Abstract：
BACKGROUND:Blood pressure is a complex quantitative trait with a strong genetic component. In this study, we leveraged the Veterans Affairs electronic medical record system to explore the relationship between Paraoxonase 1 (PON1)-108 C/T (rs705379) and mean arterial blood pressure (MAP). METHODS:Outpatient blood pressure data over an approximate 8-year period was collected from the Veterans Affairs Hypertensive Cohort (N = 1,302). Association between genotype and longitudinal MAP was further explored using a random effects model controlling for age, ancestry, renal function, and other determinants of blood pressure. To control for population stratification, principal component groupings based on ancestry informative markers in this dataset were included as covariates (in addition to self-identified ancestry). Data from the African American Study of Kidney Disease and Hypertension (AASK, N = 857) was used to confirm significant findings in an independent cohort. RESULTS:There was a significant interaction between PON1-108 C/T genotype and follow-up age group. At a younger age (<50 years), there was an estimated 2.53 mm Hg (95% confidence interval: 1.06, 4.00) increase in MAP with each additional C-allele. At the older age groups, there were no significant associations between PON1-108 C/T genotype and MAP. Using data from the AASK trial, the C-allele at PON1-108 C/T was significantly associated with a higher MAP (P = 0.005) but only among younger participants (<54 years). CONCLUSIONS:The PON1-108 polymorphism may be associated with MAP in an age-dependent manner.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Bhatnagar V,Liu L,Nievergelt CM,Richard E,Brophy VH,Pandey B,Lipkowitz MS,O'Connor DTdoi
10.1038/ajh.2012.106subject
Has Abstractpub_date
2012-11-01 00:00:00pages
1188-94issue
11eissn
0895-7061issn
1941-7225pii
ajh2012106journal_volume
25pub_type
杂志文章abstract：:To clarify characteristics of the patients in whom exercise training lowers blood pressure and to elucidate the mechanisms by which exercise training lowers blood pressure, we evaluated 24-h blood pressure, glomerular filtration rate (GFR), renal blood flow (RBF), filtration fraction (FF), plasma renin activity (PRA),...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章
doi：10.1016/s0895-7061(97)00109-x
更新日期：1997-08-01 00:00:00
abstract：BACKGROUND:The genetic component related to blood pressure (BP) changes during pregnancy is still not elucidated. Thus, the aim of the study was to evaluate the association between leptin and leptin receptor polymorphisms and systolic (SBP) and diastolic BP (DBP) variation during pregnancy and the postpartum period. M...
journal_title：American journal of hypertension
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更新日期：2017-02-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1990-12-01 00:00:00
abstract：:The comparative efficacy of the calcium antagonists isradipine and nifedipine in reducing left ventricular peak systolic wall tension was assessed in 25 patients with essential hypertension (20 men, 5 women; mean age: 49 years). After 2 weeks of treatment with either isradipine (2.5 mg twice daily) or slow-release nif...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1993-03-01 00:00:00
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更新日期：2004-06-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2010.153
更新日期：2010-11-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/5.1.26
更新日期：1992-01-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2004.04.011
更新日期：2004-09-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
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journal_title：American journal of hypertension
pub_type： 杂志文章
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更新日期：1996-11-01 00:00:00
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更新日期：1991-12-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1996-09-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
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更新日期：2014-11-01 00:00:00
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journal_title：American journal of hypertension
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更新日期：2020-12-05 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(94)00208-s
更新日期：1995-04-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
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更新日期：2001-01-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/4.8.680
更新日期：1991-08-01 00:00:00
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journal_title：American journal of hypertension
pub_type： 杂志文章,评审
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journal_title：American journal of hypertension
pub_type： 杂志文章
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pub_type： 杂志文章,多中心研究
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