Differential inhibitory effects of antidiabetic drugs on arterial smooth muscle cell proliferation.


:We compared three drugs representing different classes of antidiabetic pharmacology (glyburide, a sulfonylurea; pioglitazone, a thiazolidinedione; and metformin, a biguanide) in terms of their direct effects on proliferation of cultured arterial smooth muscle cells (SMC). Rat aortic SMC were seeded at 4 x 10(4)/35 mm well. After 24 h, they were treated every 2 to 4 days for 2 weeks with 5% fetal bovine serum (FBS) in normal culture medium containing either drug vehicles or a low and a high but nontoxic level of glyburide (0.5 and 2.5 mumol/L), pioglitazone (1 and 5 mumol/L), and metformin (20 and 100 mumol/L). Vehicle-treated cells increased from 2 +/- 0 to 6 +/- 1 to 42 +/- 3 to 210 +/- 14 (cells per well x 10(4); 5 wells each) from day zero to 4 to 9 to 14. From day 9 to 14 these cell numbers were decreased an average of 20% by the 2.5 mumol/L glyburide (P < .05) and 43% by the 5 mumol/L pioglitazone (P < .05). The low levels of glyburide and pioglitazone and both the low and high levels of metformin failed to influence cell numbers. In a second experiment, even half the abovementioned high level of pioglitazone (2.5 mumol/L) still exerted a markedly greater antiproliferative effect on aortic SMC than a high level of 2.0 mumol/L glyburide (P < .05). In addition, neither drug's antiproliferative effect was influenced by a high level of insulin added to the medium (10 mU/mL). Similarly, a small but significant stimulatory effect of this high insulin on cell proliferation (P < .05) was not significantly affected by these two drugs (although pioglitazone tended to inhibit it). These results suggest that thiazolidinediones may be more useful antidiabetic agents than sulfonylureas and biguanides in inhibiting abnormal arterial SMC proliferation associated with atherosclerosis and postangioplastic restenosis which are common in diabetic patients.


Am J Hypertens


Peuler JD,Phare SM,Iannucci AR,Hodorek MJ




Has Abstract


1996-02-01 00:00:00














  • Nocturnal Blood Pressure in Young Adults and Cognitive Function in Midlife: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.

    abstract:BACKGROUND:Nocturnal blood pressure (BP) is associated with risk for cardiovascular events. However, the relationship between nocturnal BP in young adults and cognitive function in midlife remains unclear. METHODS:We used data from the ambulatory BP monitoring substudy of the Coronary Artery Risk Development in Young ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Yano Y,Ning H,Muntner P,Reis JP,Calhoun DA,Viera AJ,Levine DA,Jacobs DR Jr,Shimbo D,Liu K,Greenland P,Lloyd-Jones D

    更新日期:2015-10-01 00:00:00

  • Erythrocyte Na-K-Cl cotransport activity in low renin essential hypertensive patients. A 23Na nuclear magnetic resonance study.

    abstract::The Na-K-Cl cotransport activity in red blood cells from essential hypertensive men with low (n = 8, mean age 42 +/- 4 years) or normal renin activity (n = 4, mean age 43 +/- 3 years), and in normotensive men with normal renin activity (n = 7, mean age 38 +/- 4 years) has been evaluated by means of a recently develope...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Cacciafesta M,Ferri C,Carlomagno A,De Angelis C,Scuteri A,Guidoni L,Luciani AM,Rosi A,Viti V,Santucci A

    更新日期:1994-02-01 00:00:00

  • Left ventricular mass is better correlated with arising blood pressure than with office or occasional blood pressure.

    abstract::The peak incidence of cardiovascular complications in the morning points to a possible role of the abrupt increase in blood pressure on arising. However, there is as yet no firm evidence linking the extent of the elevation in blood pressure on arising and the risk of cardiovascular complications. We sought a correlati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gosse P,Ansoborlo P,Lemetayer P,Clementy J

    更新日期:1997-05-01 00:00:00

  • Blood pressure among public employees after the Great East Japan Earthquake: the Watari study.

    abstract:BACKGROUND:Increases in blood pressure were reported in overworked public workers following the Mid-Niigata earthquake. This study aimed to compare blood pressure changes between public employees and the general population after the Great East Japan Earthquake of March 2011. METHODS:We analyzed 1,776 individuals from ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Konno S,Hozawa A,Munakata M

    更新日期:2013-09-01 00:00:00

  • Higher cholesterol and insulin levels in pregnancy are associated with increased risk for pregnancy-induced hypertension.

