Abstract:
OBJECTIVE:To review published literature for the highest level of evidence on the efficacy of treatment for patients with medically unexplained symptoms. METHODS:A comprehensive literature search was carried out in Cochrane library, Medline (1971-2007), PsychINFO (1974-2006), and EMBASE (1980-2007) to identify pharmacological, nonpharmacological, psychological, and other interventions, using the search terms "medically unexplained symptoms," "somatisation," "somatization," "somatoform disorders," "psychological therapies," "cognitive behavior therapy," "pharmacological therapies," "management," "therapy," "drug therapy," and "anti-depressants" with Boolean operators AND and OR on the entire text. Searches were confined to literature in English. RESULTS:Studies were carried out in primary, secondary, and tertiary care settings. The therapists ranged from medical specialists, psychiatrists, and psychologists to primary care physicians. Three types of interventions (antidepressant medication, cognitive behavioral therapy (CBT), and other nonspecific interventions) were supported by evidence on the efficacy of treatment for patients with medically unexplained symptoms. There is more level I evidence for CBT compared with the amount for other approaches. There was only one study reported from the developing world. CONCLUSIONS:CBT is efficacious for either symptom syndromes or for the broader category of medically unexplained symptoms, reducing physical symptoms, psychological distress, and disability. A relatively small number of studies were carried out in primary care, but the trend has been changing over the last decade. No studies have compared pharmacological and psychological treatments. Most trials assessed only short-term outcomes. Use of divergent selection procedures, interventions, outcome measures, and instruments, and other methodological differences observed in these studies hamper the ability to compare treatment effects across studies.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Sumathipala Adoi
10.1097/PSY.0b013e31815b5cf6subject
Has Abstractpub_date
2007-12-01 00:00:00pages
889-900issue
9eissn
0033-3174issn
1534-7796pii
69/9/889journal_volume
69pub_type
杂志文章,评审abstract:OBJECTIVES:Recent academic debate has centered on whether functional somatic syndromes should be defined as separate entities or as one syndrome. The aim of this study was to investigate whether there may be significant differences in the etiology or precipitating factors associated with two common functional syndromes...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000221384.07521.05
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVES:To elucidate the potential relationship between classification of emotional faces and impaired central processing in eating disorders and to investigate the potential mediatory role of alexithymia and depression in this relationship. METHODS:Visual-evoked potentials (VEPs) to emotional faces and classificat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31817e41e6
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:Sleep disturbances have been thought to augment pain. Sleep deprivation has been proven to produce hyperalgesic effects. It is still unclear whether these changes are truly specific to pain and not related to general changes in somatosensory functions. The aim of the present study was to evaluate the effect o...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000145912.24553.c0
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:This review examines the relationship between depression and smoking in coronary heart disease (CHD). It summarizes relevant findings from general population and smoking cessation studies and discusses the few studies that have investigated whether smoking confounds, mediates, or moderates the effect of depre...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/01.psy.0000162255.55629.9c
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:Prior attempts to measure psychological responses to exercise are potentially limited by a failure to account for participants' expectations, the absence of a valid exercise placebo, and demand characteristics. The purpose of this study was to explore the main and interactive effects of a manipulation designe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000381
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:The aging of the population implies that an increased number of people are going to need some form of care or assistance. Caregiving poses a range of physical, emotional, and financial demands and often causes burden and stress for family members. This article describes how technology can be used to provide s...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200205000-00011
更新日期:2002-05-01 00:00:00
abstract::The study of depression in cancer patients has been hampered by difficulty in establishing diagnostic criteria, since neurovegetative signs and symptoms may be attributable either to depression or physical illness. Confusion has also arisen in defining the boundary between "normal" grieving with illness, and "abnormal...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198405000-00002
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:Perceived discrimination has been associated with psychosocial distress and adverse health outcomes. We examined associations of perceived discrimination measures with changes in kidney function in a prospective cohort study, the Healthy Aging in Neighborhoods of Diversity across the Life Span. METHODS:Our s...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000478
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:To identify patterns and predictors of work status and number of hours employed in a group of men with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). METHODS:A total of 141 participants had semiannual neuropsychiatric, psychosocial, and medical assessments over a period of 30 m...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000108083.43147.6d
更新日期:2004-01-01 00:00:00
abstract::A multidimensional behavioral program was developed for the treatment of essential hypertension. Over a course of 6 weeks, 108 patients of a rehabilitation center were treated with this program consisting of health education, self-monitoring of blood pressure, relaxation techniques, and a social skill training in addi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198707000-00011
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:Psychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV). METHODS:We conducted a longitudinal analysis using data f...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000672
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To assess the biological correlates of effort-reward imbalance and overcommitment to work using measurements over the working day. METHODS:Participants were 197 working men and women aged 45 to 59 years, recruited from the Whitehall II epidemiological cohort. Salivary cortisol was sampled on waking, 30 minut...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000126198.67070.72
