Abstract:
OBJECTIVE:Contextual factors can transform how we experience pain, particularly if pain is associated with other positive outcomes. Here, we test a novel meaning-based intervention. Participants were given the opportunity to choose to receive pain on behalf of their romantic partners, situating pain experience in a positive, prosocial meaning context. We predicted that the ventromedial prefrontal cortex (vmPFC), a key structure for pain regulation and generation of affective meaning, would mediate the transformation of pain experience by this prosocial interpersonal context. METHODS:We studied fMRI activity and behavioral responses in 29 heterosexual female participants during (1) a baseline pain challenge and (2) a task in which participants decided to accept a self-selected number of additional pain trials to reduce pain in their male romantic partners ("accept-partner-pain" condition). RESULTS:Enduring extra pain for the benefit of the romantic partner reduced pain-related unpleasantness (t = -2.54, p = .016) but not intensity, and increased positive thoughts (t = 3.60, p = .001) and pleasant feelings (t = 5.39, p < .0005). Greater willingness to accept the pain of one's partner predicted greater unpleasantness reductions (t = 3.94, p = .001) and increases in positive thoughts (r = .457, p = .013). The vmPFC showed significant increases (q < .05 FDR-corrected) in activation during accept-partner-pain, especially for women with greater willingness to relieve their partner's pain (t = 2.63, p = .014). Reductions in brain regions processing pain and aversive emotion significantly mediated reductions in pain unpleasantness (q < .05 FDR-corrected). CONCLUSIONS:The vmPFC has a key role in transforming the meaning of pain, which is associated with a cascade of positive psychological and brain effects, including changes in affective meaning, value, and pain-specific neural circuits.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
López-Solà M,Koban L,Wager TDdoi
10.1097/PSY.0000000000000609subject
Has Abstractpub_date
2018-11-01 00:00:00pages
814-825issue
9eissn
0033-3174issn
1534-7796journal_volume
80pub_type
杂志文章abstract:OBJECTIVE:Brain-gut-microbiota interactions may play an important role in human health and behavior. Although rodent models have demonstrated effects of the gut microbiota on emotional, nociceptive, and social behaviors, there is little translational human evidence to date. In this study, we identify brain and behavior...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000493
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:The protective effects of female gender on the appearance and course of coronary heart disease (CHD) in nondiabetic subjects are diminished in the presence of diabetes. Depression predicts onset of and poor outcome from CHD in nondiabetic populations. We hypothesized that the doubled rates of depression in fe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000041624.96580.1f
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:This study investigates psychological and psychobiological processes in patients with somatization syndrome. METHOD:We compared physiological measures (heart rate, finger pulse volume, electrodermal activity, electromyography), cortisol levels, and subjective well-being during rest and during a mental stress...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199803000-00016
更新日期:1998-03-01 00:00:00
abstract::The personality patterns of cancer patients as found in retrospective case-control studies are often suspected to be consequences of the disease. In this study an attempt was made to remove the bias arising from the disease itself by taking into account two indicator variables for the subject's anticipation of the sub...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198705000-00009
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVE:Lactation has been associated with attenuated hormonal responses to exercise stress in humans. This study was designed to determine the effect of lactation on hypothalamic-pituitary-adrenal axis, autonomic nervous system, and anxiety responses to psychological stress. METHOD:The Trier Social Stress Test was ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200109000-00015
更新日期:2001-09-01 00:00:00
abstract::Twelve subjects with specific phobias were exposed to slides with a phobic or a neutral content while cortisol excretion, electrodermal activity, and distress-ratings were studied. Six subjects fearful of blood and mutilation, and six of snakes or spiders, were presented with two sets of ten different slides (phobic o...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198507000-00001
更新日期:1985-07-01 00:00:00
abstract:OBJECTIVE:The study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate during workday activities. METHODS:Healthy, nonsmoking, habitual coffee drinkers (N = 21) received daily doses of 100 mg and 500 mg of caffeine on 2 days in a crossover design. Treatment order was ran...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199805000-00019
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:Sleep disturbances have been thought to augment pain. Sleep deprivation has been proven to produce hyperalgesic effects. It is still unclear whether these changes are truly specific to pain and not related to general changes in somatosensory functions. The aim of the present study was to evaluate the effect o...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000145912.24553.c0
更新日期:2004-11-01 00:00:00
abstract::This study examined the effects of Hurricane Andrew on physical symptoms and functional impairments in a sample of chronic fatigue syndrome (CFS) patients residing in South Florida. In the months after Hurricane Andrew (September 15-December 31, 1992), 49 CFS patients were assessed for psychosocial and physical functi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199507000-00002
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:The John Henryism hypothesis proposes that high-effort, active coping in impoverished, low-resource environments is associated with an increased risk of cardiovascular disease, but a lower risk of disease in a high-resource environment. To test this hypothesis, we examined the association of John Henryism Act...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000308
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVE:To examine the association between personality traits and longevity. METHODS:Using the Guilford-Zimmerman Temperament Survey, personality traits were assessed in 2359 participants (38% women; age = 17 to 98 years, mean = 50 years) from the Baltimore Longitudinal Study of Aging, starting in 1958. Over the dur...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31817b9371
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:Influenza and pneumonia account for significant morbidity and mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control sub...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200011000-00010
更新日期:2000-11-01 00:00:00
abstract::Recent technologic advances have permitted the observation of rapid and significant increases in blood pressure (BP) during verbal communication. The magnitude of the increase in BP is influenced by rate of speech, audience size, status, affective content, environmental setting, and resting BP. The current study evalu...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198601000-00008
更新日期:1986-01-01 00:00:00
abstract:OBJECTIVE:Major depressive disorder (MDD) is associated with more pain complaints and an altered pain perception. Studies regarding the longitudinal relationship between depressive symptoms and pain processing have rarely been performed and have produced inconsistent results. To clarify how short-term alleviation of de...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e31815c1b5d
更新日期:2008-01-01 00:00:00
abstract::Seventy-two healthy males were divided into Type A and Type B groups using the Jenkins Activity Survey. Subjects were subdivided further into high and low self-awareness categories on the private self-consciousness factor of the Self-Consciousness Scale. After random assignment to consume alcohol (0.85 g/kg) or a plac...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-198807000-00005
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:Several studies have shown that psychiatric disorders can be associated with venous thromboembolism (VTE) risk, that is, pulmonary embolism (PE) and/or deep vein thrombosis (DVT). In this study, we provide a systematic review and meta-analyses of the studies addressing this issue. METHODS:All studies address...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000863
更新日期:2020-11-01 00:00:00
abstract::An attempt was made to relate personality to premenstrual tension (PMT), using two groups of 40 parous and 40 mulliparous women, respectively composed of 20 single and 20 married subjects with an age range of 21 to 30 years. The menstrual instruction group had identical age range and means with the nonmenstrual group....
