Platelet and erythrocyte membrane microviscosity in Lyon hypertensive rats.


:The altered membrane microviscosity demonstrated in various cells of spontaneously hypertensive rats (SHR) and essential hypertensive (EH) patients has been proposed to play an important role in the pathogenesis of genetic forms of hypertension. The aim of this study was to evaluate possible changes of membrane microviscosity in platelets and red cell ghosts of Lyon hypertensive (LH) and normotensive (LN) rats. Both erythrocyte and platelet membranes of LH rats had a clear tendency to reduced DPH fluorescence anisotropy reflecting the decreased core membrane microviscosity. On the other hand, there were no changes in TMA-DPH fluorescence anisotropy that characterizes the dynamic properties of the outer membrane leaflet. DPH, but not TMA-DPH, anisotropy correlated negatively with blood pressure. This was true for both red cell ghosts and platelets. Membrane microviscosity had no significant relationship to plasma cholesterol or triglycerides. In platelets, TMA-DPH anisotropy correlated positively with cytosolic free calcium concentration ([Ca2+]i). A similar trend was observed in erythrocytes. In contrast, DPH anisotropy had an inverse relationship to platelet [Ca2+]i. It can be concluded that the alterations of membrane microviscosity seen in LH rats are completely different from those reported in SHR animals and that surface and core membrane microviscosity differ in their relationship to blood pressure and [Ca2+]i.


Am J Hypertens


Le Quan Sang KH,Kunes J,Zicha J,Vincent M,Sassard J,Devynck MA




Has Abstract


1994-03-01 00:00:00














  • Disparate effects of weight loss on insulin sensitivity and erythrocyte sodium-lithium countertransport activity.

    abstract::Previous investigations have demonstrated an association between impaired insulin sensitivity and elevated erythrocyte sodium-lithium countertransport (Na(+)-Li+ CT) activity. It has been speculated that insulin resistance and endogenous hyperinsulinemia are causally related to the development of elevated Na(+)-Li+ CT...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Wolpert HA,Steen SN,Istfan NW,Simonson DC

    更新日期:1992-10-01 00:00:00

  • Blood pressure and cognitive functioning among independent elderly.

    abstract:BACKGROUND:The morbidity and mortality benefits of blood pressure (BP) control for the elderly is well documented. The cognitive consequences of hypertension control in this population, however, are still under debate. We aim to study the association between BP and cognitive performance in the elderly. Specifically, we...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Paran E,Anson O,Reuveni H

    更新日期:2003-10-01 00:00:00

  • An in-depth examination of the excretion of albumin and other sensitive markers of renal damage in mild hypertension.

    abstract::In an in-depth examination to better define the renal effects of mild hypertension, we used urinary proteins to indicate damage to the glomerulus (albumin), tubular reabsorption capability (retinol-binding protein), and turnover of tubular tissue (alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase) in a group ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mueller PW,Hall WD,Caudill SP,MacNeil ML,Arepally A

    更新日期:1995-11-01 00:00:00

  • Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice.

    abstract:BACKGROUND:Granulocyte colony stimulating factor (G-CSF) is a key mediator of neutrophil infiltration and is profibrotic in the liver, lung, and infarcted heart, but its roles in angiotensin II (Ang II)-induced hypertension and cardiac remodeling have not been fully determined. Thus, we sought to investigate the causal...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Jiang HM,Wang HX,Yang H,Zeng XJ,Tang CS,Du J,Li HH

    更新日期:2013-10-01 00:00:00

  • Angiotensin II regulates cytochrome P-450 steroid hydroxylase enzyme expression in human adrenal glomerulosa cells.

    abstract::We have examined the regulation of cytochrome P-450 side chain cleavage enzyme (P-450SCC) and P-45011 beta (18) hydroxylase (P-450(11) beta) enzyme expression by angiotensin II (AII), the major regulator of aldosterone biosynthesis, in cultured human adrenal glomerulosa cells. We also examined the effect of lipoxygena...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Natarajan R,Yang H,Hall PF,Nadler J

    更新日期:1992-11-01 00:00:00

  • Clofibrate acutely reverses saline-induced endothelial dysfunction: role of calcium-activated potassium channels.

