Coronary Artery Spasm, Coronary Reactivity, and Their Psychological Context.

Abstract:

:Symptomatic individuals suspected of having myocardial ischemia often have no obstructive atherosclerotic narrowing of epicardial coronary arteries. Abnormal coronary vascular reactivity and, in particular, coronary artery vasospasm (CAS) may be an explanation in a subset of these patients. Psychological factors play an important role in ischemic heart disease, but their role in CAS is not clear; autonomic dysfunction and increased inflammation are two prevailing pathophysiological mechanisms implicated in abnormal coronary reactivity resulting from mental health conditions. Interrelationships between psychological factors, abnormal coronary reactivity, and sex/gender differences are poorly defined in the etiology of CAS. In this issue of Psychosomatic Medicine (2019;81:237-245), Hung et al. report a frequency of less than 0.1% of new-onset CAS in the Taiwanese population, with higher occurrence in women and younger individuals. Patients with CAS had a higher prevalence of previous anxiety and depression compared with those with coronary artery disease and controls, with no sex differences. In this editorial comment, we discuss the potential reasons for underreporting of CAS and the challenges regarding the use of administrative health records for psychosomatic research. In this editorial, a model is presented to explain the association between emotional stressors and mental health factors with CAS, including the role of sympathetic nervous system activation, inflammation, oxidative stress, endothelial dysfunction, and smooth muscle cell dysregulation.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Mehta PK,Thobani A,Vaccarino V

doi

10.1097/PSY.0000000000000682

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

233-236

issue

3

eissn

0033-3174

issn

1534-7796

journal_volume

81

pub_type

评论,杂志文章
  • Psychiatric Disorders, Morbidity, and Mortality: Tracing Mechanistic Pathways to Accelerated Aging.

    abstract::A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance ...

    journal_title:Psychosomatic medicine

    pub_type: 评论,社论

    doi:10.1097/PSY.0000000000000373

    authors: Kiecolt-Glaser JK,Wilson SJ

    更新日期:2016-09-01 00:00:00

  • Defective nitric oxide-cyclic guanosine monophosphate signaling in patients with bipolar disorder: a potential role for platelet dysfunction.

    abstract:OBJECTIVE:Bipolar disorder (BD) is associated with elevated cardiovascular mortality rates. We investigated the modulation of l-arginine-nitric oxide (NO) signaling in platelets from patients with BD at different phases. METHODS:Platelets obtained from 28 patients with BD and 10 healthy volunteers were analyzed for l-...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3182689460

    authors: Fontoura PC,Pinto VL,Matsuura C,Resende Ade C,de Bem GF,Ferraz MR,Cheniaux E,Brunini TM,Mendes-Ribeiro AC

    更新日期:2012-10-01 00:00:00

  • Does anxiety affect risk of dementia? Findings from the Caerphilly Prospective Study.

    abstract:OBJECTIVE:To examine the association of anxiety with incident dementia and cognitive impairment not dementia (CIND). METHODS:We conducted a prospective study of men aged 48 to 67 years at baseline anxiety assessment; we measured cognition 17 years later. We studied 1481 men who were either eligible for examination or ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181a6177c

    authors: Gallacher J,Bayer A,Fish M,Pickering J,Pedro S,Dunstan F,Ebrahim S,Ben-Shlomo Y

    更新日期:2009-07-01 00:00:00

  • Shift-and-Persist Strategies: Associations With Socioeconomic Status and the Regulation of Inflammation Among Adolescents and Their Parents.

    abstract:OBJECTIVE:Shift-and-persist is a resilience construct hypothesized to be beneficial to physical health among individuals with low socioeconomic status (SES). This shift-and-persist construct entails a combination of reframing stressors more positively while also enduring adversity through finding purpose in life. In th...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/psy.0000000000000157

    authors: Chen E,McLean KC,Miller GE

    更新日期:2015-05-01 00:00:00

  • Sexual orientation and disclosure in relation to psychiatric symptoms, diurnal cortisol, and allostatic load.

    abstract:OBJECTIVES:Lesbian, gay, and bisexual (LGB) individuals-particularly those who have not disclosed their sexual orientation-are believed to experience increased chronic stress in comparison with heterosexuals. This interdisciplinary study assessed whether psychiatric symptoms (self-rated anxiety, depression, and burnout...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3182826881

    authors: Juster RP,Smith NG,Ouellet É,Sindi S,Lupien SJ

    更新日期:2013-02-01 00:00:00

  • Self-efficacy and health status in patients with coronary heart disease: findings from the heart and soul study.

