当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Chronic hypertension leads to hyperinsulinemia in Sprague-Dawley rats treated with nitric oxide synthase inhibitor.

Chronic hypertension leads to hyperinsulinemia in Sprague-Dawley rats treated with nitric oxide synthase inhibitor.

Abstract：

:Insulin resistance and hypertension, as well as dyslipidemia, frequently cooccur. Evidence that nitric oxide (NO) plays a crucial role in the long-term regulation of systolic blood pressure led us to examine whether enhanced vasoconstriction and hypertension induced by NO synthase inhibitor could lead to insulin and lipid disorders. NG-Nitro-L-arginine methyl-ester (L-NAME), an inhibitor of NO synthase, was given for 4 weeks in drinking water (100 mg/kg/day) to 12 Sprague-Dawley rats. Another nine rats received both L-NAME and verapamil (100 mg/kg/day), whereas 12 animals fed rat chow only served as controls. Systolic blood pressure was measured weekly by the indirect tail cuff method. Blood samples were taken at the beginning of the experiment, and after 2 and 4 weeks from all rats. The samples were assayed for insulin, glucose, and triglyceride concentrations. L-NAME treatment resulted in a marked and sustained increase in systolic blood pressure from 130+/-7 to 171+/-3 mm Hg by the second week, which was succeeded by a significant elevation in insulin level at the end of 4 weeks, from 2.3+/-1.8 to 5.4+/-2.0 ng/mL. Triglycerides and glucose were unaffected throughout the experiment. The combination of L-NAME and the NO-independent vasodilator, verapamil, attenuated the hypertension induced by L-NAME and prevented the following rise in insulin level. Data suggest that chronic elimination of NO after chronic inhibition of NO synthase may lead to a state of hyperinsulinemia, possibly as an outcome of insulin resistance.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Erlich Y,Rosenthal T

doi

10.1016/s0895-7061(98)00089-2

subject

Has Abstract

pub_date

1998-09-01 00:00:00

pages

1129-33

issue

9

eissn

0895-7061

issn

1941-7225

pii

S0895-7061(98)00089-2

journal_volume

11

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • An additive effect of endothelial nitric oxide synthase gene polymorphisms contributes to the severity of atherosclerosis in patients on dialysis.

    abstract：BACKGROUND:Reduced synthesis of nitric oxide (NO) is considered a major proatherogenic mechanism in patients with end-stage renal disease (ESRD), but genetic factors impinging on this mechanism have been little studied in this population. METHODS:We tested the relationship between carotid intima-media thickness (IMT) ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2007.02.009

    authors： Spoto B,Benedetto FA,Testa A,Tripepi G,Mallamaci F,Maas R,Boeger RH,Zoccali C

    更新日期：2007-07-01 00:00:00

  • Determinants of exercise capacity in hypertensive patients: new insights from tissue Doppler echocardiography.

    abstract：BACKGROUND:Determinants of exercise capacity have not been clearly defined in hypertensive patients. Doppler tissue imaging (DTI), a recently developed echocardiographic modality, is useful for evaluating left ventricular (LV) function regardless of loading conditions. The present study was performed to identify the de...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(03)00842-2

    authors： Kim HK,Kim YJ,Cho YS,Sohn DW,Lee MM,Park YB,Choi YS

    更新日期：2003-07-01 00:00:00

  • Central serotonergic mechanisms in hypertension.

    abstract：:Serotonin-containing neurons in the central nervous system are grouped into a number of discrete and distinctive collections with cell bodies in the brainstem and projections passing to many regions of the brain and spinal cord. Evidence is presented that activation of one projection of serotonin-containing neurons fr...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/1.1.79

    authors： Chalmers JP,Pilowsky PM,Minson JB,Kapoor V,Mills E,West MJ

    更新日期：1988-01-01 00:00:00

  • A cross-national comparative study of blood pressure and hypertension between English and Dutch South-Asian- and African-origin populations: the role of national context.

    abstract：BACKGROUND:We compare patterns of blood pressure (BP) and prevalence of hypertension between white-Dutch and their South-Asian and African minority groups with their corresponding white-English and their South-Asian and African ethnic minority groups; and the contribution of physical activity, body sizes, and socioecon...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,多中心研究

    doi：10.1038/ajh.2010.39

    authors： Agyemang C,Kunst A,Bhopal R,Zaninotto P,Unwin N,Nazroo J,Nicolaou M,Redekop WK,Stronks K

    更新日期：2010-06-01 00:00:00

  • Compliance in the treatment of hypertension. A need for action.

