African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures.

Abstract:

OBJECTIVES:To examine ethnic differences in pain sensitivity and relationship of pain tolerance to blood pressure and neuroendocrine factors. METHODS:Fifty-one African Americans (24 men, 27 women) and 55 people from other ethnic groups (primarily Caucasian; 26 men, 29 women) were tested twice for pain sensitivity to tourniquet ischemia, thermal heat, and cold pressor tests, once following mental stress and once following rest control. Resting and stress-induced blood pressure (BP), plasma norepinephrine (NE), and cortisol were assessed. RESULTS:In response to all three pain tests, African Americans had lower pain tolerance relative to Caucasian/Others after both rest and stress. Only the non-African American group showed the expected inverse relationship between BP and pain sensitivity. African Americans had lower cortisol concentrations at rest and stress and showed blunted NE and systolic BP responses to stress. Only in Caucasians/Others was the relationship seen between higher stress-induced BP, cortisol, and NE levels and greater pain tolerance. CONCLUSIONS:The results suggest that there are alterations in endogenous pain regulatory mechanisms involving BP, cortisol, and NE in African Americans. Such dysregulation may contribute to the greater rate of clinical pain symptoms they experience. It is hypothesized that greater chronic stress in African Americans may be a contributing factor to the alterations in pain regulation.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Mechlin MB,Maixner W,Light KC,Fisher JM,Girdler SS

doi

10.1097/01.psy.0000188466.14546.68

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

948-56

issue

6

eissn

0033-3174

issn

1534-7796

pii

67/6/948

journal_volume

67

pub_type

杂志文章
  • Blood pressure response to the "second cup of coffee".

    abstract::Twenty young male coffee-drinkers consumed 150 mg of caffeine in decaffeinated coffee three times a day for 8 days. On days 3, 4, 7, and 8, caffeine or a placebo was administered in the laboratory at 11 A.M., 8 A.M., 11 A.M., and 8 A.M., respectively, in a randomized double-blind crossover design. There was a blood pr...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00006842-199005000-00007

    authors: Goldstein IB,Shapiro D,Hui KK,Yu JL

    更新日期:1990-05-01 00:00:00

  • Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine.

    abstract:OBJECTIVE:Influenza and pneumonia account for significant morbidity and mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control sub...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-200011000-00010

    authors: Glaser R,Sheridan J,Malarkey WB,MacCallum RC,Kiecolt-Glaser JK

    更新日期:2000-11-01 00:00:00

  • Shift-and-Persist Strategies: Associations With Socioeconomic Status and the Regulation of Inflammation Among Adolescents and Their Parents.

    abstract:OBJECTIVE:Shift-and-persist is a resilience construct hypothesized to be beneficial to physical health among individuals with low socioeconomic status (SES). This shift-and-persist construct entails a combination of reframing stressors more positively while also enduring adversity through finding purpose in life. In th...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/psy.0000000000000157

    authors: Chen E,McLean KC,Miller GE

    更新日期:2015-05-01 00:00:00

  • Psychological theories of depression: potential application for the prevention of acute coronary syndrome recurrence.

    abstract:OBJECTIVE:The natural course of elevated depressive symptoms or subthreshold depression in patients with an acute coronary syndrome (ACS) is presented, as is the prognostic impact. Safe and effective psychological treatment options are desirable for subthreshold depression in patients with ACS, should they prove tolera...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.psy.0000116716.19848.65

    authors: Davidson KW,Rieckmann N,Lespérance F

    更新日期:2004-03-01 00:00:00

  • Prediction of daily food intake as a function of measurement modality and restriction status.

    abstract:OBJECTIVE:Research on eating relies on various indices (e.g., stable, momentary, neural) to accurately reflect food-related reactivity (e.g., disinhibition) and regulation (e.g., restraint) outside the laboratory. The degree to which they differentially predict real-world consumption remains unclear. Further, the predi...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000187

    authors: Giuliani NR,Tomiyama AJ,Mann T,Berkman ET

    更新日期:2015-06-01 00:00:00

  • Psychological Distress and Physiological Reactivity During In Vivo Exposure in People With Aviophobia.