    abstract::Hyperinsulinemia and dyslipidemia are known to be associated with essential hypertension but their role in pregnancy-induced hypertension remains unclear. We performed a case-control study comparing cholesterol, insulin, and glucose levels in the early third trimester of pregnancy among 31 women who developed pregnanc...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Solomon CG,Carroll JS,Okamura K,Graves SW,Seely EW

    更新日期:1999-03-01 00:00:00

  • Augmentation index relates to progression of aortic disease in adults with Marfan syndrome.

    abstract:BACKGROUND:Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS). METHOD...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mortensen K,Aydin MA,Rybczynski M,Baulmann J,Schahidi NA,Kean G,Kühne K,Bernhardt AM,Franzen O,Mir T,Habermann C,Koschyk D,Ventura R,Willems S,Robinson PN,Berger J,Reichenspurner H,Meinertz T,von Kodolitsch Y

    更新日期:2009-09-01 00:00:00

  • Lack of agreement between office and ambulatory blood pressure responses to hydrochlorothiazide.

    abstract:BACKGROUND:Differences between the antihypertensive responses to drug therapy measured by office blood pressure (OBP) and ambulatory blood pressure monitoring (ABPM) techniques have been noted but rarely analyzed. We studied whether the OBP and 24-h ABPM responses to hydrochlorothiazide differ and, if so, the relevance...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Finkielman JD,Schwartz GL,Chapman AB,Boerwinkle E,Turner ST

    更新日期:2005-03-01 00:00:00

  • Angiotensin II upregulates transforming growth factor-beta type I receptor on rat vascular smooth muscle cells.

    abstract::Angiotensin II (Ang II) and transforming growth factor-beta (TGF-beta) modulate cell growth and metabolism. Our objective was to evaluate the effect of Ang II on the characteristics and expression of TGF-beta receptors on vascular smooth muscle cells (VSMC) from Wistar-Kyoto rats. The addition of TGF-beta1 elicited a ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Fukuda N,Hu WY,Kubo A,Kishioka H,Satoh C,Soma M,Izumi Y,Kanmatsuse K

    更新日期:2000-02-01 00:00:00

  • Hypertension in young patients after renal transplantation: ambulatory blood pressure monitoring versus casual blood pressure.

    abstract::The results of ambulatory blood pressure monitoring (ABPM) in children after kidney transplant were analyzed to ascertain any alteration in circadian BP profile, degree of hypertension, and efficacy of therapy. The data were also compared with casual BP data and left ventricular mass index (LVMI). We have examined 30 ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Calzolari A,Giordano U,Matteucci MC,Pastore E,Turchetta A,Rizzoni G,Alpert B

    更新日期:1998-04-01 00:00:00

  • Blood flow pattern in the middle cerebral artery in relation to indices of arterial stiffness in the systemic circulation.

    abstract:BACKGROUND:The brain is perfused at high-volume flow throughout systole and diastole. We explored the association of blood flow in the middle cerebral artery (MCA) with the pulsatile components of blood pressure in the systemic circulation and indices of arterial stiffness. METHODS:We enrolled 334 untreated subjects (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Xu TY,Staessen JA,Wei FF,Xu J,Li FH,Fan WX,Gao PJ,Wang JG,Li Y

    更新日期:2012-03-01 00:00:00

  • Unsweetening the Heart: Possible Pleiotropic Effects of SGLT2 Inhibitors on Cardio and Cerebrovascular Alterations in Resistant Hypertensive Subjects.

    abstract::Resistant hypertension (RH) is a multifactorial disease associated with several target organ damage, such as microalbuminuria, left ventricular hypertrophy, and arterial stiffness. These subjects have high cardiovascular complications, especially when associated with diabetes condition. Sodium glucose cotransporter 2 ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Pioli MR,Ritter AMV,Modolo R

    更新日期:2018-02-09 00:00:00

  • Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats.

    abstract::The objective of the present study was to determine the relationship between plasma renin levels, and the development of hypertension and cardiac hypertrophy in TGR (mREN2)27 hypertensive rats. Systolic blood pressure and left ventricular mass index (LVMI) were measured in transgenic heterozygote and normotensive Spra...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Véniant M,Whitworth CE,Ménard J,Sharp MG,Gonzales MF,Bruneval P,Mullins JJ

    更新日期:1995-12-01 00:00:00

  • Associations of Proatrial Natriuretic Peptide with Components of the Metabolic Syndrome in Adolescents and Young Adults from the General Population.