    abstract:BACKGROUND:Endothelium-dependent vascular relaxation is impaired in various disease states including hypertension. METHODS:We investigated whether a single bolus dose of clofibrate could rapidly reverse saline-induced endothelial dysfunction, in vivo, in salt-loaded Sprague-Dawley (S-D) rats. S-D rats, 5 weeks of age,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sankaralingam S,Desai KM,Wilson TW

    更新日期:2006-11-01 00:00:00

  • LASSBio-294, A compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca²(+) influx into sarcoplasmic reticulum after myocardial infarction.

    abstract:BACKGROUND:Myocardial infarction (MI) is commonly associated with cardiac hypertrophy, reduced Ca²(+) uptake into the sarcoplasmic reticulum (SR) and impaired myocardial relaxation. Treatment to prevent MI-associated complications is currently lacking. The purpose of the present study was to investigate the remodeling ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Costa DG,da Silva JS,Kümmerle AE,Sudo RT,Landgraf SS,Caruso-Neves C,Fraga CA,de Lacerda Barreiro EJ,Zapata-Sudo G

    更新日期:2010-11-01 00:00:00

  • Association between adducin-1 G460W variant and blood pressure in Swedes is dependent on interaction with body mass index and gender.

    abstract:BACKGROUND:The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body m...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Fava C,Montagnana M,Almgren P,Rosberg L,Guidi GC,Berglund G,Melander O

    更新日期:2007-09-01 00:00:00

  • Increased expression and activity of phospholipase C in renal arterioles of young spontaneously hypertensive rats.

    abstract:BACKGROUND:The aims of this study were to document the presence of phospholipase C (PLC) isozymes beta(1), gamma(1), and delta(1) in freshly isolated renal glomeruli and resistance vessels, to compare their expression and activity to that in aorta, and to contrast values between 6-week-old Wistar-Kyoto (WKY) controls a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Peng Z,Dang A,Arendshorst WJ

    更新日期:2007-01-01 00:00:00

  • Relationship between circulating plasma matrix metalloproteinase-9 (gelatinase-B) concentration and aortic root dilatation.

    abstract:BACKGROUND:Expression of matrix metalloproteinase (MMP) has been shown in aortic dissection and aneurysms indicating increased proteolysis compared with the normal aorta. However, its role in the development of aortic root dilatation has not been studied. We therefore attempted to determine the relationship between aor...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Karakaya O,Barutcu I,Esen AM,Dogan S,Saglam M,Karapinar H,Akgun T,Karavelioglu Y,Esen O,Ozdemir N,Turkmen S,Kaymaz C

    更新日期:2006-04-01 00:00:00

  • Results of the multicenter antihypertensive treatment trials. Therapeutic implications and the role of the sympathetic nervous system.

    abstract::The results of 19 antihypertensive treatment trials spanning some 20 years of research showed that treatment had significant benefits for pressure-related complications of hypertension but generally did not prevent coronary artery disease morbidity or mortality. As possible reasons for this relative failure were explo...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,评审


    authors: Rosenman RH

    更新日期:1989-12-01 00:00:00

  • Plasma norepinephrine changes after arousal and exercise were enhanced in conscious pigs with perinephritic hypertension.

    abstract::This study found that pigs in the early stages of perinephritic hypertension had enhanced plasma norepinephrine (NE) and heart rate (HR) responses to behaviorally arousing stimuli (lifting in a canvas sling) and exercise. In the hypertensive animals, the increase in plasma NE in response to behavioral arousal caused b...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Zhao S,Pinto JM,Bergau D,Lown B,Kirby DA

    更新日期:1993-10-01 00:00:00

  • Hypertension in primary hyperparathyroidism--reduction of blood pressure by long-term treatment with vitamin D (alphacalcidol). A double-blind, placebo-controlled study.

    abstract::Patients with primary hyperparathyroidism (HPT) often have raised blood pressure but a simple cause-and-effect relationship has not been established. In 33 persons with probable primary HPT and mild hypercalcemia detected in a health survey, diastolic blood pressure (DBP) was significantly higher than among age- and s...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Lind L,Wengle B,Wide L,Sörensen OH,Ljunghall S

    更新日期:1988-10-01 00:00:00

  • MIDAS, the Multicenter Isradipine/Diuretic Atherosclerosis Study. Design features and baseline data.

    abstract::The Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS) is a randomized, double-blind, active-control trial to compare the effectiveness of two treatment regimens for the control of hypertension in reducing the rate of progression of early extracranial carotid artery atherosclerosis in hypertensive patients....

