Aortic Hemodynamics and Arterial Stiffness Responses to Muscle Metaboreflex Activation With Concurrent Cold Pressor Test.


BACKGROUND:Overweight/obese young men have increased sympatho-excitation to cold and pain stress-induced by the cold pressor test (CPT) that may lead to abnormal hemodynamic responses. Concurrent CPT and exercise may augment the sympathetic-induced increases in aortic blood pressure (BP), pressure wave reflection (augmentation index, AIx), and arterial stiffness (pulse wave velocity, PWV). Since obesity is related with hypertension and sympathetic activity, we evaluated the aortic hemodynamic and PWV responses to muscle metaboreflex activation imposed by postexercise muscle ischemia (PEMI) concurrent with CPT in overweight/obese men. METHODS:In 16 healthy (body mass index >25 and <40kg/m(2)) men (24±2 years), heart rate (HR), brachial BP, aortic BP, augmented pressure (AP), AIx, AIx adjusted to 75 beats/min (AIx@75), reflection time (Tr), first (P1) and second systolic peak (P2, wave reflection magnitude), and PWV (brachial-ankle PWV, baPWV) were evaluated at baseline, during isometric-handgrip exercise (IHG), and PEMI with (PEMI + CPT) and without CPT. RESULTS:During IHG, brachial BP, aortic BP, AP, AIx, AIx@75, P1, and P2 increased ( P < 0.01) while Tr decreased ( P < 0.05) compared with baseline. During PEMI, all hemodynamic parameters remained elevated ( P < 0.05) and baPWV increased (P < 0.05) while Tr and HR returned to baseline. Compared with PEMI, the increases in HR, brachial BP, aortic BP, AIx@75, P1, P2, and baPWV were greater ( P < 0.05) during PEMI + CPT. During PEMI + CPT, Tr remained lower ( P < 0.05) than baseline. CONCLUSIONS:Cold exposure with concurrent metaboreflex activation induces a significant increase in aortic hemodynamics and arterial stiffness, which may explain the high risk of adverse cardiovascular events during physiological stress. CLINICAL TRIALS REGISTRATION:Trial Number NCT02104375.


Am J Hypertens


Kalfon R,Campbell J,Alvarez-Alvarado S,Figueroa A




Has Abstract


2015-11-01 00:00:00














  • Aging and hypertension are independent risk factors for reduced number of circulating endothelial progenitor cells.

    abstract:BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Umemura T,Soga J,Hidaka T,Takemoto H,Nakamura S,Jitsuiki D,Nishioka K,Goto C,Teragawa H,Yoshizumi M,Chayama K,Higashi Y

    更新日期:2008-11-01 00:00:00

  • Caffeine attenuates early post-exercise hypotension in middle-aged subjects.

    abstract:BACKGROUND:Sustained hypotension after an acute dynamic exercise bout is due primarily to peripheral vasodilation. We tested the hypothesis that adenosine-mediated vasodilation contributes to hypotension after exercise, by determining the effect of blocking its actions with caffeine. METHODS:Fourteen healthy middle-ag...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,随机对照试验


    authors: Notarius CF,Morris BL,Floras JS

    更新日期:2006-02-01 00:00:00

  • Trends in Adolescents Obesity and the Association between BMI and Blood Pressure: A Cross-Sectional Study in 714,922 Healthy Teenagers.

    abstract:BACKGROUND:Seventeen percent of youth in the United States are obese. Obesity has been linked to higher prevalence of hypertension. Past studies were limited by their size and conflicting results. The aim of this study was to analyze trends in adolescents' obesity between 1998 and 2011 and to evaluate the relationship ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Chorin E,Hassidim A,Hartal M,Havakuk O,Flint N,Ziv-Baran T,Arbel Y

    更新日期:2015-09-01 00:00:00

  • Association of renal resistive index with target organ damage in essential hypertension.

    abstract:BACKGROUND:The renal resistive index (RI) measured using Doppler ultrasonography has been used as a diagnostic tool in the daily work-up of kidney diseases. A better understanding of its relationship with preclinical organ damage may help in determining overall cardiovascular risk in hypertensive patients. METHODS:We ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Doi Y,Iwashima Y,Yoshihara F,Kamide K,Takata H,Fujii T,Kubota Y,Nakamura S,Horio T,Kawano Y

    更新日期:2012-12-01 00:00:00

  • Importance of left ventricular mass as a predictor of cardiovascular morbidity in hypertension.

    abstract::Arterial hypertension is a powerful risk factor for cardiovascular disease, but the ability to use blood pressure measurements to predict complications in individual patients or small groups is limited. One possible approach to identifying hypertensive patients at high risk is based on the observation that the presenc...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Devereux RB

