Angiotensin converting enzyme inhibitors suppress the vascular renin-angiotensin system of spontaneously hypertensive rats.

abstract：:Plasma glucose and insulin responses to an oral glucose challenge and insulin-stimulated glucose uptake were measured in 47 age-, weight-, and sex-matched lean white men (16 with normal blood pressure, 14 with untreated hypertension, nine treated with a thiazide diuretic only, and eight treated with combined diuretic ...

journal_title：American journal of hypertension

authors： Swislocki AL,Hoffman BB,Reaven GM

更新日期：1989-06-01 00:00:00

abstract：:The polymorphism of the angiotensin-converting enzyme gene is considered to be associated with increased risk for stroke, but there is a diversity in the results obtained. The genetic involvement of the renin-angiotensin system in stroke also remains unclear. To predict the genetic risk of lacunar infarction, we condu...

journal_title：American journal of hypertension

authors： Takami S,Imai Y,Katsuya T,Ohkubo T,Tsuji I,Nagai K,Satoh H,Hisamichi S,Higaki J,Ogihara T

更新日期：2000-02-01 00:00:00

abstract：:To study the circulating humoral factor modifying transmembrane sodium transport, plasma was obtained from 12 patients with essential hypertension (EH) fed a high sodium diet (NaCl 15 to 17 g/d) for seven days and thereafter a low sodium diet (NaCl 2 to 3 g/d) for seven days. Ouabain-sensitive 86Rb+ influx into the re...

journal_title：American journal of hypertension

authors： Ashida T,Kuramochi M,Kojima S,Yoshimi H,Kawano Y,Kimura G,Abe H,Imanishi M,Yoshida K,Kawamura M

更新日期：1989-07-01 00:00:00

abstract：:The effects of long-term oral administration of quinapril on the occurrence of stroke and on mortality were investigated in young salt-loaded stroke-prone spontaneously hypertensive rats (SHR-SPs) during the treatment period (8th-34th week of age) and up to 6 weeks thereafter. Simultaneously, blood pressure, saline in...

journal_title：American journal of hypertension

authors： Vacher E,Fornes P,Domergue V,Richer C,Bruneval P,Giudicelli JF

更新日期：1993-11-01 00:00:00

abstract：:Nitric oxide synthase (NOS) blockade increases blood pressure (BP) and modifies glomerular and tubular function. Angiotensin II (AII) blockade restores glomerular and tubular function but does not lower BP. We measured plasma renin activity (PRA), plasma (AIIp), and kidney tissue (AIIk) AII with radioimmunoassay to in...

journal_title：American journal of hypertension

authors： Garcia GE,Brown MR,Wead LM,Braun S,Gabbai FB

更新日期：1997-10-01 00:00:00

abstract：BACKGROUND:The direct renin inhibitor aliskiren is known to exhibit a strong antihypertensive effect. However, the organoprotective potential of aliskiren beyond its antihypertensive properties is less clear. This study investigates the antifibrotic nephroprotective effects of aliskiren in a nonhypertensive mouse model...

journal_title：American journal of hypertension

authors： Gross O,Girgert R,Rubel D,Temme J,Theissen S,Müller GA

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Left ventricular (LV) concentric geometry and hypertrophy, depressed wall mechanics, and abnormal diastolic properties have been described in the diabetic heart. However, the cardiac response to dynamic exercise in diabetic patients remains controversial. The present study assessed strain rate (SR) imaging d...

journal_title：American journal of hypertension

authors： Galderisi M,de Simone G,Innelli P,Turco A,Turco S,Capaldo B,Riccardi G,de Divitiis O

更新日期：2007-05-01 00:00:00

abstract：:Post-transplant hypertension remains an important risk factor for cardiovascular mortality and graft function. There are multiple mechanisms responsible for post-transplant hypertension. The details of these mechanisms are poorly understood. Steroids, acute and chronic rejection, recurrent renal disease, native kidney...

journal_title：American journal of hypertension

authors： Laskow DA,Curtis JJ

更新日期：1990-09-01 00:00:00

abstract：:Neutral metalloendopeptidase (NEP) inhibitors delay atrial natriuretic factor (ANF) catabolism and potentiate biological responses to ANF. We describe biochemical and pharmacological profiles of a novel NEP inhibitor, SCH 42354 (N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-4-oxopropyl]-L-methionine and its orally activ...

journal_title：American journal of hypertension

authors： Watkins RW,Vemulapalli S,Chiu PJ,Foster C,Smith EM,Neustadt B,Haslanger M,Sybertz EJ

