Endothelin: key mediator of hypertension in preeclampsia.


:Preeclampsia is a pregnancy-induced hypertensive disorder characterized by proteinuria and widespread maternal endothelial dysfunction. It remains one of the most common disorders in pregnancy and remains one of the leading causes of maternal and fetal morbidity. Recent research has revealed that placental insufficiency, resulting in hypoxia and ischemia, is a central causative pathway in the development of the disorder. In response, the placenta secretes soluble substances into the maternal circulation which are responsible for the symptomatic phase of the disease. Among the most well characterized factors in the disease pathology are the anti-angiogenic protein soluble fms-like tyrosine kinase-1 (sFlt-1), inflammatory cytokines, and agonistic angiotensin II type-1 receptor autoantibodies. Each of these factors has been shown to induce hypertension experimentally through the production of endothelin-1 (ET-1), a powerful vasoconstrictor. Antagonism of the endothelin-A receptor has proved beneficial in numerous animal models of gestational hypertension, and it remains an intriguing target for pharmacological intervention in preeclampsia.


Am J Hypertens


George EM,Granger JP




Has Abstract


2011-09-01 00:00:00














  • Recent landmark clinical trials: how do they modify the therapeutic paradigm?

    abstract::Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Epstein M

    更新日期:2002-07-01 00:00:00

  • Twenty-four-hour blood pressure control with isradipine in mild essential hypertension.

    abstract::The hypotensive effect of isradipine was assessed in 26 male patients, aged 40 to 64 years, with hypertension. After withdrawal of previous antihypertensive treatment and a four-week placebo period, patients were randomized into a double-blind active-treatment period of eight weeks to receive either placebo or 1.25 to...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Viskoper JR,Laszt A,Faraggi D

    更新日期:1991-02-01 00:00:00

  • Protective action of calcium channel antagonists in atherogenesis and experimental vascular injury.

    abstract::Experimental research using in vitro and in vivo models of vascular injury have delineated several common mechanisms that characterize the arterial damage in diseases such as atherosclerosis and hypertension. Changes in endothelial permeability, smooth muscle cell proliferation, and accumulation of connective tissue m...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Weinstein DB,Heider JG

    更新日期:1989-03-01 00:00:00

  • A novel cell type in the parathyroid glands of spontaneously hypertensive rats.

    abstract::Recently, we described a circulating hypertensive factor, present in the plasma of spontaneously hypertensive rats (SHR). This factor seems to be produced by the parathyroid gland but is not identical to parathyroid hormone (PTH). In view of these findings, we attempted to search for histological differences in parath...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kaneko T,Ohtani R,Lewanczuk RZ,Pang PK

    更新日期:1989-07-01 00:00:00

  • The sympathetic drive after acute myocardial infarction in hypertensive patients.

    abstract:BACKGROUND:Sympathetic activation occurs in hypertension (HT) and after acute myocardial infarction (AMI) and is related to greater cardiovascular risk. Also, AMI in patients with HT (AMI-HT) carries greater risk than that in normal subjects (AMI-NT). We therefore planned to determine whether the sympathetic activation...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hogarth AJ,Mackintosh AF,Mary DA

    更新日期:2006-10-01 00:00:00

  • Association Between Chronic or Acute Use of Antihypertensive Class of Medications and Falls in Older Adults. A Systematic Review and Meta-Analysis.

    abstract:BACKGROUND:Evaluating effect of acute or chronic use of antihypertensives on risk of falls in older adults. METHODS:Data sources: Systematic search of primary research articles in CINAHL, Cochrane, EBM, EMBASE, and MEDLINE databases from January 1 2007 to June 1 2017. Study selection: Research studies of cohort, case-...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kahlaee HR,Latt MD,Schneider CR

    更新日期:2018-03-10 00:00:00

  • New-Onset Resistant Hypertension in a Newly Diagnosed Prostate Cancer Patient.

    abstract:BACKGROUND:New onset resistant hypertension in a previously stable patient with chronic hypertension should lead to consideration of secondary causes. Electrolyte abnormalities are useful clues for identifying some common causes, especially mineralocorticoid excess. CASE PRESENTATION:We report the case of a 69-year-ol...