    abstract:OBJECTIVES:Exposure is regarded to be a crucial component of therapies for phobias. According to emotional processing theory, the success of exposure therapy is predicted by activation of subjective and physiological fear responses and their within-session habituation and between-session adaptation. This study tested t...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000209

    authors: Busscher B,Spinhoven P,de Geus EJ

    更新日期:2015-09-01 00:00:00

  • The effects of expressive writing on lung function, quality of life, medication use, and symptoms in adults with asthma: a randomized controlled trial.

    abstract:OBJECTIVES:Asthma is a chronic condition affecting 300 million people worldwide. Management involves adherence to pharmacological treatments such as corticosteroids and β-agonists, but residual symptoms persist. As asthma symptoms are exacerbated by stress, one possible adjunct to pharmacological treatment is expressiv...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PSY.0000000000000166

    authors: Smith HE,Jones CJ,Hankins M,Field A,Theadom A,Bowskill R,Horne R,Frew AJ

    更新日期:2015-05-01 00:00:00

  • Are stress-induced cortisol changes during pregnancy associated with postpartum depressive symptoms?

    abstract:OBJECTIVE:The purpose of this study was to examine the association between psychobiological stress reactivity during healthy pregnancy and depressive symptoms in the early puerperium. METHODS:A sample of healthy nulliparous pregnant women (N = 57) between the ages of 21 and 35 years underwent a standardized psychosoci...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000244385.93141.3b

    authors: Nierop A,Bratsikas A,Zimmermann R,Ehlert U

    更新日期:2006-11-01 00:00:00

  • Validation of the Women's Health Initiative Insomnia Rating Scale in a multicenter controlled clinical trial.

    abstract:OBJECTIVE:The objective of this study was to evaluate the construct validity of the five-item Women's Health Initiative Insomnia Rating Scale (WHIIRS) by comparing women taking hormone therapy (HT) versus those taking a placebo and by comparing women known to differ in vasomotor symptoms. METHODS:The WHIIRS was includ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/01.psy.0000151743.58067.f0

    authors: Levine DW,Dailey ME,Rockhill B,Tipping D,Naughton MJ,Shumaker SA

    更新日期:2005-01-01 00:00:00

  • Altered blood coagulation in patients with posttraumatic stress disorder.

    abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) has been associated with an increased cardiovascular risk, though the pathophysiologic mechanisms involved are elusive. A hypercoagulable state before occurrence of coronary thrombosis contributes to atherosclerosis development. We investigated whether PTSD would be associ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000221229.43272.9d

    authors: von Känel R,Hepp U,Buddeberg C,Keel M,Mica L,Aschbacher K,Schnyder U

    更新日期:2006-07-01 00:00:00

  • Impact of Wartime Stress Exposures and Mental Health on Later-Life Functioning and Disability in Vietnam-Era Women Veterans: Findings From the Health of Vietnam-Era Women's Study.

    abstract:OBJECTIVE:The effect of stress exposures and mental health sequelae on health-related outcomes is understudied among older women veterans. We examined a) the impact of wartime stress exposures on later-life functioning and disability in Vietnam-era women veterans and b) the extent to which mental health conditions know...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000762

    authors: Smith BN,Spiro A,Frayne SM,Kimerling R,Cypel Y,Reinhard MJ,Kilbourne AM,Magruder KM

    更新日期:2020-02-01 00:00:00

  • Depression in hospitalized cancer patients.

    abstract::The study of depression in cancer patients has been hampered by difficulty in establishing diagnostic criteria, since neurovegetative signs and symptoms may be attributable either to depression or physical illness. Confusion has also arisen in defining the boundary between "normal" grieving with illness, and "abnormal...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198405000-00002

    authors: Bukberg J,Penman D,Holland JC

    更新日期:1984-05-01 00:00:00

  • Metabolic risk factors and posttraumatic stress disorder: the role of sleep in young, healthy adults.

    abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is associated with indicators of poor physical health and sleep disturbance. This study investigated the relationship between PTSD and metabolic risk factors and examined the role of sleep duration in medically healthy and medication-free adults. METHODS:Participants with...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000176

    authors: Talbot LS,Rao MN,Cohen BE,Richards A,Inslicht SS,OʼDonovan A,Maguen S,Metzler TJ,Neylan TC

    更新日期:2015-05-01 00:00:00

  • Self-efficacy and health status in patients with coronary heart disease: findings from the heart and soul study.

