Abstract:
OBJECTIVE:The purpose of this study was to compare baseline levels of salivary cortisol, diurnal cortisol slopes, and cortisol reactivity to a mammogram in breast cancer survivors and women without a history of cancer. METHODS:Participants were 33 breast cancer survivors (3-5 years postdiagnosis) and 21 women with no history of cancer who were scheduled for a routine follow-up mammogram. The first assessment occurred for 3 consecutive days 1 month before the mammogram, and the second assessment occurred on the day before, the day of, and the day after the mammogram. On each of these days, women completed questionnaires and collected saliva samples 6 times/day. RESULTS:Results indicated that breast cancer survivors had higher levels of cortisol at baseline than controls. There were no group differences in diurnal slopes in cortisol concentration or cortisol responses to wakening. There were group differences in cortisol responses to the mammogram: In breast cancer survivors, cortisol levels decreased from the 3-day baseline period to the 3-day period around the mammogram, whereas in the control subjects mean daily cortisol levels increased around the mammogram. Among cancer survivors, there were no significant associations between cortisol measures and general stress ratings, although there were some associations with specific psychological responses to mammography. CONCLUSIONS:Results of this pilot study indicate that breast cancer survivors show elevated levels of basal cortisol and suppressed cortisol response to a cancer-related stressor several years after completing treatment. Future research is needed to understand whether these patterns of hypothalamic-pituitary-adrenal functioning are a result of physiologic stress associated with cancer treatment or disease process, psychological stress associated with fear of recurrence, or a combination of both.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Porter LS,Mishel M,Neelon V,Belyea M,Pisano E,Soo MSdoi
10.1097/01.psy.0000088595.91705.c5subject
Has Abstractpub_date
2003-09-01 00:00:00pages
842-8issue
5eissn
0033-3174issn
1534-7796journal_volume
65pub_type
杂志文章abstract:OBJECTIVE:Contextual factors can transform how we experience pain, particularly if pain is associated with other positive outcomes. Here, we test a novel meaning-based intervention. Participants were given the opportunity to choose to receive pain on behalf of their romantic partners, situating pain experience in a pos...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000609
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Lactation has been associated with attenuated hormonal responses to exercise stress in humans. This study was designed to determine the effect of lactation on hypothalamic-pituitary-adrenal axis, autonomic nervous system, and anxiety responses to psychological stress. METHOD:The Trier Social Stress Test was ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200109000-00015
更新日期:2001-09-01 00:00:00
abstract::This investigation assessed the syndromal nature of menstrual cycle changes in women who experience significant cyclicity of mood by exploring the time course of different symptoms in relation to endocrinologically defined segments of the menstrual cycle. Participants were accepted into the protocol on the basis of a ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198903000-00007
更新日期:1989-03-01 00:00:00
abstract::Difficulties in predicting "real life" physiological variation from responses to controlled stress tasks suggest the need for more ecologically valid laboratory challenges. The Social Competence Interview (SCI) measures physiological changes elicited by re-experiencing a life situation in which a valued striving was u...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199105000-00003
更新日期:1991-05-01 00:00:00
abstract:OBJECTIVE:To examine the association of anxiety with incident dementia and cognitive impairment not dementia (CIND). METHODS:We conducted a prospective study of men aged 48 to 67 years at baseline anxiety assessment; we measured cognition 17 years later. We studied 1481 men who were either eligible for examination or ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181a6177c
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to test the hypothesis that daily stress processes, including exposure and emotional reactivity to daily stressors, are associated with response time inconsistency (RTI), an indicator of processing efficiency and cognitive health. Furthermore, we considered daily stress-cognitive hea...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000643
更新日期:2019-01-01 00:00:00
abstract::The peripheral decarboxylase inhibitor carbidopa (L-alphamethyl-dopa-hydrazine) allowed safe intravenous administration of L-DOPA in amounts sufficient to alter cortical average evoked response (AER) and learning function in 13 depressed patients. The apparently rapid conversion of L-DOPA to dopamine, as reported from...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197603000-00003
更新日期:1976-03-01 00:00:00
abstract:OBJECTIVE:To test whether the association between depression and inflammation differs by race and sex. Depressive symptoms have been associated with higher levels of C-reactive protein (CRP). However, few studies have examined this association in samples including a significant number of African Americans, or examined ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318222379c
更新日期:2011-07-01 00:00:00
abstract::Twenty-two studies on the effects of psychological treatment on cancer patients are reviewed. Only studies that compared one or more experimental conditions with at least one control group have been considered. The studies were evaluated with respect to a) research methods, b) psychological interventions, and c) resul...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/00006842-199207000-00011
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:Psychological traits such as optimism and hostility affect coronary heart disease (CHD) risk, but mechanisms for this association are unclear. We hypothesized that optimism and hostility may affect CHD risk via changes in heart rate variability (HRV). METHODS:We conducted a longitudinal analysis using data f...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000672
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:We examined the relationship between hostility and mononuclear leukocyte (MNL) beta-adrenergic receptor function in a sample of young healthy males. METHOD:Thirty subjects were selected for having scored above 20 (N = 11) and below 14 (N = 19) on the Cook-Medley Hostility (Ho) scale. MNL beta-adrenergic rece...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199709000-00004
更新日期:1997-09-01 00:00:00
abstract::Rats with a genetic susceptibility to experimental hypertension were exposed daily for 13 weeks to a conflict situation that resulted in food deprivation and the application of electric shock. Other subjects were either food deprived, shocked, both food deprived and shocked but without conflict, or not experimentally ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197509000-00004
