The dose-dependent reduction in blood pressure through administration of magnesium. A double blind placebo controlled cross-over study.

Abstract:

:Seventeen patients with a diastolic blood pressure over 90 mm Hg were recruited from a running health screening program to participate in a double blind cross-over study of magnesium supplementation (15 mmol Mg2+/day (Emgesan, Kabi Pharmacia) for 3 weeks, followed by 30 mmol Mg2+/day for another 3 weeks, finishing with 40 mmol Mg2+/day for a final 3 weeks). A significant decrease in the mean systolic blood pressure was recorded from 154.0 +/- 10.7 mm Hg to 146.1 +/- 16.9 mm Hg (P = .031) while the mean diastolic blood pressure decreased from 100.2 +/- 4.2 mm Hg to 92.0 +/- 6.6 mm Hg (P = .0001).

journal_name

Am J Hypertens

authors

Widman L,Wester PO,Stegmayr BK,Wirell M

doi

10.1093/ajh/6.1.41

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

41-5

issue

1

eissn

0895-7061

issn

1941-7225

pii

0895-7061(93)90153-D

journal_volume

6

pub_type

临床试验,杂志文章,随机对照试验
  • The role of combination antihypertensive therapy and the progression of renal disease hypertension: looking toward the next millennium.

    abstract::The importance of the level to which blood pressure is reduced becomes increasingly important when one considers preservation of renal function. It is clear that three major subsets of patients emerge as requiring levels of blood pressure control of < 130/85 mm Hg to preserve renal function. Such individuals include b...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(98)00190-3

    authors: Bakris GL

    更新日期:1998-10-01 00:00:00

  • Associations of Reservoir-Excess Pressure Parameters Derived From Central and Peripheral Arteries With Kidney Function.

    abstract:BACKGROUND:Central artery reservoir-excess pressure parameters are clinically important but impractical to record directly. However, diastolic waveform morphology is consistent across central and peripheral arteries. Therefore, peripheral artery reservoir-excess pressure parameters related to diastolic waveform morphol...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa013

    authors: Armstrong MK,Schultz MG,Picone DS,Black JA,Dwyer N,Roberts-Thomson P,Sharman JE

    更新日期:2020-04-01 00:00:00

  • I1 receptors, cardiovascular function, and metabolism.

    abstract::When injected into the medullary site of the hypotensive action of clonidine, imidazolines and related compounds decrease blood pressure (BP), whereas no phenylethylamine compounds were capable of producing such an effect at the same site. There is much biochemical and pharmacologic evidence to support the involvement...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(01)02238-5

    authors: Bousquet P

    更新日期:2001-11-01 00:00:00

  • Triacylglycerol molecular species are depleted to different extents in the myocardium of spontaneously hypertensive rats fed two oleic acid-rich oils.

    abstract:BACKGROUND:During the development of hypertension, glucose replaces triacylglycerols (TG) as the main energy source for the myocardium. However, there are no available studies investigating the TG molecular species composition of the myocardium in the spontaneously hypertensive rat (SHR). The objective of this study wa...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2004.11.012

    authors: Perona JS,Ruiz-Gutierrez V

    更新日期:2005-01-01 00:00:00

  • Effects of estradiol and progesterone on platelet calcium responses.

    abstract::We investigated the effects of 17 beta-estradiol (beta E2), alpha-estradiol (alpha E2), and progesterone (P) on baseline and vasopressin (AVP)-induced [Ca2+]i in human platelets obtained from healthy male and female volunteers. Platelets were treated with beta E2, alpha E2, P, or ethanol vehicle for 30 min at 37 degre...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(94)00168-B

    authors: Raman BB,Standley PR,Rajkumar V,Ram JL,Sowers JR

    更新日期:1995-02-01 00:00:00

  • Noninvasive brachial-ankle pulse wave velocity in hypertensive patients with left ventricular hypertrophy.

    abstract:BACKGROUND:The elevation of left ventricular filling pressure (LVFP) could be an important prognostic factor in patients with hypertension. We hypothesized that noninvasive brachial-ankle pulse wave velocity (baPWV) is associated with increased LVFP in hypertensive patients with LV hypertrophy (LVH). METHODS:We enroll...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2009.243

    authors: Park KH,Park WJ,Kim MK,Jung JH,Choi S,Cho JR,Kim HS,Lee N,Cho GY

    更新日期:2010-03-01 00:00:00

  • Angiotensin II regulates cytochrome P-450 steroid hydroxylase enzyme expression in human adrenal glomerulosa cells.

