Abstract:
:Acupuncture has been shown to ameliorate cognitive impairment of Alzheimer's disease. Acupoints and stimulation frequency influence the therapeutic effect of electroacupuncture. Rat models of Alzheimer's disease were established by injecting amyloid beta 1-42 (Aβ1-42) into the bilateral lateral ventricles. Electroacupuncture at 2, 30, and 50 Hz was carried out at Baihui (GV20; 15° obliquely to a depth of 2 mm) and Shenshu (BL23; perpendicularly to 4-6 mm depth), once a day for 20 minutes (each), for 15 days, taking a break every 7 days. The Morris water maze test was conducted to assess the learning and memory. The expression levels of glycogen synthase kinase-3β (GSK-3β), pSer9-GSK-3β, pTyr216-GSK-3β, amyloid precursor protein and Aβ1-40 in the hippocampus were determined by western blot assay. Results demonstrated that electroacupuncture treatment at different frequencies markedly improved learning and memory ability, increased synaptic curvatures, decreased the width of synaptic clefts, thickened postsynaptic densities, and downregulated the expression of GSK-3β, amyloid precursor protein, and Aβ1-40. pSer9-GSK-3β expression markedly decreased, while pTyr216-GSK-3β expression increased. High-frequency (50 Hz) electroacupuncture was more effective than low (2 Hz) or medium-frequency (30 Hz) electroacupuncture. In conclusion, electroacupuncture treatment exerts a protective effect against Aβ1-42-induced learning and memory deficits and synapse-ultrastructure impairment via inhibition of GSK-3β activity. Moreover, high-frequency electroacupuncture was the most effective therapy.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Yu CC,Wang Y,Shen F,Kong LH,Wang YW,Zhou H,Tang Ldoi
10.4103/1673-5374.238620subject
Has Abstractpub_date
2018-10-01 00:00:00pages
1833-1841issue
10eissn
1673-5374issn
1876-7958pii
NeuralRegenRes_2018_13_10_1833_238620journal_volume
13pub_type
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journal_title:Neural regeneration research
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journal_title:Neural regeneration research
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doi:10.3969/j.issn.1673-5374.2013.33.003
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2013.06.010
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.01.010
更新日期:2012-01-05 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2021-03-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
doi:10.3969/j.issn.1673-5374.2012.05.001
更新日期:2012-02-15 00:00:00
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journal_title:Neural regeneration research
pub_type: 已发布勘误
doi:10.4103/1673-5374.208598
更新日期:2017-06-01 00:00:00
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journal_title:Neural regeneration research
pub_type: 杂志文章
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neural regeneration research
pub_type: 杂志文章,评审
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更新日期:2018-04-01 00:00:00
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journal_title:Neural regeneration research
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doi:10.3969/j.issn.1673-5374.2013.35.003
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journal_title:Neural regeneration research
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