更新日期：1993-05-01 00:00:00

abstract：:We have examined the regulation of cytochrome P-450 side chain cleavage enzyme (P-450SCC) and P-45011 beta (18) hydroxylase (P-450(11) beta) enzyme expression by angiotensin II (AII), the major regulator of aldosterone biosynthesis, in cultured human adrenal glomerulosa cells. We also examined the effect of lipoxygena...

journal_title：American journal of hypertension

authors： Natarajan R,Yang H,Hall PF,Nadler J

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components. METHODS:To localize the genetic effects of pulse pressure, we conducted a genome-wide linkage analysis of 1,892 American-Indian participants of the Strong Heart Family Study (SH...

journal_title：American journal of hypertension

authors： Franceschini N,MacCluer JW,Rose KM,Rutherford S,Cole SA,Laston S,Göring HH,Diego VP,Roman MJ,Lee ET,Best LG,Howard BV,Fabsitz RR,North KE

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats. METHO...

journal_title：American journal of hypertension

authors： Hye Khan MA,Neckář J,Haines J,Imig JD

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Strong associations between blood pressure (BP) and overweight raise the question whether overweight children (body mass index (BMI) ≥85th percentile) should be included in the normative database. METHODS:Using the LMS (Lamda-Mu-Sigma) method, we developed age-, gender-, and height-adjusted percentile curve...

journal_title：American journal of hypertension

authors： Schwandt P,Scholze JE,Bertsch T,Liepold E,Haas GM

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:We examined data from a cohort of Caucasian women for evidence of an association between serum vitamin D (25-hydroxyvitamin D (25(OH)D)) insufficiency and greater risk of systolic hypertension in the population-based longitudinal Michigan Bone Health and Metabolism Study (MBHMS). METHODS:The cohort includes...

journal_title：American journal of hypertension

authors： Griffin FC,Gadegbeku CA,Sowers MR

更新日期：2011-03-01 00:00:00

abstract：:There are a variety of radiopharmaceuticals that can be used to perform captopril renography effectively. We examined a number of technetium and iodine compounds and the circumstances under which each radiopharmaceutical compound is the compound of choice. Considerations of cost, ease of use, reliability, dosage, and ...

journal_title：American journal of hypertension

authors： Blaufox MD,Dubovsky EV,Hilson AJ,Taylor A Jr,de Zeeuw R

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:The W allele of the G460W polymorphism in the adducin-1 gene has been occasionally associated with increased blood pressure (BP). The aim of this study was to test whether the G460W variant is associated with BP levels and BP progression rate and whether G460W associations with BP are affected by sex, body m...

journal_title：American journal of hypertension

authors： Fava C,Montagnana M,Almgren P,Rosberg L,Guidi GC,Berglund G,Melander O

更新日期：2007-09-01 00:00:00

abstract：:The aim of this study was to investigate the effects of dietary calcium and sodium on blood pressure (BP) in normotensive rats (Wistar, WKY), spontaneously hypertensive rats (SHR) and Dahl rats and on calmodulin (CaM) activator, a newly-discovered hydrophobic compound that increases CaM activity in SHR and spontaneous...

journal_title：American journal of hypertension

authors： Chang E,Kunes J,Hamet P,Tremblay J

更新日期：1990-08-01 00:00:00

abstract：:The regulation of atrial natriuretic peptide (ANP) synthesis within cardiac atrial myocytes was investigated in 8 patients undergoing cardiac surgery (valve replacement or coronary bypass graft). Hemodynamic data were obtained during cardiac catheterization and venous plasma samples for ANP were withdrawn prior to sur...

journal_title：American journal of hypertension

authors： Haass M,Fischer TA,Hänze J,Saggau W,Lang RE,Dietz R

更新日期：1990-03-01 00:00:00

abstract：:Left ventricular hypertrophy (LVH) has been identified as one of the strongest blood pressure-independent risk factors for sudden death, acute myocardial infarction, congestive heart failure, and other cardiovascular morbidity and mortality. Hypertensive patients with LVH have a significantly greater prevalence of pre...

journal_title：American journal of hypertension

authors： Messerli FH

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:Carotid-femoral pulse-wave velocity (PWV) provides a comprehensive noninvasive indication of arterial stiffness, and is now established as a strong marker of cardiovascular disease (CVD). The correlation between peripheral blood pressure (BP) and PWV and their respective influences on mortality have been poo...