    abstract::We have examined the regulation of cytochrome P-450 side chain cleavage enzyme (P-450SCC) and P-45011 beta (18) hydroxylase (P-450(11) beta) enzyme expression by angiotensin II (AII), the major regulator of aldosterone biosynthesis, in cultured human adrenal glomerulosa cells. We also examined the effect of lipoxygena...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.11.800

    authors: Natarajan R,Yang H,Hall PF,Nadler J

    更新日期:1992-11-01 00:00:00

  • Effects of gender on sympathovagal imbalance, prehypertension status, and cardiovascular risks in first-degree relatives of type 2 diabetics.

    abstract:BACKGROUND:Although cardiovascular (CV) risks are reported in first-degree relatives (FDRs) of type 2 diabetics, effects of gender on sympathovagal imbalance (SVI) and CV risks in these subjects have not been investigated. METHODS:Body mass index (BMI), blood pressure variability parameters including baroreflex sensit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpt219

    authors: Pal GK,Adithan C,Ananthanarayanan PH,Pal P,Nanda N,Durgadevi T,Lalitha V,Syamsunder AN,Dutta TK

    更新日期:2014-03-01 00:00:00

  • Methods and devices for measuring arterial compliance in humans.

    abstract::This review analyses methods and devices used worldwide to evaluate the arterial stiffness. Three main methodologies are based upon analysis of pulse transit time, of wave contour of the arterial pulse, and of direct measurement of arterial geometry and pressure, corresponding to regional, systemic and local determina...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(02)02962-x

    authors: Pannier BM,Avolio AP,Hoeks A,Mancia G,Takazawa K

    更新日期:2002-08-01 00:00:00

  • Paraoxonase 1 (PON1) C/T-108 association with longitudinal mean arterial blood pressure.

    abstract:BACKGROUND:Blood pressure is a complex quantitative trait with a strong genetic component. In this study, we leveraged the Veterans Affairs electronic medical record system to explore the relationship between Paraoxonase 1 (PON1)-108 C/T (rs705379) and mean arterial blood pressure (MAP). METHODS:Outpatient blood press...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2012.106

    authors: Bhatnagar V,Liu L,Nievergelt CM,Richard E,Brophy VH,Pandey B,Lipkowitz MS,O'Connor DT

    更新日期:2012-11-01 00:00:00

  • Reference values for clinic pulse pressure in a nonselected population.

    abstract::A wide pulse pressure (PP) may constitute an independent predictor of cardiovascular morbidity and mortality. We assessed the reference values of brachial clinic PP, according to age and gender in a nonselected population (61,724 subjects) who were undergoing a routine systematic health examination. According to mean ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(01)01284-5

    authors: Asmar R,Vol S,Brisac AM,Tichet J,Topouchian J

    更新日期:2001-05-01 00:00:00

  • Left ventricular mass is better correlated with arising blood pressure than with office or occasional blood pressure.

    abstract::The peak incidence of cardiovascular complications in the morning points to a possible role of the abrupt increase in blood pressure on arising. However, there is as yet no firm evidence linking the extent of the elevation in blood pressure on arising and the risk of cardiovascular complications. We sought a correlati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(96)00048-9

    authors: Gosse P,Ansoborlo P,Lemetayer P,Clementy J

    更新日期:1997-05-01 00:00:00

  • Chronic local cold stress to the soles induces hypertension in rats.

    abstract::The purpose of this study was to determine whether cold-stress stimulation to the soles of paws produces continuous hypertension in rats. Wistar-Kyoto rats were kept in cages with a 0 degrees C floor and 23 degrees C room temperature (cold-stressed group, n = 10) or in cages with 23 degrees C floor and 23 degrees C ro...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00144-2

    authors: Kanayama N,Khatun S,Belayet H,She L,Terao T

    更新日期:1999-11-01 00:00:00

  • Prevalence of hyperhomocysteinemia in an elderly population.

    abstract:BACKGROUND:Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carry out epidemiologic s...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(01)02165-3

    authors: Janson JJ,Galarza CR,Murúa A,Quintana I,Przygoda PA,Waisman G,Camera L,Kordich L,Morales M,Mayorga LM,Camera MI

