Cyclic-AMP-dependent protein kinase type II is associated with the Golgi complex and with centrosomes.

abstract：:The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite a marked interest in the physiological roles of brain ECS, its structure and dynamics remain largely inaccessible for experimenters. We combined 3D-STED micros...

journal_title：Cell

authors： Tønnesen J,Inavalli VVGK,Nägerl UV

更新日期：2018-02-22 00:00:00

abstract：:Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they represent secondary messengers affecting numerous responses of the prokaryotic cell, whereas in the latter, they act as agonists of the inn...

journal_title：Cell

authors： Danilchanka O,Mekalanos JJ

更新日期：2013-08-29 00:00:00

abstract：:The linear extrachromosomal ribosomal DNA of Tetrahymena is generated from a single integrated copy during macronuclear development. The free ends of this extrachromosomal gene contain 20-70 tandem repeats of the hexanucleotide CCCCAA. We have determined the nucleotide sequence at the same (3') end of the single, inte...

journal_title：Cell

authors： King BO,Yao MC

更新日期：1982-11-01 00:00:00

abstract：:CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear. We found that GATA-3 was selectively expressed in Th2 cells. GATA-3 is expressed at a hi...

journal_title：Cell

authors： Zheng W,Flavell RA

更新日期：1997-05-16 00:00:00

abstract：:Rhythmic cardiac contractions depend on the organized propagation of depolarizing and repolarizing wavefronts. Repolarization is spatially heterogeneous and depends largely on gradients of potassium currents. Gradient disruption in heart disease may underlie susceptibility to fatal arrhythmias, but it is not known how...

journal_title：Cell

authors： Costantini DL,Arruda EP,Agarwal P,Kim KH,Zhu Y,Zhu W,Lebel M,Cheng CW,Park CY,Pierce SA,Guerchicoff A,Pollevick GD,Chan TY,Kabir MG,Cheng SH,Husain M,Antzelevitch C,Srivastava D,Gross GJ,Hui CC,Backx PH,Bruneau

更新日期：2005-10-21 00:00:00

abstract：:We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

journal_title：Cell

authors： Thomas KR,Capecchi MR

更新日期：1987-11-06 00:00:00

abstract：:In mouse intestinal tumors induced by the inhibition of APC, the restoration of APC function causes complete tumor regression with normal differentiation and return of stem cell function irrespective of whether tumors also carried mutations in Kras and p53. These findings by Dow et al. validate the Wnt pathway as an e...

journal_title：Cell

authors： Krimpenfort P,Berns A

更新日期：2015-06-18 00:00:00

abstract：:The segment polarity genes engrailed and wingless are expressed in neighboring stripes of cells on opposite sides of the Drosophila parasegment boundary. Each gene is mutually required for maintenance of the other's expression; continued expression of both also requires several other segment polarity genes. We show he...

journal_title：Cell

authors： Lee JJ,von Kessler DP,Parks S,Beachy PA

更新日期：1992-10-02 00:00:00

abstract：:Using double-label quantitative immunoelectron microscopy on ultrathin cryosections of rat liver, we have compared the endocytotic pathways of the receptors for asialoglycoprotein (ASGP-R), mannose-6-phosphate ligands (MP-R), and polymeric IgA (IgA-R). All three were found within the Golgi complex, along the entire pl...

journal_title：Cell

authors： Geuze HJ,Slot JW,Strous GJ,Peppard J,von Figura K,Hasilik A,Schwartz AL

更新日期：1984-05-01 00:00:00

abstract：:The therapeutic value of DNA-damaging antineoplastic agents is dependent upon their ability to induce tumor cell apoptosis while sparing most normal tissues. Here, we show that a component of the apoptotic response to these agents in several different types of tumor cells is the deamidation of two asparagines in the u...

journal_title：Cell

authors： Deverman BE,Cook BL,Manson SR,Niederhoff RA,Langer EM,Rosová I,Kulans LA,Fu X,Weinberg JS,Heinecke JW,Roth KA,Weintraub SJ

更新日期：2002-10-04 00:00:00

abstract：:Telomere capping is the essential function of telomeres. To identify new genes involved in telomere capping, we carried out a genome-wide screen in Saccharomyces cerevisiae for suppressors of cdc13-1, an allele of the telomere-capping protein Cdc13. We report the identification of five novel suppressors, including the...

