Abstract:
:Inflammation is implicated in the etiology of major depressive disorder (MDD). Human neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation, and cognition and its relationship to MDD. In this issue of Psychosomatic Medicine, Byrne and colleagues report the first systematic review of these studies. The systematic review provides a much-needed synthesis of current research findings and highlights the role of cortical and subcortical brain structure and function. In this accompanying commentary, we highlight further points of particular relevance to future studies, including the potential advantages of functional phenotype models rather than the emphasis on mutually exclusive diagnostic categories in describing MDD and other psychiatric disorders. Novel imaging techniques will further enhance possibilities to clarify the link between inflammation and depression. New research challenges are described regarding the relationships between behavioral phenotype, brain structure and function, and peripheral inflammation.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Krishnadas R,Harrison NAdoi
10.1097/PSY.0000000000000339subject
Has Abstractpub_date
2016-05-01 00:00:00pages
384-8issue
4eissn
0033-3174issn
1534-7796pii
00006842-201605000-00002journal_volume
78pub_type
评论,社论abstract::A number of psychosomatic studies have suggested that alexithymia, impairment in identifying and expressing inner feelings, might somehow affect the course of various illnesses. However, none of these studies have distinguished between an impact of alexithymia on actual pathophysiological change versus an impact only ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199405000-00010
更新日期:1994-05-01 00:00:00
abstract:OBJECTIVE:Sleep disturbances have been thought to augment pain. Sleep deprivation has been proven to produce hyperalgesic effects. It is still unclear whether these changes are truly specific to pain and not related to general changes in somatosensory functions. The aim of the present study was to evaluate the effect o...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000145912.24553.c0
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:Persons with elevated blood pressure (BP) show dampened emotional responses to affect-laden stimuli. We sought to further examine cardiovascular-emotional dampening by examination of the relationship between resting hemodynamic measures and recognition of emotion in an African American community-based sample....
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318235ed55
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:Somatic symptom disorder (SSD) often co-occurs with major depressive disorder (MDD). Both conditions share common psychobiological and biobehavioral characteristics, but little is known about differential patterns in brain function. In this study, we compared resting-state functional brain connectivity betwee...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000490
更新日期:2017-11-01 00:00:00
abstract::Previous research has suggested that patients with amyotrophic lateral sclerosis (ALS) demonstrate similar psychological characteristics that distinguish them from the medically ill populations, and that these findings may bear etiologic and prognostic importance. In this report, a larger sample was studied and the pr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197709000-00003
更新日期:1977-09-01 00:00:00
abstract:OBJECTIVES:To determine if: 1) depressed patients with a recent acute myocardial infarction (AMI) have higher nighttime heart rate (HR) than nondepressed patients, and 2) elevated nighttime HR is associated with decreased survival post AMI. Depression is a risk factor for mortality post AMI. It is also associated with ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181835ca3
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:This study examined the genetic and environmental contributions to the individual differences in blood pressure (BP) levels and underlying hemodynamic characteristics at rest and during mental challenge tasks in a large twin cohort of youth. Including both European American and African American twins further ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31828d3cb6
更新日期:2013-05-01 00:00:00
abstract::Subjects with reported sleep-onset disturbance were given progressive relaxation training, placebo, or no-treatment. All three conditions showed significant improvement in daily reported sleep onset over the duration of the study. Between-condition effects were limited to relaxation superiority over no-treatment on St...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章
doi:10.1097/00006842-197605000-00003
更新日期:1976-05-01 00:00:00
abstract:OBJECTIVE:This study investigated the physiological and somatic changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in adolescent and adult rats, with a focus on cardiovascular function. The long-term effects of stress exposure during adolescenc...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000141
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To investigate the association between vitamin D deficiency and depressive symptoms in a national community sample of older people. Vitamin D deficiency is common in older people with potential effects on mood. METHODS:Data were analyzed from 2070 participants aged ≥65 years who had participated in the 2005 ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181e9bf15
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:Rumination has been linked to self-reported sleep quality. However, whether rumination is related to an objective sleep parameter has not been tested. This study examined whether rumination predicts sleep onset latency (SOL) on the night after an acute psychosocial stressor. We hypothesized that those who ru...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181ae58e8
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:Altered autonomic nervous system activity is considered to be involved in the pathophysiology of somatic symptom disorder (SSD). This study aimed to investigate whether patients with SSD have disturbed autonomic activity during rest and reactivity to emotional processing and whether altered autonomic nervous ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000622
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Primary insomnia is one of the most prevalent sleep disorders and assumed to be initiated and maintained, among other factors, by psychological variables such as coping strategies, sleep hygiene techniques, and arousability. Althouugh the number and kind of stressors seem to be important initiators of insomni...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000195881.01317.d9
更新日期:2006-01-01 00:00:00
