What is the evidence for the efficacy of treatments for somatoform disorders? A critical review of previous intervention studies.

Abstract:

OBJECTIVE:To review published literature for the highest level of evidence on the efficacy of treatment for patients with medically unexplained symptoms. METHODS:A comprehensive literature search was carried out in Cochrane library, Medline (1971-2007), PsychINFO (1974-2006), and EMBASE (1980-2007) to identify pharmacological, nonpharmacological, psychological, and other interventions, using the search terms "medically unexplained symptoms," "somatisation," "somatization," "somatoform disorders," "psychological therapies," "cognitive behavior therapy," "pharmacological therapies," "management," "therapy," "drug therapy," and "anti-depressants" with Boolean operators AND and OR on the entire text. Searches were confined to literature in English. RESULTS:Studies were carried out in primary, secondary, and tertiary care settings. The therapists ranged from medical specialists, psychiatrists, and psychologists to primary care physicians. Three types of interventions (antidepressant medication, cognitive behavioral therapy (CBT), and other nonspecific interventions) were supported by evidence on the efficacy of treatment for patients with medically unexplained symptoms. There is more level I evidence for CBT compared with the amount for other approaches. There was only one study reported from the developing world. CONCLUSIONS:CBT is efficacious for either symptom syndromes or for the broader category of medically unexplained symptoms, reducing physical symptoms, psychological distress, and disability. A relatively small number of studies were carried out in primary care, but the trend has been changing over the last decade. No studies have compared pharmacological and psychological treatments. Most trials assessed only short-term outcomes. Use of divergent selection procedures, interventions, outcome measures, and instruments, and other methodological differences observed in these studies hamper the ability to compare treatment effects across studies.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Sumathipala A

doi

10.1097/PSY.0b013e31815b5cf6

subject

Has Abstract

pub_date

2007-12-01 00:00:00

pages

889-900

issue

9

eissn

0033-3174

issn

1534-7796

pii

69/9/889

journal_volume

69

pub_type

杂志文章,评审
  • To "lump" or to "split" the functional somatic syndromes: can infectious and emotional risk factors differentiate between the onset of chronic fatigue syndrome and irritable bowel syndrome?

    abstract:OBJECTIVES:Recent academic debate has centered on whether functional somatic syndromes should be defined as separate entities or as one syndrome. The aim of this study was to investigate whether there may be significant differences in the etiology or precipitating factors associated with two common functional syndromes...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000221384.07521.05

    authors: Moss-Morris R,Spence M

    更新日期:2006-05-01 00:00:00

  • Impaired central processing of emotional faces in anorexia nervosa.

    abstract:OBJECTIVES:To elucidate the potential relationship between classification of emotional faces and impaired central processing in eating disorders and to investigate the potential mediatory role of alexithymia and depression in this relationship. METHODS:Visual-evoked potentials (VEPs) to emotional faces and classificat...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e31817e41e6

    authors: Pollatos O,Herbert BM,Schandry R,Gramann K

    更新日期:2008-07-01 00:00:00

  • Sleep deprivation affects thermal pain thresholds but not somatosensory thresholds in healthy volunteers.

    abstract:OBJECTIVE:Sleep disturbances have been thought to augment pain. Sleep deprivation has been proven to produce hyperalgesic effects. It is still unclear whether these changes are truly specific to pain and not related to general changes in somatosensory functions. The aim of the present study was to evaluate the effect o...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/01.psy.0000145912.24553.c0

    authors: Kundermann B,Spernal J,Huber MT,Krieg JC,Lautenbacher S

    更新日期:2004-11-01 00:00:00

  • Depression and smoking in coronary heart disease.

    abstract:OBJECTIVE:This review examines the relationship between depression and smoking in coronary heart disease (CHD). It summarizes relevant findings from general population and smoking cessation studies and discusses the few studies that have investigated whether smoking confounds, mediates, or moderates the effect of depre...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.psy.0000162255.55629.9c

    authors: Freedland KE,Carney RM,Skala JA

    更新日期:2005-05-01 00:00:00

  • The Effect of Light-Intensity Cycling on Mood and Working Memory in Response to a Randomized, Placebo-Controlled Design.

