当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension.

Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension.

Abstract：

BACKGROUND:Hypertensive disorders of pregnancy, including preeclampsia (PE), affect approximately 7-10% of pregnancies in the US. Clinical and experimental studies strongly suggest that the maternal immune system plays a role in the development of these disorders; however, few therapeutic options exist aside from delivery. METHODS:Using a deoxycorticosterone acetate (DOCA)/salt-low renin rat model, which exhibits hypertension, proteinuria, endothelial dysfunction, and intrauterine growth restriction (IUGR), we measured serum cytokine levels as an indication of immune system activation. In addition, we suppressed the immune system with either azathioprine (Aza) or mycophenolate mofetil (MMF) during the second half of pregnancy to determine whether the these symptoms could be ameliorated. RESULTS:Our results demonstrate that serum T helper-1 (Th1)-type inflammatory cytokines interleukin (IL)-2, IL-12, interferon-gamma (IFNgamma), and RANTES were significantly elevated in hypertensive pregnant rats while the Th2-type cytokine IL-4 was elevated in normal pregnant animals. Either Aza or MMF significantly attenuated the hypertension, proteinuria, and endothelial dysfunction as well as the increased proinflammatory Th1 cytokine profile in pregnant rats treated with DOCA/salt, and had no effect on these parameters in normal pregnant rats. CONCLUSION:These data strongly suggest that maternal immune system activation plays a role in the development of pregnancy-induced hypertension (PIH).

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Tinsley JH,Chiasson VL,South S,Mahajan A,Mitchell BM

doi

10.1038/ajh.2009.125

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

1107-14

issue

10

eissn

0895-7061

issn

1941-7225

pii

ajh2009125

journal_volume

22

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Effects of calcium channel and renin-angiotensin system blockade on intravascular and neurohormonal mechanisms of hypertensive vascular disease.

    abstract：:Several classes of antihypertensive drugs have been shown to improve vascular function through mechanisms other than reducing blood pressure (BP) alone. Certain dihydropyridine calcium channel blockers (CCBs) and inhibitors of the renin-angiotensin system (RAS) increase nitric oxide (NO) bioavailability and decrease o...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/ajh.2008.258

    authors： Mizuno Y,Jacob RF,Mason RP

    更新日期：2008-10-01 00:00:00

  • Effect of reduction of nitric oxide on plasma and kidney tissue angiotensin II levels.

    abstract：:Nitric oxide synthase (NOS) blockade increases blood pressure (BP) and modifies glomerular and tubular function. Angiotensin II (AII) blockade restores glomerular and tubular function but does not lower BP. We measured plasma renin activity (PRA), plasma (AIIp), and kidney tissue (AIIk) AII with radioimmunoassay to in...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(97)00123-4

    authors： Garcia GE,Brown MR,Wead LM,Braun S,Gabbai FB

    更新日期：1997-10-01 00:00:00

  • Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart Study.

    abstract：BACKGROUND:Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components. METHODS:To localize the genetic effects of pulse pressure, we conducted a genome-wide linkage analysis of 1,892 American-Indian participants of the Strong Heart Family Study (SH...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2007.34

    authors： Franceschini N,MacCluer JW,Rose KM,Rutherford S,Cole SA,Laston S,Göring HH,Diego VP,Roman MJ,Lee ET,Best LG,Howard BV,Fabsitz RR,North KE

    更新日期：2008-02-01 00:00:00

  • Plasma marinobufagenin-like and ouabain-like immunoreactivity in adrenocorticotropin-treated rats.

    abstract：:Recently, an endogenous digitalis-like factor (EDLF) was shown to be stimulated in corticotropin (ACTH) hypertension in the rat. We have shown that mammalian plasma contains a vasoconstrictor Na,K-ATPase inhibitor, which cross-reacts with an antibody to amphibian EDLF, marinobufagenin. In the present experiment, the e...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00042-9

    authors： Fedorova OV,Anderson DE,Bagrov AY

    更新日期：1998-07-01 00:00:00

  • Angiotensin-converting enzyme inhibitors. Emerging differences and new compounds.

    abstract：:Angiotensin-converting enzyme inhibitors (ACEIs), introduced in clinical practice in 1980, are a relatively new class of drugs. They have been useful in the treatment of hypertension, where they are effective monotherapy in 40% to 50% of the patients and in combination therapy in up to 90%. They are also useful in the...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/2.1.57

    authors： Kostis JB

    更新日期：1989-01-01 00:00:00

  • Prognostic value of left ventricular concentric remodeling in uncomplicated mild hypertension.

