Abstract：
:To examine the effects of hypertension on renal graft function, we studied the clinical course of 144 kidney transplant recipients who had functioning grafts for three to 13 years. The patients were divided into three groups: normotensive (n = 32), controlled hypertensive (n = 49) and uncontrolled hypertensive group (n = 63). In addition to the difference in their blood pressure status, the three groups had significantly different levels of serum creatinine at entry to the study (mean +/- SE in mg/dL: 1.41 +/- 0.02, 8.89 +/- 0.02 and 2.30 +/- 0.03, respectively, P = .0002). Cumulative graft survival (CGS) at ten years for normotensive patients was 81%, whereas it was 58% for controlled hypertensive patients and 50% for uncontrolled hypertensive patients. The difference of CGS between normotensive and hypertensive patients was significant (P = .01), whereas the difference between the two hypertensive groups, controlled v. uncontrolled, was not. If serum creatinine levels at entry to the study were adjusted and the CGS of hypertensive patients was compared to normotensive patients with comparable levels of serum creatinine, the differences in CGS between the two groups were no longer significant. Regression analyses for potential prognostic factors revealed that serum creatinine levels were of more primary importance as a prognostic variable than blood pressure status. We conclude that hypertension is an important risk factor for renal graft survival, but control of hypertension alone does not appear to improve it. Graft survival appears to be influenced more by the severity of graft dysfunction at entry to the study irrespective of blood pressure control.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Cheigh JS,Haschemeyer RH,Wang JC,Riggio RR,Tapia L,Stenzel KH,Rubin ALdoi
10.1093/ajh/2.5.341subject
Has Abstractpub_date
1989-05-01 00:00:00pages
341-8issue
5 Pt 1eissn
0895-7061issn
1941-7225journal_volume
2pub_type
杂志文章abstract：BACKGROUND:This structured metaanalysis focused on determining the relationship between hypertension (HTN) and thoracic aortic dissection (TAD). METHODS:Electronic searches were conducted using the MedLine database, for the period 1946 through May 2013, and manual searches from reference lists. Demographic data, patie...
journal_title：American journal of hypertension
pub_type： 杂志文章,meta分析
doi：10.1093/ajh/hpt293
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Feeding stroke-prone spontaneously hypertensive rats (SHRSP) a diet rich in fructose results in a profound glucose intolerance not observed in the normotensive Wistar Kyoto (WKY) strain. The aim of this study was to investigate the role of the liver in the underlying mechanisms in the SHRSP. METHODS:SHRSP a...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2008.41
更新日期：2008-06-01 00:00:00
abstract：:Cigarette smoking, an established cardiovascular (CV) disease risk factor, is known to impair pulsatile arterial function. However, information is scant in this regard on asymptomatic younger adult former smokers. As part of the Bogalusa Heart Study, the pulsatile arterial function was examined noninvasively in 278 no...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2006.02.004
更新日期：2006-09-01 00:00:00
abstract：:Ca2+ efflux from cultured vascular smooth muscle cells (VSMC) consists of two mechanisms: one is dependent on extracellular sodium, mediated by the Na(+)-Ca2+ exchange (Na+o-dependent Ca2+ efflux), and the other is independent of extracellular sodium but is mediated by the Ca(2+)-pump (Na+o-independent Ca2+ efflux). I...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/7.7.597
更新日期：1994-07-01 00:00:00
abstract：BACKGROUND:High salt diet causes cardiac hypertrophy and fibrosis and increases cardiac aldosterone, while decreasing plasma aldosterone. The present study assessed, in Wistar rats, the effect of high salt diet on left and right ventricle (LV and RV, respectively) weight and fibrosis both with and without the aldostero...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(02)03268-5
更新日期：2003-04-01 00:00:00
abstract：:The Multicenter Isradipine/Diuretic Atherosclerosis Study (MIDAS) is a randomized, double-blind, active-control trial to compare the effectiveness of two treatment regimens for the control of hypertension in reducing the rate of progression of early extracranial carotid artery atherosclerosis in hypertensive patients....
