Abstract:
:To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected to analyses for serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) using high performance liquid chromatography with EC detection. Lower levels of 5-HT were found in the midbrain, cortex, and hippocampus of rats with gastric lesions compared to either the no lesion group, subjected to shorter periods of activity--stress, or the home--cage control group. Levels of 5-HT and 5-HIAA were elevated in the pons/medulla oblongata of both the lesion and the no lesion groups compared to the home--cage controls. Corticosterone levels in blood were also significantly elevated in the lesion group. These data on serotonin changes in the CNS suggest a possible role for this neurotransmitter in stress-induced gastric pathology.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Hellhammer DH,Hingtgen JN,Wade SE,Shea PA,Aprison MHdoi
10.1097/00006842-198305000-00004subject
Has Abstractpub_date
1983-05-01 00:00:00pages
115-22issue
2eissn
0033-3174issn
1534-7796journal_volume
45pub_type
杂志文章abstract::Three studies on the relationship between life stresses and premature labor were conducted. The first was a retrospective comparison of life events between a group of women who had had premature labor and a group of controls. It was carried out between 3 and 6 months after the premature delivery to neutralize possible...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198605000-00006
更新日期:1986-05-01 00:00:00
abstract::Using a prospective design, this study examined the hypothesis that a predisposition to focus on internal aspects of the self serves as a stress resistance resource. One hundred and twenty subjects filled out the Private Self-Consciousness inventory, a schedule of recent life events and a symptom checklist. Two months...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198509000-00007
更新日期:1985-09-01 00:00:00
abstract::This study investigated the relationship between anxiety and coronary artery disease (CAD). State (S-ANX) and trait (T-ANX) anxiety were assessed with the State-Trait Personality Inventory (STPI), which was administered to 373 patients (230 males, 143 females) 12 to 18 hr prior to their undergoing coronary arteriograp...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198703000-00002
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVES:The two objectives are to test the hypothesis that women in a profession with low decision latitude will have greater catecholamine excretion and higher blood pressure than women in a profession with greater decision latitude, and to assess the influence of ethnicity on the occupational comparison. METHODS:...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000222356.71315.8e
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:The present investigation was designed to provide the first empirical examination of the effects of clonidine, a selective alpha 2-adrenergic agonist, on sexual arousal in women with and without prior sympathetic nervous system [SNS] stimulation by exercise. The purpose was to help elucidate the influence of ...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199707000-00010
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVES:To determine the effect of two kinds of intimate partner violence (IPV) (physical and psychological) in the previous 12 months (current) and before the previous 12 months (past) on psychological well-being among women aged 18 to 70 years who attend primary healthcare centers in Spain; and to analyze the effe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181d2f0dd
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:Ambulatory saliva collections for subsequent analysis of free cortisol levels are now frequently applied to measure adrenocortical activity in healthy subjects and patient populations. Despite the prime importance of accurate timing of saliva collection outside the laboratory, no data are available on the com...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000058374.50240.bf
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:To hypothesize in a new and different population that administrative database (ADB) screening would identify somatizing patients by increasing numbers of visits, female gender, and greater percent of International Classification of Diseases, 9th Edition (ICD-9) primary diagnosis codes in musculoskeletal, ner...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31819cc783
更新日期:2009-04-01 00:00:00
abstract::This study examines the effectiveness of an intervention for minor depression in primary care patients. One hundred fifty public care medical patients were randomly assigned to either an 8-week cognitive-behavioral course intended to help them use pleasant activities, constructive thinking, and interpersonal relations...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199403000-00009
更新日期:1994-03-01 00:00:00
abstract::Twenty young male coffee-drinkers consumed 150 mg of caffeine in decaffeinated coffee three times a day for 8 days. On days 3, 4, 7, and 8, caffeine or a placebo was administered in the laboratory at 11 A.M., 8 A.M., 11 A.M., and 8 A.M., respectively, in a randomized double-blind crossover design. There was a blood pr...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199005000-00007
更新日期:1990-05-01 00:00:00
abstract::Seventy-two healthy males were divided into Type A and Type B groups using the Jenkins Activity Survey. Subjects were subdivided further into high and low self-awareness categories on the private self-consciousness factor of the Self-Consciousness Scale. After random assignment to consume alcohol (0.85 g/kg) or a plac...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-198807000-00005
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:Contextual factors can transform how we experience pain, particularly if pain is associated with other positive outcomes. Here, we test a novel meaning-based intervention. Participants were given the opportunity to choose to receive pain on behalf of their romantic partners, situating pain experience in a pos...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000609
更新日期:2018-11-01 00:00:00
abstract::We studied the cardiovascular responses to orthostatic and mental stress of 43 healthy subjects who daily received six cups of boiled or filtered coffee and of 21 healthy subjects who abstained from caffeine-containing beverages. All 64 subjects first received six cups of filtered coffee/day for 2 weeks. Then blood pr...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199205000-00010
更新日期:1992-05-01 00:00:00
