Defective nitric oxide-cyclic guanosine monophosphate signaling in patients with bipolar disorder: a potential role for platelet dysfunction.

Abstract:

OBJECTIVE:Bipolar disorder (BD) is associated with elevated cardiovascular mortality rates. We investigated the modulation of l-arginine-nitric oxide (NO) signaling in platelets from patients with BD at different phases. METHODS:Platelets obtained from 28 patients with BD and 10 healthy volunteers were analyzed for l-arginine transport, NO synthase (NOS) activity, cyclic guanosine monophosphate content, and biomarkers of oxidative stress. Expressions of NOS isoforms, soluble guanylyl cyclase, and arginase were also measured in platelets. Amino acid and C-reactive protein levels in plasma were assessed. RESULTS:Plasma concentrations of l-arginine (mean [M] ± standard error of the mean [SEM] = 97 ± 10 versus 121 ± 10 µM) and its transport into platelets (median [interquartile range] = 26.0 [28.6] versus 26.5 [43.9] pmol/10(9) cells per minute) did not differ between patients with BD and controls (p > .05). Patients with BD showed reduced NOS activity (M ± SEM = 0.037 ± 0.003 versus 0.135 ± 0.022 pmol/10(8) cells, p < .001), but not endothelial NOS, inducible NOS, and arginase expression, compared with controls (p > .05). Cyclic guanosine monophosphate content was reduced (M ± SEM = 0.022 ± 0.003 versus 0.086 ± 0.020 pmol/10(8) cells, p < .05) despite the absence of changes in soluble guanylyl cyclase expression (median [interquartile range] = 21.6 [15.5] versus 9.5 [9.4] arbitrary units, p > .05) in patients with BD. Superoxide dismutase activity, but not catalase activity, was increased in patients with BD in the manic phase (M ± SEM = 2094 ± 335 versus 172 ± 17 U/mg protein, p < .001). C-reactive protein was elevated only in manic episodes (M ± SEM = 0.8 ± 0.2 versus 0.1 ± 0.02 mg/L, p < .001). CONCLUSIONS:Impaired NO generation from platelets, inflammation, and oxidative stress may play pivotal roles in the multifaceted process of cardiovascular events in BD.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Fontoura PC,Pinto VL,Matsuura C,Resende Ade C,de Bem GF,Ferraz MR,Cheniaux E,Brunini TM,Mendes-Ribeiro AC

doi

10.1097/PSY.0b013e3182689460

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

873-7

issue

8

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e3182689460

journal_volume

74

pub_type

杂志文章
  • An Attachment-Based Model of the Relationship Between Childhood Adversity and Somatization in Children and Adults.

    abstract:OBJECTIVE:An attachment model was used to understand how maternal sensitivity and adverse childhood experiences are related to somatization. METHODS:We examined maternal sensitivity at 6 and 18 months and somatization at 5 years in 292 children in a longitudinal cohort study. We next examined attachment insecurity and...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000437

    authors: Maunder RG,Hunter JJ,Atkinson L,Steiner M,Wazana A,Fleming AS,Moss E,Gaudreau H,Meaney MJ,Levitan RD

    更新日期:2017-06-01 00:00:00

  • Psychological stress, cytokine production, and severity of upper respiratory illness.

    abstract:OBJECTIVE:The purpose of this study is to assess the role of psychological stress in the expression of illness among infected subjects and to test the plausibility of local proinflammatory cytokine production as a pathway linking stress to illness. METHODS:After completing a measure of psychological stress, 55 subject...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199903000-00009

    authors: Cohen S,Doyle WJ,Skoner DP

    更新日期:1999-03-01 00:00:00

  • Childhood Bullying Victimization and Overweight in Young Adulthood: A Cohort Study.

    abstract:OBJECTIVE:To test whether bullied children have an elevated risk of being overweight in young adulthood and whether this association is: (1) consistent with a dose-response relationship, namely, its strength increases with the chronicity of victimization; (2) consistent across different measures of overweight; (3) spec...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000388

    authors: Baldwin JR,Arseneault L,Odgers C,Belsky DW,Matthews T,Ambler A,Caspi A,Moffitt TE,Danese A

    更新日期:2016-11-01 00:00:00

  • Self-awareness, alcohol consumption, and reduced cardiovascular reactivity.

