Protein kinase C mediates insulin-inhibited Ca2+ transport and contraction of vascular smooth muscle.

abstract：BACKGROUND:Adiposity measures are associated with increased pediatric blood pressure (BP). However, this correlation can be confounded by the relationship of both variables to height. We evaluated whether adiposity and anthropometric measures were associated with pediatric BP before and after adjusting each value for h...

journal_title：American journal of hypertension

authors： Willig AL,Casazza K,Dulin-Keita A,Franklin FA,Amaya M,Fernandez JR

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Carotid-femoral pulse-wave velocity (PWV) provides a comprehensive noninvasive indication of arterial stiffness, and is now established as a strong marker of cardiovascular disease (CVD). The correlation between peripheral blood pressure (BP) and PWV and their respective influences on mortality have been poo...

journal_title：American journal of hypertension

authors： Miljkovic D,Perret-Guillaume C,Alla F,Salvi P,Erpelding ML,Benetos A

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND:Progression of atherosclerosis with increased arterial stiffness is associated with increased cardiovascular morbidity and mortality in patients with chronic kidney disease (CKD). Compliance index (CI) derived from digital volume pulse (DVP), measuring the relationship between volume and pressure changes in ...

journal_title：American journal of hypertension

authors： Wang MC,Wu AB,Cheng MF,Chen JY,Ho CS,Tsai WC

更新日期：2011-05-01 00:00:00

abstract：:In normal subjects, insulin decreases the urinary excretion of sodium, potassium, and uric acid. We tested whether these renal effects of insulin are altered in insulin resistant hypertension. In 37 patients with essential hypertension, we measured the changes in urinary excretion of sodium, potassium, and uric acid i...

journal_title：American journal of hypertension

authors： Muscelli E,Natali A,Bianchi S,Bigazzi R,Galvan AQ,Sironi AM,Frascerra S,Ciociaro D,Ferrannini E

更新日期：1996-08-01 00:00:00

abstract：:The present study evaluates the growth promoting effect of insulin on the proliferative activity of cells from rat mesenteric arteries in culture in order to test the hypothesis that insulin may play a pathogenetic role in the hypertrophy of resistance vessels. The proliferative effect of insulin was studied in cultur...

journal_title：American journal of hypertension

authors： Cruzado M,Risler N,Castro C,Ortiz A,Rüttler ME

更新日期：1998-01-01 00:00:00

abstract：:This article examines the results of the Joint National Committee's Fifth Report on the treatment of hypertension (JNC-V), especially regarding the economic arguments put forth therein. Economics are a poor basis for treatment decisions, as the cheapest therapies may not be the best for any given patient. Broad treatm...

journal_title：American journal of hypertension

authors： Ménard J

更新日期：1994-10-01 00:00:00

abstract：BACKGROUND:Obesity is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis. Nifedipine, a calcium-channel blocker, has a number of blood pressure (BP)-independent effects as well, such as improving endothelial function and decreasing oxidative stress. Here, we inve...

journal_title：American journal of hypertension

authors： Kito T,Shibata R,Kondo M,Yamamoto T,Suzuki H,Ishii M,Murohara T

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:The role of C825T polymorphism of the candidate GNB3 gene in predicting cerebrovascular outcome has been poorly explored in longitudinal setting at a population level. METHODS:In an epidemiological setting, 1,678 men and women from general population were genotyped for C825T polymorphism of GNB3 gene and fo...

journal_title：American journal of hypertension

authors： Casiglia E,Tikhonoff V,Boschetti G,Bascelli A,Saugo M,Guglielmi G,Caffi S,Rigoni G,Giordano N,Grasselli C,Martini B,Mazza A,De Lazzari F,Palatini P

更新日期：2012-04-01 00:00:00

abstract：:The relationship between erythrocyte cation transport systems and membrane and plasma lipids was examined in normal men and patients with insulin-dependent diabetes mellitus (IDDM). Different measurements of erythrocyte transport systems were obtained in patients with IDDM and in age- and weight-matched healthy men: N...

journal_title：American journal of hypertension

authors： Lijnen P,Fenyvesi A,Bex M,Bouillon R,Amery A

更新日期：1993-09-01 00:00:00

abstract：:The hypotensive effect of isradipine was assessed in 26 male patients, aged 40 to 64 years, with hypertension. After withdrawal of previous antihypertensive treatment and a four-week placebo period, patients were randomized into a double-blind active-treatment period of eight weeks to receive either placebo or 1.25 to...