更新日期:2004-05-01 00:00:00
abstract::Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated following social and physical stress exposure. Although social isolation following tumor cell transplantation enhanced tumor growth, it appeared that it was the abrupt change in social conditions, rather than the isolation per se which was responsi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198005000-00005
更新日期:1980-05-01 00:00:00
abstract::Social interactions have long-term physiological, psychological, and behavioral consequences. Social isolation is a well-recognized but little understood risk factor and prognostic marker of disease; it can have profoundly detrimental effects on both mental and physical well-being, particularly during states of compro...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/PSY.0b013e3182002116
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVES:The objectives of the study described here were to 1) examine the coping style of patients with functional dyspepsia (FD) and 2) adopt a new interview questionnaire to examine the extent of discriminativeness in the use of coping strategies across different stressful situations. METHODS:A matched case-contr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199911000-00011
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Despite the abundant literature on the consequences of intimate partner violence (IPV) on mental health, psychological abuse has rarely been considered, and the separate effects of the different types of IPV have been understudied. The aim of this study was to analyze the association between physical, psychol...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000181269.11979.cd
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:The objectives of this study were to assess whether socioeconomic status (SES) is associated with dysregulation of the cortisol diurnal rhythm and whether this association is independent of race and occurs equally in whites and blacks; and to determine if an association between SES and cortisol can be explai...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000195967.51768.ea
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare baseline levels of salivary cortisol, diurnal cortisol slopes, and cortisol reactivity to a mammogram in breast cancer survivors and women without a history of cancer. METHODS:Participants were 33 breast cancer survivors (3-5 years postdiagnosis) and 21 women with no ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000088595.91705.c5
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:A model for the development of anxiety disorders (panic disorder with or without agoraphobia) is needed. Patients with an implantable cardioverter/defibrillator (ICD) are exposed to repeated electric shocks. If the theory of anxiety development by aversive classic conditioning processes is valid, these repeat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200103000-00006
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To determine whether the relationship between interleukin (IL)-6 and depressive symptoms is moderated by participation in moderate-intensity physical activity in a sample of primary care patients. Elevated inflammation has been associated with a number of poor health outcomes. Depressive symptoms may be relat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182108412
更新日期:2011-04-01 00:00:00
abstract::To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected t...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198305000-00004
更新日期:1983-05-01 00:00:00
abstract::Impatience, one major Type A characteristic, alters the performance of tasks requiring anticipation and accurate responding. Beat-by-beat changes in heart rate are also known to occur during anticipatory attention. In college- and middle-aged adult samples, impatience is related to these beat-by-beat heart rate change...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198411000-00003
更新日期:1984-11-01 00:00:00
abstract:OBJECTIVES:Rumination has been linked to self-reported sleep quality. However, whether rumination is related to an objective sleep parameter has not been tested. This study examined whether rumination predicts sleep onset latency (SOL) on the night after an acute psychosocial stressor. We hypothesized that those who ru...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181ae58e8
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:This article reports a case series of atypical sexual behavior during sleep, which is often harmful to patients or bed partners. METHODS:Eleven subjects underwent clinical evaluation of complaints of sleep-related atypical sexual behavior. Complaints included violent masturbation, sexual assaults, and contin...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200203000-00017
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions. METHODS:We used a prospective twin study with a 12-year follow-up. In 1992, lifetime diagnosis of depression was assessed in 1159 male-male twins and...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e3181d28125
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that perfectionism is an important moderator of the neuroendocrine stress response, with higher perfectionism predicting increased neuroendocrine activation. METHODS:A total of 50 middle-aged men underwent an acute standardized psychosocial stress task (Trier Social Stress Test). Perfe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318042589e
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. METHODS:Participants were 789 men and 1105 women from the ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000151745.67285.c2
更新日期:2005-01-01 00:00:00
abstract::Inflammation is implicated in the etiology of major depressive disorder (MDD). Human neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation, and cognition and its relationship to MDD. In this issue of Psychosomatic Medicine, Byrne and co...
journal_title:Psychosomatic medicine
pub_type: 评论,社论
doi:10.1097/PSY.0000000000000339
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:This study evaluated the ability of mental stress testing to discriminate between women with and without CHD, and among women with different disease manifestations, taking into account history of hypertension and beta-blocker use. METHODS:Analyses were based on data from a community-based case-control study ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200111000-00010
更新日期:2001-11-01 00:00:00
abstract::Using a prospective design, this study examined the hypothesis that a predisposition to focus on internal aspects of the self serves as a stress resistance resource. One hundred and twenty subjects filled out the Private Self-Consciousness inventory, a schedule of recent life events and a symptom checklist. Two months...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198509000-00007
更新日期:1985-09-01 00:00:00