当前位置： SCI文献检索 > AMERICAN JOURNAL OF HYPERTENSION期刊下所有文献 > Improved cardiovascular risk stratification by a simple ECG index in hypertension.

Improved cardiovascular risk stratification by a simple ECG index in hypertension.

Abstract：

BACKGROUND:We determined the prognostic value of the Cornell/strain [C/S] index, a simple electrocardiographic (ECG) index for left ventricular hypertrophy (LVH) defined by the presence of either a classic strain pattern or a Cornell voltage (sum of R in aVL + S in V(3)) >2.0 mV in women or 2.4 mV in men, or both. METHODS:In a prospective, cohort study, 2190 initially untreated subjects (age 51 [+/- 12], 47% women) with essential hypertension without prior events were followed for up to 14 years (median, 5 years). RESULTS:Prevalence of LVH at entry was 16.3% by using the C/S index, which yielded 33.6% sensitivity and 91.0% specificity. Other ECG criteria for LVH including Sokolow-Lyon, Romhilt-Estes, Framingham, Cornell, and strain alone, achieved a lower sensitivity and prevalence. Over the subsequent follow-up, 244 patients experienced a first major cardiovascular event. Event rate (x 100 person-years) was 2.01 in those without and 4.44 in those with LVH by the C/S index (P <.001). After adjustment for age, sex, smoking, and other counfounders, the C/S index identified subjects at increased risk of events (relative risk 1.76; 95% confidence interval 1.32-2.33). The C/S index achieved the highest population-attributable risk (16.1%) for cardiovascular events. CONCLUSIONS:A simple ECG index that can be quickly measured from nondigital machines and without algorithms identifies LVH in a consistent proportion (16.3%) of hypertensive subjects. The LVH defined by such technique allows identification of individuals at high risk for cardiovascular events.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Verdecchia P,Angeli F,Reboldi G,Carluccio E,Benemio G,Gattobigio R,Borgioni C,Bentivoglio M,Porcellati C,Ambrosio G

doi

10.1016/s0895-7061(03)00912-9

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

646-52

issue

8

eissn

0895-7061

issn

1941-7225

pii

S0895706103009129

journal_volume

16

pub_type

临床试验,杂志文章

相关文献

AMERICAN JOURNAL OF HYPERTENSION文献大全
  • Increasing prevalence of hypertension among patients with thoracic aorta dissection: trends over eight decades--a structured meta-analysis.

    abstract：BACKGROUND:This structured metaanalysis focused on determining the relationship between hypertension (HTN) and thoracic aortic dissection (TAD). METHODS:Electronic searches were conducted using the MedLine database, for the period 1946 through May 2013, and manual searches from reference lists. Demographic data, patie...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,meta分析

    doi：10.1093/ajh/hpt293

    authors： Chan KK,Rabkin SW

    更新日期：2014-07-01 00:00:00

  • Effects of hyperinsulinemia on the regulation of regional blood flow and blood pressure in anesthetized dogs: hemodynamic role of nitric oxide.

    abstract：:The purpose of this study was to investigate whether acute hyperinsulinemia induces selective hemodynamic effects in the mesenteric, renal, and iliac vascular beds, and to determine whether nitric oxide (NO) plays a role in the regulation of blood flow and mean arterial pressure (MAP) during acute hyperinsulinism. In ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(98)00133-2

    authors： Villa E,García-Robles R,Romero JC

    更新日期：1998-10-01 00:00:00

  • How to explain the differences between renin angiotensin system modulators.

    abstract：:Angiotensin II (Ang II) plays important roles in the development of cardiovascular diseases including hypertension, renal diseases, cardiac hypertrophy, congestive heart failure, and ischemic heart disease. Angiotensin II exerts classic hemodynamic and renal effects, but it is also a local biologically active mediator...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/j.amjhyper.2005.05.005

    authors： Levy BI

    更新日期：2005-09-01 00:00:00

  • Neural control of renin release.

