Chronic stress modulates the immune response to a pneumococcal pneumonia vaccine.

Abstract:

OBJECTIVE:Influenza and pneumonia account for significant morbidity and mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control subjects. This study tested the hypothesis that stress can also significantly inhibit the IgG antibody response to a pneumococcal bacterial vaccine. METHOD:We measured antibody titers of current caregivers, former caregivers, and control subjects after vaccination with a pneumococcal bacterial vaccine. RESULTS:Caregivers showed deficits relative to controls and former caregivers in their antibody responses to vaccination. Although the groups did not differ before vaccination or in the rise in antibody 2 weeks or 1 month after vaccination, current caregivers had lower antibody titers 3 and 6 months after vaccination than either former caregivers or controls. CONCLUSIONS:These data, the first evidence that chronic stress can inhibit the stability of the IgG antibody response to a bacterial vaccine for pneumonia, provide additional evidence of health risks associated with dementia caregiving.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Glaser R,Sheridan J,Malarkey WB,MacCallum RC,Kiecolt-Glaser JK

doi

10.1097/00006842-200011000-00010

subject

Has Abstract

pub_date

2000-11-01 00:00:00

pages

804-7

issue

6

eissn

0033-3174

issn

1534-7796

journal_volume

62

pub_type

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