    更新日期:2002-05-01 00:00:00

  • Prevalence, awareness, treatment, and risk factors associated with hypertension in the Iranian population: the national survey of risk factors for noncommunicable diseases of Iran.

    abstract:BACKGROUND:The prevalence of hypertension in the Middle East is not well defined. We examined the prevalence, awareness, treatment, and control of hypertension in Iran. METHODS:The Survey of Risk Factors of Noncommunicable Diseases was conducted in 2005 and contains a representative sample of the Iranian adult populat...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.154

    authors: Esteghamati A,Abbasi M,Alikhani S,Gouya MM,Delavari A,Shishehbor MH,Forouzanfar M,Hodjatzadeh A,Ramezani RD

    更新日期:2008-06-01 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract::The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/1.3.106s

    authors: Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期:1988-07-01 00:00:00

  • Role of the sympathetic nervous system during the development of obesity-induced hypertension in rabbits.

    abstract::We have previously reported that weight gain induced by high-fat diet (HFD) leads to an increase in mean arterial pressure (MAP, +14%) and heart rate (HR, +31%) in the adult rabbit. In the present study, we tested the hypothesis that an increased activity of the sympathetic nervous system may contribute to the develop...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00267-8

    authors: Antic V,Kiener-Belforti F,Tempini A,Van Vliet BN,Montani JP

    更新日期:2000-05-01 00:00:00

  • Sympathetic nervous control of blood pressure. Role in primary hypertension.

    abstract::After a brief historic survey, sympathetic-neurogenic contributions to the multifactorial, polygenetically linked etiology of primary (essential) hypertension are outlined towards the background of experimental findings both in various rat models and in human subjects. It is emphasized how at least some variants of bo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/2.3.103s

    authors: Folkow B

    更新日期:1989-03-01 00:00:00

  • Geographic variation in hypertension prevalence among blacks and whites: the multi-ethnic study of atherosclerosis.

    abstract:BACKGROUND:Many studies have examined differences in hypertension across race/ethnic groups but few have evaluated differences within groups. METHODS:We investigated within-group geographic variations in hypertension prevalence among 3,322 black and white participants of the Multi-Ethnic Study of Atherosclerosis (MESA...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2009.211

    authors: Kershaw KN,Diez Roux AV,Carnethon M,Darwin C,Goff DC Jr,Post W,Schreiner PJ,Watson K

    更新日期:2010-01-01 00:00:00

  • Twenty-Five-Year Changes in Office and Ambulatory Blood Pressure: Results from the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

    abstract:BACKGROUND:Blood pressure (BP) measured in the office setting increases from early through later adulthood. However, it is unknown to what extent out-of-office BP derived via ambulatory BP monitoring (ABPM) increases over time, and which participant characteristics and risk factors might contribute to these increases. ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa189

    authors: Bundy JD,Jaeger BC,Huffman MD,Knox SS,Thomas SJ,Shimbo D,Booth Iii JN,Lewis CE,Edwards LJ,Schwartz JE,Muntner P

    更新日期:2020-11-17 00:00:00

  • Common genetic variations in the vitamin D pathway in relation to blood pressure.

    abstract:BACKGROUND:Vitamin D is involved in blood pressure (BP) regulation. Genetic variations may influence the effect of vitamin D on BP, but data from epidemiologic studies remain inconsistent. METHODS:We conducted a comprehensive genetic association study in the Women's Genome Health Study (WGHS) with genome-wide genotype...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,meta分析

    doi:10.1093/ajh/hpu049

    authors: Wang L,Chu A,Buring JE,Ridker PM,Chasman DI,Sesso HD

    更新日期:2014-11-01 00:00:00

  • Association of central aortic pressures indexes with development of diabetes mellitus in essential hypertension.

    abstract:BACKGROUND:Diabetes mellitus (DM) and hypertension (HT) frequently coexist. Increased central aortic pressures indexes are associated with HT; however, possible associations of these indexes with future development of DM have never been studied in HT. METHODS:We recruited 178 patients with uncomplicated nondiabetic HT...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.145

    authors: Chen JY,Chou CH,Lee YL,Tsai WC,Lin CC,Huang YY,Chen JH

    更新日期:2010-10-01 00:00:00

  • Racial/ethnic differences in hypertension prevalence, treatment, and control for outpatients in northern California 2010-2012.