    journal_title:American journal of hypertension



    authors: Klomjit N,Rowan DJ,Kattah AG,Bancos I,Taler SJ

    更新日期:2019-11-15 00:00:00

  • Blood pressure and angiotensin converting enzyme inhibitor use in hypertensive patients with chronic renal insufficiency.

    abstract:BACKGROUND:Hypertension treatment is important in managing chronic renal insufficiency (CRI). Little is known, however, about the blood pressure (BP) control achieved or the pattern of antihypertensive drug prescription among CRI patients. METHODS:Using computerized medical records, we studied 3,089 adult hypertensive...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hsu CY,Bates DW,Kuperman GJ,Curhan GC

    更新日期:2001-12-01 00:00:00

  • Effect of insulin on renal sodium and uric acid handling in essential hypertension.

    abstract::In normal subjects, insulin decreases the urinary excretion of sodium, potassium, and uric acid. We tested whether these renal effects of insulin are altered in insulin resistant hypertension. In 37 patients with essential hypertension, we measured the changes in urinary excretion of sodium, potassium, and uric acid i...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Muscelli E,Natali A,Bianchi S,Bigazzi R,Galvan AQ,Sironi AM,Frascerra S,Ciociaro D,Ferrannini E

    更新日期:1996-08-01 00:00:00

  • Increased levels of beta-human atrial natriuretic peptide-like immunoreactivity in chronically overloaded atrial tissue.

    abstract::The levels and molecular form of atrial natriuretic peptide-like immunoreactivity (ANP-LI) in human atrial tissue were investigated. The levels of right atrial ANP-LI were significantly higher in mitral disease than in other cardiac or noncardiac diseases. The increased ANP-LI was mainly accounted for by an increase i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Naruse M,Hiroe M,Naruse K,Nagata M,Ohno H,Hashimoto A,Koyanagi H,Sekiguchi M,Demura H,Hirosawa K

    更新日期:1990-02-01 00:00:00

  • Effect of amlodipine on mesangial cell proliferation and protein synthesis.

    abstract::Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shultz PJ,Raij L

    更新日期:1992-12-01 00:00:00

  • An in-depth examination of the excretion of albumin and other sensitive markers of renal damage in mild hypertension.

    abstract::In an in-depth examination to better define the renal effects of mild hypertension, we used urinary proteins to indicate damage to the glomerulus (albumin), tubular reabsorption capability (retinol-binding protein), and turnover of tubular tissue (alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase) in a group ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mueller PW,Hall WD,Caudill SP,MacNeil ML,Arepally A

    更新日期:1995-11-01 00:00:00

  • High K diets markedly reduce atherosclerotic cholesterol ester deposition in aortas of rats with hypercholesterolemia and hypertension.

    abstract::High K diets prevent hypertensive endothelial injury and intimal thickening. Cholesterol esters often deposit during hypercholesterolemia. Would a high K diet influence cholesterol ester deposits? In a normal rat on a normal diet, no cholesterol esters are detected in the aorta. Stroke prone SHR rats were fed for 3 mo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tobian L,Jahner TM,Johnson MA

    更新日期:1990-02-01 00:00:00

  • Arterial stiffness, its assessment, prognostic value, and implications for treatment.

    abstract::Arterial stiffness has been known as a sign of cardiovascular risk since the 19th century. Despite this, accurate measurement and clinical utility have only emerged in recent times. Arterial stiffness and its hemodynamic consequences are now established as predictors of adverse cardiovascular outcome. They are easily ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Adji A,O'Rourke MF,Namasivayam M

    更新日期:2011-01-01 00:00:00

  • The sympathetic nervous system and long-term blood pressure regulation.

    abstract::There is considerable evidence that activation of the sympathetic nervous system plays an important role in the pathogenesis of several cardiovascular diseases, including hypertension. However, the mechanisms that account for sympathetic activation and the precise mechanisms that mediate neurally induced hypertension ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Lohmeier TE

    更新日期:2001-06-01 00:00:00

  • The effect of sodium supplementation on glucose tolerance and insulin concentrations in patients with hypertension and diabetes mellitus.

