Adipose tissue-specific regulation of angiotensinogen in obese humans and mice: impact of nutritional status and adipocyte hypertrophy.


BACKGROUND:The adipose tissue renin-angiotensin system (RAS) has been implicated in the pathophysiology of obesity and dysfunction of adipose tissue. However, neither regulation of angiotensinogen (AGT) expression in adipose tissue nor secretion of adipose tissue-derived AGT has been fully elucidated in humans. METHODS:Human subcutaneous abdominal adipose tissue (SAT) biopsies were performed for 46 subjects with a wide range of body mass index (BMI). Considering the mRNA level of AGT and indices of body fat mass, the amount of adipose tissue-derived AGT secretion (A-AGT-S) was estimated. Using a mouse model of obesity and weight reduction, plasma AGT levels were measured with a newly developed enzyme-linked immunosorbent assay (ELISA), and the contribution of A-AGT-S to plasma AGT levels was assessed. RESULTS:A-AGT-S was substantially increased in obese humans and the value was correlated with the plasma AGT level in mice. A-AGT-S and plasma AGT were higher in obese mice, whereas lower in mice with weight reduction. However, the AGT mRNA levels in the liver, kidney, and aorta were not altered in the mouse models. In both humans and mice, the AGT mRNA levels in mature adipocytes (MAs) were comparable to those in stromal-vascular cells. Coulter Multisizer analyses revealed that AGT mRNA levels in the MAs were inversely correlated with the average size of mature adipocytes. CONCLUSIONS:This study demonstrates that adipose tissue-derived AGT is substantially augmented in obese humans, which may contribute considerably to elevated levels of circulating AGT. Adipose tissue-specific regulation of AGT provides a novel insight into the clinical implications of adipose tissue RAS in human obesity.


Am J Hypertens


Yasue S,Masuzaki H,Okada S,Ishii T,Kozuka C,Tanaka T,Fujikura J,Ebihara K,Hosoda K,Katsurada A,Ohashi N,Urushihara M,Kobori H,Morimoto N,Kawazoe T,Naitoh M,Okada M,Sakaue H,Suzuki S,Nakao K




Has Abstract


2010-04-01 00:00:00














  • Estimated healthcare savings associated with adequate dairy food intake.

    abstract::Medical literature that has coalesced during the past two to three decades has identified adequate intake of nutrients from dairy foods as a common factor in the reduction of the disease burden of several common medical conditions. These include obesity, hypertension, type 2 diabetes, osteoporosis, kidney stones, cert...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: McCarron DA,Heaney RP

    更新日期:2004-01-01 00:00:00

  • High K diets markedly reduce atherosclerotic cholesterol ester deposition in aortas of rats with hypercholesterolemia and hypertension.

    abstract::High K diets prevent hypertensive endothelial injury and intimal thickening. Cholesterol esters often deposit during hypercholesterolemia. Would a high K diet influence cholesterol ester deposits? In a normal rat on a normal diet, no cholesterol esters are detected in the aorta. Stroke prone SHR rats were fed for 3 mo...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tobian L,Jahner TM,Johnson MA

    更新日期:1990-02-01 00:00:00

  • Incomplete benefit of antihypertensive therapy on stroke reduction in older hypertensives with abnormal nocturnal blood pressure dipping (extreme-dippers and reverse-dippers).

    abstract::To determine whether the benefits of antihypertensive treatment vary according to dipper status, 811 asymptomatic elderly Japanese hypertensives underwent 24-h ambulatory blood pressure monitoring. During a mean follow-up period of 41 months, 32 stroke events were observed in patients who remained nonmedicated (n = 38...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Hoshide Y,Kario K,Schwartz JE,Hoshide S,Pickering TG,Shimada K

    更新日期:2002-10-01 00:00:00

  • Relationship of insulin resistance to macro- and microvasculature reactivity in hypertension.

    abstract:BACKGROUND:Although insulin resistance (IR) is thought to be related to vascular dysfunction, the difference in the relationship of IR to microvasculature and macrovasculature reactivity has not yet been clarified. The present study was conducted to clarify whether the IR is more closely related to the macrovasculature...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Yoshida M,Tomiyama H,Yamada J,Matsumoto C,Odaira M,Shiina K,Yamashina A

    更新日期:2010-05-01 00:00:00

  • Is endothelial function of the radial artery altered in human essential hypertension?