    abstract：:Among the major mechanisms controlling the renal release of renin, renal nerves are known to exert a direct stimulating action on juxtaglomerular cells that is mediated by beta-adrenoceptors. Activation of the renal nerves also exerts an important permissive role in order to amplify and possibly accelerate responses t...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/2.2.7s

    authors： Stella A,Golin R,Zanchetti A

    更新日期：1989-02-01 00:00:00

  • Cardiovascular responses to aversive and nonaversive stressors in Schlager genetically hypertensive mice.

    abstract：BACKGROUND:Schlager inbred hypertensive mice (BPH/2J) have been suggested to have high blood pressure (BP) due to an overactive sympathetic nervous system (SNS). The brain nuclei associated with the hypertension are also those involved in the integration of the cardiovascular responses to stress. Therefore, in the pres...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2010.69

    authors： Davern PJ,Jackson KL,Nguyen-Huu TP,La Greca L,Head GA

    更新日期：2010-08-01 00:00:00

  • The plasma renin test reveals the contribution of body sodium-volume content (V) and renin-angiotensin (R) vasoconstriction to long-term blood pressure.

    abstract：:Body sodium works together with the plasma renin-angiotensin system to ensure adequate blood flow to the tissues. Body sodium content determines the extracellular fluid (ECF) volume ensuring that, with each heart beat, a sufficient volume of fluid is delivered into the arterial space. At the same time the kidneys moni...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/ajh.2011.171

    authors： Laragh JH,Sealey JE

    更新日期：2011-11-01 00:00:00

  • Importance of left ventricular mass as a predictor of cardiovascular morbidity in hypertension.

    abstract：:Arterial hypertension is a powerful risk factor for cardiovascular disease, but the ability to use blood pressure measurements to predict complications in individual patients or small groups is limited. One possible approach to identifying hypertensive patients at high risk is based on the observation that the presenc...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/2.8.650

    authors： Devereux RB

    更新日期：1989-08-01 00:00:00

  • A longitudinal study of urinary creatinine and creatinine clearance in normal subjects. Race, sex, and age differences.

    abstract：:The purpose of this study was to examine the variability of 24-hour urinary and serum creatinine levels and creatinine clearance in normal subjects and to develop nomograms for assessing the adequacy of 24-hour urine collections. The data were from a longitudinal research program examining biochemical, hormonal, and h...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/1.2.124

    authors： James GD,Sealey JE,Alderman M,Ljungman S,Mueller FB,Pecker MS,Laragh JH

    更新日期：1988-04-01 00:00:00

  • Sympathetic nervous control of blood pressure. Role in primary hypertension.

    abstract：:After a brief historic survey, sympathetic-neurogenic contributions to the multifactorial, polygenetically linked etiology of primary (essential) hypertension are outlined towards the background of experimental findings both in various rat models and in human subjects. It is emphasized how at least some variants of bo...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1093/ajh/2.3.103s

    authors： Folkow B

    更新日期：1989-03-01 00:00:00

  • Trends in Hospitalization for Hypertensive Emergency, and Relationship of End-Organ Damage With In-Hospital Mortality.

    abstract：BACKGROUND:There are no comprehensive guidelines on management of hypertensive emergency (HTNE) and complications. Despite advances in antihypertensive medications HTNE is accompanied with significant morbidity and mortality. METHODS:We queried the 2002-2012 nationwide inpatient sample database to identify patients wi...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hpx048

    authors： Shah M,Patil S,Patel B,Arora S,Patel N,Garg L,Agrawal S,Jacobs L,Steigerwalt SP,Martinez MW

    更新日期：2017-07-01 00:00:00

  • Effects of aging and hypertension on plasma angiotensin II and platelet angiotensin II receptor density.

