforward, and the definitions and criteria u...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Ruilope LM,Schmieder RE

    更新日期:2008-05-01 00:00:00

  • Quality-adjusted meta-analysis of the hypertension/coronary dilemma.

    abstract::Primary investigators of randomized drug trials in hypertension were invited to rate quality of such trials. The intention of the survey was to ask if antihypertensive drug therapy reduces incidence of coronary heart disease (CHD) in hypertensive patients. Response was obtained for 7 of the 11 invited investigators, c...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,meta分析


    authors: Holme I,Ekelund LG,Hjermann I,Leren P

    更新日期:1994-08-01 00:00:00

  • Increasing sensitivity of blood pressure to dietary sodium and potassium with increasing age. A population study using casual urine specimens.

    abstract::In a population of 887 men and 1159 women aged 40 to 89 years in southern California, age adjusted systolic and diastolic blood pressures correlated significantly with sodium/potassium ratios estimated from casual urine samples. The relationship was apparent over the whole range of blood pressures and urinary electrol...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Khaw KT,Barrett-Connor E

    更新日期:1990-06-01 00:00:00

  • Chronic hypotension. In the shadow of hypertension.

    abstract::Understanding the causes and treatment of chronic hypotension is of benefit to affected patients and may also shed light on the physiology and genetics of mechanisms of blood pressure control. Symptomatic hypotension (almost always with a blood pressure fall greater than or equal to 20/10 mm Hg) may reflect unrecogniz...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Robertson D,Mosqueda-Garcia R,Robertson RM,Biaggioni I

    更新日期:1992-06-01 00:00:00

  • Blood pressure evaluation by noninvasive and traditional methods. Consistencies and discrepancies among photoplethysmomanometry, office sphygmomanometry, and ambulatory monitoring. Effects of blood pressure measurement.

    abstract::Three hundred eight outpatients referred for hypertension were studied. A continuous beat-to-beat noninvasive recording (Finapres) of blood pressure evaluated the blood pressure increase (9 mm Hg systolic and 4 mm Hg diastolic) induced by office sphygmomanometry. Thereafter, patients underwent a 24-h ambulatory blood ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Musso NR,Giacchè M,Galbariggi G,Vergassola C

    更新日期:1996-04-01 00:00:00

  • Post-transplant hypertension.

    abstract::Post-transplant hypertension remains an important risk factor for cardiovascular mortality and graft function. There are multiple mechanisms responsible for post-transplant hypertension. The details of these mechanisms are poorly understood. Steroids, acute and chronic rejection, recurrent renal disease, native kidney...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Laskow DA,Curtis JJ

    更新日期:1990-09-01 00:00:00

  • Polymorphisms in the RAC1 gene are associated with hypertension risk factors in a Chilean pediatric population.

    abstract:BACKGROUND:The GTPase Rac1 has been implicated in hypertension as a modulator of mineralocorticoid receptor activity. Our aim is to investigate the frequency of polymorphisms rs10951982 (intron 1, G>A) and rs836478 (intron 3, T>C) in the RAC1 gene and perform association studies with clinical and biochemical parameters...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tapia-Castillo A,Carvajal CA,Campino C,Vecchiola A,Allende F,Solari S,García L,Lavanderos S,Valdivia C,Fuentes C,Lagos CF,Martínez-Aguayo A,Baudrand R,Aglony M,García H,Fardella CE

    更新日期:2014-03-01 00:00:00

  • Use of an automated blood pressure recording device, the BpTRU, to reduce the "white coat effect" in routine practice.

    abstract:BACKGROUND:Patients often exhibit higher blood pressure (BP) readings in the doctor's office, a phenomenon known as the white coat effect. This study examines the presence of a physician in the examining room as a possible factor in provoking a white coat effect. METHODS:Blood pressure measurements taken by an automat...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Myers MG,Valdivieso MA

    更新日期:2003-06-01 00:00:00

  • Oil and water? Economic advantage and biomedical progress do not mix well in a government guidelines committee.

    abstract::This article examines the results of the Joint National Committee's Fifth Report on the treatment of hypertension (JNC-V), especially regarding the economic arguments put forth therein. Economics are a poor basis for treatment decisions, as the cheapest therapies may not be the best for any given patient. Broad treatm...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Ménard J

    更新日期:1994-10-01 00:00:00

  • Detection of arteriolar narrowing in fundoscopic examination: evidence of a low performance of direct ophthalmoscopy in comparison with a microdensitometric method.

    abstract:BACKGROUND:Retinal abnormalities, particularly arteriolar narrowing, are powerful predictors of cardiovascular events. The precision of internists and ophthalmologists in the assessment of retinal vessels widths has been disputed but not evaluated against a technology of edge detection. METHODS:Fifty-two patients with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Maestri MM,Fuchs SC,Ferlin E,Pakter HM,Nunes G,Moraes RS,Gus M,Moreira LB,Fuchs FD