    abstract:OBJECTIVE:To examine the relationship between cardiac self-efficacy and health status, including symptom burden, physical limitation, quality of life, and overall health among outpatients with stable coronary heart disease (CHD). We hypothesized that lower self-efficacy would predict worse health status, independent of...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3180514d57

    authors: Sarkar U,Ali S,Whooley MA

    更新日期:2007-05-01 00:00:00

  • The influence of concentration/meditation on autonomic nervous system activity and the innate immune response: a case study.

    abstract:OBJECTIVE:In this case study, we describe the effects of a particular individual's concentration/meditation technique on autonomic nervous system activity and the innate immune response. The study participant holds several world records with regard to tolerating extreme cold and claims that he can influence his autonom...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3182583c6d

    authors: Kox M,Stoffels M,Smeekens SP,van Alfen N,Gomes M,Eijsvogels TM,Hopman MT,van der Hoeven JG,Netea MG,Pickkers P

    更新日期:2012-06-01 00:00:00

  • Psychological correlates of progression of atherosclerosis in men.

    abstract::Patients who underwent repetitive repetitive coronary angiograms at an average interval of 17 months completed the Jenkins Activity Survey (n = 66) and were given the Rosenman diagnostic interview to measure Type A behavior (n = 45). Significant progression of coronary artery disease was judged to be an increase in oc...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-197910000-00003

    authors: Krantz DS,Sanmarco MI,Selvester RH,Matthews KA

    更新日期:1979-10-01 00:00:00

  • Family adversity and autonomic reactivity association with immune changes in HIV-affected school children.

    abstract:OBJECTIVE:To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status. METHODS:Data from 38 HIV-positive and 29 HIV-negative children born to serop...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e31829807fb

    authors: Thomas MR,Wara D,Saxton K,Truskier M,Chesney MA,Boyce WT

    更新日期:2013-07-01 00:00:00

  • Long-term psychological adjustment of acute leukemia survivors: impact of bone marrow transplantation versus conventional chemotherapy.

    abstract::As increasing numbers of patients survive acute leukemia, it has become important to study the long-term psychological and social adjustment of patients who have successfully completed their leukemia treatment. An important aspect of this inquiry is comparing the long-term psychosocial impact of two treatments for acu...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199201000-00006

    authors: Lesko LM,Ostroff JS,Mumma GH,Mashberg DE,Holland JC

    更新日期:1992-01-01 00:00:00

  • Longitudinal follow-up of amenorrhea in eating disorders.

    abstract::The authors recruited 229 treatment-seeking anorexic and bulimic women for a prospective, longitudinal study. Telephone interviews were arranged every 3 months for at least 1 year for 225 patients. At intake, 132 subjects were menstruating, 34 subjects were taking oral contraceptives, 5 subjects had an organic cause f...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199503000-00004

    authors: Copeland PM,Sacks NR,Herzog DB

    更新日期:1995-03-01 00:00:00

  • Social problem solving and noncardiac chest pain.

    abstract:OBJECTIVE:To investigate differences in social problem solving (SPS) between individuals with noncardiac chest pain (NCCP) and persons with chest pain who tested positive for underlying cardiac disease. METHODS:The major design involved a matched case-control methodology and compared a group of patients with NCCP (n =...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e31815a995a

    authors: Nezu AM,Nezu CM,Jain D,Xanthopoulos MS,Cos TA,Friedman J,Lee M

    更新日期:2007-12-01 00:00:00

  • Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: cardiovascular risk in young Finns study.

    abstract:OBJECTIVE:To examine the potential moderating role of DRD2 polymorphism (rs1800497) in the association between stressful life events and depressive symptoms among young adults. Although stressful life events, such as divorce, unemployment, and serious illness in the family, are generally associated with negative health...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/psy.0b013e31806bf365

    authors: Elovainio M,Jokela M,Kivimäki M,Pulkki-Råback L,Lehtimäki T,Airla N,Keltikangas-Järvinen L

    更新日期:2007-06-01 00:00:00

  • Social integration and mortality in patients with coronary heart disease: findings from the Heart and Soul Study.

