Sympathetic nervous control of blood pressure. Role in primary hypertension.

Abstract:

:After a brief historic survey, sympathetic-neurogenic contributions to the multifactorial, polygenetically linked etiology of primary (essential) hypertension are outlined towards the background of experimental findings both in various rat models and in human subjects. It is emphasized how at least some variants of both human and rat primary hypertension show a genetically linked, central nervous system (CNS)-dependent increase of responsiveness to ordinary daily psychosocial stimuli. Such influences, conveyed by way of neurohormonal response patterns, seem to act in concert with cardiovascular structural adaptation, also sometimes genetically reinforced, so as to gradually elevate the pressure equilibrium until a state of "established" hypertension is reached. However, also in variants characterized by, eg, a genetically increased sensitivity to salt intake of renal or other origin, neurohormonal mechanisms seem to be involved early, though probably via other types of central mechanisms, thereby helping to convey the pressure-elevating influences of the altered salt-volume handling. Evidence is now at hand to indicate that these two "environmental factors," ie, excitatory psychosocial influences and increased salt intake, which at least partly operate via different genetic elements, are in fact closely intertwined, and even mutually reinforcing as to their actions. It is also briefly outlined how neurogenic contributions seem to vary in extent and type of impact, not only between different variants of hypertension but also along with the stage of disorder, probably being, in most cases, particularly important in the early stages.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Am J Hypertens

authors

Folkow B

doi

10.1093/ajh/2.3.103s

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

103S-111S

issue

3 Pt 2

eissn

0895-7061

issn

1941-7225

journal_volume

2

pub_type

杂志文章,评审
  • Serum vitamin D insufficiency is related to blood pressure in diabetic pregnancy.

    abstract:BACKGROUND:Vitamin D deficiency in pregnancy has been associated with an increased risk of preeclampsia. However, the association between serum vitamin D and blood pressure in pregnant women has been scarcely evaluated, particularly in women with a high risk of developing hypertensive disorders of pregnancy. We sought ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu043

    authors: Weinert LS,Reichelt AJ,Schmitt LR,Boff R,Oppermann ML,Camargo JL,Silveiro SP

    更新日期:2014-10-01 00:00:00

  • Effects of a human-derived sodium transport inhibitor on in vitro vascular reactivity.

    abstract::Concentrations of sodium-transport inhibitors (STI) which block the sodium-potassium-ATPase pump are increased in the plasma and urine of volume-expanded and low-renin hypertensive humans and animals. To evaluate the physiologic relevance of STI to blood-pressure-raising mechanisms, we have examined the in vitro prope...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.10.754

    authors: Weber MA,Weiler E,Gonick HC,Prins BA,Purdy RE

    更新日期:1989-10-01 00:00:00

  • Plasma norepinephrine changes after arousal and exercise were enhanced in conscious pigs with perinephritic hypertension.

    abstract::This study found that pigs in the early stages of perinephritic hypertension had enhanced plasma norepinephrine (NE) and heart rate (HR) responses to behaviorally arousing stimuli (lifting in a canvas sling) and exercise. In the hypertensive animals, the increase in plasma NE in response to behavioral arousal caused b...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/6.10.844

    authors: Zhao S,Pinto JM,Bergau D,Lown B,Kirby DA

    更新日期:1993-10-01 00:00:00

  • Prevalence of Self-Reported Hypertension in Deaf Adults Who Use American Sign Language.

    abstract:BACKGROUND:In the United States, roughly one-third of adults have hypertension; another third have prehypertension. The prevalence of hypertension in deaf American Sign Language (ASL) users is unknown. We address this gap through a descriptive study for the prevalence of hypertension in the American Deaf community and ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpy111

    authors: Simons AN,Moreland CJ,Kushalnagar P

    更新日期:2018-10-15 00:00:00

  • Glucose metabolism and insulin receptor binding and mRNA levels in tissues of Dahl hypertensive rats.

    abstract::Increased insulinemic response to an oral glucose load has been demonstrated in Dahl salt-sensitive hypertensive rats. To determine whether this abnormality is mediated at the level of the insulin receptor, we compared insulin receptor binding and mRNA levels in tissues of Dahl salt-sensitive rats (DS) and in their no...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(97)00220-3

    authors: Sechi LA,Griffin CA,Zingaro L,Catena C,De Carli S,Schambelan M,Bartoli E

    更新日期:1997-11-01 00:00:00

  • Associations Between Genetic Variants of NADPH Oxidase-Related Genes and Blood Pressure Responses to Dietary Sodium Intervention: The GenSalt Study.

