Influence of Tanshinone IIa on heat shock protein 70, Bcl-2 and Bax expression in rats with spinal ischemia/reperfusion injury.

Abstract:

:Tanshinone IIa is an effective monomer component of Danshen, which is a traditional Chinese medicine for activating blood circulation to dissipate blood stasis. Tanshinone IIa can effectively improve brain tissue ischemia/hypoxia injury. The present study established a rat model of spinal cord ischemia/reperfusion injury and intraperitoneally injected Tanshinone IIa, 0.5 hour prior to model establishment. Results showed that Tanshinone IIa promoted heat shock protein 70 and Bcl-2 protein expression, but inhibited Bax protein expression in the injured spinal cord after ischemia/reperfusion injury. Furthermore, Nissl staining indicated a reduction in nerve cell apoptosis and fewer pathological lesions in the presence of Tanshinone IIa, compared with positive control Danshen injection.

journal_name

Neural Regen Res

authors

Zhang L,Gan W,An G

doi

10.3969/j.issn.1673-5374.2012.36.005

subject

Has Abstract

pub_date

2012-12-25 00:00:00

pages

2882-8

issue

36

eissn

1673-5374

issn

1876-7958

pii

NRR-7-2882

journal_volume

7

pub_type

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