journal_title：American journal of hypertension

authors： Viskoper JR,Laszt A,Faraggi D

更新日期：1991-02-01 00:00:00

abstract：:Three hundred eight outpatients referred for hypertension were studied. A continuous beat-to-beat noninvasive recording (Finapres) of blood pressure evaluated the blood pressure increase (9 mm Hg systolic and 4 mm Hg diastolic) induced by office sphygmomanometry. Thereafter, patients underwent a 24-h ambulatory blood ...

journal_title：American journal of hypertension

authors： Musso NR,Giacchè M,Galbariggi G,Vergassola C

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND:Few population studies have described the heritability and intrafamilial concordance of the retinal microvessels, or the genetic or environmental correlations of the phenotypes of these vessels. METHODS:We randomly selected 413 participants from 70 families (mean age, 51.5 years; 50.1% women) from a Flemish...

journal_title：American journal of hypertension

authors： Liu YP,Kuznetsova T,Jin Y,Thijs L,Asayama K,Gu YM,Bochud M,Verhamme P,Struijker-Boudier HA,Staessen JA

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Beetroot has attracted much attention because of its blood pressure-lowering properties. Although beetroot contains various nutritional compounds, including inorganic nitrate, some of their physiological properties are not fully understood. In this study, we examined whether betanin, a beetroot component, ha...

journal_title：American journal of hypertension

authors： Tawa M,Masuoka T,Yamashita Y,Nakano K,Ishibashi T

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Nifedipine has been reported to cause impairment of insulin sensitivity. But recently a controlled-released formulation of nifedipine (nifedipine-GITS) has been reported that it could improve insulin sensitivity. METHODS:We evaluated insulin sensitivity in two groups of essential hypertensive subjects befor...

journal_title：American journal of hypertension

authors： Koyama Y,Kodama K,Suzuki M,Harano Y

更新日期：2002-11-01 00:00:00

abstract：:Cardiovascular morbid events occur as a consequence of vascular and cardiac disease, which can be identified long before symptoms of organ involvement become apparent. Early detection of abnormalities in the small arteries, especially deficiency of endothelial nitric oxide bioactivity, and of structural changes of rem...

journal_title：American journal of hypertension

authors： Cohn JN

更新日期：2001-06-01 00:00:00

abstract：BACKGROUND:Determinants of exercise capacity have not been clearly defined in hypertensive patients. Doppler tissue imaging (DTI), a recently developed echocardiographic modality, is useful for evaluating left ventricular (LV) function regardless of loading conditions. The present study was performed to identify the de...

journal_title：American journal of hypertension

authors： Kim HK,Kim YJ,Cho YS,Sohn DW,Lee MM,Park YB,Choi YS

更新日期：2003-07-01 00:00:00

abstract：:Using a new ion selective electrode (ISE) to measure ionized magnesium (IMg2+), we compared levels of IMg2+ with total magnesium (TMg) and serum ionized calcium levels (ICa2+) in umbilical arterial and venous serum of 13 parturients who developed transient hypertension in labor with levels in 38 who remained normotens...

journal_title：American journal of hypertension

authors： Handwerker SM,Altura BT,Royo B,Altura BM

更新日期：1993-06-01 00:00:00

abstract：:Most ambulatory blood pressure monitoring (ABPM) studies have used a mechanical clock as the reference time, but there is no biologic background for assuming that midnight by the mechanical clock is zero hour by the biologic clock. The aim of this study was to determine the biologic zero hour as the zero reference tim...

journal_title：American journal of hypertension

authors： Okutani M,Komori S,Iwasaki H,Mochizuki Y,Kohno I,Mochizuki S,Ishii H,Ijiri H,Tamura K

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Clonidine, a centrally acting antihypertensive agent, has been used successfully in pregnancy. We sought to describe the pharmacodynamic effects of clonidine in pregnancy and the associated impact on fetal growth. METHODS:A retrospective cohort study was performed. Maternal hemodynamics were measured before...

journal_title：American journal of hypertension

authors： Rothberger S,Carr D,Brateng D,Hebert M,Easterling TR

更新日期：2010-11-01 00:00:00

abstract：:Previous studies have shown that erythrocytes from the Milan hypertensive strain of rats (MHS) differ from erythrocytes from the control normotensive strain (MNS). These differences are determined within the stem cells, are genetically associated with the development of hypertension, and are similar to those found bet...

journal_title：American journal of hypertension

authors： Salardi S,Saccardo B,Borsani G,Modica R,Ferrandi M,Tripodi MG,Soria M,Ferrari P,Baralle FE,Sidoli A