    abstract:BACKGROUND:Hypertension (HTN) is a known major cardiovascular disease risk factor, but prevalence, treatment, and control of HTN among rapidly growing minority groups such as Asian Americans and Hispanics are unknown largely due to either underrepresentation in epidemiologic studies or aggregation of Asian American sub...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ajh/hpu189

    authors: Zhao B,Jose PO,Pu J,Chung S,Ancheta IB,Fortmann SP,Palaniappan LP

    更新日期:2015-05-01 00:00:00

  • Erythrocyte Na-K-Cl cotransport activity in low renin essential hypertensive patients. A 23Na nuclear magnetic resonance study.

    abstract::The Na-K-Cl cotransport activity in red blood cells from essential hypertensive men with low (n = 8, mean age 42 +/- 4 years) or normal renin activity (n = 4, mean age 43 +/- 3 years), and in normotensive men with normal renin activity (n = 7, mean age 38 +/- 4 years) has been evaluated by means of a recently develope...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/7.2.151

    authors: Cacciafesta M,Ferri C,Carlomagno A,De Angelis C,Scuteri A,Guidoni L,Luciani AM,Rosi A,Viti V,Santucci A

    更新日期:1994-02-01 00:00:00

  • Do beta-blockers really increase peripheral vascular resistance? Review of the literature and new observations under basal conditions.

    abstract::Most antihypertensive drugs act by counteracting vasoconstrictor mechanisms and lower blood pressure by lowering vascular resistance. The beta-blockers, which have the unique feature of counteracting cardiac sympathetic drive, seem to be a major exception to this generalization. Moreover, their degree of cardiodepress...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/1.1.91

    authors: Man in't Veld AJ,Van den Meiracker AH,Schalekamp MA

    更新日期:1988-01-01 00:00:00

  • The relationship of electronically monitored physical activity to blood pressure, heart rate, and the circadian blood pressure profile.

    abstract::We studied how closely changes in electronically monitored physical activity are reflected in changes in blood pressure and heart rate in a group of untreated hypertensive subjects. Thirty-nine hypertensive patients (office blood pressure > 140/ 90 mm Hg) of mean age 57 +/- 10 years (mean +/-SD) wore an ambulatory blo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00147-8

    authors: Mansoor GA,White WB,McCabe EJ,Giacco S

    更新日期:2000-03-01 00:00:00

  • Clinical overview of hypertension and emerging treatment considerations.

    abstract::Managing hypertension is a complex undertaking, where even the definition of the disorder is subject to discussion. Recently, there has been controversy concerning the most appropriate measure to determine health risks associated with hypertension. In the past, diastolic blood pressure (DBP) was the prime measure for ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(01)02131-8

    authors: Cushman WC

    更新日期:2001-07-01 00:00:00

  • Plasma viscosity in isolated systolic hypertension: the role of pulse pressure.

    abstract::Atherosclerosis is increasingly recognized as an inflammatory vascular disease, and high blood pressure (BP) has been suggested to exert a proinflammatory action. Whether plasma viscosity (PV), a major determinant of blood flow in microcirculation and a marker of systemic inflammation and cardiovascular risk, is incre...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2005.01.014

    authors: Ciuffetti G,Schillaci G,Lombardini R,Pirro M,Vaudo G,Mannarino E

    更新日期:2005-07-01 00:00:00

  • Association of Maternal Plasma Folate and Cardiometabolic Risk Factors in Pregnancy with Elevated Blood Pressure of Offspring in Childhood.

    abstract:BACKGROUND:The prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), o...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpx003

    authors: Wang H,Mueller NT,Li J,Sun N,Huo Y,Ren F,Wang X

    更新日期:2017-05-01 00:00:00

  • Effects of hypertrophy and heart failure on [Na+]i in pressure-overloaded guinea pig heart.

    abstract::Intracellular free sodium levels ([Na+]i) were assessed with 23Na nuclear magnetic resonance (NMR) spectroscopy in isolated, Langendorff-perfused normal, compensated hypertrophied, and hypertrophied failing guinea pig hearts under several conditions. Baseline [Na+]i measured with a shift reagent was significantly grea...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00219-F

    authors: Jelicks LA,Siri FM

    更新日期:1995-09-01 00:00:00