    abstract：:Compliance is commonly defined as the extent to which a person's behavior coincides with medical or health advice. There is evidence that noncompliance is a common problem with many medications, including antihypertensive treatment. Since noncompliance can have serious adverse effects on patient health it is important...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/0895-7061(95)00195-6

    authors： Sanson-Fisher RW,Clover K

    更新日期：1995-10-01 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract：:The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/1.3.106s

    authors： Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期：1988-07-01 00:00:00

  • Blood pressure and angiotensin converting enzyme inhibitor use in hypertensive patients with chronic renal insufficiency.

    abstract：BACKGROUND:Hypertension treatment is important in managing chronic renal insufficiency (CRI). Little is known, however, about the blood pressure (BP) control achieved or the pattern of antihypertensive drug prescription among CRI patients. METHODS:Using computerized medical records, we studied 3,089 adult hypertensive...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02202-6

    authors： Hsu CY,Bates DW,Kuperman GJ,Curhan GC

    更新日期：2001-12-01 00:00:00

  • Defining normal ambulatory blood pressure in relation to target organ damage and prognosis.

    abstract：:It is premature to state that ambulatory blood pressure (ABP) values below a given level should be considered normal, and those above it abnormal, in terms of prognostic implications on cardiovascular (CV) morbidity. We do not know whether CV morbidity in hypertensive subjects with apparently normal ABP (white coat hy...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：

    authors： Verdecchia P,Porcellati C

    更新日期：1993-06-01 00:00:00

  • Recent landmark clinical trials: how do they modify the therapeutic paradigm?

    abstract：:Despite intense investigation and clinical attention, many challenges remain in the management of the hypertensive patient. It is clear that hypertension remains inadequately controlled worldwide, with the control rate in the United States approximating 27%. Furthermore, several recent studies have underscored that it...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(02)02948-5

    authors： Epstein M

    更新日期：2002-07-01 00:00:00

  • Aortic Fibrosis, Induced by High Salt Intake in the Absence of Hypertensive Response, is Reduced by a Monoclonal Antibody to Marinobufagenin.

    abstract：BACKGROUND:Marinobufagenin (MBG) is an endogenous Na/K-ATPase inhibitor, a natriuretic and a vasoconstrictor. MBG is implicated in salt-sensitive hypertension, cardiac hypertrophy, and initiate the pro-fibrotic signaling. Previously it was demonstrated that immunoneutralization of an endogenous MBG by 3E9 anti-MBG-anti...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv155

    authors： Grigorova YN,Juhasz O,Zernetkina V,Fishbein KW,Lakatta EG,Fedorova OV,Bagrov AY

    更新日期：2016-05-01 00:00:00

  • Effects of dietary fish oil on Rb+ efflux from aorta of stroke prone spontaneously hypertensive rats.

    abstract：:The effect of fish oil on potassium efflux and basal tension in aortas from stroke prone spontaneously hypertensive rats (SHRSP) was evaluated. Four-week-old male Wistar-Kyoto rats (WKY) and SHRSP were divided into two groups: one received a 5% corn oil diet; the other a 5% menhaden oil diet. After 15 weeks, mean syst...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/5.7.473

    authors： Smith JM,Paulson DJ,Labak S

    更新日期：1992-07-01 00:00:00

  • Increased Circulating Visfatin Is Associated With Progression of Kidney Disease in Non-Diabetic Hypertensive Patients.

    abstract：BACKGROUD:Declining renal function is an independent risk factor for all-cause mortality in cardiovascular disease. Visfatin has been described as a marker of inflammation and endothelial dysfunction, but whether circulating visfatin levels are predictive to a subsequent decline in renal function remains unclear. METH...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv132

    authors： Hsu CY,Huang PH,Chen TH,Chiang CH,Leu HB,Huang CC,Chen JW,Lin SJ

    更新日期：2016-04-01 00:00:00

  • Gender differences in insulin-stimulated glucose utilization among African-Americans.

    abstract：:The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (B...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/7.11.948

    authors： Falkner B,Hulman S,Kushner H

    更新日期：1994-11-01 00:00:00

  • The influence of physical activity on the variability of ambulatory blood pressure.

    abstract：:The aim of this study was to assess the contribution of physical activity levels to blood pressure (BP) variability, and to assess the effect age, gender, body mass index, and use of antihypertensive medications on this relationship. We simultaneously monitored 24-h ambulatory BP by automated recorder and activity by ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(00)01186-9

    authors： Leary AC,Donnan PT,MacDonald TM,Murphy MB

    更新日期：2000-10-01 00:00:00

  • The heme oxygenase system selectively suppresses the proinflammatory macrophage m1 phenotype and potentiates insulin signaling in spontaneously hypertensive rats.

