当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Mesenteric artery contractile properties during dietary calcium manipulation in spontaneously hypertensive and Wistar Kyoto normotensive rats.

Mesenteric artery contractile properties during dietary calcium manipulation in spontaneously hypertensive and Wistar Kyoto normotensive rats.

Abstract：

:The hypothesis that elevated Ca2+ intake lowers blood pressure in the spontaneously hypertensive rat (SHR) by altering intrinsic contractile properties of vascular smooth muscle was tested. The effect of 0.5, 1, and 2% Ca2+ in the diet on systolic blood pressure, serum-ionized Ca2+, and contractile properties of mesenteric arteries isolated from SHR and normotensive Wistar-Kyoto (WKY) rats maintained on diets for 6 and 12 weeks was examined. Blood pressure was significantly elevated in SHR on 0.5% Ca2+ diets after both 6 and 12 weeks, as well as in WKY receiving 1% Ca2+. After six weeks on the diets for the SHR and 6 and 12 weeks for the WKY, serum-ionized Ca2+ was a function of the amount of Ca2+ in the diet. When contractile force generation in response tp KCl or norepinephrine was examined, small diet-related differences were detected, but no consistent linear effect associated with the level of Ca2+ in the diet was observed in either strain. When the sensitivity of the vessels to KCl and norepinephrine was examined, no effects of oral Ca2+ intake were detected. The results indicate that oral Ca2+ loading has modest effects on blood pressure at both 12 and 18 weeks of age in the SHR and WKY and in the younger rat, where Ca2+ intake modulates serum ionized Ca2+ levels. At no age does modification of Ca2+ intake have a consistent effect on mesenteric artery sensitivity or force-generating ability in response to KCl or norepinephrine. These findings do not support the hypothesis that oral Ca2+ loading lowers blood pressure in the rat by altering intrinsic contractile properties of vascular smooth muscle.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Bukoski RD,Xue H,McCarron DA

doi

10.1093/ajh/2.6.440

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

440-8

issue

6 Pt 1

eissn

0895-7061

issn

1941-7225

journal_volume

2

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Gender differences in insulin-stimulated glucose utilization among African-Americans.

    abstract：:The purpose of this study was to determine whether there are gender differences in plasma insulin levels or insulin resistance in young adult African-Americans. Male (n = 53) and female (n = 45) subjects (age 23 to 28 years) included normotensives (N, blood pressure [BP] < 135/85 mm Hg) and borderline hypertensives (B...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/7.11.948

    authors： Falkner B,Hulman S,Kushner H

    更新日期：1994-11-01 00:00:00

  • Role for granulocyte colony stimulating factor in angiotensin II-induced neutrophil recruitment and cardiac fibrosis in mice.

    abstract：BACKGROUND:Granulocyte colony stimulating factor (G-CSF) is a key mediator of neutrophil infiltration and is profibrotic in the liver, lung, and infarcted heart, but its roles in angiotensin II (Ang II)-induced hypertension and cardiac remodeling have not been fully determined. Thus, we sought to investigate the causal...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpt095

    authors： Jiang HM,Wang HX,Yang H,Zeng XJ,Tang CS,Du J,Li HH

    更新日期：2013-10-01 00:00:00

  • The relation between peripheral vascular structure, left ventricular hypertrophy, and ambulatory blood pressure in essential hypertension.

    abstract：:The relations between left ventricular mass (LVM), peripheral resistance artery structure, and ambulatory BP were studied in 83 patients with previously untreated or poorly regulated essential hypertension and 20 healthy controls of similar age and sex. LVM was assessed by echocardiography. Signs of left ventricular h...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(95)00220-0

    authors： Sihm I,Schroeder AP,Aalkjaer C,Holm M,Mørn B,Mulvany M,Thygesen K,Lederballe O

