Abstract:
BACKGROUND:Overweight/obese young men have increased sympatho-excitation to cold and pain stress-induced by the cold pressor test (CPT) that may lead to abnormal hemodynamic responses. Concurrent CPT and exercise may augment the sympathetic-induced increases in aortic blood pressure (BP), pressure wave reflection (augmentation index, AIx), and arterial stiffness (pulse wave velocity, PWV). Since obesity is related with hypertension and sympathetic activity, we evaluated the aortic hemodynamic and PWV responses to muscle metaboreflex activation imposed by postexercise muscle ischemia (PEMI) concurrent with CPT in overweight/obese men. METHODS:In 16 healthy (body mass index >25 and <40kg/m(2)) men (24±2 years), heart rate (HR), brachial BP, aortic BP, augmented pressure (AP), AIx, AIx adjusted to 75 beats/min (AIx@75), reflection time (Tr), first (P1) and second systolic peak (P2, wave reflection magnitude), and PWV (brachial-ankle PWV, baPWV) were evaluated at baseline, during isometric-handgrip exercise (IHG), and PEMI with (PEMI + CPT) and without CPT. RESULTS:During IHG, brachial BP, aortic BP, AP, AIx, AIx@75, P1, and P2 increased ( P < 0.01) while Tr decreased ( P < 0.05) compared with baseline. During PEMI, all hemodynamic parameters remained elevated ( P < 0.05) and baPWV increased (P < 0.05) while Tr and HR returned to baseline. Compared with PEMI, the increases in HR, brachial BP, aortic BP, AIx@75, P1, P2, and baPWV were greater ( P < 0.05) during PEMI + CPT. During PEMI + CPT, Tr remained lower ( P < 0.05) than baseline. CONCLUSIONS:Cold exposure with concurrent metaboreflex activation induces a significant increase in aortic hemodynamics and arterial stiffness, which may explain the high risk of adverse cardiovascular events during physiological stress. CLINICAL TRIALS REGISTRATION:Trial Number NCT02104375.
journal_name
Am J Hypertensjournal_title
American journal of hypertensionauthors
Kalfon R,Campbell J,Alvarez-Alvarado S,Figueroa Adoi
10.1093/ajh/hpv043subject
Has Abstractpub_date
2015-11-01 00:00:00pages
1332-8issue
11eissn
0895-7061issn
1941-7225pii
hpv043journal_volume
28pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Obstructive sleep apnea (OSA) and left ventricular (LV) hypertrophy are considered to be closely associated. However, the relationship has not yet been fully demonstrated and is hence still controversial. The purpose of this study was to assess in hypertensive male patients the relationship between OSA and c...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpv115
更新日期:2016-03-01 00:00:00
abstract::This study was undertaken to examine whether prostaglandin (PG) inhibition with indomethacin interferes with angiotensin II receptor blockade (losartan) during treatment for arterial hypertension. In a double-blind crossover design 10 patients with essential arterial hypertension and treated with losartan were randomi...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0895-7061(98)00228-3
更新日期:1999-02-01 00:00:00
abstract:BACKGROUND:Obesity has been described as a predictor of cardiovascular mortality, and some studies have reported an association with obesity and increased aortic stiffness. Other studies have not identified obesity to be an independent risk factor. Therefore, the purpose of our study was to determine the association be...
journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:The adipose tissue renin-angiotensin system (RAS) has been implicated in the pathophysiology of obesity and dysfunction of adipose tissue. However, neither regulation of angiotensinogen (AGT) expression in adipose tissue nor secretion of adipose tissue-derived AGT has been fully elucidated in humans. METHOD...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2009.263
更新日期:2010-04-01 00:00:00
abstract:BACKGROUND:Chronic systemic inflammation has been implicated in the pathogenesis of hypertension and cardiovascular disease. Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation and an increased risk for cardiovascular disease. Currently few studies have evaluated the potent...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2011.143
更新日期:2011-11-01 00:00:00
abstract::The aim of the present study was to assess the efficacy and tolerability of a calcium antagonist/beta-blocker fixed combination tablet used as first-line antihypertesnive therapy in comparison with an angiotensin converting enzyme inhibitor and placebo. Patients with uncomplicated essential hypertension (diastolic blo...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/s0895-7061(99)00067-9
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Hypertension is the leading global preventable risk factor for premature death. While hypertension prevalence has been declining in high-income countries, it has increased continuously in low- and middle-income countries. METHODS:We conducted a cross-sectional survey in 7,524 women and men aged 35-74 years ...