    abstract:BACKGROUND:In middle-aged and elderly populations, circulating natriuretic peptide concentrations are negatively associated with several components of the metabolic syndrome. Whether these negative associations are also present in healthy adolescents and young adults from the general population are unknown. METHODS:In...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Goharian TS,Goetze JP,Faber J,Andersen LB,Grøntved A,Jeppesen JL

    更新日期:2017-06-01 00:00:00

  • Cardioprotective Effects of Paricalcitol Alone and in Combination With FGF23 Receptor Inhibition in Chronic Renal Failure: Experimental and Clinical Studies.

    abstract:BACKGROUND:In uremic animals, vitamin D receptor (VDR) agonists like paricalcitol (Pc) attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans with chronic kidney disease. Elevated fibroblast growth factor 23 (FGF23) levels cause cardiac hypertrophy with activation of the myocardia...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Czaya B,Seeherunvong W,Singh S,Yanucil C,Ruiz P,Quiroz Y,Grabner A,Katsoufis C,Swaminathan S,Abitbol C,Rodriguez-Iturbe B,Faul C,Freundlich M

    更新日期:2019-01-01 00:00:00

  • Relationship Between Dynamic Changes in Body Weight and Blood Pressure: The ESTEBAN Survey.

    abstract:BACKGROUND:Obesity is one of the main determinants of blood pressure. The aim of this study was to evaluate and quantify the relations between the different anthropometric indices and blood pressure (BP) stratified by gender. METHODS:Cross-sectional analyses were performed using data from 2,105 adults from the ESTEBAN...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Vallée A,Perrine AL,Deschamps V,Blacher J,Olié V

    更新日期:2019-09-24 00:00:00

  • The essence of effective treatment and compliance is simplicity.

    abstract::In recent years, several international bodies of experts have established extensive guidelines for the prevention and treatment of coronary heart disease (CHD) that clearly define the importance of altering patients' lifestyles and administering therapeutic agents that positively affect disease progression. However, s...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Erhardt LR

    更新日期:1999-10-01 00:00:00

  • L-dopa and streptozotocin-induced diabetic nephropathy in rats.

    abstract::The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Barthelmebs M,Vailly B,Velly J,Grima M,Imbs JL

    更新日期:1990-06-01 00:00:00

  • Trends in Hospitalization for Hypertensive Emergency, and Relationship of End-Organ Damage With In-Hospital Mortality.

    abstract:BACKGROUND:There are no comprehensive guidelines on management of hypertensive emergency (HTNE) and complications. Despite advances in antihypertensive medications HTNE is accompanied with significant morbidity and mortality. METHODS:We queried the 2002-2012 nationwide inpatient sample database to identify patients wi...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shah M,Patil S,Patel B,Arora S,Patel N,Garg L,Agrawal S,Jacobs L,Steigerwalt SP,Martinez MW

    更新日期:2017-07-01 00:00:00

  • Impact of Visit-to-Visit Variability in Systolic Blood Pressure on Cardiovascular Outcomes in Korean National Health Insurance Service-National Sample Cohort.

    abstract:BACKGROUND:Despite an association between visit-to-visit blood pressure (BP) variability (VV-BPV) and cardiovascular (CV) outcomes, many studies performed during the past 4 years have shown conflicting results. This study investigated the impact of VV-BPV on CV outcomes in the Korean National Health Insurance Service (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Choi S,Shin J,Choi SY,Sung KC,Ihm SH,Kim KI,Kim YM

    更新日期:2017-06-01 00:00:00

  • Report of the Working Party Group on Determining the Radionuclide of Choice.

    abstract::There are a variety of radiopharmaceuticals that can be used to perform captopril renography effectively. We examined a number of technetium and iodine compounds and the circumstances under which each radiopharmaceutical compound is the compound of choice. Considerations of cost, ease of use, reliability, dosage, and ...

    journal_title:American journal of hypertension

    pub_type: 共识发展会议,杂志文章,评审


    authors: Blaufox MD,Dubovsky EV,Hilson AJ,Taylor A Jr,de Zeeuw R

    更新日期:1991-12-01 00:00:00

  • Association of the complement factor H Y402H polymorphism with cardiovascular disease is dependent upon hypertension status: The ARIC study.

    abstract:BACKGROUND:Complement factor H (CFH) is a plasma protein that is essential in the regulation of the alternative complement pathway and has been implicated as taking part in complement inhibition in atherogenesis. We evaluated the association of the Y402H polymorphism with incident coronary heart disease (CHD), incident...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Volcik KA,Ballantyne CM,Braun MC,Coresh J,Mosley TH,Boerwinkle E

