Major depressive disorder predicts cardiac events in patients with coronary artery disease.

Abstract:

:Fifty-two patients undergoing cardiac catheterization and subsequently found to have significant coronary artery disease (CAD) were given structured psychiatric interviews before catheterization. Nine of these patients met criteria for major depressive disorder. All 52 patients were contacted 12 months after catheterization, and the occurrence of myocardial infarction, angioplasty, coronary bypass surgery and death was determined. Results of the study show that major depressive disorder was the best predictor of these major cardiac events during the 12 months following catheterization. The predictive effect was independent of the severity of CAD, left ventricular ejection fraction, and the presence of smoking. Furthermore, with the exception of smoking, there were no statistically significant differences between those patients with major depressive disorder and the remaining patients on any variable studied. The possible mechanisms relating major depressive disorder to subsequent cardiac events are discussed. It is concluded that major depressive disorder is an important independent risk factor for the occurrence of major cardiac events in patients with CAD.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Carney RM,Rich MW,Freedland KE,Saini J,teVelde A,Simeone C,Clark K

doi

10.1097/00006842-198811000-00009

subject

Has Abstract

pub_date

1988-11-01 00:00:00

pages

627-33

issue

6

eissn

0033-3174

issn

1534-7796

journal_volume

50

pub_type

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