    abstract::There is controversy over whether endothelial function is impaired in human essential hypertension. All studies to date have used measurements of forearm blood flow by plethysmography to assess endothelium-dependent vasodilation and endothelial function. In contrast to these studies, which have focused on resistance v...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Schmieder RE,Weihprecht H,Schobel H,John S,Weidinger G,Gatzka C,Veelken R

    更新日期:1997-03-01 00:00:00

  • Prevalence and Determinants of Hypertension in India Based on the 2017 ACC/AHA Guideline: Evidence from the India National Family Health Survey.

    abstract:OBJECTIVE:To estimate the prevalence and determinants of hypertension in India based on a new definition by the 2017 American College of Cardiology/American Heart Association (2017 ACC/AHA) Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults, and compare prevalence estima...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Abariga SA,Khachan H,Al Kibria GM

    更新日期:2020-03-13 00:00:00

  • Factors Associated With Treatment and Control of Hypertension in a Healthy Elderly Population Free of Cardiovascular Disease: A Cross-sectional Study.

    abstract:BACKGROUND:Despite readily available treatments, control of blood pressure (BP) with population aging remains suboptimal. Further, there are gaps in the understanding of the management of high BP in the aged. We explored antihypertensive treatment and control among elderly hypertensive participants free from overt card...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Chowdhury EK,Nelson MR,Ernst ME,Margolis KL,Beilin LJ,Johnston CI,Woods RL,Murray AM,Wolfe R,Storey E,Shah RC,Lockery JE,Tonkin AM,Newman AB,Williamson JD,Abhayaratna WP,Stocks NP,Fitzgerald SM,Orchard SG,Trevaks RE

    更新日期:2020-04-01 00:00:00

  • Hypertension in HIV-infected patients: prevalence and related factors.

    abstract:BACKGROUND:Little is known about hypertension in the HIV-infected population. This study aimed to assess the prevalence of hypertension and related factors in HIV-infected patients. METHODS:In this prospective cross-sectional study, 710 HIV-infected patients (626 on combination antiretroviral therapy and 84 naive) man...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Jericó C,Knobel H,Montero M,Sorli ML,Guelar A,Gimeno JL,Saballs P,López-Colomés JL,Pedro-Botet J

    更新日期:2005-11-01 00:00:00

  • Aftershock Triggers Augmented Pressor Effects in Survivors: Follow-Up of the Great East Japan Earthquake.

    abstract:BACKGROUND:Previous reports focused on the significant acute effects immediately after an earthquake on an increase in blood pressure (BP) assessed by ambulatory BP monitoring. However, there have been no data on the impact of environmental triggers on the long-term response to earthquake. METHODS:We analyzed the ambu...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Nishizawa M,Hoshide S,Okawara Y,Shimpo M,Matsuo T,Kario K

    更新日期:2015-12-01 00:00:00

  • Physical Activity Is Associated With Reduced Left Ventricular Mass in Obese and Hypertensive African Americans.

    abstract:BACKGROUND:Physical activity (PA) has been associated with decreased left ventricular (LV) hypertrophy in previous studies. However, little is known about the relationship between PA and LV structure and factors which influence this relationship among African Americans. METHODS:We evaluated 1,300 African Americans wit...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kamimura D,Loprinzi PD,Wang W,Suzuki T,Butler KR,Mosley TH,Hall ME

    更新日期:2017-06-01 00:00:00

  • Recent landmark clinical trials: how do they modify the therapeutic paradigm?

    abstract::Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Epstein M

    更新日期:2002-07-01 00:00:00

  • Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats.

    abstract:BACKGROUND:This study investigates the effects of chronic administration of omapatrilat (OMA) on blood pressure (BP), renal injury, and other variables in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension and in the low-renin model produced by the simultaneous administration of L-NAME and deoxycorticosterone...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Rodriguez-Gomez I,Wangensteen R,Atucha NM,O'Valle F,Del Moral RG,Garcia-Estañ J,Vargas F,Osuna A

    更新日期:2003-01-01 00:00:00

  • Association of Post-Saline Load Plasma Aldosterone Levels With Left Ventricular Hypertrophy in Primary Hypertension.

