Abstract：
:Abnormal TAR DNA-binding protein 43 (TDP-43) inclusion bodies can be detected in the degenerative neurons of amyotrophic lateral sclerosis. In this study, we induced chronic oxidative stress injury by applying malonate to cultured mouse cortical motor neurons. In the later stages of the malonate insult, TDP-43 expression reduced in the nuclei and transferred to the cytoplasm. This was accompanied by neuronal death, mimicking the pathological changes in TDP-43 that are seen in patients with amyotrophic lateral sclerosis. Interestingly, in the early stages of the response to malonate treatment, nuclear TDP-43 expression increased, and neurons remained relatively intact, without inclusion bodies or fragmentation. Therefore, we hypothesized that the increase of nuclear TDP-43 expression might be a pro-survival factor against oxidative stress injury. This hypothesis was confirmed by an in vitro transgenic experiment, in which overexpression of wild type mouse TDP-43 in cultured cortical motor neurons significantly reduced malonate-induced neuronal death. Our findings suggest that the loss of function of TDP-43 is an important cause of neuronal degeneration, and upregulation of nuclear TDP-43 expression might be neuroprotective in amyotrophic lateral sclerosis.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zheng M,Shi Y,Fan Ddoi
10.3969/j.issn.1673-5374.2013.35.003subject
Has Abstractpub_date
2013-12-15 00:00:00pages
3284-95issue
35eissn
1673-5374issn
1876-7958pii
NRR-8-3284journal_volume
8pub_type
杂志文章abstract：:The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that el...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.213534
更新日期：2017-08-01 00:00:00
abstract：:The location of an acute ischemic stroke is associated with its prognosis. The widely used Gaussian model-based parameter, apparent diffusion coefficient (ADC), cannot reveal microstructural changes in different locations or the degree of infarction. This prospective observational study was reviewed and approved by th...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.244791
更新日期：2019-02-01 00:00:00
abstract：:Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica and Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory and anti-oxidant properties. Therefore, we hypothesiz...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.27.001
更新日期：2012-09-25 00:00:00
abstract：:In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne (CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive day...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.177735
更新日期：2016-02-01 00:00:00
abstract：:Neurotrophins play a major role in the regulation of neuronal growth such as neurite sprouting or regeneration in response to nerve injuries. The role of nerve growth factor, neurotrophin-3, and brain-derived neurotrophic factor in maintaining the survival of peripheral neurons remains poorly understood. In regenerati...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.276338
更新日期：2020-09-01 00:00:00
abstract：:Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion inj...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.36.005
更新日期：2012-12-25 00:00:00
abstract：:An increasing amount of evidence demonstrates the anti-aging effect of Heshouwu in pill form. In this study, a subacute aging rat model was established by continuous intraperitoneal injection of D-galactose and treated with Heshouwu decoction (a Chinese herb for tonifying the kidney, comprising Heshouwu pill, Herba Ep...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.21.002
更新日期：2012-07-25 00:00:00
abstract：:Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer's disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the diffe...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.30.001
更新日期：2013-10-25 00:00:00
abstract：:Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/euka...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.162755
更新日期：2015-08-01 00:00:00
abstract：:Amniotic membranes have been widely used in ophthalmology and skin injury repair because of their anti-inflammatory properties. In this study, we measured therapeutic efficacy and determined if amniotic membranes could be used for facial nerve repair. The facial nerves of eight rats were dissected and end-to-end anast...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.11.002
更新日期：2013-04-15 00:00:00
abstract：:In this study, recombinant baculovirus carrying the microdystrophin and β-catenin genes was used to infect adipose-derived stem cells from a dystrophin-utrophin double knock-out mouse. Results showed that, after baculovirus transgene infection, microdystrophin and β-catenin genes were effectively expressed in adipose-...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.22.003
更新日期：2012-08-05 00:00:00
abstract：Objective:To judge the efficacies of neural stem cell (NSC) transplantation on functional recovery following contusion spinal cord injuries (SCIs). Data sources:Studies in which NSCs were transplanted into a clinically relevant, standardized rat model of contusion SCI were identified by searching the PubMed, Embase an...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.266915
更新日期：2020-04-01 00:00:00
abstract：:The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for con...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.165496
更新日期：2015-09-01 00:00:00
abstract：:Neurological abnormalities identified via neuroimaging are common in patients with Alzheimer's disease. However, it is not yet possible to easily detect these abnormalities using head computed tomography in the early stages of the disease. In this review, we evaluated the ways in which modern imaging techniques such a...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.286957
更新日期：2021-01-01 00:00:00
abstract：:Previous animal studies have shown that stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor-4 (CXCR4) signaling pathway plays an important role in the targeted migration of bone marrow-derived mesenchymal stem cells (BMSCs) to the injured area. In the present study, we aimed to investigate the potential role ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.224382
更新日期：2018-01-01 00:00:00
