Opposite changes in the serum brain-derived neurotrophic factor in anorexia nervosa and obesity.


OBJECTIVE:A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. METHODS:We measured morning serum levels of BDNF in 22 women with AN, 24 women with obesity (body mass index [BMI] > 30 kg/m2), and 27 nonobese healthy women. All the subjects were drug-free and underwent a clinical assessment by means of rating scales measuring both eating-related psychopathology and depressive symptoms. RESULTS:As compared with the nonobese healthy controls, circulating BDNF was significantly reduced in AN patients and significantly increased in obese subjects. No significant difference was observed in serum BDNF concentrations between AN women with or without a comorbid depressive disorder. Moreover, serum BDNF levels were significantly and positively correlated with the subjects' body weight and BMI. CONCLUSION:The BDNF changes observed in AN and obesity are likely secondary adaptive mechanisms aimed at counteracting the change in energy balance that occurs in these syndromes.


Psychosom Med


Psychosomatic medicine


Monteleone P,Tortorella A,Martiadis V,Serritella C,Fuschino A,Maj M




Has Abstract


2004-09-01 00:00:00














  • Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: cardiovascular risk in young Finns study.

    abstract:OBJECTIVE:To examine the potential moderating role of DRD2 polymorphism (rs1800497) in the association between stressful life events and depressive symptoms among young adults. Although stressful life events, such as divorce, unemployment, and serious illness in the family, are generally associated with negative health...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Elovainio M,Jokela M,Kivimäki M,Pulkki-Råback L,Lehtimäki T,Airla N,Keltikangas-Järvinen L

    更新日期:2007-06-01 00:00:00

  • Generalized anxiety disorder, major depressive disorder, and their comorbidity as predictors of all-cause and cardiovascular mortality: the Vietnam experience study.

    abstract:OBJECTIVE:To examine whether the 1-year prevalence of major depressive disorder (MDD), generalized anxiety disorder (GAD), and their comorbidity were associated with subsequent all-cause and cardiovascular disease (CVD) mortality during 15 years in Vietnam veterans. METHODS:Participants (N = 4256) were from the Vietna...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Phillips AC,Batty GD,Gale CR,Deary IJ,Osborn D,MacIntyre K,Carroll D

    更新日期:2009-05-01 00:00:00

  • Hostility, gender, and cardiac autonomic control.

    abstract:OBJECTIVE:Although considerable evidence implicates hostility in the development of coronary artery disease (CAD), the pathogenic mechanisms remain poorly understood. We have developed a psychophysiological model that holds that altered autonomic nervous system function links psychological traits with CAD outcomes. In ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Sloan RP,Bagiella E,Shapiro PA,Kuhl JP,Chernikhova D,Berg J,Myers MM

    更新日期:2001-05-01 00:00:00

  • Another Step Toward Clarifying the Benefits and Burdens of Selective Serotonin Reuptake Inhibitors.

    abstract::Selective serotonin reuptake inhibitors (SSRIs) have substantial beneficial effects for the treatment of major depressive mood disorders and other conditions but can also result in unwanted clinical outcomes. One of the reported disadvantages of SSRIs, based on cross-sectional studies, is their adverse effects on glyc...

    journal_title:Psychosomatic medicine

    pub_type: 评论,社论


    authors: Wulsin LR

    更新日期:2019-09-01 00:00:00

  • Cerebral blood flow dynamics during pain processing in patients with fibromyalgia syndrome.

    abstract:OBJECTIVES:Increased cerebral blood flow during processing of acute pain has repeatedly been observed in fibromyalgia syndrome. The study investigated the time dynamics of the pain-related hemodynamic response in fibromyalgia using transcranial Doppler sonography. METHODS:In 25 women with fibromyalgia and 25 healthy p...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Duschek S,Mannhart T,Winkelmann A,Merzoug K,Werner NS,Schuepbach D,Montoya P

    更新日期:2012-10-01 00:00:00

  • Neural correlates of levels of emotional awareness during trauma script-imagery in posttraumatic stress disorder.