    abstract：:Plasma renin activity (PRA) declines with age in normal individuals, but the effect of age on plasma angiotensin II (ANG II) is less clear. A decline in plasma ANG II with age could result in altered platelet ANG II receptor density since plasma hormone levels influence their target organ receptors. To investigate thi...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/5.10.687

    authors： Duggan J,Kilfeather S,O'Brien E,O'Malley K,Nussberger J

    更新日期：1992-10-01 00:00:00

  • Analysis of molecular heterogeneity of Dahl/Iwai salt-sensitive rats and salt-resistant rats.

    abstract：:Molecular evidence, using DNA fingerprint analyses, of extensive genetic heterogeneity between spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY) and even within some of the WKY colonies has been reported. Thus we investigated the genetic relations between Dahl S and R rats newly inbred by Dr. Iwai. Gen...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：

    authors： Umemura S,Yamaguchi S,Hayashi S,Nyui N,Yokoyama N,Sumita YI,Hibi K,Yabana M,Kihara M,Tamura K,Ishigami T,Ishii M

    更新日期：1997-05-01 00:00:00

  • Antihypertensive and humoral effects of nifedipine in essential hypertension uncontrolled by hydrochlorothiazide alone.

    abstract：:This double-blind placebo controlled study investigated the antihypertensive and humoral effects of nifedipine capsules in patients with essential hypertension inadequately controlled (seated diastolic blood pressure greater than or equal to 95 mm Hg) by hydrochlorothiazide (HCTZ) alone. Nifedipine acutely (first dose...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章

    doi：10.1093/ajh/2.11.828

    authors： Opsahl JA,Halstenson CE,Abraham PA

    更新日期：1989-11-01 00:00:00

  • Reexamining the quality of life of hypertensive patients. A new self-structured measure.

    abstract：:This study included the introduction of a new, qualitative, self-structured measure of quality of life (QOL) after meta-analysis had shown that prestructured quantitative measures yielded insignificant results. This study compared the pre- and post-treatment evaluations of 268 men with mild hypertension, aged 40 to 65...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1093/ajh/6.3.62s

    authors： Bar-On D,Amir M

    更新日期：1993-03-01 00:00:00

  • Sildenafil citrate for erectile dysfunction in men receiving multiple antihypertensive agents: a randomized controlled trial.

    abstract：BACKGROUND:Erectile dysfunction (ED) is common among men taking antihypertensive drugs to control blood pressure. We evaluated the safety and efficacy of sildenafil citrate for treating ED in men taking multiple antihypertensive medications in a randomized, double-blind, placebo-controlled trial. METHODS:A total of 56...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.amjhyper.2004.07.004

    authors： Pickering TG,Shepherd AM,Puddey I,Glasser DB,Orazem J,Sherman N,Mancia G

    更新日期：2004-12-01 00:00:00

  • Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study.

    abstract：BACKGROUND:Microalbuminuria is recognized as a marker of generalized vascular dysfunction. However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated. METHODS:Brachial-ankle PWV (b...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2007.77

    authors： Ishikawa T,Hashimoto J,Morito RH,Hanazawa T,Aikawa T,Hara A,Shintani Y,Metoki H,Inoue R,Asayama K,Kikuya M,Ohkubo T,Totsune K,Hoshi H,Satoh H,Imai Y

    更新日期：2008-04-01 00:00:00

  • Insulin-stimulated NADH/NAD+ redox state increases NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells.

    abstract：BACKGROUND:We reported that insulin modestly stimulates NAD(P)H oxidase activity in cultured rat vascular smooth muscle cells (VSMC) and synergistically stimulates enzyme activity with angiotensin II (Ang II), leading to synergistic stimulation of VSMC migration. The aim of this study was to determine the mechanism of ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.11.017

    authors： Yang M,Kahn AM

    更新日期：2006-06-01 00:00:00

  • Increasing sensitivity of blood pressure to dietary sodium and potassium with increasing age. A population study using casual urine specimens.

