Age-related changes in membrane fluidity of erythrocytes in essential hypertension.


:In the present study, age- and calcium-related changes in the membrane fluidity of erythrocytes were examined in patients with essential hypertension by use of electron spin resonance method (ESR). The erythrocytes were obtained from patients with essential hypertension. We examined the ESR spectra for a fatty acid spin label agent (5-nitroxy stearate) incorporated into the erythrocyte membranes. The values of outer hyperfine splitting and order parameter (S) were significantly higher in subjects with essential hypertension than in the normotensive subjects. This finding indicates that the membrane fluidity of erythrocytes was lower in essential hypertension. Calcium-loading of erythrocytes with the Ca-ionophore A23187 decreased the membrane fluidity (S value was increased) more strongly in essential hypertension than in the normotensive subjects. Furthermore, this Ca-induced change in membrane fluidity was significantly correlated with age in essential hypertension. These results demonstrate that the membrane fluidity of erythrocytes is markedly decreased by calcium, especially in essential hypertension in older patients. This suggests an increased calcium-sensitivity of cell membranes in the aged hypertensive patient.


Am J Hypertens


Tsuda K,Masuyama Y




Has Abstract


1990-09-01 00:00:00












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    abstract::Blood pressure responses to 1 week of low (20 mmol sodium/day) and high (300 mmol sodium/day) salt intake were investigated in a double-blind, randomized study in 46 white, nonobese subjects with essential hypertension (13 women, 33 men; mean age 45.3 +/- 2.2 years, age range 25 to 80 years). The individuals were clas...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Overlack A,Ruppert M,Kolloch R,Kraft K,Stumpe KO

    更新日期:1995-08-01 00:00:00

  • Antagonism of the renin-angiotensin system can counteract cardiac angiogenic vascular endothelial growth factor gene therapy and myocardial angiogenesis in the normal heart.

    abstract:BACKGROUND:The aim of this study was to test the hypothesis that angiotensin converting enzyme inhibition or angiotensin II antagonism can counteract cardiac human vascular endothelial growth factor-A165 (phVEGF-A165) induced angiogenesis. METHODS:Mice were given a single intramyocardial injection of phVEGF-A165. Eith...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Siddiqui AJ,Mansson-Broberg A,Gustafsson T,Grinnemo KH,Dellgren G,Hao X,Fischer H,Sylvén C

    更新日期:2005-10-01 00:00:00

  • Protein kinase C mediates insulin-inhibited Ca2+ transport and contraction of vascular smooth muscle.

    abstract::Insulin acutely inhibits contraction of primary cultured vascular smooth muscle (VSM) cells from canine femoral artery by inhibiting contractile agonist-induced Ca2+ influx. Insulin also inhibits contraction at step(s) distal to intracellular Ca2+ concentration (Ca2+i) by stimulating cyclic guanosine monophosphate (GM...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kahn AM,Allen JC,Seidel CL,Song T

    更新日期:2000-04-01 00:00:00

  • Postprandial hypotension: evaluation by ambulatory blood pressure monitoring.

    abstract::To elucidate whether postprandial hypotension (PPH) is associated with any diurnal change of blood pressure, ambulatory blood pressure monitoring was performed on 121 hospitalized essential hypertensive patients who received standardized meals. Postprandial change in blood pressure was defined as the difference betwee...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kohara K,Uemura K,Takata Y,Okura T,Kitami Y,Hiwada K

    更新日期:1998-11-01 00:00:00

  • Impaired fibrinolysis and insulin resistance in patients with hypertension.

    abstract::Plasma plasminogen activator inhibitor type 1 (PAI-1) and tissue plasminogen activator (tPA) antigens and activities were measured in 28 patients with hypertension and 12 normal controls. Steady state plasma glucose (SSPG) concentrations were also determined after an infusion of somatostatin, insulin and glucose. Pati...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Jeng JR,Sheu WH,Jeng CY,Huang SH,Shieh SM

    更新日期:1996-05-01 00:00:00

  • Azilsartan improves glycemic status and reduces kidney damage in zucker diabetic fatty rats.

    abstract:BACKGROUND:Azilsartan medoxomil (AZL-M), an angiotensin II receptor blocker, demonstrates antihypertensive and organ protective effects in hypertension. We investigated the efficacy of AZL-M to ameliorate metabolic syndrome and kidney damage associated with type 2 diabetes using Zucker diabetic fatty (ZDF) rats. METHO...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hye Khan MA,Neckář J,Haines J,Imig JD

    更新日期:2014-08-01 00:00:00

  • Characterization of a Na+/K+-ATPase inhibitor from human plasma: preliminary data.

    abstract::The role of an endogenous sodium pump inhibitor in the pathogenesis of hypertension has been reported in several papers. Unfortunately, because of the unknown structure and lack of biochemical characterization, some discrepancies have arisen. In this study we report a method to obtain extracts from human plasma that a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Boschi S,Munarini A,Borghi C,Strocchi E,Costa FV,Mussi A,Ettore A

    更新日期:1988-07-01 00:00:00

  • Developmental studies demonstrate age-dependent elevation of renin activity in TGR(mRen2)27 rats.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Véniant M,Whitworth CE,Ménard J,Sharp MG,Gonzales MF,Bruneval P,Mullins JJ

    更新日期:1995-12-01 00:00:00

  • Differential regulation of osteopontin expression in the clipped and nonclipped kidney of two-kidney, one-clip hypertensive rats.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Gauer S,Hartner A,Hauser IA,Fierlbeck W,Eberhardt W,Geiger H

    更新日期:2003-03-01 00:00:00

  • The heme oxygenase system selectively suppresses the proinflammatory macrophage m1 phenotype and potentiates insulin signaling in spontaneously hypertensive rats.