    更新日期:2007-05-01 00:00:00

  • Effects of aging on the insulin actions for the glucose metabolism and renal function in normotensives and essential hypertensives.

    abstract::It has been suggested that hyperinsulinemia compensating insulin resistance in glucose metabolism may be a pathogenic factor in essential hypertension. On the other hand, age-associated increases in the prevalence of glucose intolerance and hypertension are also well established. The aim of this study is to clarify th...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Miyazaki Y,Hirata A,Murakami H,Fukuoka M,Agata J,Higashiura K,Masuda A,Ura N,Shimamoto K

    更新日期:1998-09-01 00:00:00

  • Quinapril prevents stroke both during and after the treatment period in stroke-prone spontaneously hypertensive rats.

    abstract::The effects of long-term oral administration of quinapril on the occurrence of stroke and on mortality were investigated in young salt-loaded stroke-prone spontaneously hypertensive rats (SHR-SPs) during the treatment period (8th-34th week of age) and up to 6 weeks thereafter. Simultaneously, blood pressure, saline in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Vacher E,Fornes P,Domergue V,Richer C,Bruneval P,Giudicelli JF

    更新日期:1993-11-01 00:00:00

  • Insulin resistance in secondary hypertension.

    abstract::The insulin sensitivity of five essential hypertensive patients was compared to five patients with renovascular hypertension, five patients with primary hyperaldosteronism, and five normotensive subjects, using the euglycemic hyperinsulinemic clamp technique. Essential hypertensive patients had significantly lower ins...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shamiss A,Carroll J,Rosenthal T

    更新日期:1992-01-01 00:00:00

  • Intramyocellular and Extramyocellular Lipids Are Associated With Arterial Stiffness.

    abstract:BACKGROUND:Obese and overweight patients are at increased risk of arterial stiffness, and visceral, epicardial and hepatic fat accumulation is associated with cardiovascular disease risk. In general, muscular lipids are stored either in interstitial adipose tissue (extramyocellular lipid (EMCL)) or in lipid droplets wi...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hasegawa N,Kurihara T,Sato K,Homma T,Fujie S,Fujita S,Sanada K,Hamaoka T,Iemitsu M

    更新日期:2015-12-01 00:00:00

  • Arterial stiffness and fetal growth in normotensive pregnancy.

    abstract:BACKGROUND:Normal pregnancy is characterized by a decrease in peripheral resistance and generalized vasodilation resulting in plasma volume expansion, which is associated with intrauterine growth. Stiffness of the arterial system may be a measure of the degree of plasma volume expansion. Pulse wave velocity (PWV), meas...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Elvan-Taspinar A,Franx A,Bots ML,Koomans HA,Bruinse HW

    更新日期:2005-03-01 00:00:00

  • Different Angiotensin-converting enzyme inhibitors and the associations with overall and cause-specific mortalities in patients with hypertension.

    abstract:BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors have been widely used in the treatment of hypertension, but the comparative effectiveness in reducing mortality among different drugs is seldom reported. METHODS:We identified hypertensive patients who started captopril, enalapril, lisinopril, fosinopril, perin...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Chang CH,Lin JW,Caffrey JL,Wu LC,Lai MS

    更新日期:2015-06-01 00:00:00

  • Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats.

    abstract::Stroke-prone spontaneously hypertensive rats (SHRSP), subjected to high NaCl, show severe hypertension, organ damage, and early death. Preventive treatment with angiotensin II type 1 (AT1) receptor antagonists is known to be effective. Previously, we found that angiotensin converting enzyme (ACE) inhibition could redu...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Blezer EL,Nicolay K,Koomans HA,Joles JA

    更新日期:2001-01-01 00:00:00

  • Serum ionized magnesium: relation to blood pressure and racial factors.

    abstract::To study potential ionic factors predisposing to vascular disease in hypertension, particularly among black subjects, we used a recently developed combined magnesium and calcium specific, ion selective electrode apparatus to measure extracellular ionized calcium (Ca-ion), ionized magnesium (Mg-ion), and Ca-ion/Mg-ion ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Resnick LM,Bardicef O,Altura BT,Alderman MH,Altura BM

    更新日期:1997-12-01 00:00:00

  • Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women.

    abstract::The results of our previous studies suggested that endothelin-1 (ET-1) might be contributory to the impaired uteroplacental blood flow seen in preeclampsia. The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kublickiene KR,Wolff K,Kublickas M,Lindblom B,Lunell NO,Nisell H

    更新日期:1994-07-01 00:00:00

  • Association of blood pressure and cardiovascular mortality in India: Mumbai cohort study.

    abstract:BACKGROUND:To determine all-cause and circulatory system (cardiovascular)-related mortality in subjects with different grades of hypertension, we performed a prospective study. METHODS:A total of 148,173 individuals aged > or =35 years were recruited in Mumbai, India in years 1991-1997. Clinical history and anthropome...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Pednekar MS,Gupta R,Gupta PC

    更新日期:2009-10-01 00:00:00