    abstract:OBJECTIVE:Prior attempts to measure psychological responses to exercise are potentially limited by a failure to account for participants' expectations, the absence of a valid exercise placebo, and demand characteristics. The purpose of this study was to explore the main and interactive effects of a manipulation designe...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000381

    authors: Lindheimer JB,OʼConnor PJ,McCully KK,Dishman RK

    更新日期:2017-02-01 00:00:00

  • Telecommunications technology as an aid to family caregivers of persons with dementia.

    abstract:OBJECTIVE:The aging of the population implies that an increased number of people are going to need some form of care or assistance. Caregiving poses a range of physical, emotional, and financial demands and often causes burden and stress for family members. This article describes how technology can be used to provide s...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-200205000-00011

    authors: Czaja SJ,Rubert MP

    更新日期:2002-05-01 00:00:00

  • Depression in hospitalized cancer patients.

    abstract::The study of depression in cancer patients has been hampered by difficulty in establishing diagnostic criteria, since neurovegetative signs and symptoms may be attributable either to depression or physical illness. Confusion has also arisen in defining the boundary between "normal" grieving with illness, and "abnormal...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198405000-00002

    authors: Bukberg J,Penman D,Holland JC

    更新日期:1984-05-01 00:00:00

  • Perceived Discrimination and Longitudinal Change in Kidney Function Among Urban Adults.

    abstract:OBJECTIVE:Perceived discrimination has been associated with psychosocial distress and adverse health outcomes. We examined associations of perceived discrimination measures with changes in kidney function in a prospective cohort study, the Healthy Aging in Neighborhoods of Diversity across the Life Span. METHODS:Our s...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000478

    authors: Beydoun MA,Poggi-Burke A,Zonderman AB,Rostant OS,Evans MK,Crews DC

    更新日期:2017-09-01 00:00:00

  • Predictors of employment of men with HIV/AIDS: a longitudinal study.

    abstract:OBJECTIVE:To identify patterns and predictors of work status and number of hours employed in a group of men with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). METHODS:A total of 141 participants had semiannual neuropsychiatric, psychosocial, and medical assessments over a period of 30 m...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000108083.43147.6d

    authors: Rabkin JG,McElhiney M,Ferrando SJ,Van Gorp W,Lin SH

    更新日期:2004-01-01 00:00:00

  • Long-term effects of a complex behavioral treatment of essential hypertension.

    abstract::A multidimensional behavioral program was developed for the treatment of essential hypertension. Over a course of 6 weeks, 108 patients of a rehabilitation center were treated with this program consisting of health education, self-monitoring of blood pressure, relaxation techniques, and a social skill training in addi...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198707000-00011

    authors: Lehnert H,Kaluza K,Vetter H,Losse H,Dorst K

    更新日期:1987-07-01 00:00:00

  • Psychological Traits, Heart Rate Variability, and Risk of Coronary Heart Disease in Healthy Aging Women-The Women's Health Initiative.

    abstract:OBJECTIVE:Psychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV). METHODS:We conducted a longitudinal analysis using data f...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0000000000000672

    authors: Salmoirago-Blotcher E,Hovey KM,Andrews CA,Allison M,Brunner RL,Denburg NL,Eaton C,Garcia L,Sealy-Jefferson SM,Zaslavsky O,Kang J,López L,Post SG,Tindle H,Wassertheil-Smoller S

    更新日期:2019-04-01 00:00:00

  • Effort-reward imbalance, overcommitment, and measures of cortisol and blood pressure over the working day.

    abstract:OBJECTIVE:To assess the biological correlates of effort-reward imbalance and overcommitment to work using measurements over the working day. METHODS:Participants were 197 working men and women aged 45 to 59 years, recruited from the Whitehall II epidemiological cohort. Salivary cortisol was sampled on waking, 30 minut...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000126198.67070.72

    authors: Steptoe A,Siegrist J,Kirschbaum C,Marmot M

    更新日期:2004-05-01 00:00:00

  • Social stress influences tumor growth.

    abstract::Growth of syngeneic P815 mastocytoma in DBA/2J male mice was evaluated following social and physical stress exposure. Although social isolation following tumor cell transplantation enhanced tumor growth, it appeared that it was the abrupt change in social conditions, rather than the isolation per se which was responsi...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198005000-00005

    authors: Sklar LS,Anisman H

    更新日期:1980-05-01 00:00:00

  • Modeling social influences on human health.