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1093/ajh/4.2.114s
更新日期：1991-02-01 00:00:00
abstract：BACKGROUND:Complement factor H (CFH) is a plasma protein that is essential in the regulation of the alternative complement pathway and has been implicated as taking part in complement inhibition in atherogenesis. We evaluated the association of the Y402H polymorphism with incident coronary heart disease (CHD), incident...
journal_title：American journal of hypertension
pub_type： 杂志文章,多中心研究
doi：10.1038/ajh.2007.81
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:The elevation of left ventricular filling pressure (LVFP) could be an important prognostic factor in patients with hypertension. We hypothesized that noninvasive brachial-ankle pulse wave velocity (baPWV) is associated with increased LVFP in hypertensive patients with LV hypertrophy (LVH). METHODS:We enroll...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2009.243
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Substantial epidemiological evidence documents diverse health benefits, including reduced risks of hypertension, associated with diets high in fiber. Few studies, however, have investigated the extent to which dietary fiber intake in early pregnancy is associated with reductions in preeclampsia risk. We asse...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2008.209
更新日期：2008-08-01 00:00:00
abstract：BACKGROUND:Debate exists about the relationship between hypovitaminosis D and cardiovascular (CVD) risk. METHODS:This study investigated baseline (n=2,271) 25-hydroxyvitamin D (25(OH)D) and baseline and 4 year (n=1,957) CVD risk in a cohort of Finnish middle-aged male smokers. RESULTS:The prevalences of measured hype...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpt051
更新日期：2013-08-01 00:00:00
abstract：:This review and update focuses on the clinical features of hydrochlorothiazide (HCTZ), the thiazide-like agents chlorthalidone (CTDN) and indapamide (INDAP), potassium-sparing ENaC inhibitors and aldosterone receptor antagonists, and loop diuretics. Diuretics are the second most commonly prescribed class of antihypert...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1093/ajh/hpw030
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:A successful weight loss program is essential treatment for obesity-related diseases, but it is well known that the majority of individuals do not succeed in weight loss maintenance. The present study evaluates hormonal mechanisms and the relationship of beta2-adrenoceptor polymorphisms involved in individua...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2005.05.006
更新日期：2005-11-01 00:00:00
abstract：:Endothelin-1 (ET-1) is a powerful vasoconstrictor peptide and regulator of blood flow that plays an important role in blood pressure (BP) elevation in some models of experimental hypertension such as DOCA-salt rat, DOCA-salt-treated spontaneously hypertensive rats (SHR), stroke-prone SHR, Dahl salt-sensitive rats, ang...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(01)02074-x
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Blood pressure (BP) measured in the office setting increases from early through later adulthood. However, it is unknown to what extent out-of-office BP derived via ambulatory BP monitoring (ABPM) increases over time, and which participant characteristics and risk factors might contribute to these increases. ...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpaa189
更新日期：2020-11-17 00:00:00
abstract：:We have previously reported that weight gain induced by high-fat diet (HFD) leads to an increase in mean arterial pressure (MAP, +14%) and heart rate (HR, +31%) in the adult rabbit. In the present study, we tested the hypothesis that an increased activity of the sympathetic nervous system may contribute to the develop...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(99)00267-8
更新日期：2000-05-01 00:00:00
abstract：:Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...
journal_title：American journal of hypertension
pub_type： 杂志文章,评审
doi：10.1016/s0895-7061(02)02948-5
更新日期：2002-07-01 00:00:00
abstract：BACKGROUND:Whether left ventricular (LV) geometric remodeling, as indexed by relative wall thickness (RWT), aggregates in families and is inherited independent of LV mass (LVM) and additional confounders is uncertain. METHODS:We determined whether RWT as assessed from 2D targeted M-mode echocardiography shows intrafam...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpu202
更新日期：2015-05-01 00:00:00
abstract：BACKGROUND:The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and en...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/s0895-7061(02)02967-9
更新日期：2002-09-01 00:00:00
abstract：:Endothelin-1 is a potent vasoconstrictor peptide produced in blood vessels and other tissues that may play an important role in the control of local blood flow and could be involved in the pathogenesis of hypertension. Our previous studies have documented increases in endothelin-1 peptide content and gene expression i...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(95)96213-4
更新日期：1995-03-01 00:00:00
abstract：BACKGROUND:It is not clear which educational strategy is most effective in helping patients to change their lifestyles. This study compared the efficacy of two different educational models on reducing blood pressure (BP). METHODS:This was a randomized controlled trial in ambulatory hypertensive patients >65 years of a...