    abstract:BACKGROUND:Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular morbidity in hypertension. Current evidence suggests a contribution to LVH of plasma aldosterone levels that are inappropriately elevated for the salt status. The aim of this study was to investigate whether inappropriate mod...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Catena C,Verheyen ND,Url-Michitsch M,Kraigher-Krainer E,Colussi G,Pilz S,Tomaschitz A,Pieske B,Sechi LA

    更新日期:2016-03-01 00:00:00

  • Left ventricular function and regression of left ventricular hypertrophy in essential hypertension.

    abstract::Although left ventricular hypertrophy (LVH) is an adaptive response to the increased load imposed on the heart in patients with hypertension, it ultimately is itself a major risk factor for cardiovascular disease. The influence of LVH on left ventricular function and on the coronary circulation, and the occurrence of ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Clement DL,De Buyzere M,Duprez D

    更新日期:1993-03-01 00:00:00

  • Intranasal angiotensin II directly influences central nervous regulation of blood pressure.

    abstract::Intranasal administration of some peptides has been shown to directly influence central nervous functions, thus pointing to a nose-brain pathway for these substances in humans. The present study investigated whether intranasal administration of angiotensin II (ANG II) affects central nervous functions of cardiovascula...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Derad I,Willeke K,Pietrowsky R,Born J,Fehm HL

    更新日期:1998-08-01 00:00:00

  • Prevalence, Awareness, Treatment, and Control of Hypertension in the Southern Cone of Latin America.

    abstract:BACKGROUND:Hypertension is the leading global preventable risk factor for premature death. While hypertension prevalence has been declining in high-income countries, it has increased continuously in low- and middle-income countries. METHODS:We conducted a cross-sectional survey in 7,524 women and men aged 35-74 years ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: Rubinstein AL,Irazola VE,Calandrelli M,Chen CS,Gutierrez L,Lanas F,Manfredi JA,Mores N,Poggio R,Ponzo J,Seron P,Bazzano LA,He J

    更新日期:2016-12-01 00:00:00

  • Changes of plasma endothelin and growth factor levels, and of left ventricular mass, after chronic AT1-receptor blockade in human hypertension.

    abstract::The stimulation of autocrine and paracrine factors such as basic fibroblast- (bFGF) and platelet-derived (PDGF) growth factors mediates many of the growth-promoting actions of angiotensin II. The aim of this study was to evaluate the effect of chronic AT1-receptor blockade on plasma endothelin-1 (ET-1) and growth fact...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Cottone S,Vadalà A,Vella MC,Nardi E,Mulé G,Contorno A,Riccobene R,Cerasola G

    更新日期:1998-05-01 00:00:00

  • Silent cerebral infarcts in basal ganglia are advanced in congenital protein C-deficient heterozygotes with hypertension.

    abstract::Congenital protein C deficiency is now widely recognized as a genetic risk for venous thrombosis. However, it remains uncertain whether this condition also confers risk for arterial thrombosis. We evaluated the association of congenital protein C deficiency with hypertension and silent cerebrovascular disease using br...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kario K,Sakata T,Higashikawa M,Katayama Y,Hoshide S,Shimada K,Miyata T

    更新日期:2001-08-01 00:00:00

  • What, if anything, is controversial about calcium antagonists?

    abstract::Recent publications purporting to show that calcium antagonists, when used for the treatment of hypertension or in the post myocardial infarction patient, would paradoxically increase the rate of heart attack and mortality have cast doubts on the safety and efficacy of this drug class. All three studies are retrospect...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Messerli FH

    更新日期:1996-12-01 00:00:00

  • Associations of Reservoir-Excess Pressure Parameters Derived From Central and Peripheral Arteries With Kidney Function.

    abstract:BACKGROUND:Central artery reservoir-excess pressure parameters are clinically important but impractical to record directly. However, diastolic waveform morphology is consistent across central and peripheral arteries. Therefore, peripheral artery reservoir-excess pressure parameters related to diastolic waveform morphol...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Armstrong MK,Schultz MG,Picone DS,Black JA,Dwyer N,Roberts-Thomson P,Sharman JE

    更新日期:2020-04-01 00:00:00

  • Relationship Between Dynamic Changes in Body Weight and Blood Pressure: The ESTEBAN Survey.

    abstract:BACKGROUND:Obesity is one of the main determinants of blood pressure. The aim of this study was to evaluate and quantify the relations between the different anthropometric indices and blood pressure (BP) stratified by gender. METHODS:Cross-sectional analyses were performed using data from 2,105 adults from the ESTEBAN...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Vallée A,Perrine AL,Deschamps V,Blacher J,Olié V

    更新日期:2019-09-24 00:00:00

  • Training students in education of the hypertensive patient: enhanced performance after a simulated patient instructor (SPI)-based exercise.

    abstract::The process whereby a physician explains to the ill patient what has gone wrong and what can be done about it can be taught and evaluated by simulated patients (SPIs). This study was designed to determine whether a training experience in educating a diabetic SPI improves subsequent performance with a hypertensive SPI....