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198003000-00002
更新日期:1980-03-01 00:00:00
abstract:OBJECTIVE:Biochemical host defenses at mucosal sites, such as the oral cavity, play a key role in the regulation of microbial ecology and the prevention of infectious disease. These biochemical factors have distinct features, some of which benefit the host and some that benefit bacteria. We investigated the effects of ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200001000-00006
更新日期:2000-01-01 00:00:00
abstract::We studied the cardiovascular responses to orthostatic and mental stress of 43 healthy subjects who daily received six cups of boiled or filtered coffee and of 21 healthy subjects who abstained from caffeine-containing beverages. All 64 subjects first received six cups of filtered coffee/day for 2 weeks. Then blood pr...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199205000-00010
更新日期:1992-05-01 00:00:00
abstract:OBJECTIVES:To document changes in Axis I psychiatric disorders after bariatric surgery and examine their relationship with postsurgery weight loss. METHODS:As part of a three-site substudy of the Longitudinal Assessment of Bariatric Surgery Research Consortium, 199 patients completed the Structured Clinical Interview ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000277
更新日期:2016-04-01 00:00:00
abstract::Difficulties in predicting "real life" physiological variation from responses to controlled stress tasks suggest the need for more ecologically valid laboratory challenges. The Social Competence Interview (SCI) measures physiological changes elicited by re-experiencing a life situation in which a valued striving was u...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199105000-00003
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:Accurate perception of asthma episodes increases the likelihood that they will be managed effectively. The purpose of the study was to examine the effect of feedback in a signal detection task on perception of increased airflow obstruction in children with persistent asthma. METHODS:The effect of feedback tr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e3182a8bcde
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status. METHODS:Data from 38 HIV-positive and 29 HIV-negative children born to serop...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31829807fb
更新日期:2013-07-01 00:00:00
abstract::Twenty-one healthy women were studied during one menstrual cycle in order to determine whether cortisol and growth hormone responsivity to psychological stress was related to estrogen levels. Blood was drawn approximately three times per week for analysis of estradiol, progesterone, cortisol, and human growth hormone....
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197705000-00002
更新日期:1977-05-01 00:00:00
abstract:OBJECTIVE:To determine whether the relationship between interleukin (IL)-6 and depressive symptoms is moderated by participation in moderate-intensity physical activity in a sample of primary care patients. Elevated inflammation has been associated with a number of poor health outcomes. Depressive symptoms may be relat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182108412
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:Cancer-related distress due to the psychological and physical challenges of metastatic breast cancer (MBC) may result in symptoms of depression, which negatively affects quality and may influence quantity of life. This study investigated how depression affects MBC stress reactivity, including autonomic (ANS) ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000238216.88515.e5
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To assess the association of baseline anxiety with depression persistence and change in depressive symptoms 6 months after cardiac hospitalization. METHODS:Data were analyzed from 137 depressed patients hospitalized on inpatient cardiac units for acute coronary syndrome, decompensated heart failure, or arrhy...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e31823d38bc
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:This study investigated whether altruistic social interest behaviors such as engaging in helping others were associated with better physical and mental health in a stratified random sample of 2016 members of the Presbyterian Church throughout the United States. METHODS:Mailed questionnaires evaluated giving ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000079378.39062.d4
更新日期:2003-09-01 00:00:00
abstract::We studied 572 men and women who participated in a blood pressure screening program at a government unemployment office. Before having their blood pressures taken, the subjects completed a brief questionnaire that included two items measuring conflict over anger expression. Information was also obtained on obesity, ra...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198607000-00005
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:To examine the association between the experience of daily interpersonal stress and levels of C-reactive protein (CRP), an inflammatory marker that is a key indicator of cardiovascular risk, during the teenage years. METHODS:A total of 69 adolescents (Mage= 17.78 years) completed daily diary checklists each ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181921b1f
更新日期:2009-04-01 00:00:00