    abstract::Seventy-two healthy males were divided into Type A and Type B groups using the Jenkins Activity Survey. Subjects were subdivided further into high and low self-awareness categories on the private self-consciousness factor of the Self-Consciousness Scale. After random assignment to consume alcohol (0.85 g/kg) or a plac...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00006842-198807000-00005

    authors: Niaura R,Wilson GT,Westrick E

    更新日期:1988-07-01 00:00:00

  • Psychological and perceptual factors associated with arrhythmias and benign palpitations.

    abstract:OBJECTIVE:Little is known about how patients who seek medical help for benign palpitations can be distinguished from those with clinically significant arrhythmias. This study tested whether patients with arrhythmia can be distinguished from those who are aware of sinus rhythm or extrasystoles on the basis of sex, preva...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-200009000-00014

    authors: Ehlers A,Mayou RA,Sprigings DC,Birkhead J

    更新日期:2000-09-01 00:00:00

  • Association of baseline anxiety with depression persistence at 6 months in patients with acute cardiac illness.

    abstract:OBJECTIVE:To assess the association of baseline anxiety with depression persistence and change in depressive symptoms 6 months after cardiac hospitalization. METHODS:Data were analyzed from 137 depressed patients hospitalized on inpatient cardiac units for acute coronary syndrome, decompensated heart failure, or arrhy...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PSY.0b013e31823d38bc

    authors: Celano CM,Mastromauro CA,Lenihan EC,Januzzi JL,Rollman BL,Huffman JC

    更新日期:2012-01-01 00:00:00

  • Why is evidence on job strain and coronary heart disease mixed? An illustration of measurement challenges in the Whitehall II study.

    abstract:OBJECTIVE:Evidence regarding the status of job strain as a risk factor for coronary heart disease (CHD) is mixed, including both results supporting the risk status and null findings. However, previous studies have typically assessed job strain at one point in time only. We examined whether the failure of such measureme...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000221252.84351.e2

    authors: Kivimäki M,Head J,Ferrie JE,Brunner E,Marmot MG,Vahtera J,Shipley MJ

    更新日期:2006-05-01 00:00:00

  • Mental disorders and hypertension: factors associated with awareness and treatment of hypertension in the general population of Germany.

    abstract:OBJECTIVE:The aim of the present study was to identify the association between mental disorders and awareness and treatment of hypertension in a large representative community sample. METHODS:The analysis was based on data from 4149 respondents, ages 18 to 65 years, from the German National Health Interview and Examin...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000204883.77284.6b

    authors: Schmitz N,Thefeld W,Kruse J

    更新日期:2006-03-01 00:00:00

  • Relationship between work stress and body mass index among 45,810 female and male employees.

    abstract:OBJECTIVE:The proportion of overweight and obese people has grown rapidly, and obesity has now been widely recognized as an important public health problem. At the same time, stress has increased in working life. The 2 problems could be connected if work stress promotes unhealthy eating habits and sedentary behavior an...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000170330.08704.62

    authors: Kouvonen A,Kivimäki M,Cox SJ,Cox T,Vahtera J

    更新日期:2005-07-01 00:00:00

  • Ethnographic assessment of pain coping perceptions.

    abstract::A sample consisting of 54 patients and 31 dentists of Chinese, Anglo-American, and Scandinavian ethnic origin were interviewed about their ways of coping with pain. Instruments designed to assess pain coping were constructed from the descriptions elicited by the interviews. The interview data thus served as the basis ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199003000-00005

    authors: Moore R

    更新日期:1990-03-01 00:00:00

  • Domain and facet personality predictors of all-cause mortality among Medicare patients aged 65 to 100.

    abstract:OBJECTIVES:Our objectives were to test whether Conscientiousness, the other 4 domains of the Five-Factor Model, and their facets predicted mortality in older, frail individuals. METHODS:Controlling for demographic and health measures, we used Cox regression to test whether the NEO Five-Factor Inventory (NEO-FFI) Neuro...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000181272.58103.18

    authors: Weiss A,Costa PT Jr

    更新日期:2005-09-01 00:00:00

  • The effect of intranasal oxytocin administration on acute cold pressor pain: a placebo-controlled, double-blind, within-participants crossover investigation.

    abstract:BACKGROUND:This study examined the effect of synthetic oxytocin delivered intranasally on acute pain sensitivity using a placebo-controlled, double-blind, within-participant crossover design. METHODS:Thirty-seven (18 were male) pain-free young adults underwent two laboratory sessions separated by 1 week. Each session ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000068

    authors: Rash JA,Campbell TS

    更新日期:2014-07-01 00:00:00

  • Serotonergic changes in specific areas of rat brain associated with activity--stress gastric lesions.

