The Metabolic Syndrome Does Not Affect Development of Collateral Circulation in the Poststenotic Swine Kidney.

Abstract:

BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We hypothesized that MetS increased collateral circulation around the renal artery. METHODS:Twenty-one domestic pigs were randomly divided into unilateral RAS fed an atherogenic (high-fat/high-fructose, MetS-RAS) or standard diet, or controls (n = 7 each). RBF, glomerular filtration rate (GFR), and the peristenotic collateral circulation were assessed after 10 weeks using multidetector computed tomography (CT) and the intrarenal microcirculation by micro-CT. Vascular endothelial growth factor (VEGF) expression was studied in the renal artery wall, kidney, and perirenal fat. Renal fibrosis and stiffness were examined by trichrome and magnetic resonance elastography. RESULTS:Compared with controls, RBF and GFR were decreased in RAS, but not in MetS-RAS. MetS-RAS formed peristenotic collaterals to the same extent as RAS pigs but induced greater intrarenal microvascular loss, fibrosis, stiffness, and inflammation. MetS-RAS also attenuated VEGF expression in the renal tissue compared with RAS, despite increased expression in the perirenal fat. CONCLUSIONS:MetS does not interfere with collateral vessel formation in the stenotic kidney, possibly because decreased renal arterial VEGF expression offsets its upregulation in perirenal fat, arguing against a major contribution of the collateral circulation to preserve renal function in MetS-RAS. Furthermore, preserved renal function does not protect the poststenotic kidney from parenchymal injury.

journal_name

Am J Hypertens

authors

Zhang X,Kim SR,Ferguson CM,Ebrahimi B,Hedayat AF,Lerman A,Lerman LO

doi

10.1093/ajh/hpy127

subject

Has Abstract

pub_date

2018-11-13 00:00:00

pages

1307-1316

issue

12

eissn

0895-7061

issn

1941-7225

pii

5068671

journal_volume

31

pub_type

杂志文章
  • Childhood predictors of high blood pressure.

    abstract::Longitudinal studies in children have tracked blood pressure through childhood and from childhood into adult life. However, many children do not maintain their rank during these periods of observation. Several of the factors contributing to maintenance of rank order are reviewed, such as initial level of blood pressur...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/4.11s.608s

    authors: Mahoney LT,Clarke WR,Burns TL,Lauer RM

    更新日期:1991-11-01 00:00:00

  • L-dopa and streptozotocin-induced diabetic nephropathy in rats.

    abstract::The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/3.6.72s

    authors: Barthelmebs M,Vailly B,Velly J,Grima M,Imbs JL

    更新日期:1990-06-01 00:00:00

  • Interdependence of blood pressure and heart period regulation in mild hypertension.

    abstract::Blood pressure and heart period variability have been measured directly in 142 subjects with mild hypertension over 24 h. The variabilities have been expressed as the standard deviation of 2 min averages of all beats over 24 h. Baroreflex sensitivity was assessed in 102 subjects by the phenylephrine method. Blood pres...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.3.234

    authors: Coats AJ,Conway J,Sleight P,Meyer TE,Somers VK,Floras JS,Vann Jones J

    更新日期:1991-03-01 00:00:00

  • Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.

    abstract:BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2005.09.005

    authors: Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

    更新日期:2006-03-01 00:00:00

  • Blood pressure in people in Greenland assessed by measuring renovasculopathies of hypertension at autopsy.

    abstract::Surveys taken of blood pressure in Greenland indicated prevailing levels similar to those in the USA. Morphometrically measured renovasculopathies in 88 autopsies confirmed blood pressure levels comparable to the survey findings. At clinic visits, the recorded blood pressures in 48 of the autopsies verified the morpho...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00440-8

    authors: Tracy RE,Mulvad G,Pederson HS,Jul E,Bjerregaard P,Newman WP 3rd

    更新日期:1996-06-01 00:00:00

  • Hypertension and insulin resistant models have divergent propensities to learned helpless behavior in rodents.

    abstract::The induction of learned helpless (LH) behavior in rats is a widely used model of unipolar depression. Recent studies have linked depression with hypertension and insulin resistance as observed in obesity, but the propensity of these disorders to manifest depression has not been reported. In this study, the LH behavio...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(99)00271-x

    authors: Edwards E,King JA,Fray J

    更新日期:2000-06-01 00:00:00

  • A single mechanism to explain the effect of calcium on renal function.

    abstract::It is known that calcium induces the formation of potent vasodilators in endothelial cells and vasoconstriction in smooth muscle cells, whereas in the renal parenchyma, it modulates sodium excretion through vascular and tubular mechanisms. Consequently, an increased concentration of calcium in renal circulation may in...