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Zweifler AJ,Sisson JC,Wolf FM,Trabin NL,Dicken LL,Gruppen LD,Grum CM,Baum KD

    更新日期:1998-05-01 00:00:00

  • Disparate effects of weight loss on insulin sensitivity and erythrocyte sodium-lithium countertransport activity.

    abstract::Previous investigations have demonstrated an association between impaired insulin sensitivity and elevated erythrocyte sodium-lithium countertransport (Na(+)-Li+ CT) activity. It has been speculated that insulin resistance and endogenous hyperinsulinemia are causally related to the development of elevated Na(+)-Li+ CT...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Wolpert HA,Steen SN,Istfan NW,Simonson DC

    更新日期:1992-10-01 00:00:00

  • Antihypertensive drug treatment and fibrinolytic function.

    abstract::Thromboembolic complications such as ischemic stroke and myocardial infarction are significantly more frequent in patients with arterial hypertension. From the available intervention studies, it appears that pharmacologic treatment of hypertension-at least with diuretics and beta-blockers-may more effectively protect ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Lottermoser K,Weisser B,Hertfelder HJ,Wöstmann B,Vetter H,Düsing R

    更新日期:1998-03-01 00:00:00

  • Association study of the elastin microfibril interfacer 1 (EMILIN1) gene in essential hypertension.

    abstract:BACKGROUND:Elastin microfibril interfacer 1 (EMILIN-1) is a negative regulator of the transforming growth factor-beta (TGF-beta) signaling, which is involved in blood pressure (BP) homeostasis. Emilin1 knockout mice display elevated BP. The aim of the present study was to assess the association between the human EMILIN...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shimodaira M,Nakayama T,Sato N,Naganuma T,Yamaguchi M,Aoi N,Sato M,Izumi Y,Soma M,Matsumoto K

    更新日期:2010-05-01 00:00:00

  • Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: the Ohasama study.

    abstract:BACKGROUND:To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. METHODS:HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Inoue R,Ohkubo T,Kikuya M,Metoki H,Asayama K,Kanno A,Obara T,Hirose T,Hara A,Hoshi H,Totsune K,Satoh H,Kondo Y,Imai Y

    更新日期:2012-05-01 00:00:00

  • An in-depth examination of the excretion of albumin and other sensitive markers of renal damage in mild hypertension.

    abstract::In an in-depth examination to better define the renal effects of mild hypertension, we used urinary proteins to indicate damage to the glomerulus (albumin), tubular reabsorption capability (retinol-binding protein), and turnover of tubular tissue (alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase) in a group ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mueller PW,Hall WD,Caudill SP,MacNeil ML,Arepally A

    更新日期:1995-11-01 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract::The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期:1988-07-01 00:00:00

  • Aspirin test for differentiation of unilateral renovascular hypertension from hyperreninemic essential hypertension.

    abstract::Responses of renin release and blood pressure to aspirin DL-lysine (ASP) were examined to find out if the responses could help in the differentiation between unilateral renovascular hypertension (RVH) and hyperreninemic essential hypertension (EHT). The two studies involved ten patients with unilateral RVH, eight with...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Imanishi M,Ohta M,Kawamura M,Akabane S,Matsushima Y,Kuramochi M,Kojima S,Kimura K,Takamiya M,Ito K

    更新日期:1991-09-01 00:00:00

  • Body mass index is not independently associated with increased aortic stiffness in a Brazilian population.

    abstract:BACKGROUND:Obesity has been described as a predictor of cardiovascular mortality, and some studies have reported an association with obesity and increased aortic stiffness. Other studies have not identified obesity to be an independent risk factor. Therefore, the purpose of our study was to determine the association be...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Rodrigues SL,Baldo MP,Lani L,Nogueira L,Mill JG,Sa Cunha Rd

    更新日期:2012-10-01 00:00:00