Abstract:
OBJECTIVE:A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. METHODS:We measured morning serum levels of BDNF in 22 women with AN, 24 women with obesity (body mass index [BMI] > 30 kg/m2), and 27 nonobese healthy women. All the subjects were drug-free and underwent a clinical assessment by means of rating scales measuring both eating-related psychopathology and depressive symptoms. RESULTS:As compared with the nonobese healthy controls, circulating BDNF was significantly reduced in AN patients and significantly increased in obese subjects. No significant difference was observed in serum BDNF concentrations between AN women with or without a comorbid depressive disorder. Moreover, serum BDNF levels were significantly and positively correlated with the subjects' body weight and BMI. CONCLUSION:The BDNF changes observed in AN and obesity are likely secondary adaptive mechanisms aimed at counteracting the change in energy balance that occurs in these syndromes.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Monteleone P,Tortorella A,Martiadis V,Serritella C,Fuschino A,Maj Mdoi
10.1097/01.psy.0000138119.12956.99subject
Has Abstractpub_date
2004-09-01 00:00:00pages
744-8issue
5eissn
0033-3174issn
1534-7796pii
66/5/744journal_volume
66pub_type
杂志文章abstract:OBJECTIVE:To investigate the association of a range of temporally prior physical conditions with the subsequent first onset of suicidal ideation, plans, and attempts in large, general population, cross-national sample. The associations between physical conditions and suicidal behavior remain unclear due to sparse data ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181e3333d
更新日期:2010-09-01 00:00:00
abstract::Social support is defined as information leading the subject to believe that he is cared for and loved, esteemed, and a member of a network of mutual obligations. The evidence that supportive interactions among people are protective against the health consequences of life stress is reviewed. It appears that social sup...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197609000-00003
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
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journal_title:Psychosomatic medicine
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更新日期:2003-05-01 00:00:00
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doi:10.1097/00006842-197507000-00004
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pub_type: 杂志文章
doi:10.1097/00006842-199507000-00012
更新日期:1995-07-01 00:00:00
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更新日期:2014-01-01 00:00:00
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pub_type: 评论,社论
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更新日期:2019-09-01 00:00:00
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journal_title:Psychosomatic medicine
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更新日期:2000-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199905000-00009
更新日期:1999-05-01 00:00:00
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更新日期:2017-09-01 00:00:00
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更新日期:2002-03-01 00:00:00