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Applegate WB,Byington RP

    更新日期:1991-02-01 00:00:00

  • Relation of left ventricular hypertrophy, afterload, and contractility to left ventricular performance in Goldblatt hypertension.

    abstract::To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-oper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: de Simone G,Devereux RB,Volpe M,Camargo MJ,Wallerson DC,Laragh JH

    更新日期:1992-05-01 00:00:00

  • Differential effects of atrial natriuretic peptide infusion at physiological doses in different postures in humans.

    abstract::To evaluate potential physiological actions of atrial natriuretic peptide (ANP) in humans, normal male volunteers were studied in the supine and head-up tilt positions both in the absence and presence of an ANP infusion at a rate which increased plasma ANP levels to ranges observed during physiological stimuli such as...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Grandis DJ,Uretsky BF,Ray SM,Vassilaros L,Verbalis JG,Puschett JB

    更新日期:1991-03-01 00:00:00

  • Maternal Blood Pressure Before Pregnancy and Sex of the Baby: A Prospective Preconception Cohort Study.

    abstract:BACKGROUND:Population-level sociologic studies have suggested that adverse societal conditions may affect fetal viability in a sex-specific manner and thereby modify the ratio of male vs. female babies. This concept suggests that there may exist certain physiologic features in a woman that relate to her likelihood of d...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Retnakaran R,Wen SW,Tan H,Zhou S,Ye C,Shen M,Smith GN,Walker MC

    更新日期:2017-04-01 00:00:00

  • Is endothelial function of the radial artery altered in human essential hypertension?

    abstract::There is controversy over whether endothelial function is impaired in human essential hypertension. All studies to date have used measurements of forearm blood flow by plethysmography to assess endothelium-dependent vasodilation and endothelial function. In contrast to these studies, which have focused on resistance v...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Schmieder RE,Weihprecht H,Schobel H,John S,Weidinger G,Gatzka C,Veelken R

    更新日期:1997-03-01 00:00:00

  • Gender-specific correlates of leptin with hypertension-related phenotypes in African Americans.

    abstract::Leptin may be a link in the relationship of obesity with hypertension. We evaluated associations of leptin with blood pressure (BP) in 54 normotensive and 114 hypertensive African American individuals. Plasma leptin was higher (P <.03) in hypertensive women than in normotensive women, although body mass index did not ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: El-Gharbawy AH,Kotchen JM,Grim CE,Kaldunski M,Hoffmann RG,Pausova Z,Hamet P,Kotchen TA

    更新日期:2002-11-01 00:00:00

  • Hormone replacement therapy increases plasma level of angiotensin II in postmenopausal hypertensive women.

    abstract::The renin-angiotensin-aldosterone system plays a major role in the pathogenesis of hypertension by enhancing the production or the activity of angiotensin II (ANG II). We evaluated the effects of hormone replacement therapy (HRT) on the renin-angiotensin-aldosterone system and on bradykinin in postmenopausal women (PM...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Umeda M,Ichikawa S,Kanda T,Sumino H,Kobayashi I

    更新日期:2001-03-01 00:00:00

  • Ambulatory blood pressure after acute exercise in older men with essential hypertension.

    abstract::We sought to determine whether reductions in blood pressure in hypertensives after acute exercise persist for more than the 2 to 3 h found in controlled laboratory settings. Subjects (n = 11) were obese (32 +/- 4% body fat), sedentary (VO2max 27 +/- 4 mL/kg/min) 60 +/- 6-year-old men with stage 1 or 2 essential hypert...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Taylor-Tolbert NS,Dengel DR,Brown MD,McCole SD,Pratley RE,Ferrell RE,Hagberg JM

    更新日期:2000-01-01 00:00:00

  • The relationship of electronically monitored physical activity to blood pressure, heart rate, and the circadian blood pressure profile.

    abstract::We studied how closely changes in electronically monitored physical activity are reflected in changes in blood pressure and heart rate in a group of untreated hypertensive subjects. Thirty-nine hypertensive patients (office blood pressure > 140/ 90 mm Hg) of mean age 57 +/- 10 years (mean +/-SD) wore an ambulatory blo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mansoor GA,White WB,McCabe EJ,Giacco S

    更新日期:2000-03-01 00:00:00

  • Blood pressure, brain structure, and cognition: opposite associations in men and women.