journal_title：American journal of hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.amjhyper.2005.10.005
更新日期：2006-07-01 00:00:00
abstract：:The effects of long-term oral administration of quinapril on the occurrence of stroke and on mortality were investigated in young salt-loaded stroke-prone spontaneously hypertensive rats (SHR-SPs) during the treatment period (8th-34th week of age) and up to 6 weeks thereafter. Simultaneously, blood pressure, saline in...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/6.11.951
更新日期：1993-11-01 00:00:00
abstract：:The goal of this study was to investigate the activity of the Na+/H+ exchanger in erythrocytes of patients with essential hypertension and its relation with urinary Na+ excretion. The study was performed in cells from 27 untreated hypertensive patients and 30 normotensive controls with similar age and sex distribution...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/0895-7061(94)00172-8
更新日期：1995-02-01 00:00:00
abstract：BACKGROUND:Salt sensitivity of blood pressure (SSBP) increases the risk of cardiovascular complications, and the heritability of SSBP is about 50% in Chinese population. However, studies identifying genes involved in BP responses to acute sodium loading and diuresis shrinkage are still limited. METHOD:A total of 342 e...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpx179
更新日期：2018-03-10 00:00:00
abstract：BACKGROUND:Central artery reservoir-excess pressure parameters are clinically important but impractical to record directly. However, diastolic waveform morphology is consistent across central and peripheral arteries. Therefore, peripheral artery reservoir-excess pressure parameters related to diastolic waveform morphol...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpaa013
更新日期：2020-04-01 00:00:00
abstract：:Alcohol consumption has been recognized as an important correlate of blood pressure in many epidemiologic studies, but few interventional studies have been conducted to examine the effect of a reduction in alcohol intake on blood pressure. Because these studies have usually included few subjects and been of short dura...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1093/ajh/7.9.814
更新日期：1994-09-01 00:00:00
abstract：BACKGROUND:In the hypertensive heart, epicardial arteries are not enlarged, despite increased total coronary flow related to augmented cardiac workload, wall stress, and left ventricular (LV) mass. The aims of this study were to assess the impact of different hemodynamic factors and LV mass on baseline left main corona...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1016/j.amjhyper.2006.07.003
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:The association of adiposity during childhood with future risk of elevated blood pressure (BP) in South Asian children is not known. We aimed to investigate the relationship between waist circumference (WC) and body mass index (BMI) with BP over a 2-year period, independent of the baseline BP. METHODS:We an...
journal_title：American journal of hypertension
pub_type： 杂志文章,随机对照试验
doi：10.1038/ajh.2011.67
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Liddle's syndrome (LS) is a monogenic form of hypertension simulating a mineralocorticoid excess, and is currently suspected in young hypokalemic hypertensives. The aims of the study were: (i) to evaluate the clinical phenotype of LS in a newly identified Italian family of Sicilian origin carrying a gain-of-...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1038/ajh.2011.76
更新日期：2011-08-01 00:00:00
abstract：BACKGROUND:Matrix Gla protein (MGP) is a vascular calcification inhibitor dependent upon vitamin K for activation. Evidence suggests that elevated plasma inactive MGP levels (desphospho-uncarboxylated MGP, dp-ucMGP; indicating poorer vascular vitamin K status) are associated with greater cardiovascular disease (CVD) ri...
journal_title：American journal of hypertension
pub_type： 杂志文章
doi：10.1093/ajh/hpy049
更新日期：2018-05-07 00:00:00
abstract：:Use of thiazide diuretics and beta-blockers in the treatment of hypertension may result in metabolic derangements and/or disturbances in the parameters of renal function, which offset the benefits of blood pressure reduction by adversely affecting other cardiovascular risk factors, particularly in special patient grou...
journal_title：American journal of hypertension
pub_type： 临床试验,杂志文章,多中心研究
doi：
更新日期：1990-12-01 00:00:00