    abstract：BACKGROUND:The mechanisms by which heme oxygenase (HO) improves glucose metabolism in essential hypertension are not completely understood. Because dysfunctional insulin signaling is associated with elevated inflammation and high cholesterol and triglycerides, we investigated the effects of HO on the proinflammatory ma...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpt082

    authors： Ndisang JF,Mishra M

    更新日期：2013-09-01 00:00:00

  • Serum uric acid is associated with new-onset diabetes in hypertensive patients with left ventricular hypertrophy: The LIFE Study.

    abstract：BACKGROUND:It is unclear whether serum uric acid (SUA) is associated with development of new-onset diabetes (NOD) in patients with hypertension and left ventricular hypertrophy (LVH). The aim of the present investigation was to test the hypothesis that SUA predicts development of NOD in these patients. METHODS:In the ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,随机对照试验

    doi：10.1038/ajh.2010.89

    authors： Wiik BP,Larstorp AC,Høieggen A,Kjeldsen SE,Olsen MH,Ibsen H,Lindholm L,Dahlöf B,Devereux RB,Okin PM,Wachtell K

    更新日期：2010-08-01 00:00:00

  • Results of the multicenter antihypertensive treatment trials. Therapeutic implications and the role of the sympathetic nervous system.

    abstract：:The results of 19 antihypertensive treatment trials spanning some 20 years of research showed that treatment had significant benefits for pressure-related complications of hypertension but generally did not prevent coronary artery disease morbidity or mortality. As possible reasons for this relative failure were explo...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究,评审

    doi：10.1093/ajh/2.12.313s

    authors： Rosenman RH

    更新日期：1989-12-01 00:00:00

  • Relation of left ventricular hypertrophy, afterload, and contractility to left ventricular performance in Goldblatt hypertension.

    abstract：:To analyze the determinants of left ventricular (LV) performance (myocardial afterload, chamber size, mass, and contractility) in Goldblatt hypertension, 19 anesthetized one-kidney, one-clip (1K1C) and 28 two-kidney, one-clip (2K1C) male Wistar rats were studied 58 to 62 days after clipping, together with 19 sham-oper...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/5.5.292

    authors： de Simone G,Devereux RB,Volpe M,Camargo MJ,Wallerson DC,Laragh JH

    更新日期：1992-05-01 00:00:00

  • Aftershock Triggers Augmented Pressor Effects in Survivors: Follow-Up of the Great East Japan Earthquake.

    abstract：BACKGROUND:Previous reports focused on the significant acute effects immediately after an earthquake on an increase in blood pressure (BP) assessed by ambulatory BP monitoring. However, there have been no data on the impact of environmental triggers on the long-term response to earthquake. METHODS:We analyzed the ambu...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv044

    authors： Nishizawa M,Hoshide S,Okawara Y,Shimpo M,Matsuo T,Kario K

    更新日期：2015-12-01 00:00:00

  • Circadian blood pressure overswinging in a physically fit, normotensive African American woman.

    abstract：:Ambulatory blood pressure (BP) and heart rate (HR) were measured in a physically fit, normotensive postmenopausal African American woman, before and after 15 weeks of aerobic training. Mean BP, HR, and HR variability were normal at the outset and were further improved by training. Training had no effect on circadian B...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(02)02973-4

    authors： Borer KT,Cornelissen G,Halberg F,Brook R,Rajagopalan S,Fay W

    更新日期：2002-09-01 00:00:00

  • The relation between peripheral vascular structure, left ventricular hypertrophy, and ambulatory blood pressure in essential hypertension.

    abstract：:The relations between left ventricular mass (LVM), peripheral resistance artery structure, and ambulatory BP were studied in 83 patients with previously untreated or poorly regulated essential hypertension and 20 healthy controls of similar age and sex. LVM was assessed by echocardiography. Signs of left ventricular h...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00220-0

    authors： Sihm I,Schroeder AP,Aalkjaer C,Holm M,Mørn B,Mulvany M,Thygesen K,Lederballe O

    更新日期：1995-10-01 00:00:00

  • The Metabolic Syndrome Does Not Affect Development of Collateral Circulation in the Poststenotic Swine Kidney.

