The Metabolic Syndrome Does Not Affect Development of Collateral Circulation in the Poststenotic Swine Kidney.


BACKGROUND:The collateral circulation is important in maintenance of blood supply to the ischemic kidney distal to renal artery stenosis (RAS). Obesity metabolic syndrome (MetS) preserves renal blood flow (RBF) in the stenotic kidney, but whether this is related to an increase of collateral vessel growth is unknown. We hypothesized that MetS increased collateral circulation around the renal artery. METHODS:Twenty-one domestic pigs were randomly divided into unilateral RAS fed an atherogenic (high-fat/high-fructose, MetS-RAS) or standard diet, or controls (n = 7 each). RBF, glomerular filtration rate (GFR), and the peristenotic collateral circulation were assessed after 10 weeks using multidetector computed tomography (CT) and the intrarenal microcirculation by micro-CT. Vascular endothelial growth factor (VEGF) expression was studied in the renal artery wall, kidney, and perirenal fat. Renal fibrosis and stiffness were examined by trichrome and magnetic resonance elastography. RESULTS:Compared with controls, RBF and GFR were decreased in RAS, but not in MetS-RAS. MetS-RAS formed peristenotic collaterals to the same extent as RAS pigs but induced greater intrarenal microvascular loss, fibrosis, stiffness, and inflammation. MetS-RAS also attenuated VEGF expression in the renal tissue compared with RAS, despite increased expression in the perirenal fat. CONCLUSIONS:MetS does not interfere with collateral vessel formation in the stenotic kidney, possibly because decreased renal arterial VEGF expression offsets its upregulation in perirenal fat, arguing against a major contribution of the collateral circulation to preserve renal function in MetS-RAS. Furthermore, preserved renal function does not protect the poststenotic kidney from parenchymal injury.


Am J Hypertens


Zhang X,Kim SR,Ferguson CM,Ebrahimi B,Hedayat AF,Lerman A,Lerman LO




Has Abstract


2018-11-13 00:00:00














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    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Mahoney LT,Clarke WR,Burns TL,Lauer RM

    更新日期:1991-11-01 00:00:00

  • L-dopa and streptozotocin-induced diabetic nephropathy in rats.

    abstract::The purpose of the present study was to determine whether the physiological dopamine prodrug, L-dopa, could suppress streptozotocin-induced diabetic glomerular hyperfiltration, and thus prevent further evolution of the diabetic nephropathy. Male Wistar rats treated with streptozotocin (60 mg/kg, intravenously) rapidly...

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    authors: Barthelmebs M,Vailly B,Velly J,Grima M,Imbs JL

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  • Interdependence of blood pressure and heart period regulation in mild hypertension.

    abstract::Blood pressure and heart period variability have been measured directly in 142 subjects with mild hypertension over 24 h. The variabilities have been expressed as the standard deviation of 2 min averages of all beats over 24 h. Baroreflex sensitivity was assessed in 102 subjects by the phenylephrine method. Blood pres...

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    authors: Coats AJ,Conway J,Sleight P,Meyer TE,Somers VK,Floras JS,Vann Jones J

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  • Relation of C-reactive protein to oxidative stress and to endothelial activation in essential hypertension.

    abstract:BACKGROUND:C-reactive protein (CRP) predicts cardiovascular outcome. Oxidative stress is considered to be involved in endothelial alteration. We hypothesized that in essential hypertension (EH), oxidative stress, as measured by 8-iso-prostaglandin-F(2alpha) (8-iso-PGF(2alpha)), should be associated with increased CRP a...

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    authors: Cottone S,Mulè G,Nardi E,Vadalà A,Guarneri M,Briolotta C,Arsena R,Palermo A,Riccobene R,Cerasola G

    更新日期:2006-03-01 00:00:00

  • Blood pressure in people in Greenland assessed by measuring renovasculopathies of hypertension at autopsy.

    abstract::Surveys taken of blood pressure in Greenland indicated prevailing levels similar to those in the USA. Morphometrically measured renovasculopathies in 88 autopsies confirmed blood pressure levels comparable to the survey findings. At clinic visits, the recorded blood pressures in 48 of the autopsies verified the morpho...

    journal_title:American journal of hypertension

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    authors: Tracy RE,Mulvad G,Pederson HS,Jul E,Bjerregaard P,Newman WP 3rd

    更新日期:1996-06-01 00:00:00

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    abstract::The induction of learned helpless (LH) behavior in rats is a widely used model of unipolar depression. Recent studies have linked depression with hypertension and insulin resistance as observed in obesity, but the propensity of these disorders to manifest depression has not been reported. In this study, the LH behavio...

    journal_title:American journal of hypertension

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    authors: Edwards E,King JA,Fray J

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    journal_title:American journal of hypertension

    pub_type: 杂志文章,评审


    authors: Lahera V,Ruilope LM,Romero JC

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    abstract::Hyperinsulinemia and dyslipidemia are known to be associated with essential hypertension but their role in pregnancy-induced hypertension remains unclear. We performed a case-control study comparing cholesterol, insulin, and glucose levels in the early third trimester of pregnancy among 31 women who developed pregnanc...

    journal_title:American journal of hypertension

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    authors: Solomon CG,Carroll JS,Okamura K,Graves SW,Seely EW

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    authors: Psaty BM,Arnold AM,Olson J,Saad MF,Shea S,Post W,Burke GL

    更新日期:2006-11-01 00:00:00

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    journal_title:American journal of hypertension

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    authors: Bukoski RD,Xue H,McCarron DA

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    journal_title:American journal of hypertension

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    authors: Zhao Q,Gu D,Kelly TN,Hixson JE,Rao DC,Jaquish CE,Chen J,Huang J,Chen CS,Gu CC,Whelton PK,He J

    更新日期:2010-06-01 00:00:00

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    authors: Freeman K,Farrow S,Schmaier A,Freedman R,Schork T,Lockette W

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    journal_title:American journal of hypertension

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    authors: Holzgreve H,Nakov R,Beck K,Janka HU

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    authors: Lenz T,Müller FB,Sotelo JE,Laragh JH,August P

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    authors: Lee JS,Greco L,Migirov A,Li Y,Gerdes AM,Zhang Y

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    authors: Losi MA,Izzo R,Canciello G,Giamundo A,Manzi MV,Strisciuglio T,Stabile E,De Luca N,de Simone G,Trimarco B

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    journal_title:American journal of hypertension

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    authors: Bloch MJ,Trost DA,Whitmer J,Pickering TG,Sos TA,August P

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    更新日期:2002-06-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 杂志文章


    authors: Dawson A,Davies JI,Morris AD,Struthers AD

    更新日期:2005-12-01 00:00:00

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    journal_title:American journal of hypertension

    pub_type: 临床试验,杂志文章


    authors: Musso NR,Vergassola C,Barone C,Lotti G

    更新日期:1997-08-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:American journal of hypertension

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