    abstract：BACKGROUND:The prognostic value of left ventricular (LV) concentric remodeling in essential hypertension, and particularly in uncomplicated mild hypertension, is not yet completely clear. We investigated cardiovascular outcome in uncomplicated mild hypertensive patients with normal LV geometry and LV concentric remodel...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2004.06.016

    authors： Pierdomenico SD,Lapenna D,Bucci A,Manente BM,Cuccurullo F,Mezzetti A

    更新日期：2004-11-01 00:00:00

  • Relationship between autonomic function and progression of renal disease in diabetic proteinuria: clinical correlations and implications for blood pressure control.

    abstract：:The objective of this study was to test the relationship between neurologic and microvascular complications of type 1 diabetes mellitus. It was hypothesized that the mechanisms operative in autonomic dysfunction seen in diabetic patients with microangiopathy play a role in the rapidity of progression to renal failure....

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(97)00472-x

    authors： Weinrauch LA,Kennedy FP,Gleason RE,Keough J,D'Elia JA

    更新日期：1998-03-01 00:00:00

  • Adiposity and blood pressure in South Asian children and adolescents in Karachi.

    abstract：BACKGROUND:The association of adiposity during childhood with future risk of elevated blood pressure (BP) in South Asian children is not known. We aimed to investigate the relationship between waist circumference (WC) and body mass index (BMI) with BP over a 2-year period, independent of the baseline BP. METHODS:We an...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ajh.2011.67

    authors： Almas A,Jafar TH

    更新日期：2011-08-01 00:00:00

  • Association of home and ambulatory blood pressure changes with changes in cardiovascular biomarkers during antihypertensive treatment.

    abstract：BACKGROUND:Our aim was to assess whether home blood pressure (HBP) and ambulatory BP monitoring measurement (ABPM), in addition to office BP (OBP) predict changes of cardiovascular biomarkers during antihypertensive treatment. METHODS:Two hundred and fifty-two hypertensive patients (mean age, 68 years; men: 41%) under...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究

    doi：10.1038/ajh.2011.229

    authors： Yano Y,Hoshide S,Shimizu M,Eguchi K,Ishikawa J,Ishikawa S,Shimada K,Kario K

    更新日期：2012-03-01 00:00:00

  • Arterial stiffness and fetal growth in normotensive pregnancy.

    abstract：BACKGROUND:Normal pregnancy is characterized by a decrease in peripheral resistance and generalized vasodilation resulting in plasma volume expansion, which is associated with intrauterine growth. Stiffness of the arterial system may be a measure of the degree of plasma volume expansion. Pulse wave velocity (PWV), meas...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2004.10.020

    authors： Elvan-Taspinar A,Franx A,Bots ML,Koomans HA,Bruinse HW

    更新日期：2005-03-01 00:00:00

  • Higher cholesterol and insulin levels in pregnancy are associated with increased risk for pregnancy-induced hypertension.

    abstract：:Hyperinsulinemia and dyslipidemia are known to be associated with essential hypertension but their role in pregnancy-induced hypertension remains unclear. We performed a case-control study comparing cholesterol, insulin, and glucose levels in the early third trimester of pregnancy among 31 women who developed pregnanc...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00258-1

    authors： Solomon CG,Carroll JS,Okamura K,Graves SW,Seely EW

    更新日期：1999-03-01 00:00:00

  • Enhanced efficacy of nilvadipine in hypertensives whose raised ambulatory blood pressure is sustained during sleep.

    abstract：:This study was designed to clarify the relationship between the antihypertensive effects of the calcium antagonist nilvadipine, and circadian changes in blood pressure. Based on measurements using an ambulatory blood pressure monitoring system (ABPM), 17 outpatients with untreated essential hypertension were divided i...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(97)00406-8

    authors： Yoshikawa H,Ohta A,Kasamatsu K,Ueno C,Funai H,Kuse S,Satani O,Nakamura N,Fukuda K,Hano T,Ueno Y,Nishio I,Iseki Y

    更新日期：1998-01-01 00:00:00

  • Changes of plasma endothelin and growth factor levels, and of left ventricular mass, after chronic AT1-receptor blockade in human hypertension.

    abstract：:The stimulation of autocrine and paracrine factors such as basic fibroblast- (bFGF) and platelet-derived (PDGF) growth factors mediates many of the growth-promoting actions of angiotensin II. The aim of this study was to evaluate the effect of chronic AT1-receptor blockade on plasma endothelin-1 (ET-1) and growth fact...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00027-2

    authors： Cottone S,Vadalà A,Vella MC,Nardi E,Mulé G,Contorno A,Riccobene R,Cerasola G