    abstract:OBJECTIVE:To examine the relationship between cardiac self-efficacy and health status, including symptom burden, physical limitation, quality of life, and overall health among outpatients with stable coronary heart disease (CHD). We hypothesized that lower self-efficacy would predict worse health status, independent of...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3180514d57

    authors: Sarkar U,Ali S,Whooley MA

    更新日期:2007-05-01 00:00:00

  • Adjustment in diabetic adolescent girls: II. Adjustment, self-esteem, and depression in diabetic adolescent girls.

    abstract::The Rosenberg Self-Esteem Scale, Beck Depression Inventory, and Sullivan Diabetic Adjustment Scale were administered to 105 adolescent girls with diabetes. Results indicate that levels of self-esteem and depression highly correlate with the level of adjustment as assessed on the Diabetic Adjustment Scale (DAS). That i...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-197903000-00006

    authors: Sullivan BJ

    更新日期:1979-03-01 00:00:00

  • Dependence between apolipoprotein E phenotypes and temperament in children, adolescents, and young adults.

    abstract::The association of apolipoprotein E (apoE) polymorphism with temperament and Type A behavior was studied in 1577 randomly selected healthy children, adolescents, and young adults during a follow-up period of 9 years. Temperament was correlated with apoE phenotypes. Motor activity, even hyperactivity, in childhood and ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00006842-199303000-00004

    authors: Keltikangas-Järvinen L,Räikkönen K,Lehtimäki T

    更新日期:1993-03-01 00:00:00

  • Insomnia and depression prior to myocardial infarction.

    abstract::Insomnia is common among patients who subsequently experience an acute myocardial infarction (MI), and is a major symptom of psychiatric depression. The purpose of this study was to determine what proportion of patients reporting insomnia prior to MI have depression. Of 70 patients with a recent MI, 27 (39%) reported ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199011000-00001

    authors: Carney RM,Freedland KE,Jaffe AS

    更新日期:1990-11-01 00:00:00

  • Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging.

    abstract:OBJECTIVE:To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions. METHODS:We used a prospective twin study with a 12-year follow-up. In 1992, lifetime diagnosis of depression was assessed in 1159 male-male twins and...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PSY.0b013e3181d28125

    authors: Xian H,Scherrer JF,Franz CE,McCaffery J,Stein PK,Lyons MJ,Jacobsen K,Eisen SA,Kremen WS

    更新日期:2010-05-01 00:00:00

  • Major depressive disorder predicts cardiac events in patients with coronary artery disease.

    abstract::Fifty-two patients undergoing cardiac catheterization and subsequently found to have significant coronary artery disease (CAD) were given structured psychiatric interviews before catheterization. Nine of these patients met criteria for major depressive disorder. All 52 patients were contacted 12 months after catheteri...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198811000-00009

    authors: Carney RM,Rich MW,Freedland KE,Saini J,teVelde A,Simeone C,Clark K

    更新日期:1988-11-01 00:00:00

  • Acute psychological stress: effects on chemotaxis and cellular adhesion molecule expression.

    abstract:OBJECTIVE:Activation of a psychological stress response increases autonomic activity and enhances immune function by inducing a significant increase in numbers of leukocytes at sites of inflammation. Chemotaxis and cellular adhesion are thought to mediate leukocyte trafficking. In this study, we examine the effects of ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000079377.86193.a8

    authors: Redwine L,Snow S,Mills P,Irwin M

    更新日期:2003-07-01 00:00:00

  • What is the evidence for the efficacy of treatments for somatoform disorders? A critical review of previous intervention studies.

    abstract:OBJECTIVE:To review published literature for the highest level of evidence on the efficacy of treatment for patients with medically unexplained symptoms. METHODS:A comprehensive literature search was carried out in Cochrane library, Medline (1971-2007), PsychINFO (1974-2006), and EMBASE (1980-2007) to identify pharmac...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/PSY.0b013e31815b5cf6

    authors: Sumathipala A

    更新日期:2007-12-01 00:00:00

  • Validation of the type A interview assessment of adolescents: a multidimensional approach.

    abstract::The Adolescent Structured Interview (ASI), adapted from the interview that assesses Type A behavior of adults, was administered to 204 adolescents. These adolescents also completed a battery of self-report questionnaires that measured the three major components of Pattern A: competitive achievement-striving, speed and...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198108000-00004

    authors: Siegel JM,Matthews KA,Leitch CJ

    更新日期:1981-08-01 00:00:00

  • Association of anxiety disorders and depression with incident heart failure.