    abstract：:In a population of 887 men and 1159 women aged 40 to 89 years in southern California, age adjusted systolic and diastolic blood pressures correlated significantly with sodium/potassium ratios estimated from casual urine samples. The relationship was apparent over the whole range of blood pressures and urinary electrol...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/3.6.505

    authors： Khaw KT,Barrett-Connor E

    更新日期：1990-06-01 00:00:00

  • Predictive value for mortality of the double product at rest obtained by home blood pressure measurement: the Ohasama study.

    abstract：BACKGROUND:To clarify whether the double product (DP) (product of systolic blood pressure (SBP) and pulse rate (PR)) at rest based on home blood pressure (HBP) measurement has prognostic value for mortality. METHODS:HBP data of 2,583 participants from a Japanese general population (40% men) ≥35 years of age (mean, 59 ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.3

    authors： Inoue R,Ohkubo T,Kikuya M,Metoki H,Asayama K,Kanno A,Obara T,Hirose T,Hara A,Hoshi H,Totsune K,Satoh H,Kondo Y,Imai Y

    更新日期：2012-05-01 00:00:00

  • New approaches to screening for vascular and cardiac risk.

    abstract：:Cardiovascular morbid events occur as a consequence of vascular and cardiac disease, which can be identified long before symptoms of organ involvement become apparent. Early detection of abnormalities in the small arteries, especially deficiency of endothelial nitric oxide bioactivity, and of structural changes of rem...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1016/s0895-7061(01)02092-1

    authors： Cohn JN

    更新日期：2001-06-01 00:00:00

  • Increased arterial stiffness in pre-eclamptic pregnancy at term and early and late postpartum: a combined echocardiographic and tonometric study.

    abstract：BACKGROUND:Pre-eclampsia (PE) is characterized by hypertension and proteinuria, and complicates from 3%-10% of all pregnancies. The hemodynamic pathophysiology of the heart and systemic arteries in pre-eclamptic patients has not been well described. We therefore performed a comprehensive comparison of the systemic arte...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/hps067

    authors： Estensen ME,Remme EW,Grindheim G,Smiseth OA,Segers P,Henriksen T,Aakhus S

    更新日期：2013-04-01 00:00:00

  • Arterial stiffness is associated with carotid atherosclerosis in hypertensive patients (the Campania Salute Network).

    abstract：BACKGROUND:Pulse pressure/stroke volume indexed to height(2.04) (PP/SVi) is a validated measure of arterial stiffness, but its relation to carotid atherosclerosis is unknown. METHODS:Clinical, echocardiographic, and carotid ultrasound data from 6,209 hypertensive patients without prevalent cardiovascular (CV) disease ...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2012.38

    authors： Casalnuovo G,Gerdts E,de Simone G,Izzo R,De Marco M,Giudice R,Trimarco B,De Luca N

    更新日期：2012-07-01 00:00:00

  • Hormone replacement therapy increases plasma level of angiotensin II in postmenopausal hypertensive women.

    abstract：:The renin-angiotensin-aldosterone system plays a major role in the pathogenesis of hypertension by enhancing the production or the activity of angiotensin II (ANG II). We evaluated the effects of hormone replacement therapy (HRT) on the renin-angiotensin-aldosterone system and on bradykinin in postmenopausal women (PM...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/s0895-7061(00)01253-x

    authors： Umeda M,Ichikawa S,Kanda T,Sumino H,Kobayashi I

    更新日期：2001-03-01 00:00:00

  • Left ventricular hypertrophy and clinical outcomes in hypertensive patients.

    abstract：:The prevalence of left ventricular hypertrophy (LVH) rises with severity of hypertension (HT), age, and obesity. Its prevalence ranges from 20% in mildly hypertensive patients to almost 100% in those with severe or complicated HT. However, the diagnosis of LVH is not straightforward, and the definitions and criteria u...