    abstract:BACKGROUND:Research on associations between blood pressure, brain structure, and cognitive function has produced somewhat inconsistent results. In part, this may be due to differences in age ranges studied and because of sex differences in physiology and/or exposure to risk factors, which may lead to different time cou...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Cherbuin N,Mortby ME,Janke AL,Sachdev PS,Abhayaratna WP,Anstey KJ

    更新日期:2015-02-01 00:00:00

  • Sodium lithium countertransport and blood pressure. Longitudinal findings.

    abstract::A significant and positive association between red blood cell sodium lithium countertransport (Na-Li CT) and blood pressure has been found in numerous studies. However, the majority of the studies presented to date are cross-sectional in nature and limited information exists on the longitudinal association between Na-...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Trevisan M,Strazzullo P,Cappuccio F,Jossa F,Iacone R,Russo I,Farinaro E

    更新日期:1996-11-01 00:00:00

  • Increased arterial stiffness in pre-eclamptic pregnancy at term and early and late postpartum: a combined echocardiographic and tonometric study.

    abstract:BACKGROUND:Pre-eclampsia (PE) is characterized by hypertension and proteinuria, and complicates from 3%-10% of all pregnancies. The hemodynamic pathophysiology of the heart and systemic arteries in pre-eclamptic patients has not been well described. We therefore performed a comprehensive comparison of the systemic arte...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Estensen ME,Remme EW,Grindheim G,Smiseth OA,Segers P,Henriksen T,Aakhus S

    更新日期:2013-04-01 00:00:00

  • Erythrocyte adducin differential properties in the normotensive and hypertensive rats of the Milan strain. Characterization of spleen adducin m-RNA.

    abstract::Previous studies have shown that erythrocytes from the Milan hypertensive strain of rats (MHS) differ from erythrocytes from the control normotensive strain (MNS). These differences are determined within the stem cells, are genetically associated with the development of hypertension, and are similar to those found bet...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Salardi S,Saccardo B,Borsani G,Modica R,Ferrandi M,Tripodi MG,Soria M,Ferrari P,Baralle FE,Sidoli A

    更新日期:1989-04-01 00:00:00

  • The relation between peripheral vascular structure, left ventricular hypertrophy, and ambulatory blood pressure in essential hypertension.

    abstract::The relations between left ventricular mass (LVM), peripheral resistance artery structure, and ambulatory BP were studied in 83 patients with previously untreated or poorly regulated essential hypertension and 20 healthy controls of similar age and sex. LVM was assessed by echocardiography. Signs of left ventricular h...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sihm I,Schroeder AP,Aalkjaer C,Holm M,Mørn B,Mulvany M,Thygesen K,Lederballe O

    更新日期:1995-10-01 00:00:00

  • Determinants of long-term mortality in patients with type B acute aortic dissection.

    abstract:BACKGROUND:Type B acute aortic dissection (AAD) carries a high short- and midterm mortality rate; however, knowledge related to long-term outcome is largely incomplete. The objective of this study was to identify long-term predictors including antihypertensive medications in type B AAD. METHODS:We conducted a clinical...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sakakura K,Kubo N,Ako J,Fujiwara N,Funayama H,Ikeda N,Nakamura T,Sugawara Y,Yasu T,Kawakami M,Momomura S

    更新日期:2009-04-01 00:00:00

  • Quinapril prevents stroke both during and after the treatment period in stroke-prone spontaneously hypertensive rats.

    abstract::The effects of long-term oral administration of quinapril on the occurrence of stroke and on mortality were investigated in young salt-loaded stroke-prone spontaneously hypertensive rats (SHR-SPs) during the treatment period (8th-34th week of age) and up to 6 weeks thereafter. Simultaneously, blood pressure, saline in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Vacher E,Fornes P,Domergue V,Richer C,Bruneval P,Giudicelli JF

    更新日期:1993-11-01 00:00:00

  • Geographic variation in hypertension prevalence among blacks and whites: the multi-ethnic study of atherosclerosis.

    abstract:BACKGROUND:Many studies have examined differences in hypertension across race/ethnic groups but few have evaluated differences within groups. METHODS:We investigated within-group geographic variations in hypertension prevalence among 3,322 black and white participants of the Multi-Ethnic Study of Atherosclerosis (MESA...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kershaw KN,Diez Roux AV,Carnethon M,Darwin C,Goff DC Jr,Post W,Schreiner PJ,Watson K

    更新日期:2010-01-01 00:00:00