    abstract::Social interactions have long-term physiological, psychological, and behavioral consequences. Social isolation is a well-recognized but little understood risk factor and prognostic marker of disease; it can have profoundly detrimental effects on both mental and physical well-being, particularly during states of compro...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,评审

    doi:10.1097/PSY.0b013e3182002116

    authors: Karelina K,DeVries AC

    更新日期:2011-01-01 00:00:00

  • Coping style of individuals with functional dyspepsia.

    abstract:OBJECTIVES:The objectives of the study described here were to 1) examine the coping style of patients with functional dyspepsia (FD) and 2) adopt a new interview questionnaire to examine the extent of discriminativeness in the use of coping strategies across different stressful situations. METHODS:A matched case-contr...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-199911000-00011

    authors: Cheng C,Hui WM,Lam SK

    更新日期:1999-11-01 00:00:00

  • Intimate partner violence and mental health consequences in women attending family practice in Spain.

    abstract:OBJECTIVE:Despite the abundant literature on the consequences of intimate partner violence (IPV) on mental health, psychological abuse has rarely been considered, and the separate effects of the different types of IPV have been understudied. The aim of this study was to analyze the association between physical, psychol...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000181269.11979.cd

    authors: Ruiz-Pérez I,Plazaola-Castaño J

    更新日期:2005-09-01 00:00:00

  • Socioeconomic status, race, and diurnal cortisol decline in the Coronary Artery Risk Development in Young Adults (CARDIA) Study.

    abstract:OBJECTIVES:The objectives of this study were to assess whether socioeconomic status (SES) is associated with dysregulation of the cortisol diurnal rhythm and whether this association is independent of race and occurs equally in whites and blacks; and to determine if an association between SES and cortisol can be explai...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000195967.51768.ea

    authors: Cohen S,Schwartz JE,Epel E,Kirschbaum C,Sidney S,Seeman T

    更新日期:2006-01-01 00:00:00

  • Cortisol levels and responses to mammography screening in breast cancer survivors: a pilot study.

    abstract:OBJECTIVE:The purpose of this study was to compare baseline levels of salivary cortisol, diurnal cortisol slopes, and cortisol reactivity to a mammogram in breast cancer survivors and women without a history of cancer. METHODS:Participants were 33 breast cancer survivors (3-5 years postdiagnosis) and 21 women with no ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000088595.91705.c5

    authors: Porter LS,Mishel M,Neelon V,Belyea M,Pisano E,Soo MS

    更新日期:2003-09-01 00:00:00

  • Classic conditioning and dysfunctional cognitions in patients with panic disorder and agoraphobia treated with an implantable cardioverter/defibrillator.

    abstract:OBJECTIVE:A model for the development of anxiety disorders (panic disorder with or without agoraphobia) is needed. Patients with an implantable cardioverter/defibrillator (ICD) are exposed to repeated electric shocks. If the theory of anxiety development by aversive classic conditioning processes is valid, these repeat...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-200103000-00006

    authors: Godemann F,Ahrens B,Behrens S,Berthold R,Gandor C,Lampe F,Linden M

    更新日期:2001-03-01 00:00:00

  • Moderating effects of moderate-intensity physical activity in the relationship between depressive symptoms and interleukin-6 in primary care patients.

    abstract:OBJECTIVE:To determine whether the relationship between interleukin (IL)-6 and depressive symptoms is moderated by participation in moderate-intensity physical activity in a sample of primary care patients. Elevated inflammation has been associated with a number of poor health outcomes. Depressive symptoms may be relat...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3182108412

    authors: Rethorst CD,Moynihan J,Lyness JM,Heffner KL,Chapman BP

    更新日期:2011-04-01 00:00:00

  • Serotonergic changes in specific areas of rat brain associated with activity--stress gastric lesions.

    abstract::To study serotonergic involvement in the development of gastric lesions following activity wheel stress, three groups of rats (gastric lesions, no gastric lesions, and home--cage controls) were killed following exposure to the experimental procedures. The brains were dissected into eight specific areas and subjected t...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198305000-00004

    authors: Hellhammer DH,Hingtgen JN,Wade SE,Shea PA,Aprison MH

    更新日期:1983-05-01 00:00:00

  • The impatience of youth: phasic cardiovascular response in type A and type B elementary school-aged boys.

    abstract::Impatience, one major Type A characteristic, alters the performance of tasks requiring anticipation and accurate responding. Beat-by-beat changes in heart rate are also known to occur during anticipatory attention. In college- and middle-aged adult samples, impatience is related to these beat-by-beat heart rate change...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198411000-00003

    authors: Jennings JR,Matthews KA

    更新日期:1984-11-01 00:00:00

  • Rumination predicts longer sleep onset latency after an acute psychosocial stressor.