    journal_title：American journal of hypertension

    pub_type： 杂志文章,评审

    doi：10.1038/ajh.2008.16

    authors： Ruilope LM,Schmieder RE

    更新日期：2008-05-01 00:00:00

  • Report of the Working Party Group on Determining the Radionuclide of Choice.

    abstract：:There are a variety of radiopharmaceuticals that can be used to perform captopril renography effectively. We examined a number of technetium and iodine compounds and the circumstances under which each radiopharmaceutical compound is the compound of choice. Considerations of cost, ease of use, reliability, dosage, and ...

    journal_title：American journal of hypertension

    pub_type： 共识发展会议,杂志文章,评审

    doi：10.1093/ajh/4.12.747s

    authors： Blaufox MD,Dubovsky EV,Hilson AJ,Taylor A Jr,de Zeeuw R

    更新日期：1991-12-01 00:00:00

  • Renal tissue kallikrein in newborn and young SHR.

    abstract：:Since young SHR excrete less urinary kallikrein than WKY, active and total kallikrein (A and T Kall, respectively) was measured (amidolytic assay) in the renal cortex of both strains. Neither at birth nor at age 4 weeks did renal T Kall differ between SHR and WKY. Renal A Kall was significantly lower in newborn SHR an...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/1.3.53s

    authors： Ader JL,Tran-Van T,Praddaude F

    更新日期：1988-07-01 00:00:00

  • Nifedipine ameliorates ischemia-induced revascularization in diet-induced obese mice.

    abstract：BACKGROUND:Obesity is a risk factor for the development of cardiovascular diseases that are associated with impaired angiogenesis. Nifedipine, a calcium-channel blocker, has a number of blood pressure (BP)-independent effects as well, such as improving endothelial function and decreasing oxidative stress. Here, we inve...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1038/ajh.2011.239

    authors： Kito T,Shibata R,Kondo M,Yamamoto T,Suzuki H,Ishii M,Murohara T

    更新日期：2012-04-01 00:00:00

  • Correspondences between the activity of the renin-angiotensin system and the erythrocyte Na+ transport abnormalities in hypertension.

    abstract：:Plasma renin activity and the relationship of renin activity and sodium excretion were analyzed in 50 untreated essential hypertensives classified according to their erythrocyte Na+ transport abnormalities. Renin activity was inappropriately high in 7 patients with increased activity of Na+,Li+ countertransport, inapp...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1093/ajh/3.5.412

    authors： Arrázola A,Díez J

    更新日期：1990-05-01 00:00:00

  • Felodipine-metoprolol combination tablet: a valuable option to initiate antihypertensive therapy?

    abstract：:The aim of the present study was to assess the efficacy and tolerability of a calcium antagonist/beta-blocker fixed combination tablet used as first-line antihypertesnive therapy in comparison with an angiotensin converting enzyme inhibitor and placebo. Patients with uncomplicated essential hypertension (diastolic blo...

    journal_title：American journal of hypertension

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1016/s0895-7061(99)00067-9

    authors： Waeber B,Detry JM,Dahlöf B,Puig JG,Gundersen T,Hosie J,Januszewicz W,Lindström CJ,Magometschnigg D,Safar M,Tanser P,Toutouzas P

    更新日期：1999-09-01 00:00:00

  • B-type natriuretic Peptide is associated with both augmentation index and left ventricular mass in diabetic patients without heart failure.

    abstract：BACKGROUND:B-type natriuretic peptide (BNP) increases the risk of death and cardiovascular events in patients without heart failure, even at BNP values within the "normal" range. The reasons for this are unclear. METHODS:We performed two separate studies (n = 33 and n = 129) on subjects with type 2 diabetes mellitus i...

    journal_title：American journal of hypertension

    pub_type： 杂志文章

    doi：10.1016/j.amjhyper.2005.06.016

    authors： Dawson A,Davies JI,Morris AD,Struthers AD

    更新日期：2005-12-01 00:00:00