Abstract:
OBJECTIVE:A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. METHODS:We measured morning serum levels of BDNF in 22 women with AN, 24 women with obesity (body mass index [BMI] > 30 kg/m2), and 27 nonobese healthy women. All the subjects were drug-free and underwent a clinical assessment by means of rating scales measuring both eating-related psychopathology and depressive symptoms. RESULTS:As compared with the nonobese healthy controls, circulating BDNF was significantly reduced in AN patients and significantly increased in obese subjects. No significant difference was observed in serum BDNF concentrations between AN women with or without a comorbid depressive disorder. Moreover, serum BDNF levels were significantly and positively correlated with the subjects' body weight and BMI. CONCLUSION:The BDNF changes observed in AN and obesity are likely secondary adaptive mechanisms aimed at counteracting the change in energy balance that occurs in these syndromes.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Monteleone P,Tortorella A,Martiadis V,Serritella C,Fuschino A,Maj Mdoi
10.1097/01.psy.0000138119.12956.99subject
Has Abstractpub_date
2004-09-01 00:00:00pages
744-8issue
5eissn
0033-3174issn
1534-7796pii
66/5/744journal_volume
66pub_type
杂志文章abstract:OBJECTIVE:Placebo effects relieve various somatic symptoms, but it is unclear how they can be enhanced to maximize positive treatment outcomes. Oxytocin administration may potentially enhance placebo effects, but few studies have been performed, and they have had conflicting findings. The study aim was to investigate t...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
abstract:OBJECTIVES:Somatic symptom ratings covary with neuroticism. Yet, people vary from one another in their ability to report their own emotions and differentiate them from bodily sensations. We hypothesized that stressed individuals with greater emotional awareness would experience somatic symptoms in a more differentiated...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318203b86a
更新日期:2011-02-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000399
更新日期:2016-11-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199001000-00002
更新日期:1990-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
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更新日期:2005-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181fd944c
更新日期:2011-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200105000-00022
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31815a995a
更新日期:2007-12-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181835ca3
更新日期:2008-09-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 评论,社论
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更新日期:2019-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
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更新日期:2005-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000596
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200105000-00012
更新日期:2001-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-09-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199709000-00004
更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181921b1f
更新日期:2009-04-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181a63b2e
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pub_type: 评论,社论
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198001001-00010
更新日期:1980-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181bc7739
更新日期:2009-11-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198507000-00001
更新日期:1985-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000603
更新日期:2018-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000730
更新日期:2020-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000169
更新日期:2015-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000160464.63264.5d
更新日期:2005-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182689460
更新日期:2012-10-01 00:00:00