    abstract::To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected t...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198305000-00004

    authors: Hellhammer DH,Hingtgen JN,Wade SE,Shea PA,Aprison MH

    更新日期:1983-05-01 00:00:00

  • Relationship of clinic, ambulatory, and laboratory stress blood pressure to left ventricular mass in overweight men and women with high blood pressure.

    abstract:OBJECTIVE:This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP monitoring, and in the laboratory environment during behavioral st...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-200203000-00007

    authors: Sherwood A,Gullette EC,Hinderliter AL,Georgiades A,Babyak M,Waugh RA,Blumenthal JA

    更新日期:2002-03-01 00:00:00

  • Altruistic social interest behaviors are associated with better mental health.

    abstract:OBJECTIVE:This study investigated whether altruistic social interest behaviors such as engaging in helping others were associated with better physical and mental health in a stratified random sample of 2016 members of the Presbyterian Church throughout the United States. METHODS:Mailed questionnaires evaluated giving ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000079378.39062.d4

    authors: Schwartz C,Meisenhelder JB,Ma Y,Reed G

    更新日期:2003-09-01 00:00:00

  • A follow-up study of thirty hospitalized bulimics.

    abstract::Thirty normal-weight female bulimics were followed up 2-5 years following hospital admission using semistructured interviews and psychometric measures. Inasmuch as bulimia was only recently designated a distinct disorder, questions have emerged with regard to its clinical course and diagnostic validity. Results of thi...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198701000-00004

    authors: Swift WJ,Ritholz M,Kalin NH,Kaslow N

    更新日期:1987-01-01 00:00:00

  • Suggestions to Reduce Clinical Fibromyalgia Pain and Experimentally Induced Pain Produce Parallel Effects on Perceived Pain but Divergent Functional MRI-Based Brain Activity.

    abstract:OBJECTIVE:Hypnotic suggestion is an empirically validated form of pain control; however, the underlying mechanism remains unclear. METHODS:Thirteen fibromyalgia patients received suggestions to alter their clinical pain, and 15 healthy controls received suggestions to alter experimental heat pain. Suggestions were del...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000370

    authors: Derbyshire SW,Whalley MG,Seah ST,Oakley DA

    更新日期:2017-02-01 00:00:00

  • Transgenic and null mutant animals for psychosomatic research.

    abstract:OBJECTIVE:Progress in the use of genetically altered animals for psychosomatic research is reviewed. METHOD:Analysis of the strengths and weaknesses of these models, particularly from a developmental and behavioral prospective is used to assess the validity of these models. RESULTS:Genetically altered animals can be ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00006842-199611000-00010

    authors: Crnic LS

    更新日期:1996-11-01 00:00:00

  • A life-style physical activity intervention and the antibody response to pneumococcal vaccination in women.

    abstract:OBJECTIVE:To assess whether a life-style physical activity intervention improved antibody response to a pneumococcal vaccination in sedentary middle-aged women. METHODS:Eighty-nine sedentary women completed a 16-week exercise (physical activity consultation, pedometer, telephone/e-mail prompts; n = 44) or control (adv...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PSY.0b013e3182a0b664

    authors: Long JE,Ring C,Bosch JA,Eves F,Drayson MT,Calver R,Say V,Allen D,Burns VE

    更新日期:2013-10-01 00:00:00

  • Trends in ambulatory self-report: the role of momentary experience in psychosomatic medicine.

    abstract::In this article, we review the differences between momentary, retrospective, and trait self-report techniques and discuss the unique role that ambulatory reports of momentary experience play in psychosomatic medicine. After a brief historical review of self-report techniques, we discuss the latest perspective that lin...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/PSY.0b013e3182546f18

    authors: Conner TS,Barrett LF

    更新日期:2012-05-01 00:00:00

  • Effects of progressive relaxation on sleep disturbance: an electroencephalographic evaluation.

    abstract::Subjects with reported sleep-onset disturbance were given progressive relaxation training, placebo, or no-treatment. All three conditions showed significant improvement in daily reported sleep onset over the duration of the study. Between-condition effects were limited to relaxation superiority over no-treatment on St...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00006842-197605000-00003

    authors: Borkovec TD,Weerts TC

    更新日期:1976-05-01 00:00:00

  • Symptom profile of multiple chemical sensitivity in actual life.