    abstract:OBJECTIVE:To examine individual differences in levels of emotional awareness as a predictor of the blood oxygenation level dependent (BOLD) response to trauma script-driven imagery in trauma-exposed individuals with (n = 25) and without (n = 16) posttraumatic stress disorder (PTSD). METHODS:Participants completed the ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Frewen P,Lane RD,Neufeld RW,Densmore M,Stevens T,Lanius R

    更新日期:2008-01-01 00:00:00

  • Globus sensation and psychopathology in men: the Vietnam experience study.

    abstract:OBJECTIVE:To assess whether globus is associated with psychopathology in men. Globus-a persistent sensation of having a lump in the throat with no detectable physical cause-has long been thought a predominantly female disorder. Several small studies, based wholly or largely on women, suggested that globus is associated...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Gale CR,Wilson JA,Deary IJ

    更新日期:2009-11-01 00:00:00

  • Psychiatric Disorders, Morbidity, and Mortality: Tracing Mechanistic Pathways to Accelerated Aging.

    abstract::A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance ...

    journal_title:Psychosomatic medicine

    pub_type: 评论,社论


    authors: Kiecolt-Glaser JK,Wilson SJ

    更新日期:2016-09-01 00:00:00

  • Estranged bodies, simulated harmony, and misplaced cultures: neurasthenia in contemporary Chinese society.

    abstract:OBJECTIVE:To study the sociocultural transformation of neurasthenia (shenjing shuairuo, SJSR), as both disease and illness, in Chinese society. METHOD:This is based on a critical review of evidence drawn from the psychiatric and anthropological literature, and the use of a single case study. RESULTS:SJSR remains a ub...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审


    authors: Lee S

    更新日期:1998-07-01 00:00:00

  • Psychobiologic reactivity to stress and childhood respiratory illnesses: results of two prospective studies.

    abstract::Psychological stress is thought to undermine host resistance to infection through neuroendocrine-mediated changes in immune competence. Associations between stress and infection have been modest in magnitude, however, suggesting individual variability in stress response. We therefore studied environmental stressors, p...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审


    authors: Boyce WT,Chesney M,Alkon A,Tschann JM,Adams S,Chesterman B,Cohen F,Kaiser P,Folkman S,Wara D

    更新日期:1995-09-01 00:00:00

  • Effects of psychological treatment on cancer patients: a critical review.

    abstract::Twenty-two studies on the effects of psychological treatment on cancer patients are reviewed. Only studies that compared one or more experimental conditions with at least one control group have been considered. The studies were evaluated with respect to a) research methods, b) psychological interventions, and c) resul...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审


    authors: Trijsburg RW,van Knippenberg FC,Rijpma SE

    更新日期:1992-07-01 00:00:00

  • Increased risks of acute organ dysfunction and mortality in intensive care unit patients with schizophrenia: a nationwide population-based study.

    abstract:OBJECTIVE:To investigate the risks of acute organ dysfunction and death in intensive care unit (ICU) patients with schizophrenia. METHODS:Using a retrospective matched cohort design, we compared 203 schizophrenic patients to 2036 demographically matched (1:10) nonschizophrenic patients with first-time ICU admission be...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Shen HN,Lu CL,Yang HH

    更新日期:2011-09-01 00:00:00

  • Hypertension affects neurobehavioral functioning.

    abstract::This study compared the neurobehavioral performance of hypertensive and normotensive men and women using neuropsychological, information-processing, and psychometric assessments. One hundred subjects, including 68 hypertensive and 32 normotensive individuals, completed a test battery that yielded scores on measures of...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Blumenthal JA,Madden DJ,Pierce TW,Siegel WC,Appelbaum M

    更新日期:1993-01-01 00:00:00

  • Mood and somatic symptoms during pregnancy.