    更新日期：1998-05-01 00:00:00

  • What time is the "biologic zero hour" of circadian variability?

    abstract：:Most ambulatory blood pressure monitoring (ABPM) studies have used a mechanical clock as the reference time, but there is no biologic background for assuming that midnight by the mechanical clock is zero hour by the biologic clock. The aim of this study was to determine the biologic zero hour as the zero reference tim...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：

    authors： Okutani M,Komori S,Iwasaki H,Mochizuki Y,Kohno I,Mochizuki S,Ishii H,Ijiri H,Tamura K

    更新日期：1997-07-01 00:00:00

  • Gender differences in insulin-stimulated glucose utilization among African-Americans.

    abstract：:The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (B...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/7.11.948

    authors： Falkner B,Hulman S,Kushner H

    更新日期：1994-11-01 00:00:00

  • Intranasal angiotensin II directly influences central nervous regulation of blood pressure.

    abstract：:Intranasal administration of some peptides has been shown to directly influence central nervous functions, thus pointing to a nose-brain pathway for these substances in humans. The present study investigated whether intranasal administration of angiotensin II (ANG II) affects central nervous functions of cardiovascula...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0895-7061(98)00095-8

    authors： Derad I,Willeke K,Pietrowsky R,Born J,Fehm HL

    更新日期：1998-08-01 00:00:00

  • Effects of galanin on dopamine release in the central nervous system of normotensive and spontaneously hypertensive rats.

    abstract：:Galanin is a 29-amino acid peptide and widely distributed in the brain, although its significance in the control of neural activities is undefined. In the present study, we describe the effects of galanin on the electrically evoked release of dopamine in the rat central nervous system. In addition, to elucidate a poss...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00168-x

    authors： Tsuda K,Tsuda S,Nishio I,Masuyama Y,Goldstein M

    更新日期：1998-12-01 00:00:00

  • Association between levels of blood pressure and measures of subclinical disease multi-ethnic study of atherosclerosis.

    abstract：BACKGROUND:High blood pressure (BP) is associated with the presence and severity of subclinical disease. Less is known about associations between normal levels of BP and various measures of subclinical disease. METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled 6814 participants free of clinical cardiov...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.04.002

    authors： Psaty BM,Arnold AM,Olson J,Saad MF,Shea S,Post W,Burke GL

    更新日期：2006-11-01 00:00:00

  • Potassium inhibits cultured vascular smooth muscle cell proliferation.

    abstract：:Increased dietary K+ increases plasma [K+] and is linked to or associated with reduced mortality from stroke and reduced blood pressure in humans and animals. We hypothesized that physiologic increases in extracellular [K+] ([K]o) directly inhibit cultured vascular smooth muscle cell (VSMC) proliferation. Studies were...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/7.4.346

    authors： McCabe RD,Young DB

    更新日期：1994-04-01 00:00:00

  • Association of Orthostatic Hypotension Timing With Clinical Events in Adults With Diabetes and Hypertension: Results From the ACCORD Trial.

    abstract：OBJECTIVE:To determine the effects of orthostatic hypotension (OH) measurement timing on its associations with dizziness, falls, fractures, cardiovascular disease (CVD), and mortality. METHODS:We analyzed OH measurements from the Action to Control Cardiovascular Risk in Diabetes BP trial, which evaluated two blood pre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpz015

    authors： Juraschek SP,Lipsitz LA,Beach JL,Mukamal KJ

    更新日期：2019-06-11 00:00:00

  • Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats.

    abstract：:The objective of the present study was to determine the relationship between plasma renin levels, and the development of hypertension and cardiac hypertrophy in TGR (mREN2)27 hypertensive rats. Systolic blood pressure and left ventricular mass index (LVMI) were measured in transgenic heterozygote and normotensive Spra...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00254-5

    authors： Véniant M,Whitworth CE,Ménard J,Sharp MG,Gonzales MF,Bruneval P,Mullins JJ

    更新日期：1995-12-01 00:00:00

  • Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: a randomized controlled trial.

    abstract：BACKGROUND:Erectile dysfunction (ED) is common among men taking antihypertensive drugs to control blood pressure. We evaluated the safety and efficacy of sildenafil citrate for treating ED in men taking multiple antihypertensive medications in a randomized, double-blind, placebo-controlled trial. METHODS:A total of 56...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.amjhyper.2004.07.004

    authors： Pickering TG,Shepherd AM,Puddey I,Glasser DB,Orazem J,Sherman N,Mancia G