    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1093/ajh/4.7.473s

    authors: Lahera V,Ruilope LM,Romero JC

    更新日期:1991-07-01 00:00:00

  • Higher cholesterol and insulin levels in pregnancy are associated with increased risk for pregnancy-induced hypertension.

    abstract::Hyperinsulinemia and dyslipidemia are known to be associated with essential hypertension but their role in pregnancy-induced hypertension remains unclear. We performed a case-control study comparing cholesterol, insulin, and glucose levels in the early third trimester of pregnancy among 31 women who developed pregnanc...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(98)00258-1

    authors: Solomon CG,Carroll JS,Okamura K,Graves SW,Seely EW

    更新日期:1999-03-01 00:00:00

  • Association between levels of blood pressure and measures of subclinical disease multi-ethnic study of atherosclerosis.

    abstract:BACKGROUND:High blood pressure (BP) is associated with the presence and severity of subclinical disease. Less is known about associations between normal levels of BP and various measures of subclinical disease. METHODS:The Multi-Ethnic Study of Atherosclerosis (MESA) enrolled 6814 participants free of clinical cardiov...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2006.04.002

    authors: Psaty BM,Arnold AM,Olson J,Saad MF,Shea S,Post W,Burke GL

    更新日期:2006-11-01 00:00:00

  • Mesenteric artery contractile properties during dietary calcium manipulation in spontaneously hypertensive and Wistar Kyoto normotensive rats.

    abstract::The hypothesis that elevated Ca2+ intake lowers blood pressure in the spontaneously hypertensive rat (SHR) by altering intrinsic contractile properties of vascular smooth muscle was tested. The effect of 0.5, 1, and 2% Ca2+ in the diet on systolic blood pressure, serum-ionized Ca2+, and contractile properties of mesen...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/2.6.440

    authors: Bukoski RD,Xue H,McCarron DA

    更新日期:1989-06-01 00:00:00

  • Association of genetic variants in the apelin-APJ system and ACE2 with blood pressure responses to potassium supplementation: the GenSalt study.

    abstract:BACKGROUND:Genetic factors may influence blood pressure (BP) responses to dietary potassium intake. We examined the association of genetic variants in the apelin-APJ system and angiotensin-converting enzyme 2 (ACE2) with BP responses to potassium supplementation. METHODS:We conducted a 7-day potassium supplementation ...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2010.36

    authors: Zhao Q,Gu D,Kelly TN,Hixson JE,Rao DC,Jaquish CE,Chen J,Huang J,Chen CS,Gu CC,Whelton PK,He J

    更新日期:2010-06-01 00:00:00

  • Short-term oral folic acid supplementation enhances endothelial function in patients with type 2 diabetes.

    abstract:BACKGROUND:Endothelial dysfunction and arterial stiffening are commonly observed in type 2 diabetes. These abnormalities might be secondary to increased plasma concentrations of homocysteine. We sought to determine whether oral folic acid supplementation, by lowering homocysteine levels, enhanced endothelial function a...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.amjhyper.2004.08.036

    authors: Mangoni AA,Sherwood RA,Asonganyi B,Swift CG,Thomas S,Jackson SH

    更新日期:2005-02-01 00:00:00

  • Genetic polymorphism of the alpha 2-adrenergic receptor is associated with increased platelet aggregation, baroreceptor sensitivity, and salt excretion in normotensive humans.

    abstract::It is likely that a number of independent heritable traits, each encoded by a singular gene, contribute to pathologic elevations in blood pressure in humans. Genetic polymorphisms of individual genes may result in intermediate phenotypes which, by themselves, do not raise blood pressure, but, coupled with environmenta...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/0895-7061(95)00155-I

    authors: Freeman K,Farrow S,Schmaier A,Freedman R,Schork T,Lockette W

    更新日期:1995-09-01 00:00:00

  • Antihypertensive therapy with verapamil SR plus trandolapril versus atenolol plus chlorthalidone on glycemic control.

    abstract:BACKGROUND:There is evidence that diuretics and beta blockers impair glucose tolerance, whereas calcium channel blockers and angiotensin converting enzyme blockers lack this metabolic effect. We compared the effect of a combination therapy with a nondihydropyridine calcium channel blocker plus an angiotensin converting...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1016/s0895-7061(03)00062-1

    authors: Holzgreve H,Nakov R,Beck K,Janka HU

    更新日期:2003-05-01 00:00:00

  • Hemodynamic responses to verapamil monotherapy in patients with renal disease.

    abstract::We have explored the effect of verapamil on renal hemodynamics and the renin-aldosterone system in ten patients with chronic renal disease and hypertension before and after 3 months of therapy. The mean +/- SEM glomerular filtration rates were 55 +/- 7 mL/min pre- and 55 +/- 8 mL/min posttherapy; the renal plasma flow...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.12.939

    authors: Lenz T,Müller FB,Sotelo JE,Laragh JH,August P

    更新日期:1991-12-01 00:00:00

  • Chronic Dantrolene Treatment Does Not Affect Hypertension, but Attenuates Sympathetic Stimulation Enhanced Atrial Fibrillation Inducibility in SHR.