journal_title：Cell

authors： Downey M,Houlsworth R,Maringele L,Rollie A,Brehme M,Galicia S,Guillard S,Partington M,Zubko MK,Krogan NJ,Emili A,Greenblatt JF,Harrington L,Lydall D,Durocher D

更新日期：2006-03-24 00:00:00

abstract：:The yeast [PSI+] factor is inherited by a prion mechanism involving self-propagating Sup35p aggregates. We find that Sup35p prion function is conserved among distantly related yeasts. As with mammalian prions, a species barrier inhibits prion induction between Sup35p from different yeast species. This barrier is faith...

journal_title：Cell

authors： Santoso A,Chien P,Osherovich LZ,Weissman JS

更新日期：2000-01-21 00:00:00

abstract：:In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to ...

journal_title：Cell

authors： Bhoj VG,Chen ZJ

更新日期：2008-08-22 00:00:00

abstract：:During metastasis, migrating breast cancer stem cells undergo a loss of polarity leading to an epithelial-to-mesenchymal transition (EMT). Gupta et al. (2009) use this attribute of cancer stem cells to develop a high-throughput screen, which successfully identifies small molecules that specifically inhibit cancer stem...

journal_title：Cell

authors： Beug H

更新日期：2009-08-21 00:00:00

abstract：:The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression t...

journal_title：Cell

authors： Mellor J

更新日期：2006-07-14 00:00:00

abstract：:Biomechanical stress is a major stimulus for cardiac hypertrophy and the transition to heart failure. By generating mice that harbor a ventricular restricted knockout of the gp130 cytokine receptor via Cre-IoxP-mediated recombination, we demonstrate a critical role for a gp130-dependent myocyte survival pathway in the...

journal_title：Cell

authors： Hirota H,Chen J,Betz UA,Rajewsky K,Gu Y,Ross J Jr,Müller W,Chien KR

更新日期：1999-04-16 00:00:00

abstract：:22q11.2 microdeletions result in specific cognitive deficits and schizophrenia. Analysis of Df(16)A(+/-) mice, which model this microdeletion, revealed abnormalities in the formation of neuronal dendrites and spines, as well as altered brain microRNAs. Here, we show a drastic reduction of miR-185, which resides within...

journal_title：Cell

authors： Xu B,Hsu PK,Stark KL,Karayiorgou M,Gogos JA

更新日期：2013-01-17 00:00:00

abstract：:Cell-penetrating peptides (CPPs) are short protein segments that can transport cargos into cells. Although CPPs are widely studied as potential drug delivery tools, their role in normal cell physiology is poorly understood. Early during infection, the L2 capsid protein of human papillomaviruses binds retromer, a cytop...

journal_title：Cell

authors： Zhang P,Monteiro da Silva G,Deatherage C,Burd C,DiMaio D

更新日期：2018-09-06 00:00:00

abstract：:We chemically synthesized 20 peptides corresponding to 75% of the HA1 molecule of the influenza virus. Antibodies to the majority (18) of these peptides were capable of reacting with the hemagglutinin molecule. These 18 peptides are not confined to the known antigenic determinants of the hemagglutinin molecule, but ra...

journal_title：Cell

authors： Green N,Alexander H,Olson A,Alexander S,Shinnick TM,Sutcliffe JG,Lerner RA

更新日期：1982-03-01 00:00:00

abstract：:Polyadenylation of mRNA precursors by poly(A) polymerase depends on a specificity factor, CPF, recognizing the polyadenylation signal AAUAAA. This paper describes an apparently novel poly(A)-binding protein that acts as a second specificity factor, mediating the recognition of the growing poly(A) tail. A transition fr...

journal_title：Cell

authors： Wahle E

更新日期：1991-08-23 00:00:00

abstract：:A 57 kd component of oligosaccharyl transferase, termed glycosylation site binding protein, specifically recognizes a photoaffinity probe containing the N-glycosylation site sequence Asn-Lys-Thr. It is present in the lumen of the ER (endoplasmic reticulum) and its release from this compartment results in a loss of N-g...

