Abstract:
:Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone IIa promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone IIa, compared with positive control Danshen injection.
journal_name
Neural Regen Resjournal_title
Neural regeneration researchauthors
Zhang L,Gan W,An Gdoi
10.3969/j.issn.1673-5374.2012.36.005subject
Has Abstractpub_date
2012-12-25 00:00:00pages
2882-8issue
36eissn
1673-5374issn
1876-7958pii
NRR-7-2882journal_volume
7pub_type
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