    abstract::Severe short-term sodium restriction or extreme sodium loading may alter glucose tolerance and insulin resistance in patients with hypertension, but it is unclear whether variations in sodium intake within the clinically observed range affect glucose tolerance. To examine this issue, 21 patients with primary hypertens...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Ames RP

    更新日期:2001-07-01 00:00:00

  • Effects of calcium channel and renin-angiotensin system blockade on intravascular and neurohormonal mechanisms of hypertensive vascular disease.

    abstract::Several classes of antihypertensive drugs have been shown to improve vascular function through mechanisms other than reducing blood pressure (BP) alone. Certain dihydropyridine calcium channel blockers (CCBs) and inhibitors of the renin-angiotensin system (RAS) increase nitric oxide (NO) bioavailability and decrease o...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Mizuno Y,Jacob RF,Mason RP

    更新日期:2008-10-01 00:00:00

  • Increase of calmodulin activator in hypertension. Modulation by dietary sodium and calcium.

    abstract::The aim of this study was to investigate the effects of dietary calcium and sodium on blood pressure (BP) in normotensive rats (Wistar, WKY), spontaneously hypertensive rats (SHR) and Dahl rats and on calmodulin (CaM) activator, a newly-discovered hydrophobic compound that increases CaM activity in SHR and spontaneous...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Chang E,Kunes J,Hamet P,Tremblay J

    更新日期:1990-08-01 00:00:00

  • Maternal Blood Pressure Before Pregnancy and Sex of the Baby: A Prospective Preconception Cohort Study.

    abstract:BACKGROUND:Population-level sociologic studies have suggested that adverse societal conditions may affect fetal viability in a sex-specific manner and thereby modify the ratio of male vs. female babies. This concept suggests that there may exist certain physiologic features in a woman that relate to her likelihood of d...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Retnakaran R,Wen SW,Tan H,Zhou S,Ye C,Shen M,Smith GN,Walker MC

    更新日期:2017-04-01 00:00:00

  • Contributions of hypoxia and respiratory disturbance index to sympathetic activation and blood pressure in obstructive sleep apnea syndrome.

    abstract::Hypertension is a common finding among obstructive sleep apnea (OSA) patients, and is thought to be caused by sympathetic hyperactivity. The present study compares the contributions of the respiratory disturbance index (RDI) as a reflection of sleep fragmentation, and the magnitude of oxygen desaturation, to sympathet...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Peled N,Greenberg A,Pillar G,Zinder O,Levi N,Lavie P

    更新日期:1998-11-01 00:00:00

  • Renovascular hypertension induces myocardial mitochondrial damage, contributing to cardiac injury and dysfunction in pigs with metabolic syndrome.

    abstract:BACKGROUND:Subjects with renovascular hypertension (RVH) often manifest with metabolic syndrome (MetS) as well. Coexisting MetS and hypertension increases cardiovascular morbidity and mortality, but the mechanisms underlying cardiac injury remain unknown. We hypothesized that superimposition of MetS induces myocardial ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Aghajani Nargesi A,Farah MC,Zhu XY,Zhang L,Tang H,Jordan KL,Saadiq IM,Lerman A,Lerman LO,Eirin A

    更新日期:2020-12-05 00:00:00

  • Expression of Na+-K+ -2Cl- cotransporter 1 is epigenetically regulated during postnatal development of hypertension.

    abstract:BACKGROUND:The expression of Na(+)-K(+)-2Cl(-) cotransporter 1 (NKCC1) is upregulated in spontaneously hypertensive rat (SHR). We investigated whether expression of NKCC1 is epigenetically regulated during postnatal development of hypertension. METHODS:The mesenteric arteries from 5-, 10-, and 18-week-old Wistar-Kyoto...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Cho HM,Lee HA,Kim HY,Han HS,Kim IK

    更新日期:2011-12-01 00:00:00

  • Fixed-dose combination therapy with trandolapril and verapamil SR is effective in primary hypertension. Trandolapril Study Group.