abstract::The differential relationship between specific subtypes of premenstrual changes and specific subtypes of mental disorder was studied. Premenstrual changes were evaluated with the Premenstrual Assessment Form, which provides specific criteria for the classification of the various subtypes of premenstrual change. The Re...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198112000-00008
更新日期:1981-12-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between cardiac self-efficacy and health status, including symptom burden, physical limitation, quality of life, and overall health among outpatients with stable coronary heart disease (CHD). We hypothesized that lower self-efficacy would predict worse health status, independent of...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3180514d57
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:To assess the relationship among Type D personality, self-efficacy, and medication adherence in patients with coronary heart disease. METHODS:The study design was prospective and observational. Type D personality, self-efficacy for illness management behaviors, and medication adherence were measured 3 weeks ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31823a5b2f
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:Patients' expectations have been shown to predict the course and treatment success of a variety of medical conditions. Therefore, expectation-focused psychological interventions (EFPIs) have been developed to use these expectation effects clinically. Importantly, EFPI differ with regard to the particular expe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000596
更新日期:2018-07-01 00:00:00
abstract::A multidimensional behavioral program was developed for the treatment of essential hypertension. Over a course of 6 weeks, 108 patients of a rehabilitation center were treated with this program consisting of health education, self-monitoring of blood pressure, relaxation techniques, and a social skill training in addi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198707000-00011
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVE:Research on eating relies on various indices (e.g., stable, momentary, neural) to accurately reflect food-related reactivity (e.g., disinhibition) and regulation (e.g., restraint) outside the laboratory. The degree to which they differentially predict real-world consumption remains unclear. Further, the predi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000187
更新日期:2015-06-01 00:00:00
abstract::Recent technologic advances have permitted the observation of rapid and significant increases in blood pressure (BP) during verbal communication. The magnitude of the increase in BP is influenced by rate of speech, audience size, status, affective content, environmental setting, and resting BP. The current study evalu...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198601000-00008
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. METHODS:We measured morn...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000138119.12956.99
更新日期:2004-09-01 00:00:00
abstract::Social interactions have long-term physiological, psychological, and behavioral consequences. Social isolation is a well-recognized but little understood risk factor and prognostic marker of disease; it can have profoundly detrimental effects on both mental and physical well-being, particularly during states of compro...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/PSY.0b013e3182002116
更新日期:2011-01-01 00:00:00
abstract::This study was conducted to test the hypothesis that patients with MI are distinguished from persons with a less serious illness, more by subjective interpretations of the emotional impact of life events than by exposure to a surfeit of life events that purportedly representative samples of the population have judged ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198001000-00001
更新日期:1980-01-01 00:00:00
abstract:OBJECTIVE:We examined whether depression is independently associated with implantable cardioverter defibrillator (ICD) therapy for ventricular tachyarrhythmias and mortality. METHODS:A cohort of 430 consecutive patients with a first-time ICD (79% men; mean [standard deviation] age = 57.8 [12.1] years) completed the Ho...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000017
更新日期:2014-01-01 00:00:00
abstract::The study of depression in cancer patients has been hampered by difficulty in establishing diagnostic criteria, since neurovegetative signs and symptoms may be attributable either to depression or physical illness. Confusion has also arisen in defining the boundary between "normal" grieving with illness, and "abnormal...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198405000-00002
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:Contextual factors can transform how we experience pain, particularly if pain is associated with other positive outcomes. Here, we test a novel meaning-based intervention. Participants were given the opportunity to choose to receive pain on behalf of their romantic partners, situating pain experience in a pos...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000609
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Despite its simplicity, single-item measures of self-rated health have been associated with mortality independent of objective health conditions. However, little is known about the mechanisms potentially responsible for such associations. This study tested the association between self-rated heath and inflamma...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000683
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:An attachment model was used to understand how maternal sensitivity and adverse childhood experiences are related to somatization. METHODS:We examined maternal sensitivity at 6 and 18 months and somatization at 5 years in 292 children in a longitudinal cohort study. We next examined attachment insecurity and...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000437
更新日期:2017-06-01 00:00:00
abstract::Symptomatic individuals suspected of having myocardial ischemia often have no obstructive atherosclerotic narrowing of epicardial coronary arteries. Abnormal coronary vascular reactivity and, in particular, coronary artery vasospasm (CAS) may be an explanation in a subset of these patients. Psychological factors play ...
journal_title:Psychosomatic medicine
pub_type: 评论,杂志文章
doi:10.1097/PSY.0000000000000682
更新日期:2019-04-01 00:00:00
abstract::Previous studies suggest that the ways in which parents respond to children's health complaints (reinforcement) and the ways in which they cope with their own illnesses (modeling) influence the frequency of symptoms, disability days, and health care visits made by these children when they grow up. However, previous st...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199411000-00010
更新日期:1994-11-01 00:00:00