    abstract:BACKGROUND:The aim of this study was to comprehensively test the associations of genetic variants of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-related genes with blood pressure (BP) responses to dietary sodium intervention in a Chinese population. METHODS:We conducted a 7-day low-sodium intervention ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpw200

    authors: Han X,Hu Z,Chen J,Huang J,Huang C,Liu F,Gu C,Yang X,Hixson JE,Lu X,Wang L,Liu DP,He J,Chen S,Gu D

    更新日期:2017-04-01 00:00:00

  • Relevance of the trough-to-peak ratio to the 24 h blood pressure load.

    abstract::The ambulatory blood pressure load is generally defined as the proportion of elevated systolic or diastolic pressures over a 24 h period. This value represents the chronic pressure overload that induces myocardial and vascular damage associated with the hypertensive disease process. Blood pressure load has been define...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/0895-7061(96)87761-2

    authors: White WB

    更新日期:1996-10-01 00:00:00

  • Blood pressure evaluation by noninvasive and traditional methods. Consistencies and discrepancies among photoplethysmomanometry, office sphygmomanometry, and ambulatory monitoring. Effects of blood pressure measurement.

    abstract::Three hundred eight outpatients referred for hypertension were studied. A continuous beat-to-beat noninvasive recording (Finapres) of blood pressure evaluated the blood pressure increase (9 mm Hg systolic and 4 mm Hg diastolic) induced by office sphygmomanometry. Thereafter, patients underwent a 24-h ambulatory blood ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00354-1

    authors: Musso NR,Giacchè M,Galbariggi G,Vergassola C

    更新日期:1996-04-01 00:00:00

  • Antihypertensive Drug Therapy. The effect of JNC criteria on prescribing patterns and patient status through the first year.

    abstract::This study was designed to evaluate the impact of the protocol-driven antihypertensive therapy on outcomes guided by the Joint National Committee (JNC) on Detection, Evaluation, and Treatment of high blood pressure. In a systematic hypertension control program for union employees conducted in New York City, untreated ...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/0895-7061(95)00438-6

    authors: Alderman MH,Madhavan S,Cohen H

    更新日期:1996-05-01 00:00:00

  • How to Manage Hypertension in People With Diabetes.

    abstract::Hypertension is a common condition that is often seen in patients with diabetes. Both diseases increase the risk of morbidity and mortality from CV events and kidney disease progression. Factors that influence blood pressure (BP) control in diabetes include the persons' genetic background for hypertension and kidney d...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa067

    authors: Ali W,Bakris GL

    更新日期:2020-10-21 00:00:00

  • Disparate effects of weight loss on insulin sensitivity and erythrocyte sodium-lithium countertransport activity.

    abstract::Previous investigations have demonstrated an association between impaired insulin sensitivity and elevated erythrocyte sodium-lithium countertransport (Na(+)-Li+ CT) activity. It has been speculated that insulin resistance and endogenous hyperinsulinemia are causally related to the development of elevated Na(+)-Li+ CT...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/5.10.754

    authors: Wolpert HA,Steen SN,Istfan NW,Simonson DC

    更新日期:1992-10-01 00:00:00

  • Renovascular hypertension induces myocardial mitochondrial damage, contributing to cardiac injury and dysfunction in pigs with metabolic syndrome.

    abstract:BACKGROUND:Subjects with renovascular hypertension (RVH) often manifest with metabolic syndrome (MetS) as well. Coexisting MetS and hypertension increases cardiovascular morbidity and mortality, but the mechanisms underlying cardiac injury remain unknown. We hypothesized that superimposition of MetS induces myocardial ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa202

    authors: Aghajani Nargesi A,Farah MC,Zhu XY,Zhang L,Tang H,Jordan KL,Saadiq IM,Lerman A,Lerman LO,Eirin A

    更新日期:2020-12-05 00:00:00

  • Maternal body mass index, height, and risks of preeclampsia.

    abstract:BACKGROUND:There is an association between maternal body mass index (BMI) and preeclampsia, but if BMI has an effect on preeclampsia of all severities is debated. If there is an association between maternal height and preeclampsia of all severities is unknown. METHODS:In this population-based cohort study including 50...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2011.175

    authors: Sohlberg S,Stephansson O,Cnattingius S,Wikström AK

    更新日期:2012-01-01 00:00:00

  • Inhibition of oxidative stress and improvement of endothelial function by amlodipine in angiotensin II-infused rats.