journal_title:American journal of hypertension
pub_type: 杂志文章,多中心研究
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更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Although a hypertensive response to exercise (HRE) is associated with cardiac risk and masked hypertension (MHT), its mechanisms and appropriate treatment remain unclear. We investigated spironolactone as a treatment for abnormal vascular and myocardial stiffness in HRE. METHODS:In this randomized, double-b...
journal_title:American journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1093/ajh/hpt008
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Pre-eclampsia (PE) is characterized by hypertension and proteinuria, and complicates from 3%-10% of all pregnancies. The hemodynamic pathophysiology of the heart and systemic arteries in pre-eclamptic patients has not been well described. We therefore performed a comprehensive comparison of the systemic arte...
journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2013-04-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpy154
更新日期:2019-01-01 00:00:00
abstract::Mesangial cells in the glomerulus have several important physiological functions, as has been demonstrated by past research. Platelet derived growth factor, thrombin, endothelin, and angiotensin II have all been shown to affect mesangial cell growth and protein synthesis. First generation Ca channel blockers also have...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:Previous autopsy studies suggested that a reduced nephron number is associated with increased risk of hypertension and chronic kidney disease. However, the significance of the nephron number estimated from a renal biopsy in patients with hypertensive nephrosclerosis (HNS) has not yet been elucidated. METHOD...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpu267
更新日期:2015-09-01 00:00:00
abstract::In order to evaluate the effects of atrial natriuretic factor (ANF) infusion on plasma insulin (IRI) in hypertension, 32 essential hypertensives (aged 40 to 62 years) were studied. After 1 week of pharmacologic washout under normal sodium intake (120 mEq of Na+/day), patients were randomly assigned to receive either A...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1093/ajh/4.11.880
更新日期:1991-11-01 00:00:00
abstract::We sought to determine whether reductions in blood pressure in hypertensives after acute exercise persist for more than the 2 to 3 h found in controlled laboratory settings. Subjects (n = 11) were obese (32 +/- 4% body fat), sedentary (VO2max 27 +/- 4 mL/kg/min) 60 +/- 6-year-old men with stage 1 or 2 essential hypert...
journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章
doi:10.1016/s0895-7061(99)00141-7
更新日期:2000-01-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hps037
更新日期:2013-03-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/5.5.292
更新日期:1992-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(01)02267-1
更新日期:2002-02-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0895-7061(95)00037-P
更新日期:1995-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:
更新日期:1993-03-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.27
更新日期:2008-05-01 00:00:00
abstract::To evaluate potential physiological actions of atrial natriuretic peptide (ANP) in humans, normal male volunteers were studied in the supine and head-up tilt positions both in the absence and presence of an ANP infusion at a rate which increased plasma ANP levels to ranges observed during physiological stimuli such as...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/4.3.219
更新日期:1991-03-01 00:00:00
abstract::Vasoconstrictor and Na/K pump inhibitory properties of a bufodienolide Na/K-ATPase inhibitor, marinobufagenin, were studied in isolated rings of 2 to 3 order branches of human pulmonary arteries respectively. Marinobufagenin displayed concentration-dependent vasoconstrictor activity (0.01 to 10 mmol/L). In sarcolemma ...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/0895-7061(96)00148-3
更新日期:1996-10-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,随机对照试验
doi:10.1093/ajh/hpt032
更新日期:2013-07-01 00:00:00
abstract::The stimulation of autocrine and paracrine factors such as basic fibroblast- (bFGF) and platelet-derived (PDGF) growth factors mediates many of the growth-promoting actions of angiotensin II. The aim of this study was to evaluate the effect of chronic AT1-receptor blockade on plasma endothelin-1 (ET-1) and growth fact...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1016/s0895-7061(98)00027-2
更新日期:1998-05-01 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/hpx178
更新日期:2018-02-09 00:00:00
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journal_title:American journal of hypertension
pub_type: 杂志文章,评审
doi:10.1093/ajh/3.9.721
更新日期:1990-09-01 00:00:00
abstract:BACKGROUND:Recent studies have revealed the existence of bone marrow-derived endothelial progenitor cells (EPCs). The number of circulating EPCs might reflect the pathogenesis of atherosclerosis and progression of cardiovascular diseases (CVDs). The purpose of this study was to evaluate the relationship between the num...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1038/ajh.2008.278
更新日期:2008-11-01 00:00:00
abstract::This study was performed to investigate the role of endogenous epinephrine in the regulation of vascular tone in hypertension. The release of endogenous epinephrine and norepinephrine from the vascular adrenergic neurons by periarterial nerve stimulation was examined in spontaneously hypertensive rats (SHR) and age-ma...
journal_title:American journal of hypertension
pub_type: 杂志文章
doi:10.1093/ajh/3.1.52
更新日期:1990-01-01 00:00:00