Serotonergic changes in specific areas of rat brain associated with activity--stress gastric lesions.

Abstract:

:To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected to analyses for serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) using high performance liquid chromatography with EC detection. Lower levels of 5-HT were found in the midbrain, cortex, and hippocampus of rats with gastric lesions compared to either the no lesion group, subjected to shorter periods of activity--stress, or the home--cage control group. Levels of 5-HT and 5-HIAA were elevated in the pons/medulla oblongata of both the lesion and the no lesion groups compared to the home--cage controls. Corticosterone levels in blood were also significantly elevated in the lesion group. These data on serotonin changes in the CNS suggest a possible role for this neurotransmitter in stress-induced gastric pathology.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Hellhammer DH,Hingtgen JN,Wade SE,Shea PA,Aprison MH

doi

10.1097/00006842-198305000-00004

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

115-22

issue

2

eissn

0033-3174

issn

1534-7796

journal_volume

45

pub_type

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