    abstract:OBJECTIVES:Rumination has been linked to self-reported sleep quality. However, whether rumination is related to an objective sleep parameter has not been tested. This study examined whether rumination predicts sleep onset latency (SOL) on the night after an acute psychosocial stressor. We hypothesized that those who ru...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e3181ae58e8

    authors: Zoccola PM,Dickerson SS,Lam S

    更新日期:2009-09-01 00:00:00

  • Atypical sexual behavior during sleep.

    abstract:OBJECTIVE:This article reports a case series of atypical sexual behavior during sleep, which is often harmful to patients or bed partners. METHODS:Eleven subjects underwent clinical evaluation of complaints of sleep-related atypical sexual behavior. Complaints included violent masturbation, sexual assaults, and contin...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-200203000-00017

    authors: Guilleminault C,Moscovitch A,Yuen K,Poyares D

    更新日期:2002-03-01 00:00:00

  • Genetic vulnerability and phenotypic expression of depression and risk for ischemic heart disease in the Vietnam era twin study of aging.

    abstract:OBJECTIVE:To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions. METHODS:We used a prospective twin study with a 12-year follow-up. In 1992, lifetime diagnosis of depression was assessed in 1159 male-male twins and...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/PSY.0b013e3181d28125

    authors: Xian H,Scherrer JF,Franz CE,McCaffery J,Stein PK,Lyons MJ,Jacobsen K,Eisen SA,Kremen WS

    更新日期:2010-05-01 00:00:00

  • Perfectionism and the cortisol response to psychosocial stress in men.

    abstract:OBJECTIVE:To test the hypothesis that perfectionism is an important moderator of the neuroendocrine stress response, with higher perfectionism predicting increased neuroendocrine activation. METHODS:A total of 50 middle-aged men underwent an acute standardized psychosocial stress task (Trier Social Stress Test). Perfe...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/PSY.0b013e318042589e

    authors: Wirtz PH,Elsenbruch S,Emini L,Rüdisüli K,Groessbauer S,Ehlert U

    更新日期:2007-04-01 00:00:00

  • Serum cholesterol and cognitive performance in the Framingham Heart Study.

    abstract:OBJECTIVE:The objective of this study was to examine the relationship between total cholesterol (TC) and cognitive performance within the context of the Framingham Heart Study, a large, community-based, prospective investigation of cardiovascular risk factors. METHODS:Participants were 789 men and 1105 women from the ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/01.psy.0000151745.67285.c2

    authors: Elias PK,Elias MF,D'Agostino RB,Sullivan LM,Wolf PA

    更新日期:2005-01-01 00:00:00

  • Depression Phenotype, Inflammation, and the Brain: Implications for Future Research.

    abstract::Inflammation is implicated in the etiology of major depressive disorder (MDD). Human neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation, and cognition and its relationship to MDD. In this issue of Psychosomatic Medicine, Byrne and co...

    journal_title:Psychosomatic medicine

    pub_type: 评论,社论

    doi:10.1097/PSY.0000000000000339

    authors: Krishnadas R,Harrison NA

    更新日期:2016-05-01 00:00:00

  • Cardiovascular reactivity to mental stress in the Stockholm Female Coronary Risk Study.

    abstract:OBJECTIVE:This study evaluated the ability of mental stress testing to discriminate between women with and without CHD, and among women with different disease manifestations, taking into account history of hypertension and beta-blocker use. METHODS:Analyses were based on data from a community-based case-control study ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-200111000-00010

    authors: Weidner G,Kohlmann CW,Horsten M,Wamala SP,Schenck-Gustafsson K,Högbom M,Orth-Gomer K

    更新日期:2001-11-01 00:00:00

  • Self-attention, life stress, and illness: a prospective study.

    abstract::Using a prospective design, this study examined the hypothesis that a predisposition to focus on internal aspects of the self serves as a stress resistance resource. One hundred and twenty subjects filled out the Private Self-Consciousness inventory, a schedule of recent life events and a symptom checklist. Two months...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章

    doi:10.1097/00006842-198509000-00007

    authors: Suls J,Fletcher B

    更新日期:1985-09-01 00:00:00