journal_title：Cell

authors： Geetha-Habib M,Noiva R,Kaplan HA,Lennarz WJ

更新日期：1988-09-23 00:00:00

abstract：:We have used cloned chicken cDNA sequences for alpha- and beta-tubulin to investigate tubulin gene organization in Drosophila melanogaster. Experiments using genomic Drosophila DNA from several sources indicate that there are at least four copies each of the alpha-tubulin gene and the beta-tubulin gene. In situ hybrid...

journal_title：Cell

authors： Sánchez F,Natzle JE,Cleveland DW,Kirschner MW,McCarthy BJ

更新日期：1980-12-01 00:00:00

abstract：:Elucidation of endogenous cellular protein-protein interactions and their networks is most desirable for biological studies. Here we report our study of endogenous human coregulator protein complex networks obtained from integrative mass spectrometry-based analysis of 3290 affinity purifications. By preserving weak pr...

journal_title：Cell

authors： Malovannaya A,Lanz RB,Jung SY,Bulynko Y,Le NT,Chan DW,Ding C,Shi Y,Yucer N,Krenciute G,Kim BJ,Li C,Chen R,Li W,Wang Y,O'Malley BW,Qin J

更新日期：2011-05-27 00:00:00

abstract：:A mutation in any one of eight spoO genes of Bacillus subtilis blocks the process of spore formation at its earliest stage. To investigate how the products of the spoO genes may be involved in developmental gene expression, we fused the lacZ gene of E. coli to spoVG, a sporulation gene whose induction at the onset of ...

journal_title：Cell

authors： Zuber P,Losick R

更新日期：1983-11-01 00:00:00

abstract：:Thrombin stimulates 32Pi incorporation into phosphatidylinositol 4-phosphate (PIP), phosphatidylinositol 4,5-bis-phosphate (PIP2), and phosphatidylinositol (PI), and initiates DNA synthesis in hamster (NIL) fibroblasts at a half-maximal concentration of 125 ng/ml. Neomycin, which binds PIP2 and PIP, inhibits both thro...

journal_title：Cell

authors： Carney DH,Scott DL,Gordon EA,LaBelle EF

更新日期：1985-09-01 00:00:00

abstract：:The short chain aliphatic acid salts, butyrate and propionate, are effective inhibitors of histone deacetylation in chick oviduct at 2--5 mM; they also prevent the hormonal induction of the ovalbumin and transferrin genes. The less potent deacetylase inhibitor isobutyrate is correspondingly less effective in blocking ...

journal_title：Cell

authors： McKnight GS,Hager L,Palmiter RD

更新日期：1980-11-01 00:00:00

abstract：:The mitochondrial MURF4 gene of T. brucei has pronounced G versus C strand bias and heterogeneously sized transcripts, characteristic of genes encoding extensively edited transcripts. We find that MURF4 transcripts of T. brucei are extensively edited throughout by the addition and deletion of numerous uridines, creati...

journal_title：Cell

authors： Bhat GJ,Koslowsky DJ,Feagin JE,Smiley BL,Stuart K

更新日期：1990-06-01 00:00:00

abstract：:The sequences corresponding to the 18S and 28S rRNAs have been mapped within a cloned 17 kilobase (kb) fragment formed by Eco R1 cleavage of Drosophila melanogaster rDNA. This fragment, Dm103, represents the longer of two major types of repeating units that are present in the rDNA of this fly, and was cloned as a hybr...

journal_title：Cell

authors： Glover DM,Hogness DS

更新日期：1977-02-01 00:00:00

abstract：:Monkey cells synthesizing SV40 large T antigen were lysed and the extracts immunoprecipitated with either monoclonal anti-T antibody or monoclonal antibody to p110-114, the product of the retinoblastoma susceptibility gene (Rb). T and p110-114 coprecipitated in each case, implying that the proteins are complexed with ...

journal_title：Cell

authors： DeCaprio JA,Ludlow JW,Figge J,Shew JY,Huang CM,Lee WH,Marsilio E,Paucha E,Livingston DM

更新日期：1988-07-15 00:00:00

abstract：:We explored how the odor map in the Drosophila antennal lobe is represented in higher olfactory centers, the mushroom body and lateral horn. Systematic single-cell tracing of projection neurons (PNs) that send dendrites to specific glomeruli in the antennal lobe revealed their stereotypical axon branching patterns and...

journal_title：Cell

authors： Marin EC,Jefferis GS,Komiyama T,Zhu H,Luo L

更新日期：2002-04-19 00:00:00