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Recently, some investigators have shown that telmisartan, an angiotensin II (Ang II)-receptor blocker (ARB), is a partial agonist of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma). We investigate whether telmisartan improves cardiovascular remodeling associated with the production of endot...

journal_title：American journal of hypertension

authors： Kobayashi N,Ohno T,Yoshida K,Fukushima H,Mamada Y,Nomura M,Hirata H,Machida Y,Shinoda M,Suzuki N,Matsuoka H

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:A successful weight loss program is essential treatment for obesity-related diseases, but it is well known that the majority of individuals do not succeed in weight loss maintenance. The present study evaluates hormonal mechanisms and the relationship of beta2-adrenoceptor polymorphisms involved in individua...

journal_title：American journal of hypertension

authors： Masuo K,Katsuya T,Kawaguchi H,Fu Y,Rakugi H,Ogihara T,Tuck ML

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:The morbidity and mortality benefits of blood pressure (BP) control for the elderly is well documented. The cognitive consequences of hypertension control in this population, however, are still under debate. We aim to study the association between BP and cognitive performance in the elderly. Specifically, we...

journal_title：American journal of hypertension

authors： Paran E,Anson O,Reuveni H

更新日期：2003-10-01 00:00:00

abstract：:Hypertension is a common finding among obstructive sleep apnea (OSA) patients, and is thought to be caused by sympathetic hyperactivity. The present study compares the contributions of the respiratory disturbance index (RDI) as a reflection of sleep fragmentation, and the magnitude of oxygen desaturation, to sympathet...

journal_title：American journal of hypertension

authors： Peled N,Greenberg A,Pillar G,Zinder O,Levi N,Lavie P

更新日期：1998-11-01 00:00:00

abstract：:The association between obesity and hypertension is well recognized. However, the exact mechanisms whereby obesity causes hypertension are complex and multifactorial. The current article summarizes some of the known mechanisms responsible for obesity hypertension. ...

journal_title：American journal of hypertension

authors： Rocchini AP

更新日期：2002-02-01 00:00:00

abstract：:Neutral metalloendopeptidase (NEP) inhibitors delay atrial natriuretic factor (ANF) catabolism and potentiate biological responses to ANF. We describe biochemical and pharmacological profiles of a novel NEP inhibitor, SCH 42354 (N-[2(S)-(mercaptomethyl)-3-(2-methylphenyl)-4-oxopropyl]-L-methionine and its orally activ...

journal_title：American journal of hypertension

authors： Watkins RW,Vemulapalli S,Chiu PJ,Foster C,Smith EM,Neustadt B,Haslanger M,Sybertz EJ

更新日期：1993-05-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs interfere with certain antihypertensive therapies. In a double-blind study, 385 hypertensive patients stabilized on an angiotensin converting enzyme inhibitor were treated with nabumetone, celecoxib, ibuprofen, or placebo for 4 weeks. Ibuprofen caused significantly greater increase...

journal_title：American journal of hypertension

authors： Palmer R,Weiss R,Zusman RM,Haig A,Flavin S,MacDonald B

更新日期：2003-02-01 00:00:00

abstract：:We have explored the effect of verapamil on renal hemodynamics and the renin-aldosterone system in ten patients with chronic renal disease and hypertension before and after 3 months of therapy. The mean +/- SEM glomerular filtration rates were 55 +/- 7 mL/min pre- and 55 +/- 8 mL/min posttherapy; the renal plasma flow...

journal_title：American journal of hypertension

authors： Lenz T,Müller FB,Sotelo JE,Laragh JH,August P

更新日期：1991-12-01 00:00:00

abstract：:The antidiabetic drug metformin lowers blood pressure (BP) more in spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto rats (WKY), and the hypotensive effect is enhanced by high dietary salt. To determine whether enhanced hypotension is secondary to greater decreases in sympathetic nerve activity (SNA), w...

journal_title：American journal of hypertension

authors： Muntzel MS,Nyeduala B,Barrett S

更新日期：1999-12-01 00:00:00

abstract：BACKGROUND:The prevalence of childhood elevated blood pressure (BP) has increased in the United States, particularly among African Americans. The influence of maternal plasma folate levels, alone or in combination with maternal cardiometabolic risk factors (hypertensive disorders, diabetes, and prepregnancy obesity), o...

journal_title：American journal of hypertension

authors： Wang H,Mueller NT,Li J,Sun N,Huo Y,Ren F,Wang X

更新日期：2017-05-01 00:00:00