    abstract::A predominantly white, middle class sample of pregnant women (N = 93) completed the AACL (Anxiety), the DACL (Depressive Mood), the SCL (Somatic Symptoms) and the IPAT Anxiety Questionnaire at the second, fifth and eighth months of pregnancy. A menstrual history questionnaire was administered on the first testing occa...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Lubin B,Gardener SH,Roth A

    更新日期:1975-03-01 00:00:00

  • Self-awareness, alcohol consumption, and reduced cardiovascular reactivity.

    abstract::Seventy-two healthy males were divided into Type A and Type B groups using the Jenkins Activity Survey. Subjects were subdivided further into high and low self-awareness categories on the private self-consciousness factor of the Self-Consciousness Scale. After random assignment to consume alcohol (0.85 g/kg) or a plac...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Niaura R,Wilson GT,Westrick E

    更新日期:1988-07-01 00:00:00

  • Telecommunications technology as an aid to family caregivers of persons with dementia.

    abstract:OBJECTIVE:The aging of the population implies that an increased number of people are going to need some form of care or assistance. Caregiving poses a range of physical, emotional, and financial demands and often causes burden and stress for family members. This article describes how technology can be used to provide s...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Czaja SJ,Rubert MP

    更新日期:2002-05-01 00:00:00

  • Waist-to-hip ratio is positively associated with bioavailable testosterone but negatively associated with sexual desire in healthy premenopausal women.

    abstract:OBJECTIVE:We examined whether high waist-to-hip ratio (WHR) in women is a biomarker for increased testosterone (T) and higher levels of sexual desire. METHODS:Participants were 99 healthy nonobese premenopausal women. Trait levels of mean bioavailable T were estimated from three saliva samples collected at 8:00 am, 9:...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: van Anders SM,Hampson E

    更新日期:2005-03-01 00:00:00

  • Occupational differences in job strain and physiological stress: female nurses and school teachers in Hawaii.

    abstract:OBJECTIVES:The two objectives are to test the hypothesis that women in a profession with low decision latitude will have greater catecholamine excretion and higher blood pressure than women in a profession with greater decision latitude, and to assess the influence of ethnicity on the occupational comparison. METHODS:...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Brown DE,James GD,Mills PS

    更新日期:2006-07-01 00:00:00

  • Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm).

    abstract:OBJECTIVE:Melissa officinalis (lemon balm) is contemporaneously used as a mild sedative and/or calming agent. Although recent research has demonstrated modulation of mood in keeping with these roles, no studies to date have directly investigated the effects of this herbal medication on laboratory-induced psychological ...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kennedy DO,Little W,Scholey AB

    更新日期:2004-07-01 00:00:00

  • Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening.

    abstract:OBJECTIVE:There is evidence that clinical depression and negative mood are associated with elevated basal cortisol levels. Recently, measuring the cortisol response during the first hour in the morning with strict reference to the time of awakening was established as a reliable marker of individual adrenocortical activ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Pruessner M,Hellhammer DH,Pruessner JC,Lupien SJ

    更新日期:2003-01-01 00:00:00

  • Regional prevalence of fatiguing illnesses in the United States before and after the terrorist attacks of September 11, 2001.

    abstract:OBJECTIVE:Stress or emotional traumas are considered risk factors for unexplained fatiguing illnesses. From July to December 2001, the Centers for Disease Control and Prevention conducted a multigeographical pilot study to test the feasibility of a survey to estimate the prevalence of fatiguing illnesses in the United ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Heim C,Bierl C,Nisenbaum R,Wagner D,Reeves WC

    更新日期:2004-09-01 00:00:00

  • The relationship between cardiovascular reactivity in the laboratory and heart rate response in real life: active coping and beta blockade.

    abstract::Earlier studies suggest that cardiovascular responses in the laboratory and in the field are likely to be related when the laboratory tasks involve active coping, when the field measure is taken continuously, and when there is allowance for the effects of autocorrelation and physical activity on the ambulant cardiovas...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Johnston DW,Schmidt TF,Albus C,Vagt S,McSorley K,Klingmann I,Bethge H

    更新日期:1994-07-01 00:00:00

  • Depression and hypertension.

