Increase of calmodulin activator in hypertension. Modulation by dietary sodium and calcium.

abstract：:Nonsteroidal anti-inflammatory drugs interfere with certain antihypertensive therapies. In a double-blind study, 385 hypertensive patients stabilized on an angiotensin converting enzyme inhibitor were treated with nabumetone, celecoxib, ibuprofen, or placebo for 4 weeks. Ibuprofen caused significantly greater increase...

journal_title：American journal of hypertension

authors： Palmer R,Weiss R,Zusman RM,Haig A,Flavin S,MacDonald B

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:About one-half of all hypertensive adults do not have their blood pressure controlled. They are often prescribed medications that conform to national guidelines but they continue to have elevated blood pressure. This public health problem might be improved by applying plasma renin guided therapy. RESULTS:A ...

journal_title：American journal of hypertension

authors： Furberg CD,Sealey JE,Blumenfeld JD

更新日期：2017-09-01 00:00:00

abstract：:In order to evaluate the effects of atrial natriuretic factor (ANF) infusion on plasma insulin (IRI) in hypertension, 32 essential hypertensives (aged 40 to 62 years) were studied. After 1 week of pharmacologic washout under normal sodium intake (120 mEq of Na+/day), patients were randomly assigned to receive either A...

journal_title：American journal of hypertension

authors： Ferri C,De Mattia G,Piccoli A,Carlomagno A,Luparini RL,Germanò G,Giarrizzo C,Torregrossa G,Santucci A,Balsano F

更新日期：1991-11-01 00:00:00

abstract：:A negative calcium balance has previously been described in human hypertension with low levels of plasma ionized calcium (Ca2+) and an increased urinary excretion of calcium. The cause of this disturbance in mineral metabolism is not known, nor is it known if this derangement could be abolished if blood pressure is re...

journal_title：American journal of hypertension

authors： Lind L,Hänni A,Hvarfner A,Pollare T,Ljunghall S,Lithell H

更新日期：1994-04-01 00:00:00

abstract：BACKGROUND:Increased sodium intake has been positively associated with high blood pressure (BP) and hypertensive target organ damage, but associations with cardiac structure in nonhypertensive individuals have yielded inconsistent results. We tested the hypothesis that sodium intake is associated with left ventricular ...

journal_title：American journal of hypertension

authors： Dhingra R,Pencina MJ,Benjamin EJ,Levy D,Larson MG,Meigs JB,Rifai N,D'Agostino RB Sr,Vasan RS

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:The association of adiposity during childhood with future risk of elevated blood pressure (BP) in South Asian children is not known. We aimed to investigate the relationship between waist circumference (WC) and body mass index (BMI) with BP over a 2-year period, independent of the baseline BP. METHODS:We an...

journal_title：American journal of hypertension

authors： Almas A,Jafar TH

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:Increased short-term blood pressure (BP) variability (BPV) in hemodialysis is associated with increased cardiovascular and all-cause mortality. Studies on the impact of BP-lowering interventions on BPV are scarce. This study examined the effect of dry-weight reduction with a lung ultrasound-guided strategy o...

journal_title：American journal of hypertension

authors： Loutradis C,Sarafidis PA,Theodorakopoulou M,Ekart R,Alexandrou ME,Pyrgidis N,Angeloudi E,Tzanis G,Toumpourleka M,Papadopoulou D,Mallamaci F,Zoccali C,Papagianni A

更新日期：2019-07-17 00:00:00

abstract：BACKGROUND:Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. METHODS:In this randomized, double-b...

journal_title：American journal of hypertension

authors： Hare JL,Sharman JE,Leano R,Jenkins C,Wright L,Marwick TH

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects are also known to have blood pressure that is more sensitive to changes in dietary sodium intake. Whether hyperuricemia is a resulting consequence, mode...

journal_title：American journal of hypertension

authors： Todd AS,Walker RJ,MacGinley RJ,Kelly J,Merriman TR,Major TJ,Johnson RJ

更新日期：2017-11-06 00:00:00

abstract：:The treatment of diseases has been based on the concept of homeostasis and has not incorporated an understanding of biologic rhythms and their underlying mechanisms. Biologic rhythms are implicated in cardiovascular events. Failure to recognize the circadian decline in blood pressure may result in iatrogenic chronopat...

