Depression Phenotype, Inflammation, and the Brain: Implications for Future Research.

Abstract:

:Inflammation is implicated in the etiology of major depressive disorder (MDD). Human neuroimaging techniques are increasingly used to characterize the neural circuitry mediating actions of inflammation on mood, motivation, and cognition and its relationship to MDD. In this issue of Psychosomatic Medicine, Byrne and colleagues report the first systematic review of these studies. The systematic review provides a much-needed synthesis of current research findings and highlights the role of cortical and subcortical brain structure and function. In this accompanying commentary, we highlight further points of particular relevance to future studies, including the potential advantages of functional phenotype models rather than the emphasis on mutually exclusive diagnostic categories in describing MDD and other psychiatric disorders. Novel imaging techniques will further enhance possibilities to clarify the link between inflammation and depression. New research challenges are described regarding the relationships between behavioral phenotype, brain structure and function, and peripheral inflammation.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Krishnadas R,Harrison NA

doi

10.1097/PSY.0000000000000339

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

384-8

issue

4

eissn

0033-3174

issn

1534-7796

pii

00006842-201605000-00002

journal_volume

78

pub_type

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