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Angiotensin II type 1 receptor polymorphisms in the cardiovascular health study: relation to blood pressure, ethnicity, and cardiovascular events.

Abstract：

BACKGROUND:The angiotensin II type 1 receptor A1166C polymorphism has been associated with increased risks of hypertension and myocardial infarction in several small studies. We examined the association between this polymorphism and new-onset hypertension, blood pressure (BP) control, and incident cardiovascular events in a large population-based cohort of older adults. METHODS:Eight hundred self-identified African Americans and 1,371 randomly selected white participants in the Cardiovascular Health Study were genotyped. The median duration of follow-up was 8.1 years. RESULTS:The A1166C polymorphism was not associated with new-onset hypertension, with BP control, or with incident cardiovascular events in the overall population. In white participants, the CC genotype was associated with higher baseline systolic BP and pulse pressure, compared to the AC or AA genotype. In whites with treated hypertension at baseline, compared to the AA genotype, the CC genotype was associated with increased risks of incident congestive heart failure (hazard ratio = 2.5, 95% confidence interval [CI] 1.3-4.9) and incident ischemic stroke (hazard ratio = 2.6, 95% CI 1.1-6.0). These associations were not observed among white participants without treated hypertension, but the interaction of genotype with treated hypertension on ischemic stroke and heart failure was only marginally significant. CONCLUSIONS:On the whole, in this large cohort of older adults, the A1166C polymorphism was not associated with BP control or incident cardiovascular events. The subgroup findings in treated hypertensives need to be confirmed in additional studies.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Hindorff LA,Heckbert SR,Tracy R,Tang Z,Psaty BM,Edwards KL,Siscovick DS,Kronmal RA,Nazar-Stewart V

doi

10.1016/s0895-7061(02)03063-7

subject

Has Abstract

pub_date

2002-12-01 00:00:00

pages

1050-6

issue

12

eissn

0895-7061

issn

1941-7225

pii

S0895706102030637

journal_volume

15

pub_type

临床试验,杂志文章,随机对照试验

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