    abstract:BACKGROUND:Ryanodine receptor (RyR) dysfunction in skeletal muscle (RyR1) leads to malignant hyperthermia, and in cardiac muscle (RyR2) triggers cardiac arrhythmias. We hypothesized that RyR dysfunction in vascular smooth muscle could increase vascular resistance and hypertension, and may contribute to increased atrial...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpaa021

    authors: Lee JS,Greco L,Migirov A,Li Y,Gerdes AM,Zhang Y

    更新日期:2020-04-29 00:00:00

  • Association of blood pressure variability with induction of atherosclerosis in cholesterol-fed rats.

    abstract::The influence of increased lability of blood pressure on the development of aortic atherosclerosis was examined. Because sinoaortic denervation (SAD) produced increased lability of blood pressure without blood pressure elevation, the development of atheromatous plaque was examined in SAD rats. These rats were fed a hi...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/7.5.453

    authors: Sasaki S,Yoneda Y,Fujita H,Uchida A,Takenaka K,Takesako T,Itoh H,Nakata T,Takeda K,Nakagawa M

    更新日期:1994-05-01 00:00:00

  • Atrial Dilatation Development in Hypertensive Treated Patients: The Campania-Salute Network.

    abstract:BACKGROUND:Left atrial (LA) dilatation is associated with unfavorable outcome in hypertension. However, there are few data on clinical, demographic, and echocardiographic findings correlated with LA dilatation development. METHODS:From the Campania-Salute Network registry, we identified 5,375 hypertensive patients (52...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpw043

    authors: Losi MA,Izzo R,Canciello G,Giamundo A,Manzi MV,Strisciuglio T,Stabile E,De Luca N,de Simone G,Trimarco B

    更新日期:2016-09-01 00:00:00

  • Nocturnal Intermittent Hypoxia Is Associated With Left Ventricular Hypertrophy in Middle-Aged Men With Hypertension and Obstructive Sleep Apnea.

    abstract:BACKGROUND:Obstructive sleep apnea (OSA) and left ventricular (LV) hypertrophy are considered to be closely associated. However, the relationship has not yet been fully demonstrated and is hence still controversial. The purpose of this study was to assess in hypertensive male patients the relationship between OSA and c...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpv115

    authors: Yamaguchi T,Takata Y,Usui Y,Asanuma R,Nishihata Y,Kato K,Shiina K,Yamashina A

    更新日期:2016-03-01 00:00:00

  • Blood pressure early in diabetes depends on a balance between glomerular filtration rate and the renin-angiotensin system.

    abstract::Onset of diabetes increases plasma renin activity (PRA) and glomerular filtration rate (GFR), but blood pressure (BP) is normal. In this study, a 70% surgical reduction in kidney mass (RK) was used to decrease baseline GFR and to prevent hyperfiltration during diabetes, and angiotensin converting enzyme inhibitors (AC...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2006.05.012

    authors: Rojas M,Bell TD,Sturgis LC,Springfield V,Janardhanan R,Fleming C,Brands MW

    更新日期:2006-12-01 00:00:00

  • Ethnicity and differences between clinic and ambulatory blood pressure measurements.

    abstract:BACKGROUND:This study investigated the relationship of ethnicity to the differences between blood pressure (BP) measured in a clinic setting and by ambulatory blood pressure monitoring (ABPM) in individuals with a previous diagnosis of hypertension (HT) and without a previous diagnosis of hypertension (NHT). METHODS:A...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/hpu211

    authors: Martin U,Haque MS,Wood S,Greenfield SM,Gill PS,Mant J,Mohammed MA,Heer G,Johal A,Kaur R,Schwartz C,McManus RJ

    更新日期:2015-06-01 00:00:00

  • Prevalence, awareness, treatment, and risk factors associated with hypertension in the Iranian population: the national survey of risk factors for noncommunicable diseases of Iran.

    abstract:BACKGROUND:The prevalence of hypertension in the Middle East is not well defined. We examined the prevalence, awareness, treatment, and control of hypertension in Iran. METHODS:The Survey of Risk Factors of Noncommunicable Diseases was conducted in 2005 and contains a representative sample of the Iranian adult populat...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1038/ajh.2008.154

    authors: Esteghamati A,Abbasi M,Alikhani S,Gouya MM,Delavari A,Shishehbor MH,Forouzanfar M,Hodjatzadeh A,Ramezani RD