abstract::Impatience, one major Type A characteristic, alters the performance of tasks requiring anticipation and accurate responding. Beat-by-beat changes in heart rate are also known to occur during anticipatory attention. In college- and middle-aged adult samples, impatience is related to these beat-by-beat heart rate change...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198411000-00003
更新日期:1984-11-01 00:00:00
abstract:OBJECTIVES:To determine if: 1) depressed patients with a recent acute myocardial infarction (AMI) have higher nighttime heart rate (HR) than nondepressed patients, and 2) elevated nighttime HR is associated with decreased survival post AMI. Depression is a risk factor for mortality post AMI. It is also associated with ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181835ca3
更新日期:2008-09-01 00:00:00
abstract::Sixty subjects classified as either Type A or Type B interacted in pairs by pressing buttons which transmitted messages through a television screen while the heart rate and digital blood volume pulse were computer-monitored. Partners could cooperate, compete, punish, reward, or withdraw on each interaction and could s...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197902000-00002
更新日期:1979-02-01 00:00:00
abstract::Osteoporosis is a common problem in postmenopausal women. It has been linked to estrogen deficiency, other neuroendocrine processes such as hypercortisolemia and male hypogonadism, nutritional deficiencies, and other mechanisms. Some of these changes have been also reported in male and female patients with mental diso...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199509000-00011
更新日期:1995-09-01 00:00:00
abstract:OBJECTIVE:Classical conditioning of insulin effects was examined in healthy humans using a placebo-controlled design. This study examined whether subjects who experienced a conditioned stimulus (CS) paired with insulin in the acquisition phase of a conditioning protocol would show a conditioned decrease of blood glucos...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199907000-00004
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:Evidence regarding the status of job strain as a risk factor for coronary heart disease (CHD) is mixed, including both results supporting the risk status and null findings. However, previous studies have typically assessed job strain at one point in time only. We examined whether the failure of such measureme...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000221252.84351.e2
更新日期:2006-05-01 00:00:00
abstract::The personality patterns of cancer patients as found in retrospective case-control studies are often suspected to be consequences of the disease. In this study an attempt was made to remove the bias arising from the disease itself by taking into account two indicator variables for the subject's anticipation of the sub...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198705000-00009
更新日期:1987-05-01 00:00:00
abstract::As increasing numbers of patients survive acute leukemia, it has become important to study the long-term psychological and social adjustment of patients who have successfully completed their leukemia treatment. An important aspect of this inquiry is comparing the long-term psychosocial impact of two treatments for acu...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199201000-00006
更新日期:1992-01-01 00:00:00
abstract::Serial sampling of peripheral blood from six healthy adult male volunteers was performed during daytime waking and nighttime sleeping. In addition, sleep physiology was assessed in all subjects (Ss) and sleep stages scored blind by standard criteria. Samples of plasma were analyzed for cortisol (Co) levels, functional...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198605000-00001
更新日期:1986-05-01 00:00:00
abstract::The association of peripheral arterial disease (PAD) with hostility, a component of Type A behavior, has not been investigated. Previous studies have found an association between coronary arterial disease and hostility. We used Doppler tests to define PAD as consisting of a resting index less than 0.9, absence of post...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198905000-00003
更新日期:1989-05-01 00:00:00
abstract::In this industrial-based study we compared the blood pressure (BP)-lowering effectiveness of relaxation, a beta blocker, and the combined use of these two treatments in 47 untreated, mildly hypertensive blue collar steel workers. Using a randomized two by two factorial design, patients received either nadolol or place...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-198909000-00004
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVES:African Americans are characterized by higher heart rate variability (HRV), a finding ostensibly associated with beneficial health outcomes. However, these findings are at odds with other evidence that blacks have worse cardiovascular outcomes. Here, we examine associations in a large cohort from the ELSA-Br...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000359
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:To describe factors influencing chest pain expression in patients with cardiac or noncardiac disease. METHODS:The authors conducted a case presentation and review of literature. RESULTS:Causes of chest pain are diverse. Psychologic factors influence chest pain expression commonly in patients with or without...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/01.psy.0000146330.80895.77
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:During the last decade, experimental and observational studies have shown that patients with inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) may have an altered intestinal microbial composition compared with healthy individuals. However, no uniform microbial signature has as yet been detec...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/PSY.0000000000000470
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a poss...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000137
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To examine the cross-sectional association between hostility and measures of abdominal fat (visceral, subcutaneous) in middle-aged African American and white women. Because fat-patterning characteristics are known to differ by race, we were particularly interested in examining whether these associations were ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181ad13a7
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:The aims of this pilot study were: 1) to establish the reliability and validity of a new self-report instrument designed to index monitoring for sleep-related threat; 2) to determine the presence of ten monitoring types proposed in a recent cognitive model of insomnia and to examine the relationship between m...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000114870.50968.90
更新日期:2004-03-01 00:00:00