    abstract:BACKGROUND:Calcium channel blockers such as amlodipine are effective antihypertensive agents. In this study we investigated the effects of amlodipine on vascular oxidative stress, expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1), and endothelial function in angiotensin (Ang) II-infused ra...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2003.09.007

    authors: Zhou MS,Jaimes EA,Raij L

    更新日期:2004-02-01 00:00:00

  • Left ventricular function and regression of left ventricular hypertrophy in essential hypertension.

    abstract::Although left ventricular hypertrophy (LVH) is an adaptive response to the increased load imposed on the heart in patients with hypertension, it ultimately is itself a major risk factor for cardiovascular disease. The influence of LVH on left ventricular function and on the coronary circulation, and the occurrence of ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/6.3.14s

    authors: Clement DL,De Buyzere M,Duprez D

    更新日期:1993-03-01 00:00:00

  • Association of blood pressure and cardiovascular mortality in India: Mumbai cohort study.

    abstract:BACKGROUND:To determine all-cause and circulatory system (cardiovascular)-related mortality in subjects with different grades of hypertension, we performed a prospective study. METHODS:A total of 148,173 individuals aged > or =35 years were recruited in Mumbai, India in years 1991-1997. Clinical history and anthropome...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2009.131

    authors: Pednekar MS,Gupta R,Gupta PC

    更新日期:2009-10-01 00:00:00

  • Effects of isradipine on endothelin-induced constriction of myometrial arteries in normotensive pregnant women.

    abstract::The results of our previous studies suggested that endothelin-1 (ET-1) might be contributory to the impaired uteroplacental blood flow seen in preeclampsia. The aim of this study was to investigate the in vitro influence of isradipine on ET-1-induced contraction of myometrial resistance arteries from pregnant women, a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/7.7.50s

    authors: Kublickiene KR,Wolff K,Kublickas M,Lindblom B,Lunell NO,Nisell H

    更新日期:1994-07-01 00:00:00

  • Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats.

    abstract:BACKGROUND:This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)03144-8

    authors: Rodriguez-Gomez I,Wangensteen R,Atucha NM,O'Valle F,Del Moral RG,Garcia-Estañ J,Vargas F,Osuna A

    更新日期:2003-01-01 00:00:00

  • Lung Ultrasound-Guided Dry-Weight Reduction in Hemodialysis Patients Does Not Affect Short-Term Blood Pressure Variability.

    abstract:BACKGROUND:Increased short-term blood pressure (BP) variability (BPV) in hemodialysis is associated with increased cardiovascular and all-cause mortality. Studies on the impact of BP-lowering interventions on BPV are scarce. This study examined the effect of dry-weight reduction with a lung ultrasound-guided strategy o...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1093/ajh/hpz064

    authors: Loutradis C,Sarafidis PA,Theodorakopoulou M,Ekart R,Alexandrou ME,Pyrgidis N,Angeloudi E,Tzanis G,Toumpourleka M,Papadopoulou D,Mallamaci F,Zoccali C,Papagianni A

    更新日期:2019-07-17 00:00:00

  • Normal serum levels of calcitonin gene-related peptide (CGRP) in mild to moderate essential hypertension.

    abstract::Calcitonin gene-related peptide (CGRP), a highly potent vasodilator, is expressed from the calcitonin-gene and has been localized to nerve fibers of the cardiovascular system, suggesting involvement in the physiologic regulation of vascular tone. In this investigation serum concentrations of CGRP were measured in pati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/4.7.565

    authors: Schifter S,Krusell LR,Sehested J

    更新日期:1991-07-01 00:00:00

  • Correspondences between the activity of the renin-angiotensin system and the erythrocyte Na+ transport abnormalities in hypertension.

    abstract::Plasma renin activity and the relationship of renin activity and sodium excretion were analyzed in 50 untreated essential hypertensives classified according to their erythrocyte Na+ transport abnormalities. Renin activity was inappropriately high in 7 patients with increased activity of Na+,Li+ countertransport, inapp...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.5.412

    authors: Arrázola A,Díez J

    更新日期:1990-05-01 00:00:00

  • Heritability of the retinal microcirculation in Flemish families.

    abstract:BACKGROUND:Few population studies have described the heritability and intrafamilial concordance of the retinal microvessels, or the genetic or environmental correlations of the phenotypes of these vessels. METHODS:We randomly selected 413 participants from 70 families (mean age, 51.5 years; 50.1% women) from a Flemish...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hps064

    authors: Liu YP,Kuznetsova T,Jin Y,Thijs L,Asayama K,Gu YM,Bochud M,Verhamme P,Struijker-Boudier HA,Staessen JA