    abstract:OBJECTIVE:To determine why lower social integration predicts higher mortality in patients with coronary heart disease (CHD). METHODS:The association between social integration and mortality was examined prospectively in 1019 outpatients with stable CHD from the Heart and Soul Study. Baseline social integration was ass...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000100

    authors: Kreibig SD,Whooley MA,Gross JJ

    更新日期:2014-10-01 00:00:00

  • Longitudinal study of the impact of psychological distress symptoms on new-onset upper gastrointestinal symptoms in World Trade Center responders.

    abstract:OBJECTIVES:Research on the health of workers involved in the cleanup after the attack on the World Trade Center (WTC) on September 11, 2001, has documented high rates of psychological distress and upper gastrointestinal (GI) symptoms. The current article examines the concurrent and longitudinal associations of psycholo...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000116

    authors: Litcher-Kelly L,Lam Y,Broihier JA,Brand DL,Banker SV,Kotov R,Bromet E,Bucobo JC,Shaw RD,Luft BJ

    更新日期:2014-11-01 00:00:00

  • Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression.

    abstract:OBJECTIVE:Activation of a psychological stress response increases autonomic activity and enhances immune function by inducing a significant increase in numbers of leukocytes at sites of inflammation. Chemotaxis and cellular adhesion are thought to mediate leukocyte trafficking. In this study, we examine the effects of ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000079377.86193.a8

    authors: Redwine L,Snow S,Mills P,Irwin M

    更新日期:2003-07-01 00:00:00

  • African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures.

    abstract:OBJECTIVES:To examine ethnic differences in pain sensitivity and relationship of pain tolerance to blood pressure and neuroendocrine factors. METHODS:Fifty-one African Americans (24 men, 27 women) and 55 people from other ethnic groups (primarily Caucasian; 26 men, 29 women) were tested twice for pain sensitivity to t...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000188466.14546.68

    authors: Mechlin MB,Maixner W,Light KC,Fisher JM,Girdler SS

    更新日期:2005-11-01 00:00:00

  • Phobic anxiety and increased risk of mortality in coronary heart disease.

    abstract:OBJECTIVES:To evaluate whether phobic anxiety is associated with increased risk of cardiac mortality in individuals with established coronary heart disease (CHD) and to examine the role of reduced heart rate variability (HRV) in mediating this risk. Previous findings suggest that phobic anxiety may pose increased risk ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181e9f357

    authors: Watkins LL,Blumenthal JA,Babyak MA,Davidson JR,McCants CB Jr,O'Connor C,Sketch MH Jr

    更新日期:2010-09-01 00:00:00

  • Dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in early adolescence: the Ryukyus Child Health Study.

    abstract:OBJECTIVE:To examine the association between dietary folate, riboflavin, vitamin B-6, and vitamin B-12 and depressive symptoms in a group of adolescents. METHODS:This cross-sectional study, conducted in all public junior high schools in Naha City and Nago City, Okinawa, Japan, included 3,067 boys and 3,450 girls aged ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181f02f15

    authors: Murakami K,Miyake Y,Sasaki S,Tanaka K,Arakawa M

    更新日期:2010-10-01 00:00:00

  • Depression as an independent risk factor for mortality in critically ill patients.

    abstract:OBJECTIVE:Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a poss...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000137

    authors: Wewalka M,Warszawska J,Strunz V,Kitzberger R,Holzinger U,Fuhrmann V,Zauner C,Miehsler W,Moser G

    更新日期:2015-02-01 00:00:00

  • Insomnia and depression prior to myocardial infarction.

    abstract::Insomnia is common among patients who subsequently experience an acute myocardial infarction (MI), and is a major symptom of psychiatric depression. The purpose of this study was to determine what proportion of patients reporting insomnia prior to MI have depression. Of 70 patients with a recent MI, 27 (39%) reported ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199011000-00001

    authors: Carney RM,Freedland KE,Jaffe AS

    更新日期:1990-11-01 00:00:00

  • The effect of intranasal oxytocin administration on acute cold pressor pain: a placebo-controlled, double-blind, within-participants crossover investigation.

    abstract:BACKGROUND:This study examined the effect of synthetic oxytocin delivered intranasally on acute pain sensitivity using a placebo-controlled, double-blind, within-participant crossover design. METHODS:Thirty-seven (18 were male) pain-free young adults underwent two laboratory sessions separated by 1 week. Each session ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000068

    authors: Rash JA,Campbell TS

    更新日期:2014-07-01 00:00:00

  • Partner violence and psychological well-being: buffer or indirect effect of social support.

    abstract:OBJECTIVES:To determine the effect of two kinds of intimate partner violence (IPV) (physical and psychological) in the previous 12 months (current) and before the previous 12 months (past) on psychological well-being among women aged 18 to 70 years who attend primary healthcare centers in Spain; and to analyze the effe...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181d2f0dd

    authors: Escribà-Agüir V,Ruiz-Pérez I,Montero-Piñar MI,Vives-Cases C,Plazaola-Castaño J,Martín-Baena D,G6 for the Study of Gender Violence in Spain.