    更新日期:1989-08-01 00:00:00

  • Relationship among end-stage renal disease, hypertension, and sleep apnea in nondiabetic dialysis patients.

    abstract:BACKGROUND:Cardiovascular diseases (CVD) are responsible for more than 50% of the deaths in patients with end-stage renal disease (ESRD). Sleep apnea (SA) has been recognized as a risk factor for CVD. Previous studies have shown a higher prevalence of SA among patients on dialysis. METHODS:Forty-five nondiabetics pati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: de Oliveira Rodrigues CJ,Marson O,Tufic S,Kohlmann O Jr,Guimarães SM,Togeiro P,Ribeiro AB,Tavares A

    更新日期:2005-02-01 00:00:00

  • Is location associated with high risk of hypertension? Shimane COHRE Study.

    abstract:BACKGROUND:There is growing evidence that residential environment is associated with hypertension. Recently, interest has also turned toward examining the possible influence of remoteness on hypertension. The aim of this study is to explore the effect of remoteness, the shortest path between the subject location and th...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Hamano T,Kimura Y,Takeda M,Yamasaki M,Nabika T,Shiwaku K

    更新日期:2012-07-01 00:00:00

  • Increased levels of beta-human atrial natriuretic peptide-like immunoreactivity in chronically overloaded atrial tissue.

    abstract::The levels and molecular form of atrial natriuretic peptide-like immunoreactivity (ANP-LI) in human atrial tissue were investigated. The levels of right atrial ANP-LI were significantly higher in mitral disease than in other cardiac or noncardiac diseases. The increased ANP-LI was mainly accounted for by an increase i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Naruse M,Hiroe M,Naruse K,Nagata M,Ohno H,Hashimoto A,Koyanagi H,Sekiguchi M,Demura H,Hirosawa K

    更新日期:1990-02-01 00:00:00

  • Hemodynamic and renal effects of indomethacin in losartan-treated hypertensive individuals.

    abstract::This study was undertaken to examine whether prostaglandin (PG) inhibition with indomethacin interferes with angiotensin II receptor blockade (losartan) during treatment for arterial hypertension. In a double-blind crossover design 10 patients with essential arterial hypertension and treated with losartan were randomi...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Olsen ME,Thomsen T,Hassager C,Ibsen H,Dige-Petersen H

    更新日期:1999-02-01 00:00:00

  • Different effects of antihypertensive agents on cardiac and vascular hypertrophy in the transgenic rat line TGR(mRen2)27.

    abstract::The hypertensive transgenic rat model TGR(mRen2)27 has been used to investigate the development of cardiac and vascular hypertrophy in response to two different drug regimes. Cardiac hypertrophy was shown to be related to age and gender with the copy number of mouse renin transgenes having an additive effect. A simila...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Brosnan MJ,Devlin AM,Clark JS,Mullins JJ,Dominiczak AF

    更新日期:1999-07-01 00:00:00

  • Impaired vasodilator capacity and exaggerated pressor response to isometric exercise in subjects with family history of hypertension.

    abstract::The nature of the cardiovascular response to isometric exercise is still debated. An adequate blood supply to exercising muscles at the onset of contraction seems to be an important factor controlling the extent of pressor response to isometric contraction. In comparison to normotensive subjects without familiar hyper...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Borghi C,Costa FV,Boschi S,Ambrosioni E

    更新日期:1988-07-01 00:00:00

  • Different normalizations for body size and population attributable risk of left ventricular hypertrophy: the MAVI study.

    abstract:BACKGROUND:Different methods of normalizing left ventricular (LV) mass for body size identify generally similar relative risks of adverse cardiovascular outcome but with variable prevalences of LV hypertrophy (H). Preliminary results from a population with high prevalence of obesity suggest that the population attribut...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,多中心研究


    authors: de Simone G,Devereux RB,Maggioni AP,Gorini M,de Divitiis O,Verdecchia P,MAVI (MAssa Ventricolare sinistra nell'Ipertensione) Study Group.

    更新日期:2005-10-01 00:00:00

  • Association of microalbuminuria with brachial-ankle pulse wave velocity: the Ohasama study.

    abstract:BACKGROUND:Microalbuminuria is recognized as a marker of generalized vascular dysfunction. However, the associations between microalbuminuria and pulse wave velocity (PWV), carotid intima-media thickness (IMT), and ambulatory blood pressure (ABP), respectively, have not been investigated. METHODS:Brachial-ankle PWV (b...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Ishikawa T,Hashimoto J,Morito RH,Hanazawa T,Aikawa T,Hara A,Shintani Y,Metoki H,Inoue R,Asayama K,Kikuya M,Ohkubo T,Totsune K,Hoshi H,Satoh H,Imai Y

