Endothelin: key mediator of hypertension in preeclampsia.

abstract：BACKGROUND:Although insulin resistance and metabolic syndrome are often used synonymously, concordance is not established. METHODS:Metabolic, hemodynamic, and hormonal data were analyzed on 141 patients in the Trial of Preventing Hypertension (TROPHY) Sub-Study with high-normal blood pressure (BP) (130 to 139/85 to 89...

journal_title：American journal of hypertension

authors： Egan BM,Papademetriou V,Wofford M,Calhoun D,Fernandes J,Riehle JE,Nesbitt S,Michelson E,Julius S,TROPHY Sub-study Investigative Team.

更新日期：2005-01-01 00:00:00

abstract：:In a retrospective study we investigated the effects of altering treatment of type II diabetes mellitus from insulin to tolazamide on weight and blood pressure. In 17 patients, weight decreased from 136 +/- 6 to 131 +/- 6% of ideal body weight (P = .01). Even though weight loss occurred, mean systolic blood pressure i...

journal_title：American journal of hypertension

authors： Schmitt JK,Johns SB

更新日期：1995-05-01 00:00:00

abstract：BACKGROUND:The aim of this study was to test the hypothesis that angiotensin converting enzyme inhibition or angiotensin II antagonism can counteract cardiac human vascular endothelial growth factor-A165 (phVEGF-A165) induced angiogenesis. METHODS:Mice were given a single intramyocardial injection of phVEGF-A165. Eith...

journal_title：American journal of hypertension

authors： Siddiqui AJ,Mansson-Broberg A,Gustafsson T,Grinnemo KH,Dellgren G,Hao X,Fischer H,Sylvén C

更新日期：2005-10-01 00:00:00

abstract：:Neutral metalloendopeptidase (NEP) inhibitors delay atrial natriuretic factor (ANF) catabolism and potentiate biological responses to ANF. We describe biochemical and pharmacological profiles of a novel NEP inhibitor, SCH 42354 (N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-4-oxopropyl]-L-methionine and its orally activ...

journal_title：American journal of hypertension

authors： Watkins RW,Vemulapalli S,Chiu PJ,Foster C,Smith EM,Neustadt B,Haslanger M,Sybertz EJ

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Inadequately treated hypertension (HTN) leads to considerable morbidity and mortality. Despite many treatment options, blood pressure (BP) control is suboptimal. Missed opportunities due to the growing complexity of primary care office visits contribute. Electronic health records (EHRs) offer best practice a...

journal_title：American journal of hypertension

authors： Swedlund M,Norton D,Birstler J,Chen G,Cruz L,Hanrahan L

更新日期：2019-01-01 00:00:00

abstract：:We tested the reproducibility of ambulatory blood pressure monitoring (ABPM) by the use of agreement plots. Thirty-two normotensive volunteers underwent ABPM on four separate days (interval 28 days), on the same typical weekday. Sleeping time was restricted to the ABPM nighttime subperiod from 11:00 PM to 7:00 AM. Twe...

journal_title：American journal of hypertension

authors： Musso NR,Vergassola C,Barone C,Lotti G

更新日期：1997-08-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors (ACEIs), introduced in clinical practice in 1980, are a relatively new class of drugs. They have been useful in the treatment of hypertension, where they are effective monotherapy in 40% to 50% of the patients and in combination therapy in up to 90%. They are also useful in the...

journal_title：American journal of hypertension

authors： Kostis JB

更新日期：1989-01-01 00:00:00

abstract：:We studied the role of the sympathetic nervous system and the renin angiotensin system for pressure induced left ventricular hypertrophy (LVH) in 135 rats with experimental supravalvular aortic stenosis (AS). We induced this condition by a silver clip on the ascending aorta, when body weight (BW) was 90 to 100 g. Symp...

journal_title：American journal of hypertension

authors： Kromer EP,Elsner D,Riegger GA

更新日期：1991-06-01 00:00:00

abstract：:Endothelin-1 is a potent vasoconstrictor peptide produced in blood vessels and other tissues that may play an important role in the control of local blood flow and could be involved in the pathogenesis of hypertension. Our previous studies have documented increases in endothelin-1 peptide content and gene expression i...

journal_title：American journal of hypertension

authors： Day R,Larivière R,Schiffrin EL

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Hypertension and proteinuria are risk factors for adverse renal outcomes in patients with chronic kidney disease. This study investigated the associations of blood pressure and proteinuria on renal function in a community-based population. METHODS:We analyzed data from a nationwide database of 141,514 subje...