    更新日期:2008-05-01 00:00:00

  • Salt-sensitive hypertension in conscious rats induced by chronic nitric oxide blockade.

    abstract::This study examined the effects of alterations in salt-intake on blood pressure (BP) in rats chronically treated intravenously with or without the nitric oxide synthase (NOS) inhibitor N(G)-nitro-L-arginine methyl ester (L-NAME) (8.6 mg/kg/day). The changes in mean arterial pressure (MAP), the renal cortical and medul...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Nakanishi K,Hara N,Nagai Y

    更新日期:2002-02-01 00:00:00

  • Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans.

    abstract::Components of the kallikrein kinin system have been associated with the pathophysiology of hypertension in animal and human studies. In this study, we examined the distribution of four different polymorphisms of the kinin B1 and B2 receptor genes in a population of 120 normotensive and 77 hypertensive African-American...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gainer JV,Brown NJ,Bachvarova M,Bastien L,Maltais I,Marceau F,Bachvarov DR

    更新日期:2000-12-01 00:00:00

  • Ambulatory blood pressure monitoring in offspring of hypertensive patients. Relation to left ventricular structure and function.

    abstract::The relation between 24-h ambulatory blood pressure monitoring and echocardiographic left ventricular (LV) anatomy and function was examined in 30 young, normotensive offspring (16 men, 14 women) of hypertensive, parents and in 20 offspring (12 men, 8 women) of normotensive parents, comparable for age, clinical blood ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Galderisi M,Celentano A,Tammaro P,Mureddu GF,Garofalo M,de Simone G,de Divitiis O

    更新日期:1993-02-01 00:00:00

  • Association of Maternal Plasma Folate and Cardiometabolic Risk Factors in Pregnancy with Elevated Blood Pressure of Offspring in Childhood.

    abstract:BACKGROUND:The prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), o...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Wang H,Mueller NT,Li J,Sun N,Huo Y,Ren F,Wang X

    更新日期:2017-05-01 00:00:00

  • Arterial stiffness and fetal growth in normotensive pregnancy.

    abstract:BACKGROUND:Normal pregnancy is characterized by a decrease in peripheral resistance and generalized vasodilation resulting in plasma volume expansion, which is associated with intrauterine growth. Stiffness of the arterial system may be a measure of the degree of plasma volume expansion. Pulse wave velocity (PWV), meas...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Elvan-Taspinar A,Franx A,Bots ML,Koomans HA,Bruinse HW

    更新日期:2005-03-01 00:00:00

  • Lack of difference in oxalate-dependent Ca2+ uptake by membrane homogenate of African-American and white subjects.

    abstract::In order to further characterize previously described racial differences in intracellular Ca2+ homeostasis, the activity of sarcoplasmic-endoplasmic reticulum Ca2+-ATPase was measured in cultured skin fibroblasts from normotensive African-Americans and whites. Cells originated from apparently healthy, normotensive Afr...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Yang XY,Aviv A,Hopp L

    更新日期:1997-04-01 00:00:00

  • Hepatic effects of a fructose diet in the stroke-prone spontaneously hypertensive rat.

    abstract:BACKGROUND:Feeding stroke-prone spontaneously hypertensive rats (SHRSP) a diet rich in fructose results in a profound glucose intolerance not observed in the normotensive Wistar Kyoto (WKY) strain. The aim of this study was to investigate the role of the liver in the underlying mechanisms in the SHRSP. METHODS:SHRSP a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Brosnan MJ,Carkner RD

    更新日期:2008-06-01 00:00:00

  • Relationship of plasma renin with a prothrombotic state in hypertension: relevance for organ damage.

    abstract:BACKGROUND:Components of the renin-angiotensin-aldosterone system (RAAS) and a prothrombotic state are predictors of cardiovascular events in hypertensive patients. A relationship between the RAAS and the coagulation/fibrinolytic systems has been demonstrated, but its clinical relevance in hypertension is unclear. We i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sechi LA,Novello M,Colussi G,Di Fabio A,Chiuch A,Nadalini E,Casanova-Borca A,Uzzau A,Catena C

    更新日期:2008-12-01 00:00:00

  • Effect of amlodipine on mesangial cell proliferation and protein synthesis.

    abstract::Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shultz PJ,Raij L

    更新日期:1992-12-01 00:00:00