    更新日期:2013-03-01 00:00:00

  • Blood pressure and the risk of stroke, cardiovascular disease, and all-cause mortality among Japanese: the JPHC Study.

    abstract:BACKGROUND:Little is known about the influence of blood pressure (BP) on cardiovascular disease (CVD) outcomes among Asian populations. METHODS:We examined population attributable fractions (PAFs) and hazard ratios (HRs) associated with BP in relation to stroke and coronary heart disease (CHD) incident and mortality w...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.356

    authors: Ikeda A,Iso H,Yamagishi K,Inoue M,Tsugane S

    更新日期:2009-03-01 00:00:00

  • Physical Activity Is Associated With Reduced Left Ventricular Mass in Obese and Hypertensive African Americans.

    abstract:BACKGROUND:Physical activity (PA) has been associated with decreased left ventricular (LV) hypertrophy in previous studies. However, little is known about the relationship between PA and LV structure and factors which influence this relationship among African Americans. METHODS:We evaluated 1,300 African Americans wit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpx044

    authors: Kamimura D,Loprinzi PD,Wang W,Suzuki T,Butler KR,Mosley TH,Hall ME

    更新日期:2017-06-01 00:00:00

  • What time is the "biologic zero hour" of circadian variability?

    abstract::Most ambulatory blood pressure monitoring (ABPM) studies have used a mechanical clock as the reference time, but there is no biologic background for assuming that midnight by the mechanical clock is zero hour by the biologic clock. The aim of this study was to determine the biologic zero hour as the zero reference tim...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:

    authors: Okutani M,Komori S,Iwasaki H,Mochizuki Y,Kohno I,Mochizuki S,Ishii H,Ijiri H,Tamura K

    更新日期:1997-07-01 00:00:00

  • Blood pressure and cognitive functioning among independent elderly.

    abstract:BACKGROUND:The morbidity and mortality benefits of blood pressure (BP) control for the elderly is well documented. The cognitive consequences of hypertension control in this population, however, are still under debate. We aim to study the association between BP and cognitive performance in the elderly. Specifically, we...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(03)01005-7

    authors: Paran E,Anson O,Reuveni H

    更新日期:2003-10-01 00:00:00

  • Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study.

    abstract:BACKGROUND:This study was designed to evaluate whether plasma asymmetric dimethylarginine (ADMA) has any role in predicting hemodynamic responses in clinically healthy young subjects. ADMA, as an endogenous nitric oxide (NO) synthase inhibitor, has been demonstrated to associate with hypertension and vascular reactivit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.215

    authors: Päivä H,Kähönen M,Lehtimäki T,Raitakari OT,Jula A,Viikari J,Alfthan G,Juonala M,Laaksonen R,Hutri-Kähönen N

    更新日期:2008-08-01 00:00:00

  • Obesity hypertension.

    abstract::The association between obesity and hypertension is well recognized. However, the exact mechanisms whereby obesity causes hypertension are complex and multifactorial. The current article summarizes some of the known mechanisms responsible for obesity hypertension. ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1016/s0895-7061(01)02299-3

    authors: Rocchini AP

    更新日期:2002-02-01 00:00:00

  • Essential hypertension vs. secondary hypertension among children.

    abstract:BACKGROUND:The aim was to determine the proportions and correlates of essential hypertension among children in a tertiary pediatric hypertension clinic. METHODS:We evaluated 423 consecutive children and collected demographic and clinical history by retrospective chart review. RESULTS:We identified 275 (65%) hypertens...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu083

    authors: Gupta-Malhotra M,Banker A,Shete S,Hashmi SS,Tyson JE,Barratt MS,Hecht JT,Milewicz DM,Boerwinkle E

    更新日期:2015-01-01 00:00:00

  • Increased levels of beta-human atrial natriuretic peptide-like immunoreactivity in chronically overloaded atrial tissue.

    abstract::The levels and molecular form of atrial natriuretic peptide-like immunoreactivity (ANP-LI) in human atrial tissue were investigated. The levels of right atrial ANP-LI were significantly higher in mitral disease than in other cardiac or noncardiac diseases. The increased ANP-LI was mainly accounted for by an increase i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.2.105

    authors: Naruse M,Hiroe M,Naruse K,Nagata M,Ohno H,Hashimoto A,Koyanagi H,Sekiguchi M,Demura H,Hirosawa K

    更新日期:1990-02-01 00:00:00