journal_title：American journal of hypertension

authors： Hirayama A,Konta T,Kamei K,Suzuki K,Ichikawa K,Fujimoto S,Iseki K,Moriyama T,Yamagata K,Tsuruya K,Kimura K,Narita I,Kondo M,Asahi K,Kurahashi I,Ohashi Y,Watanabe T

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:Most patients with hypertension require more than one agent to control blood pressure (BP). The purpose of this study was to assess the efficacy and safety of the angiotensin II receptor blocker olmesartan medoxomil in combination with hydrochlorothiazide (HCTZ). METHODS:This was a randomized, double-blind,...

journal_title：American journal of hypertension

authors： Chrysant SG,Weber MA,Wang AC,Hinman DJ

更新日期：2004-03-01 00:00:00

abstract：:To clarify the function of polymorphonuclear leukocytes (PMN) in spontaneously hypertensive rats (SHR) and the effect of beraprost sodium (BS) on these functions, we examined superoxide anion (O2-) production and adherent activity by PMN, as well as modification of these functions by BS ex vivo and in vitro. In study ...

journal_title：American journal of hypertension

authors： Ohmori M,Kitoh Y,Kawaguchi A,Harada K,Sugimoto K,Fujimura A

更新日期：2001-07-01 00:00:00

abstract：:Echocardiography (ECHO) is useful to document changes in left ventricular mass (LVM) in groups of patients, but may be too variable for use in the individual patient. Magnetic resonance imaging (MRI) may be a more precise and reliable method to quantify the mass of the left ventricule. This study reports the accuracy,...

journal_title：American journal of hypertension

authors： Bottini PB,Carr AA,Prisant LM,Flickinger FW,Allison JD,Gottdiener JS

更新日期：1995-03-01 00:00:00

abstract：:Angiotensin II (Ang II) plays important roles in the development of cardiovascular diseases including hypertension, renal diseases, cardiac hypertrophy, congestive heart failure, and ischemic heart disease. Angiotensin II exerts classic hemodynamic and renal effects, but it is also a local biologically active mediator...

journal_title：American journal of hypertension

authors： Levy BI

更新日期：2005-09-01 00:00:00

abstract：:Alcohol consumption has been recognized as an important correlate of blood pressure in many epidemiologic studies, but few interventional studies have been conducted to examine the effect of a reduction in alcohol intake on blood pressure. Because these studies have usually included few subjects and been of short dura...

journal_title：American journal of hypertension

authors： Cushman WC,Cutler JA,Bingham SF,Harford T,Hanna E,Dubbert P,Collins JF,Dufour M,Follman D,Allender PS

更新日期：1994-09-01 00:00:00

abstract：BACKGROUND:The adverse association between blood pressure and carotid artery intima-media thickness (IMT), a surrogate measure of subclinical atherosclerosis, is well-known. However, whether the G-6A polymorphism of the angiotensinogen (AGT) gene, a candidate gene of hypertension and vascular remodeling, modulates this...

journal_title：American journal of hypertension

authors： Bhuiyan AR,Chen W,Srinivasan SR,Rice J,Mock N,Tang R,Bond MG,Boerwinkle E,Berenson GS

更新日期：2007-10-01 00:00:00

abstract：:We assessed the efficacy of monotherapy with trandolapril, an angiotensin converting enzyme (ACE) inhibitor, and of verapamil slow-release (SR), a calcium antagonist, each in a range of three doses as monotherapy, and in the nine possible combinations of therapy in patients with stage I to III diastolic hypertension. ...

journal_title：American journal of hypertension

authors： DeQuattro V,Lee D

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Hypertension treatment is important in managing chronic renal insufficiency (CRI). Little is known, however, about the blood pressure (BP) control achieved or the pattern of antihypertensive drug prescription among CRI patients. METHODS:Using computerized medical records, we studied 3,089 adult hypertensive...

journal_title：American journal of hypertension

authors： Hsu CY,Bates DW,Kuperman GJ,Curhan GC

更新日期：2001-12-01 00:00:00

abstract：:Recent publications purporting to show that calcium antagonists, when used for the treatment of hypertension or in the post myocardial infarction patient, would paradoxically increase the rate of heart attack and mortality have cast doubts on the safety and efficacy of this drug class. All three studies are retrospect...

journal_title：American journal of hypertension

authors： Messerli FH

更新日期：1996-12-01 00:00:00

abstract：:Previous assessment of beta-adrenoceptor function has shown alterations in essential hypertension (EH). In the present study, we compared lymphocyte beta-adrenoceptor density (Bmax) and adenylate cyclase (AC) activity stimulated by l-isoproterenol, Gpp(NH)p, Gpp(NH)p + l-isoproterenol, and forskolin in 46 patients wit...