    更新日期：1995-10-01 00:00:00

  • Reduced mRNA and protein content of rho guanine nucleotide exchange factor (RhoGEF) in Bartter's and Gitelman's syndromes: relevance for the pathophysiology of hypertension.

    abstract：BACKGROUND:Activation of RhoA/Rho kinase (ROK) pathway by angiotensin II (Ang II) is involved in the pathophysiology of hypertension and remodeling. In Bartter's and Gitelman's syndrome (BS/GS), the short-term and long-term signaling of Ang II are blunted. The BS/GS have also reduced expression and response on Ang II c...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.03.747

    authors： Pagnin E,Semplicini A,Sartori M,Pessina AC,Calò LA

    更新日期：2005-09-01 00:00:00

  • Blood pressure, low-density lipoprotein cholesterol, and incidences of coronary artery disease and ischemic stroke in Japanese: the Suita study.

    abstract：BACKGROUND:Blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) are risk factors for coronary artery disease (CAD) and ischemic stroke. However, the hazards of their coexistence are not fully understood in Asian populations. We investigated whether the relationship between BP and cardiovascular disease (...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpu059

    authors： Tsukinoki R,Okamura T,Watanabe M,Kokubo Y,Higashiyama A,Nishimura K,Takegami M,Murakami Y,Okayama A,Miyamoto Y

    更新日期：2014-11-01 00:00:00

  • Barriers to hypertension care and control in young urban black men.

    abstract：:Barriers to high blood pressure (HBP) care and control have been reported in the literature for > 30 years. Few reports on barriers, however, have focused on the young black man with HBP, the age/sex/race group with the highest rates of early severe and complicated HBP and the lowest rates of awareness, treatment, and...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(99)00121-1

    authors： Hill MN,Bone LR,Kim MT,Miller DJ,Dennison CR,Levine DM

    更新日期：1999-10-01 00:00:00

  • Plasma viscosity in isolated systolic hypertension: the role of pulse pressure.

    abstract：:Atherosclerosis is increasingly recognized as an inflammatory vascular disease, and high blood pressure (BP) has been suggested to exert a proinflammatory action. Whether plasma viscosity (PV), a major determinant of blood flow in microcirculation and a marker of systemic inflammation and cardiovascular risk, is incre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.01.014

    authors： Ciuffetti G,Schillaci G,Lombardini R,Pirro M,Vaudo G,Mannarino E

    更新日期：2005-07-01 00:00:00

  • Blood Pressure, Proteinuria, and Renal Function Decline: Associations in a Large Community-Based Population.

    abstract：BACKGROUND:Hypertension and proteinuria are risk factors for adverse renal outcomes in patients with chronic kidney disease. This study investigated the associations of blood pressure and proteinuria on renal function in a community-based population. METHODS:We analyzed data from a nationwide database of 141,514 subje...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpv003

    authors： Hirayama A,Konta T,Kamei K,Suzuki K,Ichikawa K,Fujimoto S,Iseki K,Moriyama T,Yamagata K,Tsuruya K,Kimura K,Narita I,Kondo M,Asahi K,Kurahashi I,Ohashi Y,Watanabe T

    更新日期：2015-09-01 00:00:00

  • Etiology and pathophysiology of stroke as a complex trait.

    abstract：:Stroke (brain attack) is currently the third leading cause of death in Western societies. Recent advances in molecular genetics have finally demonstrated what has long been suggested by the clinical observation, that is, stroke is not only the complication of major pathologic conditions such as atherosclerosis, hypert...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(00)01249-8

    authors： Rubattu S,Giliberti R,Volpe M

    更新日期：2000-10-01 00:00:00

  • Cytochrome P-450 arachidonate metabolite inhibition improves renal function in Lyon hypertensive rats.