journal_title：American journal of hypertension

authors： Miljkovic D,Perret-Guillaume C,Alla F,Salvi P,Erpelding ML,Benetos A

更新日期：2013-02-01 00:00:00

abstract：:Using a new ion selective electrode (ISE) to measure ionized magnesium (IMg2+), we compared levels of IMg2+ with total magnesium (TMg) and serum ionized calcium levels (ICa2+) in umbilical arterial and venous serum of 13 parturients who developed transient hypertension in labor with levels in 38 who remained normotens...

journal_title：American journal of hypertension

authors： Handwerker SM,Altura BT,Royo B,Altura BM

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers (CCBs) increase arterial compliance and decrease left ventricular mass in hypertensive patients. This study examined whether combined therapy has greater arterial and cardiac effects than doubled doses of the individual drugs. METHO...

journal_title：American journal of hypertension

authors： Neutel JM,Smith DH,Weber MA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Beetroot has attracted much attention because of its blood pressure-lowering properties. Although beetroot contains various nutritional compounds, including inorganic nitrate, some of their physiological properties are not fully understood. In this study, we examined whether betanin, a beetroot component, ha...

journal_title：American journal of hypertension

authors： Tawa M,Masuoka T,Yamashita Y,Nakano K,Ishibashi T

更新日期：2020-04-01 00:00:00

abstract：:Apart from the well-known role of hypertension in cerebrovascular disease, visit-to-visit blood pressure (BP) variability is emerging as an independent risk factor for stroke. Although the underlying mechanism is not fully understood, artery remodeling is thought to be closely involved in the relationship between visi...

journal_title：American journal of hypertension

authors： Nagai M,Kario K

更新日期：2013-12-01 00:00:00

abstract：:We have previously reported that young, primigravid, African-American women who developed preeclampsia exhibited insulin resistance (elevated fasting insulin:glucose ratios) and abnormal intracellular free calcium ([Ca2+]i) metabolism as early as the second trimester of pregnancy. To determine if these abnormalities p...

journal_title：American journal of hypertension

authors： Sowers JR,Standley PR,Jacober S,Niyogi T,Simpson L

更新日期：1993-04-01 00:00:00

abstract：:Arterial stiffness has been known as a sign of cardiovascular risk since the 19th century. Despite this, accurate measurement and clinical utility have only emerged in recent times. Arterial stiffness and its hemodynamic consequences are now established as predictors of adverse cardiovascular outcome. They are easily ...

journal_title：American journal of hypertension

authors： Adji A,O'Rourke MF,Namasivayam M

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Renal tubulointerstitial infiltration of activated T cells and macrophages is invariably present and plays a role in elevation of arterial pressure in nearly all animal models of hypertension (HTN). The role, if any, of elevated renal arterial pressure in the pathogenesis of this inflammatory process is unce...

journal_title：American journal of hypertension

authors： Rodriguez-Iturbe B,Quiroz Y,Kim CH,Vaziri ND

更新日期：2005-11-01 00:00:00

abstract：:Leptin, the gene product of the ob gene, is influenced by gender and insulin sensitivity. Because in human hypertension there are important endocrine-hemodynamic gender-dependent differences, we compared plasma leptin in 39 essential hypertensives (EH) and in 27 normotensive healthy subjects (HS) matched for gender, a...

journal_title：American journal of hypertension

authors： Mallamaci F,Cuzzola F,Tripepi G,Cutrupi S,Parlongo S,Tripepi R,Zoccali C

更新日期：2000-08-01 00:00:00

abstract：:The increased red blood cell Li+/Na+ exchange found in a subgroup of patients with essential hypertension (EH) may reflect an increased activity of the Na+/H+ exchange. The maximal velocity of the red cells' Na+/H+ (Na+ influx promoted by an outward H+ gradient) and Li+/Na+ (Li+ efflux promoted by external Na+) exchan...

journal_title：American journal of hypertension

authors： Semplicini A,Canessa M,Mozzato MG,Ceolotto G,Marzola M,Buzzaccarini F,Casolino P,Pessina AC

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:Exaggerated sympathetic cardiovascular (CV) reactivity to stress associates with elevated risk for clinical and preclinical end points of CV disease. It would be useful to identify these individuals, preferably from feasible measurements commonly used in health care. Our study examined the association betwee...

journal_title：American journal of hypertension

authors： Hintsala HE,Kiviniemi AM,Antikainen R,Mäntysaari M,Jokelainen J,Hassi J,Tulppo MP,Herzig KH,Keinänen-Kiukaanniemi S,Rintamäki H,Jaakkola JJK,Ikäheimo TM

更新日期：2019-05-09 00:00:00