Abstract:
OBJECTIVE:Depression has been associated with increased risk of heart failure (HF). Because anxiety is highly comorbid with depression, we sought to establish if anxiety, depression, or their co-occurrence is associated with incident HF. METHODS:A retrospective cohort (N = 236,079) including Veteran's Administration patients (age, 50-80 years) free of cardiovascular disease (CVD) at baseline was followed up between 2001 and 2007. Cox proportional hazards models were computed to estimate the association between anxiety disorders alone, major depressive disorder (MDD) alone, and the combination of anxiety and MDD, with incident HF before and after adjusting for sociodemographics, CVD risk factors (Type 2 diabetes, hypertension, hyperlipidemia, obesity), nicotine dependence/personal history of tobacco use, substance use disorders (alcohol and illicit drug abuse/dependence), and psychotropic medication. RESULTS:Compared with unaffected patients, those with anxiety only, MDD only, and both disorders were at increased risk for incident HF in age-adjusted models (hazard ratio [HR] = 1.19 [ 95% confidence interval {CI} = 1.10-1.28], HR = 1.21 [95% CI = 1.13-1.28], and HR = 1.24 [95% CI = 1.17-1.32], respectively). After controlling for psychotropics in a full model, the association between anxiety only, MDD only, and both disorders and incident HF increased (HRs = 1.46, 1.56, and 1.74, respectively). CONCLUSIONS:Anxiety disorders, MDD, and co-occurring anxiety and MDD are associated with incident HF in this large cohort of Veteran's Administration patients free of CVD at baseline. This risk of HF is greater after accounting for protective effects of psychotropic medications. Prospective studies are needed to clarify the role of depression and anxiety and their pharmacological treatment in the etiology of HF.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Garfield LD,Scherrer JF,Hauptman PJ,Freedland KE,Chrusciel T,Balasubramanian S,Carney RM,Newcomer JW,Owen R,Bucholz KK,Lustman PJdoi
10.1097/PSY.0000000000000027subject
Has Abstractpub_date
2014-02-01 00:00:00pages
128-36issue
2eissn
0033-3174issn
1534-7796pii
PSY.0000000000000027journal_volume
76pub_type
杂志文章abstract:OBJECTIVE:To examine whether increased sleep during viral or bacterial infections supports host defense mechanisms. METHODS:To test this assumption in humans, healthy male subjects were assigned either to sleep from 2300 to 0700 hours (n = 10) or to stay awake through the night (n = 10). In the sleeping subjects Salmo...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-200107000-00008
更新日期:2001-07-01 00:00:00
abstract::Thirty normal individuals were told they were inhaling a substance that would either cause breathing difficulty (N = 15) or not affect breathing (N = 15). Total respiratory resistance was measured prior to and during inhalation. In reality, the subjects inhaled no substance; inhalation consisted of breathing normally ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198709000-00009
更新日期:1987-09-01 00:00:00
abstract::Impatience, one major Type A characteristic, alters the performance of tasks requiring anticipation and accurate responding. Beat-by-beat changes in heart rate are also known to occur during anticipatory attention. In college- and middle-aged adult samples, impatience is related to these beat-by-beat heart rate change...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198411000-00003
更新日期:1984-11-01 00:00:00
abstract:OBJECTIVE:Stress or emotional traumas are considered risk factors for unexplained fatiguing illnesses. From July to December 2001, the Centers for Disease Control and Prevention conducted a multigeographical pilot study to test the feasibility of a survey to estimate the prevalence of fatiguing illnesses in the United ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000138116.12495.a2
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:We examine associations between the perception of ongoing psychological demands by ecological momentary assessment (EMA) and 6-year changes in carotid artery atherosclerosis by ultrasonography. METHODS:A total of 270 initially healthy participants collected ambulatory blood pressure (ABP) and recorded their ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182572599
更新日期:2012-05-01 00:00:00
abstract::Hypnotic relaxation was used as an adjunct to pharmacologic treatment with 39 women hospitalized for premature contractions in pregnancy. The control group received medication alone and consisted of 70 women. Treatment was started at the time of hospitalization and lasted for 3 hr on the average. Patients were also gi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198605000-00005
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP monitoring, and in the laboratory environment during behavioral st...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200203000-00007
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the construct validity of the five-item Women's Health Initiative Insomnia Rating Scale (WHIIRS) by comparing women taking hormone therapy (HT) versus those taking a placebo and by comparing women known to differ in vasomotor symptoms. METHODS:The WHIIRS was includ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/01.psy.0000151743.58067.f0
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:There is evidence that clinical depression and negative mood are associated with elevated basal cortisol levels. Recently, measuring the cortisol response during the first hour in the morning with strict reference to the time of awakening was established as a reliable marker of individual adrenocortical activ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000040950.22044.10
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVES:To investigate the impact of cigarette smoking and oral contraceptive (OC) use on hemodynamic stress responses of women. Also, to examine gender differences in stress reactivity as a function of smoking status and acute nicotine administration. METHODS:Thirty men and 46 women, differing in smoking status an...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199705000-00012
更新日期:1997-05-01 00:00:00
abstract:OBJECTIVE:This study aimed to investigate the relationship between waist circumference as a measure of abdominal obesity and brain responses to stress among patients with coronary artery disease (CAD). METHODS:Patients with CAD (N = 151) underwent acute mental stress tasks in conjunction with high-resolution positron ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000776
更新日期:2020-04-01 00:00:00
abstract::The development of seven esophageal atresia infants is described. These children differed in the quality of maternal care received and the amount of oral experience permitted during the first year of life. Observation of these infants suggest differences between effects of maternal depression and effects of abnormal o...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198001001-00010
更新日期:1980-01-01 00:00:00
abstract::Psychosocial work characteristics, such as work demand, work control, and social support at work, have been shown to be related to the development of coronary heart disease in epidemiological studies. However, the mechanisms which mediate the social and psychological effects on the cardiovascular system are not known....