    abstract::We assessed the efficacy of monotherapy with trandolapril, an angiotensin converting enzyme (ACE) inhibitor, and of verapamil slow-release (SR), a calcium antagonist, each in a range of three doses as monotherapy, and in the nine possible combinations of therapy in patients with stage I to III diastolic hypertension. ...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: DeQuattro V,Lee D

    更新日期:1997-07-01 00:00:00

  • Effects of a human-derived sodium transport inhibitor on in vitro vascular reactivity.

    abstract::Concentrations of sodium-transport inhibitors (STI) which block the sodium-potassium-ATPase pump are increased in the plasma and urine of volume-expanded and low-renin hypertensive humans and animals. To evaluate the physiologic relevance of STI to blood-pressure-raising mechanisms, we have examined the in vitro prope...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Weber MA,Weiler E,Gonick HC,Prins BA,Purdy RE

    更新日期:1989-10-01 00:00:00

  • How to explain the differences between renin angiotensin system modulators.

    abstract::Angiotensin II (Ang II) plays important roles in the development of cardiovascular diseases including hypertension, renal diseases, cardiac hypertrophy, congestive heart failure, and ischemic heart disease. Angiotensin II exerts classic hemodynamic and renal effects, but it is also a local biologically active mediator...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Levy BI

    更新日期:2005-09-01 00:00:00

  • Different normalizations for body size and population attributable risk of left ventricular hypertrophy: the MAVI study.

    abstract:BACKGROUND:Different methods of normalizing left ventricular (LV) mass for body size identify generally similar relative risks of adverse cardiovascular outcome but with variable prevalences of LV hypertrophy (H). Preliminary results from a population with high prevalence of obesity suggest that the population attribut...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: de Simone G,Devereux RB,Maggioni AP,Gorini M,de Divitiis O,Verdecchia P,MAVI (MAssa Ventricolare sinistra nell'Ipertensione) Study Group.

    更新日期:2005-10-01 00:00:00

  • A New Proposal for the Target Value for Home BP in Type 2 Diabetes Patients: The J-HOP Study.

    abstract:OBJECTIVE:The target levels of home-monitored blood pressure (BP) in patients with type 2 diabetes mellitus (T2DM) have not yet been established. We sought to examine the appropriate target home BP level in T2DM. METHODS:This is a subanalysis of the Japan Morning Surge-Home Blood Pressure (J-HOP) study. We enrolled 4,...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Eguchi K,Hoshide S,Komori T,Nagasaka S,Kario K

    更新日期:2015-08-01 00:00:00

  • R Wave in aVL Lead is a Robust Index of Left Ventricular Hypertrophy: A Cardiac MRI Study.

    abstract:BACKGROUND:In patients free from overt cardiac disease, R wave in aVL lead (RaVL) is strongly correlated with left ventricular mass index (LVMI) assessed by transthoracic echocardiography. The aim of the present study was to extend this finding to other settings (cardiomyopathy or conduction disorders), by comparing EC...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Courand PY,Grandjean A,Charles P,Paget V,Khettab F,Bricca G,Boussel L,Lantelme P,Harbaoui B

    更新日期:2015-08-01 00:00:00

  • Protein phosphorylation and intracellular free calcium in platelets of patients with essential hypertension.

    abstract::Platelet intracellular free calcium concentration [Ca2+]i from patients with essential hypertension has been found to be elevated, but the intracellular effects of this increase are still unclear. As protein phosphorylation is an important regulatory step in cell activation and increased protein phosphorylation has be...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Haller H,Lindschau C,Quass P,Distler A

    更新日期:1992-03-01 00:00:00

  • Aspirin test for differentiation of unilateral renovascular hypertension from hyperreninemic essential hypertension.

    abstract::Responses of renin release and blood pressure to aspirin DL-lysine (ASP) were examined to find out if the responses could help in the differentiation between unilateral renovascular hypertension (RVH) and hyperreninemic essential hypertension (EHT). The two studies involved ten patients with unilateral RVH, eight with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Imanishi M,Ohta M,Kawamura M,Akabane S,Matsushima Y,Kuramochi M,Kojima S,Kimura K,Takamiya M,Ito K

    更新日期:1991-09-01 00:00:00