    abstract:OBJECTIVE:Depression has been associated with increased risk of heart failure (HF). Because anxiety is highly comorbid with depression, we sought to establish if anxiety, depression, or their co-occurrence is associated with incident HF. METHODS:A retrospective cohort (N = 236,079) including Veteran's Administration p...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000027

    authors: Garfield LD,Scherrer JF,Hauptman PJ,Freedland KE,Chrusciel T,Balasubramanian S,Carney RM,Newcomer JW,Owen R,Bucholz KK,Lustman PJ

    更新日期:2014-02-01 00:00:00

  • Pancreatic abnormalities in patients with eating disorders.

    abstract::In patients with eating disorders, we evaluated pancreatic abnormalities using serum elastase 1 measurement by RIA and the 50 g oral glucose tolerance test (50 g OGTT). Twenty-one patients had anorexia nervosa (AN) with bulimia and vomiting (AN-B group), 30 had AN without bulimia or vomiting (AN-R group), and 25 had b...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198811000-00007

    authors: Kobayashi N,Tamai H,Uehata S,Komaki G,Mori K,Matsubayashi S,Nakagawa T

    更新日期:1988-11-01 00:00:00

  • Suppressed anger and blood pressure: the effects of race, sex, social class, obesity, and age.

    abstract::We studied 572 men and women who participated in a blood pressure screening program at a government unemployment office. Before having their blood pressures taken, the subjects completed a brief questionnaire that included two items measuring conflict over anger expression. Information was also obtained on obesity, ra...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198607000-00005

    authors: Dimsdale JE,Pierce C,Schoenfeld D,Brown A,Zusman R,Graham R

    更新日期:1986-07-01 00:00:00

  • Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity.

    abstract:OBJECTIVE:A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. METHODS:We measured morn...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000138119.12956.99

    authors: Monteleone P,Tortorella A,Martiadis V,Serritella C,Fuschino A,Maj M

    更新日期:2004-09-01 00:00:00

  • Chronic physical conditions and their association with first onset of suicidal behavior in the world mental health surveys.

    abstract:OBJECTIVE:To investigate the association of a range of temporally prior physical conditions with the subsequent first onset of suicidal ideation, plans, and attempts in large, general population, cross-national sample. The associations between physical conditions and suicidal behavior remain unclear due to sparse data ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181e3333d

    authors: Scott KM,Hwang I,Chiu WT,Kessler RC,Sampson NA,Angermeyer M,Beautrais A,Borges G,Bruffaerts R,de Graaf R,Florescu S,Fukao A,Haro JM,Hu C,Kovess V,Levinson D,Posada-Villa J,Scocco P,Nock MK

    更新日期:2010-09-01 00:00:00

  • Depressive symptom clusters as predictors of 6-year increases in insulin resistance: data from the Pittsburgh Healthy Heart Project.

    abstract:OBJECTIVE:To examine longitudinal bidirectional associations between two depressive symptom clusters-the cognitive-affective and somatic-vegetative clusters--and insulin resistance, a marker of prediabetes. METHODS:Participants were 269 adults aged 50 to 70 years without diabetes enrolled in the Pittsburgh Healthy Hea...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000063

    authors: Khambaty T,Stewart JC,Muldoon MF,Kamarck TW

    更新日期:2014-06-01 00:00:00

  • An Attachment-Based Model of the Relationship Between Childhood Adversity and Somatization in Children and Adults.

    abstract:OBJECTIVE:An attachment model was used to understand how maternal sensitivity and adverse childhood experiences are related to somatization. METHODS:We examined maternal sensitivity at 6 and 18 months and somatization at 5 years in 292 children in a longitudinal cohort study. We next examined attachment insecurity and...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000437

    authors: Maunder RG,Hunter JJ,Atkinson L,Steiner M,Wazana A,Fleming AS,Moss E,Gaudreau H,Meaney MJ,Levitan RD

    更新日期:2017-06-01 00:00:00

  • Depression as an independent risk factor for mortality in critically ill patients.

    abstract:OBJECTIVE:Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a poss...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000137

    authors: Wewalka M,Warszawska J,Strunz V,Kitzberger R,Holzinger U,Fuhrmann V,Zauner C,Miehsler W,Moser G

    更新日期:2015-02-01 00:00:00