    更新日期:2008-04-01 00:00:00

  • Cardioprotective Effects of Paricalcitol Alone and in Combination With FGF23 Receptor Inhibition in Chronic Renal Failure: Experimental and Clinical Studies.

    abstract:BACKGROUND:In uremic animals, vitamin D receptor (VDR) agonists like paricalcitol (Pc) attenuate cardiac hypertrophy, but this effect has not been replicated consistently in humans with chronic kidney disease. Elevated fibroblast growth factor 23 (FGF23) levels cause cardiac hypertrophy with activation of the myocardia...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Czaya B,Seeherunvong W,Singh S,Yanucil C,Ruiz P,Quiroz Y,Grabner A,Katsoufis C,Swaminathan S,Abitbol C,Rodriguez-Iturbe B,Faul C,Freundlich M

    更新日期:2019-01-01 00:00:00

  • Immunosuppression improves blood pressure and endothelial function in a rat model of pregnancy-induced hypertension.

    abstract:BACKGROUND:Hypertensive disorders of pregnancy, including preeclampsia (PE), affect approximately 7-10% of pregnancies in the US. Clinical and experimental studies strongly suggest that the maternal immune system plays a role in the development of these disorders; however, few therapeutic options exist aside from deliv...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tinsley JH,Chiasson VL,South S,Mahajan A,Mitchell BM

    更新日期:2009-10-01 00:00:00

  • Effect of amlodipine on mesangial cell proliferation and protein synthesis.

    abstract::Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Shultz PJ,Raij L

    更新日期:1992-12-01 00:00:00

  • Blood pressure, brain structure, and cognition: opposite associations in men and women.

    abstract:BACKGROUND:Research on associations between blood pressure, brain structure, and cognitive function has produced somewhat inconsistent results. In part, this may be due to differences in age ranges studied and because of sex differences in physiology and/or exposure to risk factors, which may lead to different time cou...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Cherbuin N,Mortby ME,Janke AL,Sachdev PS,Abhayaratna WP,Anstey KJ

    更新日期:2015-02-01 00:00:00

  • Overexpression of Long Noncoding RNA Uc.187 Induces Preeclampsia-Like Symptoms in Pregnancy Rats.

    abstract:BACKGROUND:As a serious pregnancy-specific condition, preeclampsia (PE) is a serious pregnancy-specific condition characterized by insufficient trophoblastic invasion and shallow placental implantation. Long noncoding RNA uc.187, which is transcribed from an ultra-conserved region is highly expressed in the placental t...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Huang J,Qian Y,Cheng Q,Yang J,Ding H,Jia R

    更新日期:2020-04-29 00:00:00

  • Prevalence of hyperhomocysteinemia in an elderly population.

    abstract:BACKGROUND:Currently, total hyperhomocysteinemia (tHHcy) is a well-known condition linked to a higher risk of vascular disease. Prevalence of HHcy increases in elderly persons as the risk associated with it persists. Because factors can be potentially reduced in the elderly, it is important to carry out epidemiologic s...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Janson JJ,Galarza CR,Murúa A,Quintana I,Przygoda PA,Waisman G,Camera L,Kordich L,Morales M,Mayorga LM,Camera MI

    更新日期:2002-05-01 00:00:00

  • Gender-dependent differences in plasma leptin in essential hypertension.

    abstract::Leptin, the gene product of the ob gene, is influenced by gender and insulin sensitivity. Because in human hypertension there are important endocrine-hemodynamic gender-dependent differences, we compared plasma leptin in 39 essential hypertensives (EH) and in 27 normotensive healthy subjects (HS) matched for gender, a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mallamaci F,Cuzzola F,Tripepi G,Cutrupi S,Parlongo S,Tripepi R,Zoccali C

    更新日期:2000-08-01 00:00:00

  • Sodium lithium countertransport and blood pressure. Longitudinal findings.

    abstract::A significant and positive association between red blood cell sodium lithium countertransport (Na-Li CT) and blood pressure has been found in numerous studies. However, the majority of the studies presented to date are cross-sectional in nature and limited information exists on the longitudinal association between Na-...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Trevisan M,Strazzullo P,Cappuccio F,Jossa F,Iacone R,Russo I,Farinaro E

    更新日期:1996-11-01 00:00:00

  • Hemodynamics of seasonal adaptation.

    abstract::To investigate the possibility that seasonal adaptation requires significant hemodynamic changes, 5 normotensive and 21 mildly hypertensive subjects were followed through 4 seasons for changes in systemic hemodynamics and sympathetic nervous activity. In the upright position wintertime blood pressures increased by 3% ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Izzo JL Jr,Larrabee PS,Sander E,Lillis LM

    更新日期:1990-05-01 00:00:00

  • Are retinal microvascular phenotypes associated with the 1675G/A polymorphism in the angiotensin II type-2 receptor gene?