    abstract：:The present study evaluated the effects of miconazole, a selective inhibitor of epoxygenase activity, on renal hemodynamics and the pressure-natriuresis response of saline-drinking, uninephrectomized Lyon hypertensive (LH) and Lyon low blood pressure (LL) rats. Infusion of miconazole (final concentration, 1 micromol/L...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00256-8

    authors： Messer-Létienne I,Bernard N,Roman RJ,Sassard J,Benzoni D

    更新日期：1999-04-01 00:00:00

  • Effects of estradiol and progesterone on platelet calcium responses.

    abstract：:We investigated the effects of 17 beta-estradiol (beta E2), alpha-estradiol (alpha E2), and progesterone (P) on baseline and vasopressin (AVP)-induced [Ca2+]i in human platelets obtained from healthy male and female volunteers. Platelets were treated with beta E2, alpha E2, P, or ethanol vehicle for 30 min at 37 degre...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(94)00168-B

    authors： Raman BB,Standley PR,Rajkumar V,Ram JL,Sowers JR

    更新日期：1995-02-01 00:00:00

  • Aerobic exercise training fails to reduce blood pressure in nondipper-type hypertension.

    abstract：:To assess whether aerobic exercise training is an effective and an alternative method to control blood pressure (BP) in hypertension, 32 uncomplicated, never treated patients suffering from mild-to-moderate essential arterial hypertension (EAH) were included in an aerobic exercise training program using a regular stan...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00265-4

    authors： Nami R,Mondillo S,Agricola E,Lenti S,Ferro G,Nami N,Tarantino M,Glauco G,Spanò E,Gennari C

    更新日期：2000-06-01 00:00:00

  • Comparisons of the effects of different long-acting delivery systems on the pharmacokinetics and pharmacodynamics of diltiazem.

    abstract：:The benzothiazepine calcium channel antagonist diltiazem is a short-acting drug. To achieve effective 24-h blood pressure control with once-daily dosing, it relies on various extended drug-delivery systems that have grown in importance as a result of the recent reports relating the use of short-acting calcium channel ...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(99)00097-7

    authors： Smith DH,Neutel JM,Weber MA

    更新日期：1999-10-01 00:00:00

  • Low-dose antihypertensive combination therapy: its rationale and role in cardiovascular risk management.

    abstract：:Antihypertensive monotherapy, although commonly used, does not address the multifactorial nature of hypertension as a disease with many pathways. Using more than one drug makes more therapeutic sense because combination agents cover more than one pathway, yet the use of drugs in tandem is typically relegated to more p...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00112-0

    authors： Neutel JM

    更新日期：1999-08-01 00:00:00

  • Bisoprolol and captopril effects on insulin receptor tyrosine kinase activity in essential hypertension.

    abstract：:Angiotension converting enzyme (ACE) inhibitors and beta-blockers have been reported to possess disparate effects on insulin sensitivity. The aim of this study was to study the effects of the selective beta-1 blocker bisoprolol and of the ACE inhibitor captopril on cellular insulin action in hypertensive individuals. ...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0895-7061(97)00320-8

    authors： Dominguez LJ,Barbagallo M,Jacober SJ,Jacobs DB,Sowers JR

    更新日期：1997-12-01 00:00:00

  • Are retinal microvascular phenotypes associated with the 1675G/A polymorphism in the angiotensin II type-2 receptor gene?

    abstract：BACKGROUND:The X-linked angiotensin II type-2 receptor (AT2R) gene 1675G/A polymorphism is located in the short intron 1 of the AT2R gene within a sequence motif conforming to a splice branch site. AT2R is expressed in the human retina, but no previous study examined the association between retinal microvascular phenot...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.151

    authors： Liu YP,Kuznetsova T,Thijs L,Jin Y,Schmitz B,Brand SM,Brand E,Manunta P,Bianchi G,Struijker-Boudier H,Staessen JA

    更新日期：2011-12-01 00:00:00

  • Major histocompatibility complex in the rat and blood pressure regulation.