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00006842-199101000-00005
更新日期:1991-01-01 00:00:00
abstract::In this article, we review the differences between momentary, retrospective, and trait self-report techniques and discuss the unique role that ambulatory reports of momentary experience play in psychosomatic medicine. After a brief historical review of self-report techniques, we discuss the latest perspective that lin...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/PSY.0b013e3182546f18
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:Autonomic nervous system activity is associated with neurobehavioral aspects of pain. Yogis use breathing, relaxation, and mindfulness to tolerate pain, which could influence autonomic responses. To evaluate how the link between autonomic responses and pain is altered by other factors, we compared perceptual ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000587
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:To focus on the relationship between pregnancy-related anxiety and spontaneous preterm birth. Psychosocial factors have been the subject of inquiries about the etiology of preterm birth; a factor of recent interest is maternal prenatal pregnancy-related anxiety (worries and concerns related to the pregnancy)....
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3180cac25d
更新日期:2007-07-01 00:00:00
abstract::Davidson and Schwartz (1) have proposed a psychobiological analysis of anxiety that emphasizes the patterning of multiple processes in the generation and self-regulation of this state. The present article specifically reviews recent research on cognitive and somatic components of anxiety. A dual component scale which ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197806000-00004
更新日期:1978-06-01 00:00:00
abstract:OBJECTIVE:The aims of this pilot study were: 1) to establish the reliability and validity of a new self-report instrument designed to index monitoring for sleep-related threat; 2) to determine the presence of ten monitoring types proposed in a recent cognitive model of insomnia and to examine the relationship between m...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000114870.50968.90
更新日期:2004-03-01 00:00:00
abstract::Insomnia is common among patients who subsequently experience an acute myocardial infarction (MI), and is a major symptom of psychiatric depression. The purpose of this study was to determine what proportion of patients reporting insomnia prior to MI have depression. Of 70 patients with a recent MI, 27 (39%) reported ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199011000-00001
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVE:A previous study suggested that insulin metabolic variables play a role in the progression of atherosclerosis in Watanabe heritable hyperlipidemic (WHHL) rabbits. The present study sought to determine: 1) if young, individually caged WHHLs are insulin-resistant relative to New Zealand white (NZW) rabbits and ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000155674.95497.ab
更新日期:2005-03-01 00:00:00
abstract::The prevalence of essential hypertension is higher among blacks than whites. One reason for this difference may be that blacks are more reactive to stressors that produce vasoconstrictive responses. Two studies were conducted to test this hypothesis, one with 10- to 14-year-old males (20 whites, 20 blacks) and one wit...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199005000-00003
更新日期:1990-05-01 00:00:00
abstract::Recent research with animals has indicated a central nervous system effect on the immune system. This report describes findings of a possible psychologically mediated effect on the delayed hypersensitivity reaction to tuberculin in humans. Seven tuberculin positive subjects evidenced a decreased response to tuberculin...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198303000-00009
更新日期:1983-03-01 00:00:00
abstract:OBJECTIVE:To assess whether globus is associated with psychopathology in men. Globus-a persistent sensation of having a lump in the throat with no detectable physical cause-has long been thought a predominantly female disorder. Several small studies, based wholly or largely on women, suggested that globus is associated...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181bc7739
更新日期:2009-11-01 00:00:00
abstract::This investigation assessed the syndromal nature of menstrual cycle changes in women who experience significant cyclicity of mood by exploring the time course of different symptoms in relation to endocrinologically defined segments of the menstrual cycle. Participants were accepted into the protocol on the basis of a ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198903000-00007
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVE:To assess the association of baseline anxiety with depression persistence and change in depressive symptoms 6 months after cardiac hospitalization. METHODS:Data were analyzed from 137 depressed patients hospitalized on inpatient cardiac units for acute coronary syndrome, decompensated heart failure, or arrhy...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e31823d38bc
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Several studies have shown that psychiatric disorders can be associated with venous thromboembolism (VTE) risk, that is, pulmonary embolism (PE) and/or deep vein thrombosis (DVT). In this study, we provide a systematic review and meta-analyses of the studies addressing this issue. METHODS:All studies address...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000863
更新日期:2020-11-01 00:00:00
abstract:OBJECTIVE:We examined whether high waist-to-hip ratio (WHR) in women is a biomarker for increased testosterone (T) and higher levels of sexual desire. METHODS:Participants were 99 healthy nonobese premenopausal women. Trait levels of mean bioavailable T were estimated from three saliva samples collected at 8:00 am, 9:...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000151747.22904.d7
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to test the hypothesis that higher childhood cognitive ability is associated with reduced risk of decline in physical capability in late midlife. METHODS:Participants were 1954 men and women from the Medical Research Council National Survey of Health and Development with complete dat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000482
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Cancer-related distress due to the psychological and physical challenges of metastatic breast cancer (MBC) may result in symptoms of depression, which negatively affects quality and may influence quantity of life. This study investigated how depression affects MBC stress reactivity, including autonomic (ANS) ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000238216.88515.e5
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:The Enhancing Recovery in Coronary Heart Disease study was a multicenter clinical trial in which patients with depression and/or low perceived social support after an acute myocardial infarction were randomly assigned to an intervention consisting of cognitive behavior therapy and, in some cases, sertraline, ...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1097/01.psy.0000133362.75075.a6
更新日期:2004-07-01 00:00:00