    abstract:BACKGROUND:The X-linked angiotensin II type-2 receptor (AT2R) gene 1675G/A polymorphism is located in the short intron 1 of the AT2R gene within a sequence motif conforming to a splice branch site. AT2R is expressed in the human retina, but no previous study examined the association between retinal microvascular phenot...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Liu YP,Kuznetsova T,Thijs L,Jin Y,Schmitz B,Brand SM,Brand E,Manunta P,Bianchi G,Struijker-Boudier H,Staessen JA

    更新日期:2011-12-01 00:00:00

  • Effect of the Nonsteroidal Mineralocorticoid Receptor Blocker, Esaxerenone, on Nocturnal Hypertension: A Post Hoc Analysis of the ESAX-HTN Study.

    abstract:BACKGROUND:Nocturnal hypertension is an important phenotype of abnormal diurnal blood pressure (BP) variability and a known risk marker for target organ damage and cardiovascular events. This study aimed to assess the differential BP-lowering effects of esaxerenone vs. eplerenone on nocturnal BP in hypertensive patient...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Kario K,Ito S,Itoh H,Rakugi H,Okuda Y,Yoshimura M,Yamakawa S

    更新日期:2020-11-09 00:00:00

  • Augmentation index relates to progression of aortic disease in adults with Marfan syndrome.

    abstract:BACKGROUND:Noninvasive applanation tonometry (APT) is useful to assess aortic stiffness and pulse wave reflection. Moreover, APT can predict outcome in many conditions such as arterial hypertension. In this study, we test whether APT measurements relate to progression of aortic disease in Marfan syndrome (MFS). METHOD...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Mortensen K,Aydin MA,Rybczynski M,Baulmann J,Schahidi NA,Kean G,Kühne K,Bernhardt AM,Franzen O,Mir T,Habermann C,Koschyk D,Ventura R,Willems S,Robinson PN,Berger J,Reichenspurner H,Meinertz T,von Kodolitsch Y

    更新日期:2009-09-01 00:00:00

  • Cognitive impairment is related to increased arterial stiffness and microvascular damage in patients with never-treated essential hypertension.

    abstract:BACKGROUND:It is known that essential hypertension may be implicated in the development of cognitive impairment that is associated to microvascular disease of the brain. It has been hypothesized that increased arterial stiffness of the large arteries may lead to microvascular changes due to increased pulsatile flow. Ou...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Triantafyllidi H,Arvaniti C,Lekakis J,Ikonomidis I,Siafakas N,Tzortzis S,Trivilou P,Zerva L,Stamboulis E,Kremastinos DT

    更新日期:2009-05-01 00:00:00

  • Associations of Reservoir-Excess Pressure Parameters Derived From Central and Peripheral Arteries With Kidney Function.

    abstract:BACKGROUND:Central artery reservoir-excess pressure parameters are clinically important but impractical to record directly. However, diastolic waveform morphology is consistent across central and peripheral arteries. Therefore, peripheral artery reservoir-excess pressure parameters related to diastolic waveform morphol...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Armstrong MK,Schultz MG,Picone DS,Black JA,Dwyer N,Roberts-Thomson P,Sharman JE

    更新日期:2020-04-01 00:00:00

  • Influences of different antihypertensive treatments on indices of systemic mineral metabolism.

    abstract::A negative calcium balance has previously been described in human hypertension with low levels of plasma ionized calcium (Ca2+) and an increased urinary excretion of calcium. The cause of this disturbance in mineral metabolism is not known, nor is it known if this derangement could be abolished if blood pressure is re...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Lind L,Hänni A,Hvarfner A,Pollare T,Ljunghall S,Lithell H

    更新日期:1994-04-01 00:00:00

  • Hypertension in kidney transplant recipients. Effect on long-term renal allograft survival.

    abstract::To examine the effects of hypertension on renal graft function, we studied the clinical course of 144 kidney transplant recipients who had functioning grafts for three to 13 years. The patients were divided into three groups: normotensive (n = 32), controlled hypertensive (n = 49) and uncontrolled hypertensive group (...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Cheigh JS,Haschemeyer RH,Wang JC,Riggio RR,Tapia L,Stenzel KH,Rubin AL

    更新日期:1989-05-01 00:00:00

  • Enhanced endogenous epinephrine release from the vascular adrenergic neurons in spontaneously hypertensive rats.

    abstract::This study was performed to investigate the role of endogenous epinephrine in the regulation of vascular tone in hypertension. The release of endogenous epinephrine and norepinephrine from the vascular adrenergic neurons by periarterial nerve stimulation was examined in spontaneously hypertensive rats (SHR) and age-ma...

    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Tsuda K,Tsuda S,Masuyama Y

    更新日期:1990-01-01 00:00:00