    abstract：:The objective of this study was to evaluate whether the major histocompatibility complex of the rat can be related to blood pressure (BP) level and BP response to stress. Blood pressure was determined under light ether anesthesia or during moderate restraint stress in normotensive Lewis rats, in rat strains congenic w...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/0895-7061(96)00023-4

    authors： Kunes J,Kohoutová M,Zicha J

    更新日期：1996-07-01 00:00:00

  • Aspirin test for differentiation of unilateral renovascular hypertension from hyperreninemic essential hypertension.

    abstract：:Responses of renin release and blood pressure to aspirin DL-lysine (ASP) were examined to find out if the responses could help in the differentiation between unilateral renovascular hypertension (RVH) and hyperreninemic essential hypertension (EHT). The two studies involved ten patients with unilateral RVH, eight with...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/4.9.761

    authors： Imanishi M,Ohta M,Kawamura M,Akabane S,Matsushima Y,Kuramochi M,Kojima S,Kimura K,Takamiya M,Ito K

    更新日期：1991-09-01 00:00:00

  • Association of arterial stiffness indexes, determined from digital volume pulse measurement and cardiovascular risk factors in chronic kidney disease.

    abstract：BACKGROUND:Progression of atherosclerosis with increased arterial stiffness is associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Compliance index (CI) derived from digital volume pulse (DVP), measuring the relationship between volume and pressure changes in ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.266

    authors： Wang MC,Wu AB,Cheng MF,Chen JY,Ho CS,Tsai WC

    更新日期：2011-05-01 00:00:00

  • How should we treat hypertensive women with cardiac and renal impairment?

    abstract：:Arterial hypertension is the most common chronic medical condition requiring office visits to physicians and is a major contributing factor to the development of myocardial infarction and stroke. Its importance as a cardiovascular risk factor is at least as significant in women as in men; however, the ever-growing lit...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(97)00330-0

    authors： Ruilope LM,Suarez C

    更新日期：1997-10-01 00:00:00

  • Rapid fusion of granules with neutrophil cell membranes in hypertensive patients may increase vascular damage.

    abstract：:In essential hypertension (EHT) the presence of a metabolic syndrome increases the risk of cardiovascular disease. A cell membrane abnormality is implicated but its role in cardiovascular disease is unclear. Neutrophil accumulation, which occurs by beta2-integrin (CD11b/CD18) expression, followed by release of proinfl...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(01)02136-7

    authors： Fardon NJ,Wilkinson R,Thomas TH

    更新日期：2001-09-01 00:00:00

  • The influence of captopril on the epinephrine response to insulin-induced hypoglycemia in humans. The interaction between the renin-angiotensin system and the sympathetic nervous system.

    abstract：:The aim of this study was to assess whether an interaction exists between the renin-angiotensin system and the sympathetic nervous system at the level of the adrenal medulla during insulin-induced hypoglycemia in normal humans. Seventeen healthy volunteers were studied in a randomized, single-dose, double-blind, cross...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1093/ajh/5.6.361

    authors： Madsen BK,Hølmer P,Ibsen H,Christensen NJ

    更新日期：1992-06-01 00:00:00

  • Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction. The Ohasama study.

    abstract：:The polymorphism of the angiotensin-converting enzyme gene is considered to be associated with increased risk for stroke, but there is a diversity in the results obtained. The genetic involvement of the renin-angiotensin system in stroke also remains unclear. To predict the genetic risk of lacunar infarction, we condu...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00184-3

    authors： Takami S,Imai Y,Katsuya T,Ohkubo T,Tsuji I,Nagai K,Satoh H,Hisamichi S,Higaki J,Ogihara T

    更新日期：2000-02-01 00:00:00

  • Measurement of central systolic blood pressure by pulse volume plethysmography with a noninvasive blood pressure monitor.

