Abstract:
OBJECTIVE:Influenza and pneumonia account for significant morbidity and mortality, particularly in older individuals. Previous studies have shown that spousal caregivers of patients with dementia have poorer antibody and virus specific T cell responses to an influenza virus vaccine relative to noncaregiving control subjects. This study tested the hypothesis that stress can also significantly inhibit the IgG antibody response to a pneumococcal bacterial vaccine. METHOD:We measured antibody titers of current caregivers, former caregivers, and control subjects after vaccination with a pneumococcal bacterial vaccine. RESULTS:Caregivers showed deficits relative to controls and former caregivers in their antibody responses to vaccination. Although the groups did not differ before vaccination or in the rise in antibody 2 weeks or 1 month after vaccination, current caregivers had lower antibody titers 3 and 6 months after vaccination than either former caregivers or controls. CONCLUSIONS:These data, the first evidence that chronic stress can inhibit the stability of the IgG antibody response to a bacterial vaccine for pneumonia, provide additional evidence of health risks associated with dementia caregiving.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Glaser R,Sheridan J,Malarkey WB,MacCallum RC,Kiecolt-Glaser JKdoi
10.1097/00006842-200011000-00010subject
Has Abstractpub_date
2000-11-01 00:00:00pages
804-7issue
6eissn
0033-3174issn
1534-7796journal_volume
62pub_type
杂志文章abstract::Although increased morbidity and mortality have been reliably associated with social isolation and less satisfying personal relationships, relatively little is known about the underlying biopsychosocial mechanisms. We assessed problem-solving behaviors and changes in immune function in 90 newlywed couples who were adm...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199309000-00001
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181990fff
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Reexamine the claim that elderly Chinese-American women are able to prolong their lives until after the celebration of the Harvest Moon Festival. METHODS:See if independent 1985 to 2000 data for Chinese-, Korean-, and Vietnamese-Americans replicate results that were reported using 1960 to 1984 data for Chine...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000127875.38685.ba
更新日期:2004-05-01 00:00:00
abstract:OBJECTIVE:We examined the relationship between hostility and mononuclear leukocyte (MNL) beta-adrenergic receptor function in a sample of young healthy males. METHOD:Thirty subjects were selected for having scored above 20 (N = 11) and below 14 (N = 19) on the Cook-Medley Hostility (Ho) scale. MNL beta-adrenergic rece...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199709000-00004
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:Little is known about how patients who seek medical help for benign palpitations can be distinguished from those with clinically significant arrhythmias. This study tested whether patients with arrhythmia can be distinguished from those who are aware of sinus rhythm or extrasystoles on the basis of sex, preva...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200009000-00014
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVES:To document changes in Axis I psychiatric disorders after bariatric surgery and examine their relationship with postsurgery weight loss. METHODS:As part of a three-site substudy of the Longitudinal Assessment of Bariatric Surgery Research Consortium, 199 patients completed the Structured Clinical Interview ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000277
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to describe the sequence of psychosocial events and infections preceding the onset of chronic fatigue syndrome (CFS). This information was related to the temporal development of crucial symptoms in relation to the onset of, namely, fatigue, sadness, irritability, pain, and feelin...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199905000-00009
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between hostility and biological risk factors for coronary heart disease (CHD) in a population of white European and South Asian men and women living in the United Kingdom. METHODS:This cross-sectional study involved a community-based sample of 1,757 healthy white and South Asian ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181fd944c
更新日期:2011-01-01 00:00:00
abstract::Twelve subjects with specific phobias were exposed to slides with a phobic or a neutral content while cortisol excretion, electrodermal activity, and distress-ratings were studied. Six subjects fearful of blood and mutilation, and six of snakes or spiders, were presented with two sets of ten different slides (phobic o...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198507000-00001
更新日期:1985-07-01 00:00:00
abstract::Denial may be adaptive during hospitalization for acute coronary disease. We studied the impact of denial in 48 patients referred to a tertiary care center for treatment of unstable angina. Using the Hackett-Cassem Denial Scale, we divided the group into 25 high deniers and 23 low deniers. The two groups were comparab...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198901000-00003
更新日期:1989-01-01 00:00:00
abstract:OBJECTIVE:This article provides the chemical basis for the molecular modification of H1 antihistamines in the rational development of some antidepressant and antipsychotic drugs. METHODS:A review of the literature and personal experiences have been compiled. CONCLUSIONS:The contributions of many basic scientists, the...