journal_title：American journal of hypertension

authors： Prisant LM

更新日期：2001-09-01 00:00:00

abstract：:It is known that calcium induces the formation of potent vasodilators in endothelial cells and vasoconstriction in smooth muscle cells, whereas in the renal parenchyma, it modulates sodium excretion through vascular and tubular mechanisms. Consequently, an increased concentration of calcium in renal circulation may in...

journal_title：American journal of hypertension

authors： Lahera V,Ruilope LM,Romero JC

更新日期：1991-07-01 00:00:00

abstract：:To evaluate the reactivity to psychological stress in patients with essential hypertension we investigated hemodynamic and endocrinologic changes during a mental arithmetic task (MAT) and a mirror drawing test (MDT) in 10 hypertensive subjects. Hemodynamic changes were assessed continuously using an ambulatory radionu...

journal_title：American journal of hypertension

authors： Yoshiuchi K,Nomura S,Ando K,Ohtake T,Shimosawa T,Kumano H,Kuboki T,Suematsu H,Fujita T

更新日期：1997-03-01 00:00:00

abstract：:Hypertension is a common finding among obstructive sleep apnea (OSA) patients, and is thought to be caused by sympathetic hyperactivity. The present study compares the contributions of the respiratory disturbance index (RDI) as a reflection of sleep fragmentation, and the magnitude of oxygen desaturation, to sympathet...

journal_title：American journal of hypertension

authors： Peled N,Greenberg A,Pillar G,Zinder O,Levi N,Lavie P

更新日期：1998-11-01 00:00:00

abstract：:National standards govern the manufacture and marketing of medical devices in the United States, including those for indirect blood pressure measurement in man. There are no comparable standards for devices for recording in laboratory animals. Noninvasive tail cuff blood pressure (BP) recording in the rat is widely ac...

journal_title：American journal of hypertension

authors： Jamieson MJ,Gonzales GM,Jackson TI,Koerth SM,Romano WF,Tan DX,Castillon F 3rd,Skinner MH,Grossmann M,Shepherd AM

更新日期：1997-02-01 00:00:00

abstract：:The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (B...

journal_title：American journal of hypertension

authors： Falkner B,Hulman S,Kushner H

更新日期：1994-11-01 00:00:00

abstract：:The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneously monitored 24-h ambulatory BP by automated recorder and activity by ...

journal_title：American journal of hypertension

authors： Leary AC,Donnan PT,MacDonald TM,Murphy MB

更新日期：2000-10-01 00:00:00

abstract：:In a 10-year prospective study, we investigated the utility of the serum creatinine level in predicting the development of hypertension in Japanese adults, all of whom lived in a rural community. The study included 229 subjects, 91 men and 138 women aged 30 to 69 years, who were normotensive (systolic blood pressure 1...

journal_title：American journal of hypertension

authors： Miura K,Nakagawa H,Nakamura H,Tabata M,Nagase H,Yoshida M,Okada A

更新日期：1994-05-01 00:00:00

abstract：:The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...

journal_title：American journal of hypertension

authors： Barthelmebs M,Vailly B,Velly J,Grima M,Imbs JL

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:Recent reports suggest that existing antihypertensive agents may not have sufficient efficacy to control blood pressure (BP) in many patients. Omapatrilat, an agent under development, has been shown to have significantly greater antihypertensive efficacy than existing agents, but may also carry increased ris...

journal_title：American journal of hypertension

authors： Kostis JB,Packer M,Black HR,Schmieder R,Henry D,Levy E

更新日期：2004-02-01 00:00:00

abstract：:In vivo studies suggest that 17 beta-estradiol (beta E) may regulate vascular tone. Results of recent studies suggest that beta E exerts rapid effects on intracellular calcium, possibly via cell surface receptors, distinct from conventional nuclear receptors for steroids. The present study was designed to determine wh...

journal_title：American journal of hypertension

authors： Ravi J,Mantzoros CS,Prabhu AS,Ram JL,Sowers JR

更新日期：1994-12-01 00:00:00

abstract：:There is controversy over whether endothelial function is impaired in human essential hypertension. All studies to date have used measurements of forearm blood flow by plethysmography to assess endothelium-dependent vasodilation and endothelial function. In contrast to these studies, which have focused on resistance v...