    abstract：BACKGROUND:Central systolic blood pressure (SBP) can be estimated by an oscillometric method developed from a pulse volume plethysmography (PVP) device. The present study applied this novel method to a noninvasive blood pressure monitor (NBPM). METHODS:We enrolled 50 patients (37 men, age range 30-84 years) referred f...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.259

    authors： Sung SH,Cheng HM,Chuang SY,Shih YT,Wang KL,Chen YH,Lin SJ,Yu WC,Chen CH

    更新日期：2012-05-01 00:00:00

  • Impaired inotropic response in type 2 diabetes mellitus: a strain rate imaging study.

    abstract：BACKGROUND:Left ventricular (LV) concentric geometry and hypertrophy, depressed wall mechanics, and abnormal diastolic properties have been described in the diabetic heart. However, the cardiac response to dynamic exercise in diabetic patients remains controversial. The present study assessed strain rate (SR) imaging d...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.12.009

    authors： Galderisi M,de Simone G,Innelli P,Turco A,Turco S,Capaldo B,Riccardi G,de Divitiis O

    更新日期：2007-05-01 00:00:00

  • Hypertension and arterial stiffness: the Atherosclerosis Risk in Communities Study. ARIC Investigators.

    abstract：:Our objective was to describe the relationship of arterial stiffness and hypertension in a large, population-based sample of men and women. Hypertension-related increases in arterial stiffness may reflect the distending pressure and/or structural alterations in the artery. Included were 10,712 participants, ages 45 to...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00281-2

    authors： Arnett DK,Boland LL,Evans GW,Riley W,Barnes R,Tyroler HA,Heiss G

    更新日期：2000-04-01 00:00:00

  • Ambulatory blood pressure monitoring: how reproducible is it?

    abstract：:We tested the reproducibility of ambulatory blood pressure monitoring (ABPM) by the use of agreement plots. Thirty-two normotensive volunteers underwent ABPM on four separate days (interval 28 days), on the same typical weekday. Sleeping time was restricted to the ABPM nighttime subperiod from 11:00 PM to 7:00 AM. Twe...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0895-7061(97)00126-x

    authors： Musso NR,Vergassola C,Barone C,Lotti G

    更新日期：1997-08-01 00:00:00

  • Effects of aging on the insulin actions for the glucose metabolism and renal function in normotensives and essential hypertensives.

    abstract：:It has been suggested that hyperinsulinemia compensating insulin resistance in glucose metabolism may be a pathogenic factor in essential hypertension. On the other hand, age-associated increases in the prevalence of glucose intolerance and hypertension are also well established. The aim of this study is to clarify th...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00113-7

    authors： Miyazaki Y,Hirata A,Murakami H,Fukuoka M,Agata J,Higashiura K,Masuda A,Ura N,Shimamoto K

    更新日期：1998-09-01 00:00:00

  • Detection of arteriolar narrowing in fundoscopic examination: evidence of a low performance of direct ophthalmoscopy in comparison with a microdensitometric method.

    abstract：BACKGROUND:Retinal abnormalities, particularly arteriolar narrowing, are powerful predictors of cardiovascular events. The precision of internists and ophthalmologists in the assessment of retinal vessels widths has been disputed but not evaluated against a technology of edge detection. METHODS:Fifty-two patients with...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2006.10.012

    authors： Maestri MM,Fuchs SC,Ferlin E,Pakter HM,Nunes G,Moraes RS,Gus M,Moreira LB,Fuchs FD

    更新日期：2007-05-01 00:00:00

  • Protein kinase C mediates insulin-inhibited Ca2+ transport and contraction of vascular smooth muscle.

    abstract：:Insulin acutely inhibits contraction of primary cultured vascular smooth muscle (VSM) cells from canine femoral artery by inhibiting contractile agonist-induced Ca2+ influx. Insulin also inhibits contraction at step(s) distal to intracellular Ca2+ concentration (Ca2+i) by stimulating cyclic guanosine monophosphate (GM...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(99)00239-3

    authors： Kahn AM,Allen JC,Seidel CL,Song T

    更新日期：2000-04-01 00:00:00