journal_title：American journal of hypertension

authors： Yurenev AP,Parfyonova EV,Krasnikova TL,Aripova NA

更新日期：1992-06-01 00:00:00

abstract：:A wide pulse pressure (PP) may constitute an independent predictor of cardiovascular morbidity and mortality. We assessed the reference values of brachial clinic PP, according to age and gender in a nonselected population (61,724 subjects) who were undergoing a routine systematic health examination. According to mean ...

journal_title：American journal of hypertension

authors： Asmar R,Vol S,Brisac AM,Tichet J,Topouchian J

更新日期：2001-05-01 00:00:00

abstract：:Essential hypertension is often accompanied by abnormalities of the coagulation/fibrinolytic system, predisposing to a procoagulant state. The aim of the present study was to compare the effects of atenolol (beta1-blocker agent) and irbesartan (angiotensin II type 1 receptor antagonist) on plasma levels of hemostatic/...

journal_title：American journal of hypertension

authors： Makris TK,Stavroulakis GA,Krespi PG,Hatzizacharias AN,Triposkiadis FK,Tsoukala CG,Votteas VV,Kyriakidis MK

更新日期：2000-07-01 00:00:00

abstract：:Ca2+ efflux from cultured vascular smooth muscle cells (VSMC) consists of two mechanisms: one is dependent on extracellular sodium, mediated by the Na(+)-Ca2+ exchange (Na+o-dependent Ca2+ efflux), and the other is independent of extracellular sodium but is mediated by the Ca(2+)-pump (Na+o-independent Ca2+ efflux). I...

journal_title：American journal of hypertension

authors： Chen S,Roufogalis BD

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Although previous studies have explored the effect of smoking on blood pressure, little is still known about the role of time to first cigarette (TTFC)-an indicator of nicotine dependence-in hypertension. Therefore, we evaluated this association using representative nationwide data. METHODS:Current daily sm...

journal_title：American journal of hypertension

authors： Bae J,Yi YH,Kim YJ,Lee JG,Tak YJ,Lee SH,Hwang HR,Lee SY,Cho YH,Ro EJ

更新日期：2019-01-15 00:00:00

abstract：:Angiotension converting enzyme (ACE) inhibitors and beta-blockers have been reported to possess disparate effects on insulin sensitivity. The aim of this study was to study the effects of the selective beta-1 blocker bisoprolol and of the ACE inhibitor captopril on cellular insulin action in hypertensive individuals. ...

journal_title：American journal of hypertension

authors： Dominguez LJ,Barbagallo M,Jacober SJ,Jacobs DB,Sowers JR

更新日期：1997-12-01 00:00:00

abstract：:Body sodium works together with the plasma renin-angiotensin system to ensure adequate blood flow to the tissues. Body sodium content determines the extracellular fluid (ECF) volume ensuring that, with each heart beat, a sufficient volume of fluid is delivered into the arterial space. At the same time the kidneys moni...

journal_title：American journal of hypertension

authors： Laragh JH,Sealey JE

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:The renin-angiotensin system (RAS) plays a major role in promoting left ventricular (LV) remodeling in essential hypertension. We designed a controlled, randomized pilot study aimed to test the hypothesis that the dual RAS blockade with angiotensin-converting enzyme (ACE) inhibitor (ACEi) + angiotensin II re...

journal_title：American journal of hypertension

authors： Grandi AM,Solbiati F,Laurita E,Maresca AM,Nicolini E,Marchesi C,Gianni M,Guasti L,Venco A

更新日期：2008-02-01 00:00:00

abstract：:Blood pressure is reportedly elevated in the spontaneously hypertensive rat (SHR) neonate, the etiology of which remains unclear. Aberrations in the hypothalamic-pituitary-adrenal axis have been implicated, as it is well accepted that excess corticosteroids are associated with hypertension. We examined aspects of adre...

journal_title：American journal of hypertension

authors： Malee MP,Wu KY

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Obesity has been described as a predictor of cardiovascular mortality, and some studies have reported an association with obesity and increased aortic stiffness. Other studies have not identified obesity to be an independent risk factor. Therefore, the purpose of our study was to determine the association be...

journal_title：American journal of hypertension

authors： Rodrigues SL,Baldo MP,Lani L,Nogueira L,Mill JG,Sa Cunha Rd

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Beetroot has attracted much attention because of its blood pressure-lowering properties. Although beetroot contains various nutritional compounds, including inorganic nitrate, some of their physiological properties are not fully understood. In this study, we examined whether betanin, a beetroot component, ha...

journal_title：American journal of hypertension

authors： Tawa M,Masuoka T,Yamashita Y,Nakano K,Ishibashi T

更新日期：2020-04-01 00:00:00