    abstract:OBJECTIVE:This study was conducted to confirm the definition of multiple chemical sensitivity (MCS) in actual life: that multiple symptoms are provoked in multiple organs by exposure to, and ameliorated by avoidance of, multiple chemicals at low levels. We used the Ecological Momentary Assessment to monitor everyday sy...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000155676.69030.28

    authors: Saito M,Kumano H,Yoshiuchi K,Kokubo N,Ohashi K,Yamamoto Y,Shinohara N,Yanagisawa Y,Sakabe K,Miyata M,Ishikawa S,Kuboki T

    更新日期:2005-03-01 00:00:00

  • Self-reported depressive symptoms and stress levels in healthy young men: associations with the cortisol response to awakening.

    abstract:OBJECTIVE:There is evidence that clinical depression and negative mood are associated with elevated basal cortisol levels. Recently, measuring the cortisol response during the first hour in the morning with strict reference to the time of awakening was established as a reliable marker of individual adrenocortical activ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000040950.22044.10

    authors: Pruessner M,Hellhammer DH,Pruessner JC,Lupien SJ

    更新日期:2003-01-01 00:00:00

  • Effects of psychological treatment on cancer patients: a critical review.

    abstract::Twenty-two studies on the effects of psychological treatment on cancer patients are reviewed. Only studies that compared one or more experimental conditions with at least one control group have been considered. The studies were evaluated with respect to a) research methods, b) psychological interventions, and c) resul...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00006842-199207000-00011

    authors: Trijsburg RW,van Knippenberg FC,Rijpma SE

    更新日期:1992-07-01 00:00:00

  • Is cancer risk associated with anger control and negative affect? Findings from a prospective cohort study.

    abstract:OBJECTIVE:To examine the associations between anger control and negative affect and the risk of five common cancers and total cancers. Possible associations between emotional states and the risk of cancer have long been postulated. METHODS:Prospective cohort study with average follow-up of 9 years. A total of 19,730 a...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e31814d4e6a

    authors: White VM,English DR,Coates H,Lagerlund M,Borland R,Giles GG

    更新日期:2007-09-01 00:00:00

  • Generalized anxiety disorder and peptic ulcer disease among adults in the United States.

    abstract:OBJECTIVE:Previous research has suggested a link between chronic anxiety and peptic ulcer disease, though recent evidence documenting an infectious cause (Helicobacter pylori) for ulcer has led to doubt about this association. The goal of the current study was to determine the relationship between generalized anxiety d...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000038935.67401.f3

    authors: Goodwin RD,Stein MB

    更新日期:2002-11-01 00:00:00

  • Hypothalamic-pituitary-adrenocortical responses to psychological stress and caffeine in men at high and low risk for hypertension.

    abstract:OBJECTIVE:This study examined pituitary-adrenocortical responses to dietary doses of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee), alone and combined with behavioral stress, in men at high risk versus low risk for hypertension. A randomized, double-blind, caffeine-placebo crossover design was used. METHOD...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00006842-199807000-00021

    authors: al'Absi M,Lovallo WR,McKey B,Sung BH,Whitsett TL,Wilson MF

    更新日期:1998-07-01 00:00:00

  • Differentiation in the momentary rating of somatic symptoms covaries with trait emotional awareness in patients at risk for sudden cardiac death.

    abstract:OBJECTIVES:Somatic symptom ratings covary with neuroticism. Yet, people vary from one another in their ability to report their own emotions and differentiate them from bodily sensations. We hypothesized that stressed individuals with greater emotional awareness would experience somatic symptoms in a more differentiated...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e318203b86a

    authors: Lane RD,Carmichael C,Reis HT

    更新日期:2011-02-01 00:00:00

  • The impatience of youth: phasic cardiovascular response in type A and type B elementary school-aged boys.

    abstract::Impatience, one major Type A characteristic, alters the performance of tasks requiring anticipation and accurate responding. Beat-by-beat changes in heart rate are also known to occur during anticipatory attention. In college- and middle-aged adult samples, impatience is related to these beat-by-beat heart rate change...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198411000-00003

    authors: Jennings JR,Matthews KA

    更新日期:1984-11-01 00:00:00

  • Presidential Address-1976. Social support as a moderator of life stress.

    abstract::Social support is defined as information leading the subject to believe that he is cared for and loved, esteemed, and a member of a network of mutual obligations. The evidence that supportive interactions among people are protective against the health consequences of life stress is reviewed. It appears that social sup...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-197609000-00003

    authors: Cobb S

    更新日期:1976-09-01 00:00:00