abstract：:Curcumin exerts a neuroprotective effect on Alzheimer's disease; however, it is not known whether microRNAs are involved in this protective effect. This study was conducted using swAPP695-HEK293 cells as an Alzheimer's disease cell model. swAPP695-HEK293 cells were treated with 0, 0.5, 1, 2, 5, and 10 μM curcumin for ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.255979
更新日期：2019-09-01 00:00:00
abstract：:The mechanism involved in neural regeneration after spinal cord injury is unclear. The myelin-derived protein Nogo-A, which is specific to the central nervous system, has been identified to negatively affect the cytoskeleton and growth program of axotomized neurons. Studies have shown that Nogo-A exerts immediate and ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.152375
更新日期：2015-02-01 00:00:00
abstract：:The present study aimed to explore the mechanism underlying the protective effects of hydrogen sulfide against neuronal damage caused by cerebral ischemia/reperfusion. We established the middle cerebral artery occlusion model in rats via the suture method. Ten minutes after middle cerebral artery occlusion, the animal...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.158353
更新日期：2015-06-01 00:00:00
abstract：:Growth arrest-specific 5 (GAS5) is an anti-oncogene that has been extensively studied in tumors. However, research on GAS5 in the context of nervous system disease is rare at present. This study aimed to investigate the role of the long non-coding RNA GAS5 in rat pheochromocytoma cells (PC12 cells). GAS5-overexpressin...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.262592
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To investigate the factors associated with sensory and motor recovery after the repair of upper limb peripheral nerve injuries. DATA SOURCES:The online PubMed database was searched for English articles describing outcomes after the repair of median, ulnar, radial, and digital nerve injuries in humans with a ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.130094
更新日期：2014-03-15 00:00:00
abstract：:Huntington's disease (HD) is an autosomal-dominant neurodegenerative disease characterized by the selective loss of neurons in the striatum and cortex, leading to progressive motor dysfunction, cognitive decline and behavioral symptoms. HD is caused by a trinucleotide (CAG) repeat expansion in the gene encoding for hu...
journal_title：Neural regeneration research
pub_type： 杂志文章,评审
doi：10.4103/1673-5374.215245
更新日期：2017-09-01 00:00:00
abstract：:In treating patients with obstetric brachial plexus palsy, we noticed that denervated intrinsic muscles of the hand become irreversibly atrophic at a faster than denervated biceps. In a rat model of obstetric brachial plexus palsy, denervated intrinsic musculature of the forepaw entered the irreversible atrophy far ea...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.272619
更新日期：2020-07-01 00:00:00
abstract：:In the present study, we examined the analgesic effect of repeated electroacupuncture at bilateral Zusanli (ST36) and Yanglingquan (GB34) once a day for 14 consecutive days in a rat model of chronic sciatic nerve constriction injury-induced neuropathic pain. In addition, concomitant changes in calcium/calmodulin-depen...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.18.003
更新日期：2012-06-25 00:00:00
abstract：:The heterogeneity of traumatic brain injury (TBI)-induced secondary injury has greatly hampered the development of effective treatments for TBI patients. Targeting common processes across species may be an innovative strategy to combat debilitating TBI. In the present study, a cross-species transcriptome comparison wa...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.301028
更新日期：2021-07-01 00:00:00
abstract：:Tissue plasminogen activator is usually used for the treatment of acute ischemic stroke, but the role of endogenous tissue plasminogen activator in traumatic brain injury has been rarely reported. A rat model of traumatic brain injury was established by weight-drop method. The tissue plasminogen activator inhibitor ne...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.266914
更新日期：2020-04-01 00:00:00
abstract：:The G-protein-coupled purinergic receptor P2Y2 (P2RY2) plays an important role in the mechanism of atherosclerosis, which is relevant to ischemic stroke. This retrospective case-control study aimed to assess the relationship between P2RY2 gene polymorphisms and ischemic stroke risk in the northern Han Chinese populati...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.245472
更新日期：2019-03-01 00:00:00
abstract：:The acute effect of acupuncture on Alzheimer's disease, i.e., on brain activation during treatment, has been reported. However, the effect of long-term acupuncture on brain activation in Alzheimer's disease is unclear. Therefore, in this study, we performed long-term needling at Zusanli (ST36) or a sham point (1.5 mm ...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.4103/1673-5374.211197
更新日期：2017-07-01 00:00:00
abstract：:Tau hyperphosphorylation is a main cause of neuronal loss in Alzheimer's disease, which can be caused by many factors, including oxidative stress. The multifunctional protein p62, which exists in neurofibrillary tangles and causes aggregation of hyperphosphorylated tau, not only serves as a receptor in selective autop...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.17.004
更新日期：2012-06-15 00:00:00
abstract：:The present study investigated the influence of anti-estrogen treatment (fulvestrant) on pituitary adenoma cell line GH3 biological activity, the estrogen receptor α pathway, the WnT pathway, and mechanisms of decreased Wnt inhibitory factor-1 expression in GH3 cells. Results showed that fulvestrant suppressed GH3 cel...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2012.04.008
更新日期：2012-02-05 00:00:00
abstract：:Emodin, an extract of dried rhizomes and the root of the Rhizoma Polygoni Cuspidati, can protect neurons from hypoxic-ischemic brain damage. This study aimed to verify the underlying mechanism. After PC12 cells had differentiated into neuron-like cells under the induction of mouse nerve growth factor, cells were subje...
journal_title：Neural regeneration research
pub_type： 杂志文章
doi：10.3969/j.issn.1673-5374.2013.15.002
更新日期：2013-05-25 00:00:00