更新日期:1975-09-01 00:00:00
abstract:OBJECTIVE:Melissa officinalis (lemon balm) is contemporaneously used as a mild sedative and/or calming agent. Although recent research has demonstrated modulation of mood in keeping with these roles, no studies to date have directly investigated the effects of this herbal medication on laboratory-induced psychological ...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/01.psy.0000132877.72833.71
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To investigate whether a support intervention (warm touch enhancement) influences physiological stress systems that are linked to important health outcomes. Growing evidence points to a protective effect of social and emotional support on both morbidity and mortality. METHODS:In this study, 34 healthy marrie...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e318187aef7
更新日期:2008-11-01 00:00:00
abstract::Factor analysis of responses from 1002 men and women were used to define two subscales of the Cook and Medley Hostility Scale. Both the Cynicism and the Paranoid Alienation subscale described attitudes of mistrust and alienation, and both were correlated with MMPI factors measuring aspects of psychopathology. It was s...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198603000-00014
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:This study assessed the relation of stressful life events with survival after breast cancer. METHODS:This study was based on women with histologically confirmed, newly diagnosed, localized or regional stage breast cancer first treated in 1 of 11 Quebec City (Canada) hospitals from 1982 through 1984. Among 76...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200103000-00017
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to test the hypothesis that higher childhood cognitive ability is associated with reduced risk of decline in physical capability in late midlife. METHODS:Participants were 1954 men and women from the Medical Research Council National Survey of Health and Development with complete dat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000482
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Prior attempts to measure psychological responses to exercise are potentially limited by a failure to account for participants' expectations, the absence of a valid exercise placebo, and demand characteristics. The purpose of this study was to explore the main and interactive effects of a manipulation designe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000381
更新日期:2017-02-01 00:00:00
abstract::The association of peripheral arterial disease (PAD) with hostility, a component of Type A behavior, has not been investigated. Previous studies have found an association between coronary arterial disease and hostility. We used Doppler tests to define PAD as consisting of a resting index less than 0.9, absence of post...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198905000-00003
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:Ambulatory saliva collections for subsequent analysis of free cortisol levels are now frequently applied to measure adrenocortical activity in healthy subjects and patient populations. Despite the prime importance of accurate timing of saliva collection outside the laboratory, no data are available on the com...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000058374.50240.bf
更新日期:2003-03-01 00:00:00
abstract::This study investigated the relationship between anxiety and coronary artery disease (CAD). State (S-ANX) and trait (T-ANX) anxiety were assessed with the State-Trait Personality Inventory (STPI), which was administered to 373 patients (230 males, 143 females) 12 to 18 hr prior to their undergoing coronary arteriograp...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198703000-00002
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status. METHODS:Data from 38 HIV-positive and 29 HIV-negative children born to serop...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31829807fb
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a poss...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000137
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess the effects of participation in a mindfulness meditation-based stress reduction program on mood disturbance and symptoms of stress in cancer outpatients. METHODS:A randomized, wait-list controlled design was used. A convenience sample of eligible cancer patients enro...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-200009000-00004
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Autonomic nervous system activity is associated with neurobehavioral aspects of pain. Yogis use breathing, relaxation, and mindfulness to tolerate pain, which could influence autonomic responses. To evaluate how the link between autonomic responses and pain is altered by other factors, we compared perceptual ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000587
更新日期:2018-11-01 00:00:00
abstract:OBJECTIVE:Reexamine the claim that elderly Chinese-American women are able to prolong their lives until after the celebration of the Harvest Moon Festival. METHODS:See if independent 1985 to 2000 data for Chinese-, Korean-, and Vietnamese-Americans replicate results that were reported using 1960 to 1984 data for Chine...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000127875.38685.ba
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:To describe factors influencing chest pain expression in patients with cardiac or noncardiac disease. METHODS:The authors conducted a case presentation and review of literature. RESULTS:Causes of chest pain are diverse. Psychologic factors influence chest pain expression commonly in patients with or without...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/01.psy.0000146330.80895.77
更新日期:2004-11-01 00:00:00
abstract::Subjects with reported sleep-onset disturbance were given progressive relaxation training, placebo, or no-treatment. All three conditions showed significant improvement in daily reported sleep onset over the duration of the study. Between-condition effects were limited to relaxation superiority over no-treatment on St...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章
doi:10.1097/00006842-197605000-00003
更新日期:1976-05-01 00:00:00
abstract:OBJECTIVES:To hypothesize in a new and different population that administrative database (ADB) screening would identify somatizing patients by increasing numbers of visits, female gender, and greater percent of International Classification of Diseases, 9th Edition (ICD-9) primary diagnosis codes in musculoskeletal, ner...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31819cc783
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To analyze in a prospective cohort study if depressive symptoms are an independent predictor of mortality in kidney transplant recipients. METHODS:Data from 840 transplanted patients followed at a single outpatient transplant center were analyzed. Sociodemographic parameters and clinical data were collected ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181dbbb7d
更新日期:2010-07-01 00:00:00