    更新日期：2004-12-01 00:00:00

  • Antihypertensive effects of angiotensin converting enzyme inhibition by lisinopril in post-transplant patients.

    abstract：BACKGROUND:It is not known whether strict control of blood pressure (BP) in mild post-transplant hypertension gives any benefit. Our primary objective was to test the antihypertensive effects of lisinopril added to standard therapy on ambulatory BP (ABP) of post-transplant patients. The secondary objective was to monit...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(02)02992-8

    authors： Opie LH,Haus M,Commerford PJ,Levetan B,Moore K,Brink J

    更新日期：2002-10-01 00:00:00

  • The dose-dependent reduction in blood pressure through administration of magnesium. A double blind placebo controlled cross-over study.

    abstract：:Seventeen patients with a diastolic blood pressure over 90 mm Hg were recruited from a running health screening program to participate in a double blind cross-over study of magnesium supplementation (15 mmol Mg2+/day (Emgesan, Kabi Pharmacia) for 3 weeks, followed by 30 mmol Mg2+/day for another 3 weeks, finishing wit...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/6.1.41

    authors： Widman L,Wester PO,Stegmayr BK,Wirell M

    更新日期：1993-01-01 00:00:00

  • High dietary salt enhances acute depressor responses to metformin.

    abstract：:The antidiabetic drug metformin lowers blood pressure (BP) more in spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto rats (WKY), and the hypotensive effect is enhanced by high dietary salt. To determine whether enhanced hypotension is secondary to greater decreases in sympathetic nerve activity (SNA), w...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00119-3

    authors： Muntzel MS,Nyeduala B,Barrett S

    更新日期：1999-12-01 00:00:00

  • Antihypertensive effects of oral calcium supplementation may be mediated through the potent vasodilator CGRP.

    abstract：:Alteration of calcium metabolism and changes in the levels of calcium-regulating hormones have been described in essential hypertension. In the majority of the reported clinical trials, calcium supplementation has resulted in a decrease in blood pressure. However, the mechanisms by which such a response would be media...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1093/ajh/6.12.996

    authors： Wimalawansa SJ

    更新日期：1993-12-01 00:00:00

  • Physical Activity Is Associated With Reduced Left Ventricular Mass in Obese and Hypertensive African Americans.

    abstract：BACKGROUND:Physical activity (PA) has been associated with decreased left ventricular (LV) hypertrophy in previous studies. However, little is known about the relationship between PA and LV structure and factors which influence this relationship among African Americans. METHODS:We evaluated 1,300 African Americans wit...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpx044

    authors： Kamimura D,Loprinzi PD,Wang W,Suzuki T,Butler KR,Mosley TH,Hall ME

    更新日期：2017-06-01 00:00:00

  • Effect of age on blood pressure parameters and risk of cardiovascular death in men.

    abstract：BACKGROUND:Elevated blood pressure (BP) is a risk factor for cardiovascular disease (CVD), but it remains unclear which component-alone or in combination-is the best predictor. We sought to determine which BP parameters are important predictors of CVD death across a wide age range. METHODS:We used a prospective cohort...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.06.024

    authors： Bowman TS,Sesso HD,Gaziano JM

    更新日期：2006-01-01 00:00:00

  • Left ventricular hypertrophy and clinical outcomes in hypertensive patients.

    abstract：:The prevalence of left ventricular hypertrophy (LVH) rises with severity of hypertension (HT), age, and obesity. Its prevalence ranges from 20% in mildly hypertensive patients to almost 100% in those with severe or complicated HT. However, the diagnosis of LVH is not straightforward, and the definitions and criteria u...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/ajh.2008.16

    authors： Ruilope LM,Schmieder RE

    更新日期：2008-05-01 00:00:00

  • Characterization of enhanced 45Ca2+ efflux in cultured vascular smooth muscle cells from spontaneously hypertensive rats.

    abstract：:In this study we have compared Ca2+ efflux in cultured aortic smooth muscle cells derived from male, 10-week-old spontaneously hypertensive and Wistar-Kyoto rats. The role of Ca(2+)-dependent protein kinase C and Ca2+ uptake in the regulation of the Ca2+ pump and Na(+)-Ca2+ exchange mediated Ca2+ efflux were investiga...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00226-X

    authors： Chen S,Monteith GR,Roufogalis BD

    更新日期：1995-10-01 00:00:00