    更新日期:2008-06-01 00:00:00

  • The influence of captopril on the epinephrine response to insulin-induced hypoglycemia in humans. The interaction between the renin-angiotensin system and the sympathetic nervous system.

    abstract::The aim of this study was to assess whether an interaction exists between the renin-angiotensin system and the sympathetic nervous system at the level of the adrenal medulla during insulin-induced hypoglycemia in normal humans. Seventeen healthy volunteers were studied in a randomized, single-dose, double-blind, cross...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1093/ajh/5.6.361

    authors: Madsen BK,Hølmer P,Ibsen H,Christensen NJ

    更新日期:1992-06-01 00:00:00

  • Losartan versus enalapril on cerebral edema and proteinuria in stroke-prone hypertensive rats.

    abstract::Stroke-prone spontaneously hypertensive rats (SHRSP), subjected to high NaCl, show severe hypertension, organ damage, and early death. Preventive treatment with angiotensin II type 1 (AT1) receptor antagonists is known to be effective. Previously, we found that angiotensin converting enzyme (ACE) inhibition could redu...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(00)01231-0

    authors: Blezer EL,Nicolay K,Koomans HA,Joles JA

    更新日期:2001-01-01 00:00:00

  • Ostial renal artery stent placement in patients 75 years of age or older.

    abstract::Renal artery stent placement has been shown to improve blood pressure (BP) and stabilize renal function in patients with atherosclerotic renovascular disease. However, limited data are available in patients > or = 75 years of age. We analyzed the prestent characteristics and clinical outcomes of patients aged > or = 7...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0895-7061(01)02168-9

    authors: Bloch MJ,Trost DA,Whitmer J,Pickering TG,Sos TA,August P

    更新日期:2001-10-01 00:00:00

  • Serum hepatocyte growth factor concentration is correlated with the forearm vasodilator response in hypertensive patients.

    abstract::To evaluate the clinical importance of serum hepatocyte growth factor (HGF) concentration, we designed two clinical investigations. The first study analyzed the correlation between serum HGF concentration and clinical arterial stiffness or the vasodilator response to reactive hyperemia in hypertensive patients. The se...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/s0895-7061(02)02274-4

    authors: Komai N,Ohishi M,Morishita R,Moriguchi A,Kaibe M,Matsumoto K,Rakugi H,Higaki J,Ogihara T

    更新日期:2002-06-01 00:00:00

  • B-type natriuretic Peptide is associated with both augmentation index and left ventricular mass in diabetic patients without heart failure.

    abstract:BACKGROUND:B-type natriuretic peptide (BNP) increases the risk of death and cardiovascular events in patients without heart failure, even at BNP values within the "normal" range. The reasons for this are unclear. METHODS:We performed two separate studies (n = 33 and n = 129) on subjects with type 2 diabetes mellitus i...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2005.06.016

    authors: Dawson A,Davies JI,Morris AD,Struthers AD

    更新日期:2005-12-01 00:00:00

  • Ambulatory blood pressure monitoring: how reproducible is it?

    abstract::We tested the reproducibility of ambulatory blood pressure monitoring (ABPM) by the use of agreement plots. Thirty-two normotensive volunteers underwent ABPM on four separate days (interval 28 days), on the same typical weekday. Sleeping time was restricted to the ABPM nighttime subperiod from 11:00 PM to 7:00 AM. Twe...

    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0895-7061(97)00126-x

    authors: Musso NR,Vergassola C,Barone C,Lotti G

    更新日期:1997-08-01 00:00:00

  • Relationship among end-stage renal disease, hypertension, and sleep apnea in nondiabetic dialysis patients.

    abstract:BACKGROUND:Cardiovascular diseases (CVD) are responsible for more than 50% of the deaths in patients with end-stage renal disease (ESRD). Sleep apnea (SA) has been recognized as a risk factor for CVD. Previous studies have shown a higher prevalence of SA among patients on dialysis. METHODS:Forty-five nondiabetics pati...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1016/j.amjhyper.2004.08.028

    authors: de Oliveira Rodrigues CJ,Marson O,Tufic S,Kohlmann O Jr,Guimarães SM,Togeiro P,Ribeiro AB,Tavares A

    更新日期:2005-02-01 00:00:00

  • Inhibition of norepinephrine release from vascular adrenergic neurons by oral administration of beta-blocker in DOCA-salt hypertension.

    abstract::The ability of a beta-blocker to inhibit vascular sympathetic nerve activity associated with hypertension was studied in DOCA-salt hypertension in rats. A seven week treatment of DOCA and salt resulted in a significant increase in the systolic blood pressure of the uninephrectomized rats. The administration of propran...

    journal_title:American journal of hypertension

    pub_type: 杂志文章

    doi:10.1093/ajh/4.1.68

    authors: Tsuda K,Masuyama Y

    更新日期:1991-01-01 00:00:00