journal_title：American journal of hypertension

authors： Schmieder RE,Weihprecht H,Schobel H,John S,Weidinger G,Gatzka C,Veelken R

更新日期：1997-03-01 00:00:00

abstract：:Antihypertensive monotherapy, although commonly used, does not address the multifactorial nature of hypertension as a disease with many pathways. Using more than one drug makes more therapeutic sense because combination agents cover more than one pathway, yet the use of drugs in tandem is typically relegated to more p...

journal_title：American journal of hypertension

authors： Neutel JM

更新日期：1999-08-01 00:00:00

abstract：:Vasoconstrictor and Na/K pump inhibitory properties of a bufodienolide Na/K-ATPase inhibitor, marinobufagenin, were studied in isolated rings of 2 to 3 order branches of human pulmonary arteries respectively. Marinobufagenin displayed concentration-dependent vasoconstrictor activity (0.01 to 10 mmol/L). In sarcolemma ...

journal_title：American journal of hypertension

authors： Bagrov AY,Dmitrieva RI,Fedorova OV,Kazakov GP,Roukoyatkina NI,Shpen VM

更新日期：1996-10-01 00:00:00

abstract：:Migration of monocytes into the subendothelial space of the aorta has been considered to be an important event in the development of atherosclerosis. Because hypertension is commonly associated with atherosclerosis, we studied the effect of applied pressure on the migration of monocytes. Direct applied pressure increa...

journal_title：American journal of hypertension

authors： Singhal PC,Sagar P,Gupta S,Arya M,Gupta M,Prasad A,Loona R,Sharma P,Mattana J

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Hypertension in African Americans is characterized by greater systemic vascular resistance (SVR) compared with Caucasian Americans, but the responsible mechanisms are not known. The present study sought to determine if peripheral vascular hypertrophy is a potential mechanism contributing to elevated SVR in A...

journal_title：American journal of hypertension

authors： Hill LK,Sherwood A,Blumenthal JA,Hinderliter AL

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...

journal_title：American journal of hypertension

authors： Umemura T,Soga J,Hidaka T,Takemoto H,Nakamura S,Jitsuiki D,Nishioka K,Goto C,Teragawa H,Yoshizumi M,Chayama K,Higashi Y

更新日期：2008-11-01 00:00:00

abstract：:This multicenter, randomized, controlled clinical trial assessed the influence of sodium chloride intake on the antihypertensive effect of the calcium channel blocker isradipine. Participants with uncomplicated hypertension controlled by isradipine entered a 4-week sodium-restricted (60 to 80 mmol/24 h) period. Partic...

journal_title：American journal of hypertension

authors： McCarron DA,Weder AB,Egan BM,Krishna GG,Morris CD,Cohen M,Oparil S

更新日期：1997-01-01 00:00:00

abstract：:The metabolic syndrome is a cluster of disturbances such as type 2 diabetes mellitus, hypertension, central obesity, dyslipidemia, and others for which insulin resistance and compensatory hyperinsulinemia have been proposed to be the underlying disorders. Several possible mechanisms linking insulin resistance and comp...

journal_title：American journal of hypertension

authors： Sarafidis PA,Lasaridis AN

更新日期：2006-06-01 00:00:00

abstract：BACKGROUD:Declining renal function is an independent risk factor for all-cause mortality in cardiovascular disease. Visfatin has been described as a marker of inflammation and endothelial dysfunction, but whether circulating visfatin levels are predictive to a subsequent decline in renal function remains unclear. METH...

journal_title：American journal of hypertension

authors： Hsu CY,Huang PH,Chen TH,Chiang CH,Leu HB,Huang CC,Chen JW,Lin SJ

更新日期：2016-04-01 00:00:00

abstract：BACKGROUND:Vitamin D is involved in blood pressure (BP) regulation. Genetic variations may influence the effect of vitamin D on BP, but data from epidemiologic studies remain inconsistent. METHODS:We conducted a comprehensive genetic association study in the Women's Genome Health Study (WGHS) with genome-wide genotype...

journal_title：American journal of hypertension

authors： Wang L,Chu A,Buring JE,Ridker PM,Chasman DI,Sesso HD

更新日期：2014-11-01 00:00:00