    abstract:BACKGROUND:The mechanisms by which heme oxygenase (HO) improves glucose metabolism in essential hypertension are not completely understood. Because dysfunctional insulin signaling is associated with elevated inflammation and high cholesterol and triglycerides, we investigated the effects of HO on the proinflammatory ma...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ndisang JF,Mishra M

    更新日期:2013-09-01 00:00:00

  • Reversible posterior leukoencephalopathy secondary to indinavir-induced hypertensive crisis: a case report.

    abstract::Reversible posterior leukoencephalopathy syndrome (RPLS) is an uncommon entity related to multiple and different pathologies, the most common being hypertensive crisis. It is believed to be secondary to the breakdown on the blood-brain barrier. At the beginning, it is undistinguishable from other leukoencephalopathies...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Giner V,Fernández C,Esteban MJ,Galindo MJ,Forner MJ,Guix J,Redón J

    更新日期:2002-05-01 00:00:00

  • Blood pressure response to dietary calcium intervention in humans.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Mikami H,Ogihara T,Tabuchi Y

    更新日期:1990-08-01 00:00:00

  • Normal serum levels of calcitonin gene-related peptide (CGRP) in mild to moderate essential hypertension.

    abstract::Calcitonin gene-related peptide (CGRP), a highly potent vasodilator, is expressed from the calcitonin-gene and has been localized to nerve fibers of the cardiovascular system, suggesting involvement in the physiologic regulation of vascular tone. In this investigation serum concentrations of CGRP were measured in pati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Schifter S,Krusell LR,Sehested J

    更新日期:1991-07-01 00:00:00

  • Moderate waist circumference and hypertension prevalence: the REGARDS Study.

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    pub_type: 杂志文章


    authors: Levine DA,Calhoun DA,Prineas RJ,Cushman M,Howard VJ,Howard G

    更新日期:2011-04-01 00:00:00

  • Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans.

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    pub_type: 杂志文章,随机对照试验


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    更新日期:2017-11-06 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Ledingham JM

    更新日期:1991-10-01 00:00:00

  • Overexpression of Long Noncoding RNA Uc.187 Induces Preeclampsia-Like Symptoms in Pregnancy Rats.

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    pub_type: 杂志文章


    authors: Huang J,Qian Y,Cheng Q,Yang J,Ding H,Jia R

    更新日期:2020-04-29 00:00:00

  • Role of Inflammatory Biomarkers in the Prevalence and Incidence of Hypertension Among HIV-Positive Participants in the START Trial.

    abstract:BACKGROUND:The association between hypertension (HTN) and inflammatory biomarkers (interleukin-6 [IL-6] and high-sensitivity C-reactive protein [hsCRP]) in HIV-positive persons with CD4+ count >500 cells/mm3 is unknown. METHODS:We studied HTN in participants of the Strategic Timing of AntiRetroviral Treatment (START) ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Ghazi L,Baker JV,Sharma S,Jain MK,Palfreeman A,Necsoi C,Murray DD,Neaton JD,Drawz PE

    更新日期:2020-01-01 00:00:00

  • Chemerin as a Driver of Hypertension: A Consideration.

    abstract::The protein chemerin (tazarotene-induced gene, TIG2; RARRES2) is a relatively new adipokine. Many studies support that circulating chemerin levels associate strongly and positively with body mass index, visceral fat, and blood pressure. Here, we focus on the specific relationship of chemerin and blood pressure with th...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ferland DJ,Mullick AE,Watts SW

    更新日期:2020-11-03 00:00:00

  • Fractional diastolic and systolic pressure in the ascending aorta are related to the extent of coronary artery disease.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Jankowski P,Kawecka-Jaszcz K,Bryniarski L,Czarnecka D,Brzozowska-Kiszka M,Pośnik-Urbańska A,Kopeć G,Dragan J,Klecha A,Dudek D

    更新日期:2004-08-01 00:00:00

  • Hypertension, pulse, and other cardiovascular risk factors and vitamin D status in Finnish men.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ke L,Graubard BI,Albanes D,Fraser DR,Weinstein SJ,Virtamo J,Brock KE

    更新日期:2013-08-01 00:00:00

  • Genetic susceptibility of the donor kidney contributes to the development of renal damage after syngeneic transplantation.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kouwenhoven EA,van Dokkum RP,Marquet RL,Heemann UW,de Bruin RW,IJzermans JN,Provoost AP

    更新日期:1999-06-01 00:00:00

  • The Role First-Day Readings Play in a 3-Day Schedule of Self-Monitoring Home Blood Pressure Based on Prognostic Data. VAMPAHICA Study.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Bayó J,Dalfó A,Barceló MA,Saez M,Roca C,Pallozzi J,Coll-De-Tuero G

    更新日期:2020-02-22 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Bukoski RD,Xue H,McCarron DA

    更新日期:1989-06-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Pernot F,Schleiffer R,Bergmann C,Vincent M,Sassard J,Gairard A

    更新日期:1990-11-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Rubattu S,Giliberti R,Volpe M

    更新日期:2000-10-01 00:00:00

  • The relation between peripheral vascular structure, left ventricular hypertrophy, and ambulatory blood pressure in essential hypertension.

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Sihm I,Schroeder AP,Aalkjaer C,Holm M,Mørn B,Mulvany M,Thygesen K,Lederballe O

    更新日期:1995-10-01 00:00:00

  • Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial.

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    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Kostis JB,Packer M,Black HR,Schmieder R,Henry D,Levy E

    更新日期:2004-02-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Hackam DG,Peterson JC,Spence JD

    更新日期:2000-01-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hvidt KN,Olsen MH,Holm JC,Ibsen H

    更新日期:2014-11-01 00:00:00