Abstract:
OBJECTIVE:The main aims of this study were a) to investigate the relationship between lightheadedness and cerebral blood flow velocity (CBFv) during hyperventilation-induced hypocapnia, and b) to investigate whether and why the relationship between lightheadedness and CBFv may change after several episodes of this sensation. METHODS:Three hypocapnic and three normocapnic overbreathing trials were administered in a semirandomized order to healthy participants (N = 33). Each type of breathing trial was consistently paired with one odor. Afterward, participants were presented each odor once in two spontaneous breathing and in two normocapnic overbreathing trials. CBFv in the right middle cerebral artery was measured by transcranial Doppler ultrasonography (TCD). Also breathing behavior and self-reported lightheadedness were measured continuously. Each trial was followed by a symptom checklist. RESULTS:Self-reported lightheadedness was closely related to changes in CBFv in the hypocapnic overbreathing trials. During the subsequent normocapnic trials, however, participants experienced more lightheadedness and "feeling unreal" to the odor that had previously been paired with hyperventilation-induced hypocapnia. These complaints were not accompanied by changes in end-tidal CO(2) nor in CBFv. CONCLUSIONS:The results show that lightheadedness is associated with changes in CBFv but that after a few episodes, the underlying mechanism for this symptom may shift to perceptual-cognitive processes. These findings may help to understand why lightheadedness occurs during emotional distress and panic. In addition, altered cerebral blood flow is unlikely to play a primary precipitating role in recurrent symptoms of lightheadedness.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Bresseleers J,Van Diest I,De Peuter S,Verhamme P,Van den Bergh Odoi
10.1097/PSY.0b013e3181e68e94subject
Has Abstractpub_date
2010-09-01 00:00:00pages
672-80issue
7eissn
0033-3174issn
1534-7796pii
PSY.0b013e3181e68e94journal_volume
72pub_type
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journal_title:Psychosomatic medicine
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
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pub_type: 评论,杂志文章
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pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181fd944c
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doi:10.1097/PSY.0000000000000144
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doi:10.1097/00006842-199003000-00005
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journal_title:Psychosomatic medicine
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journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/00006842-199807000-00010
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