Abstract:
BACKGROUND:Central artery reservoir-excess pressure parameters are clinically important but impractical to record directly. However, diastolic waveform morphology is consistent across central and peripheral arteries. Therefore, peripheral artery reservoir-excess pressure parameters related to diastolic waveform morphology may be representative of central parameters and share clinically important associations with end-organ damage. This has never been determined and was the aim of this study. METHODS:Intra-arterial blood pressure (BP) waveforms were measured sequentially at the aorta, brachial, and radial arteries among 220 individuals (aged 61 ± 10 years, 68% male). Customized software was used to derive reservoir-excess pressure parameters at each arterial site (reservoir and excess pressure, systolic and diastolic rate constants) and clinical relevance was determined by association with estimated glomerular filtration rate (eGFR). RESULTS:Between the aorta and brachial artery, the mean difference in the diastolic rate constant and reservoir pressure integral was -0.162 S-1 (P = 0.08) and -0.772 mm Hg s (P = 0.23), respectively. The diastolic rate constant had the strongest and most consistent associations with eGFR across aortic and brachial sites (β = -0.20, P = 0.02; β = -0.20, P = 0.03, respectively; adjusted for traditional cardiovascular risk factors). Aortic, but not brachial peak reservoir pressure was associated with eGFR in adjusted models (aortic β = -0.48, P = 0.02). CONCLUSIONS:The diastolic rate constant is the most consistent reservoir-excess pressure parameter, in both its absolute values and associations with kidney dysfunction, when derived from the aorta and brachial artery. Thus, the diastolic rate constant could be utilized in the clinical setting to improve BP risk stratification.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Armstrong MK,Schultz MG,Picone DS,Black JA,Dwyer N,Roberts-Thomson P,Sharman JEdoi
10.1093/ajh/hpaa013subject
Has Abstractpub_date
2020-04-01 00:00:00pages
325-330issue
4eissn
0895-7061issn
1941-7225pii
5719540journal_volume
33pub_type
杂志文章abstract:BACKGROUND:Subjects with renovascular hypertension (RVH) often manifest with metabolic syndrome (MetS) as well. Coexisting MetS and hypertension increases cardiovascular morbidity and mortality, but the mechanisms underlying cardiac injury remain unknown. We hypothesized that superimposition of MetS induces myocardial ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpaa202
更新日期:2020-12-05 00:00:00
abstract::In order to examine the relationship existing between dietary calcium and the development of hypertension, we developed a long-term study in the Lyon hypertensive rat strain (LH) and two control strains, the Lyon normotensive (LN) and low blood pressure rats (LL) given enriched (HCa, 2.5%), deprived (LCa, 0.03%) and n...
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(98)00256-8
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abstract:BACKGROUND:Whether microvascular disease contributes to the development of left ventricular hypertrophy (LVH) is unclear. We examined the relationship of retinal microvascular signs with LVH in an African-American population. METHODS:A population-based, cross-sectional study of 1,439 middle-aged African-American parti...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2007.57
更新日期:2008-03-01 00:00:00
abstract::Because left ventricular hypertrophy (LVH) is a strong risk factor for cardiac morbidity and mortality considerable interest has been generated concerning the possible effects of modifying LVH in hypertensive patients. In animal models disproportionate regression of left ventricular (LV) mass in relation to blood pres...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,评审
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更新日期:1990-06-01 00:00:00
abstract:BACKGROUND:Remnant-like lipoprotein particle cholesterol (RLP-C) is a highly atherogenic factor. RLP-C induces endothelial dysfunction and is associated with hyperinsulinemia. This study was designed to determine whether high plasma RLP-C levels predispose to the development of hypertension in subjects with normal bloo...
journal_title:American journal of hypertension
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更新日期:2013-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/2.3.205
更新日期:1989-03-01 00:00:00
abstract:BACKGROUND:High blood pressure (BP) is associated with the presence and severity of subclinical disease. Less is known about associations between normal levels of BP and various measures of subclinical disease. METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled 6814 participants free of clinical cardiov...
journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 杂志文章,多中心研究
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更新日期:2002-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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journal_title:American journal of hypertension
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2017-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
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journal_title:American journal of hypertension
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doi:10.1016/0895-7061(95)00219-F
更新日期:1995-09-01 00:00:00
abstract:BACKGROUND:Little is known about hypertension in the HIV-infected population. This study aimed to assess the prevalence of hypertension and related factors in HIV-infected patients. METHODS:In this prospective cross-sectional study, 710 HIV-infected patients (626 on combination antiretroviral therapy and 84 naive) man...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/j.amjhyper.2005.05.016
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
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journal_title:American journal of hypertension
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更新日期:2015-09-01 00:00:00
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更新日期:2002-07-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2007-12-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/0895-7061(95)00393-2
更新日期:1996-02-01 00:00:00
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journal_title:American journal of hypertension
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更新日期:2018-02-09 00:00:00
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更新日期:2009-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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