    abstract::The study consisted of 1101 Caucasian, male outpatients, who were screened for depression and hypertension in order to test the hypothesis that there is a unique relationship between these two illnesses. Depression was assessed by the Zung Self-Rating Depression Scale (SDS) while diastolic blood pressure (BP) was acce...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Friedman MJ,Bennet PL

    更新日期:1977-03-01 00:00:00

  • Videotape preparation of patients before hip replacement surgery reduces stress.

    abstract:OBJECTIVE:Elective surgery represents a considerable source of stress for the patient. Many attempts have been made to prepare patients before surgery with the aim of reducing stress and improving outcome. This study used a novel approach to fulfill this aim by showing a videotape of a patient undergoing total hip repl...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章


    authors: Doering S,Katzlberger F,Rumpold G,Roessler S,Hofstoetter B,Schatz DS,Behensky H,Krismer M,Luz G,Innerhofer P,Benzer H,Saria A,Schuessler G

    更新日期:2000-05-01 00:00:00

  • Prediction of daily food intake as a function of measurement modality and restriction status.

    abstract:OBJECTIVE:Research on eating relies on various indices (e.g., stable, momentary, neural) to accurately reflect food-related reactivity (e.g., disinhibition) and regulation (e.g., restraint) outside the laboratory. The degree to which they differentially predict real-world consumption remains unclear. Further, the predi...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Giuliani NR,Tomiyama AJ,Mann T,Berkman ET

    更新日期:2015-06-01 00:00:00

  • Long-term psychological adjustment of acute leukemia survivors: impact of bone marrow transplantation versus conventional chemotherapy.

    abstract::As increasing numbers of patients survive acute leukemia, it has become important to study the long-term psychological and social adjustment of patients who have successfully completed their leukemia treatment. An important aspect of this inquiry is comparing the long-term psychosocial impact of two treatments for acu...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Lesko LM,Ostroff JS,Mumma GH,Mashberg DE,Holland JC

    更新日期:1992-01-01 00:00:00

  • Increased affective bias revealed using experimental graded heat stimuli in young depressed adults: evidence of "emotional allodynia".

    abstract:OBJECTIVE:To examine the hypothesis that young adults with major depressive disorder (MDD) would show increased affective bias to painful and nonpainful experimental heat stimuli, as evidenced by an increased responsiveness to warm and hot temperatures. Pain and depression often occur together. Pain is both a sensation...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Strigo IA,Simmons AN,Matthews SC,Craig AD,Paulus MP

    更新日期:2008-04-01 00:00:00

  • Immune responses to experimental stress: effects of mental effort and uncontrollability.

    abstract:OBJECTIVE:Two important determinants of physiological stress responses have been identified, uncontrollability of the stressor and amount of effort involved in coping with the stressor. In the present experiment, we tried to identify the specific contributions of effort and uncontrollability to immune system responses ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Peters ML,Godaert GL,Ballieux RE,Brosschot JF,Sweep FC,Swinkels LM,van Vliet M,Heijnen CJ

    更新日期:1999-07-01 00:00:00

  • Depression predicts revascularization procedures for 5 years after coronary angiography.

    abstract:OBJECTIVE:Depression has been reported to increase cardiac event rates and functional impairment in patients with coronary disease. This article describes the impact of depression on subsequent healthcare utilization for such patients. METHODS:One hundred ninety-eight health maintenance organization patients with stab...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Sullivan MD,LaCroix AZ,Spertus JA,Hecht J,Russo J

    更新日期:2003-03-01 00:00:00

  • The effect of stress on colon motor and electrical activity in irritable bowel syndrome.

    abstract::The present investigation was designed to study the role of stress on the physiologic mechanisms of the colon in irritable bowel syndrome (IBS). Patients with IBS were compared with normal controls during resting and stress (mental arithmetic, cold pressor, and fear stressor). The results indicated that IBS patients h...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Welgan P,Meshkinpour H,Hoehler F

    更新日期:1985-03-01 00:00:00