    abstract：BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpy127

    authors： Zhang X,Kim SR,Ferguson CM,Ebrahimi B,Hedayat AF,Lerman A,Lerman LO

    更新日期：2018-11-13 00:00:00

  • Genetic polymorphism of the alpha 2-adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans.

    abstract：:It is likely that a number of independent heritable traits, each encoded by a singular gene, contribute to pathologic elevations in blood pressure in humans. Genetic polymorphisms of individual genes may result in intermediate phenotypes which, by themselves, do not raise blood pressure, but, coupled with environmenta...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00155-I

    authors： Freeman K,Farrow S,Schmaier A,Freedman R,Schork T,Lockette W

    更新日期：1995-09-01 00:00:00

  • Recommendations for special populations: diabetes mellitus and the metabolic syndrome.

    abstract：:Cardiovascular diseases (CVD) are the major causes of mortality in persons with diabetes, and many factors, including hypertension, contribute to this high prevalence of CVD. The incidence of hypertension in patients with diabetes is approximately twofold higher than in age-matched subjects without the disease, and co...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/j.amjhyper.2003.07.009

    authors： Sowers JR

    更新日期：2003-11-01 00:00:00

  • Reversal of one-kidney, one-clip hypertension in rats. Effects on myocardial Na+, K(+)-ATPase, arterial Na(+)-K+ pump, arterial membrane potential, and plasma Na(+)-K+ pump inhibitory activity.

    abstract：:We have previously reported that myocardial microsomal Na+,K(+)-ATPase activity, arterial wall ouabain-sensitive 86Rb uptake, and arterial smooth muscle cell membrane potentials are decreased and plasma Na(+)-K+ pump inhibitory activity is increased in rats during the fifth week of one-kidney, one-clip hypertension. W...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：

    authors： Pamnani MB,Bryant HJ,Clough DL,Haddy FJ

    更新日期：1991-10-01 00:00:00

  • Association study of the elastin microfibril interfacer 1 (EMILIN1) gene in essential hypertension.

    abstract：BACKGROUND:Elastin microfibril interfacer 1 (EMILIN-1) is a negative regulator of the transforming growth factor-beta (TGF-beta) signaling, which is involved in blood pressure (BP) homeostasis. Emilin1 knockout mice display elevated BP. The aim of the present study was to assess the association between the human EMILIN...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.16

    authors： Shimodaira M,Nakayama T,Sato N,Naganuma T,Yamaguchi M,Aoi N,Sato M,Izumi Y,Soma M,Matsumoto K

    更新日期：2010-05-01 00:00:00

  • The diagnosis of renovascular hypertension. A clinician's viewpoint.

    abstract：:The sensitivity and specificity of screening and diagnostic studies for renovascular hypertension has been the focus of debate and disappointment for many years. The use of these studies has been further restricted by the insistence of clinicians that studies provide visual identification of the anatomy of the renal v...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/4.12.663s

    authors： Vidt DG

    更新日期：1991-12-01 00:00:00

  • Angiotensin receptors: history and mysteries.

    abstract：:Angiotensin receptors became relatively easy to study when radioactive derivatives of the peptide were synthesized for radioimmunoassays. Binding assays in vitro led to the discovery of receptors in many tissues different from those involved in the classic actions of angiotensin. The physiologic significance of recept...

    journal_title：American journal of hypertension

    pub_type： 历史文章,杂志文章

    doi：10.1016/s0895-7061(99)00212-5

    authors： Goodfriend TL

    更新日期：2000-04-01 00:00:00

  • An in-depth examination of the excretion of albumin and other sensitive markers of renal damage in mild hypertension.

    abstract：:In an in-depth examination to better define the renal effects of mild hypertension, we used urinary proteins to indicate damage to the glomerulus (albumin), tubular reabsorption capability (retinol-binding protein), and turnover of tubular tissue (alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase) in a group ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00231-d

    authors： Mueller PW,Hall WD,Caudill SP,MacNeil ML,Arepally A

    更新日期：1995-11-01 00:00:00

  • Pseudo renal artery stenosis (PRAS) syndrome.

    abstract：:During the course of a long-term, prospective, randomized study in 77 hypertensive nephrosclerosis patients, five patients developed evidence suggestive of renal artery stenosis. However, arteriography demonstrated patent renal arteries. The evidence suggestive of renal artery stenosis was: (1) converting-enzyme inhib...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/2.5.349

    authors： Pettinger WA,Mitchell HC,Lee HC,Redman HC

    更新日期：1989-05-01 00:00:00