    更新日期:2010-05-01 00:00:00

  • Thresholds and perception of cold pain, heat pain, and the thermal grill illusion in patients with major depressive disorder.

    abstract:OBJECTIVE:The thermal grill illusion (TGI) in which interlacing cold and warm bars create the illusion of a painful sensation has been suggested as an experimental model for central pain states and pain processing. The aim of this study was to use this technique to gain further insights into the altered pain perception...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3182881a9c

    authors: Boettger MK,Grossmann D,Bär KJ

    更新日期:2013-04-01 00:00:00

  • Adjustment in diabetic adolescent girls: II. Adjustment, self-esteem, and depression in diabetic adolescent girls.

    abstract::The Rosenberg Self-Esteem Scale, Beck Depression Inventory, and Sullivan Diabetic Adjustment Scale were administered to 105 adolescent girls with diabetes. Results indicate that levels of self-esteem and depression highly correlate with the level of adjustment as assessed on the Diabetic Adjustment Scale (DAS). That i...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-197903000-00006

    authors: Sullivan BJ

    更新日期:1979-03-01 00:00:00

  • The relation between dominance, anger, and hormones in normally aging men: results from the Massachusetts Male Aging Study.

    abstract::This paper examines the relation of two personality characteristics (dominance and anger) to hormones in normally aging men. The relation of the Jackson Personality Research Form E Dominance subscale and the Spielberger Anger Expression scale to serum levels of 17 endocrine variables, including testosterone (T) and di...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199107000-00003

    authors: Gray A,Jackson DN,McKinlay JB

    更新日期:1991-07-01 00:00:00

  • Cultural models and somatic syndromes.

    abstract:OBJECTIVES:To review the relevance of cultural models in the generation and amplification of somatic symptoms and syndromes. METHODS:Based on a selective review of literature, we examine evidence that cultural and personal explanatory models can contribute to the pathogenesis, symptomatology, and chronicity of medical...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/PSY.0b013e31815b002c

    authors: Kirmayer LJ,Sartorius N

    更新日期:2007-12-01 00:00:00

  • Depressive symptoms predict norepinephrine response to a psychological stressor task in Alzheimer's caregivers.

    abstract:OBJECTIVE:Increased depressive symptoms have been associated with increased basal plasma norepinephrine (NE), and may be associated with exaggerated NE response to stress. This exaggerated response may play a role in health consequences associated with caring for a loved-one with Alzheimer's disease. The current study ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000173312.90148.97

    authors: Mausbach BT,Dimsdale JE,Ziegler MG,Mills PJ,Ancoli-Israel S,Patterson TL,Grant I

    更新日期:2005-07-01 00:00:00

  • Modeling and reinforcement of the sick role during childhood predicts adult illness behavior.

    abstract::Previous studies suggest that the ways in which parents respond to children's health complaints (reinforcement) and the ways in which they cope with their own illnesses (modeling) influence the frequency of symptoms, disability days, and health care visits made by these children when they grow up. However, previous st...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199411000-00010

    authors: Whitehead WE,Crowell MD,Heller BR,Robinson JC,Schuster MM,Horn S

    更新日期:1994-11-01 00:00:00

  • Psychobiologic reactivity to stress and childhood respiratory illnesses: results of two prospective studies.

    abstract::Psychological stress is thought to undermine host resistance to infection through neuroendocrine-mediated changes in immune competence. Associations between stress and infection have been modest in magnitude, however, suggesting individual variability in stress response. We therefore studied environmental stressors, p...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00006842-199509000-00001

    authors: Boyce WT,Chesney M,Alkon A,Tschann JM,Adams S,Chesterman B,Cohen F,Kaiser P,Folkman S,Wara D

    更新日期:1995-09-01 00:00:00