journal_title:Psychosomatic medicine
pub_type: 历史文章,杂志文章
doi:10.1097/00006842-199909000-00002
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVE:This study evaluated the ability of mental stress testing to discriminate between women with and without CHD, and among women with different disease manifestations, taking into account history of hypertension and beta-blocker use. METHODS:Analyses were based on data from a community-based case-control study ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200111000-00010
更新日期:2001-11-01 00:00:00
abstract::The Adolescent Structured Interview (ASI), adapted from the interview that assesses Type A behavior of adults, was administered to 204 adolescents. These adolescents also completed a battery of self-report questionnaires that measured the three major components of Pattern A: competitive achievement-striving, speed and...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198108000-00004
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVE:To understand the mechanisms underlying chronic interpersonal difficulties and their detrimental influence on mental and physical health. METHODS:A total of 103 healthy young women (mean age = 17 years) were administered a structured interview to assess the degree of chronic interpersonal stress in their liv...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318190d7de
更新日期:2009-01-01 00:00:00
abstract::Twenty-two studies on the effects of psychological treatment on cancer patients are reviewed. Only studies that compared one or more experimental conditions with at least one control group have been considered. The studies were evaluated with respect to a) research methods, b) psychological interventions, and c) resul...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/00006842-199207000-00011
更新日期:1992-07-01 00:00:00
abstract::This study examined the effects of Hurricane Andrew on physical symptoms and functional impairments in a sample of chronic fatigue syndrome (CFS) patients residing in South Florida. In the months after Hurricane Andrew (September 15-December 31, 1992), 49 CFS patients were assessed for psychosocial and physical functi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199507000-00002
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:Depression and coronary heart disease (CHD) are comorbid conditions, and it is thought that depression may increase the risk of CHD. However, the evidence for the latter relationship is sparse and difficult to collect. Cynomolgus monkeys (Macaca fascicularis) have been used effectively as animal models of CHD...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000021951.59258.c7
更新日期:2002-09-01 00:00:00
abstract::Three studies on the relationship between life stresses and premature labor were conducted. The first was a retrospective comparison of life events between a group of women who had had premature labor and a group of controls. It was carried out between 3 and 6 months after the premature delivery to neutralize possible...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198605000-00006
更新日期:1986-05-01 00:00:00
abstract:OBJECTIVE:A model for the development of anxiety disorders (panic disorder with or without agoraphobia) is needed. Patients with an implantable cardioverter/defibrillator (ICD) are exposed to repeated electric shocks. If the theory of anxiety development by aversive classic conditioning processes is valid, these repeat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200103000-00006
更新日期:2001-03-01 00:00:00
abstract::This study's purpose was to examine the extent to which optimism, knowledge, attitudes, and beliefs predict use of HIV testing services in a group of at-risk female adolescents. We prospectively interviewed 124 consecutive girls engaging in risky behaviors before regularly scheduled pediatric clinic appointments at a ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199511000-00006
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:Previous research demonstrated that social environment can influence progression of atherosclerosis in the Watanabe Heritable Hyperlipidemic (WHHL) rabbit. This study examined the effect of social environment on markers of oxidative stress and inflammation to clarify the physiological pathways potentially res...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181646753
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:Medically unexplained symptoms (MUS), which are highly prevalent in all fields of medicine, are considered difficult to treat. The primary objective of this systematic review and meta-analysis was to assess the efficacy of self-help for adults with MUS. METHODS:Four electronic databases were searched for rel...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,meta分析,评审
doi:10.1097/PSY.0000000000000325
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To assess the relationship among Type D personality, self-efficacy, and medication adherence in patients with coronary heart disease. METHODS:The study design was prospective and observational. Type D personality, self-efficacy for illness management behaviors, and medication adherence were measured 3 weeks ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31823a5b2f
更新日期:2012-01-01 00:00:00
abstract::Patients who underwent repetitive repetitive coronary angiograms at an average interval of 17 months completed the Jenkins Activity Survey (n = 66) and were given the Rosenman diagnostic interview to measure Type A behavior (n = 45). Significant progression of coronary artery disease was judged to be an increase in oc...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197910000-00003
更新日期:1979-10-01 00:00:00
abstract:OBJECTIVE:We examined whether high waist-to-hip ratio (WHR) in women is a biomarker for increased testosterone (T) and higher levels of sexual desire. METHODS:Participants were 99 healthy nonobese premenopausal women. Trait levels of mean bioavailable T were estimated from three saliva samples collected at 8:00 am, 9:...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000151747.22904.d7
更新日期:2005-03-01 00:00:00
abstract::Several pathologies of the oral cavity have been associated with stress, so we investigated salivary-induced aggregation during psychological stress. In addition, salivary total protein, alpha-amylase, and secretory immunoglobulin A (s-IgA) were assessed. In this longitudinal study, 28 dental students provided unstimu...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199607000-00010
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:Macrophage migration inhibitory factor (MIF), a protein secreted by immune cells and the pituitary gland, may be associated with coronary artery disease (CAD) and the mental state of coronary patients. The first origin of MIF suggests positive, the second negative associations. The aim of this study was to ex...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/PSY.0b013e31802b8750
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:The study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate during workday activities. METHODS:Healthy, nonsmoking, habitual coffee drinkers (N = 21) received daily doses of 100 mg and 500 mg of caffeine on 2 days in a crossover design. Treatment order was ran...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199805000-00019
更新日期:1998-05-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that perfectionism is an important moderator of the neuroendocrine stress response, with higher perfectionism predicting increased neuroendocrine activation. METHODS:A total of 50 middle-aged men underwent an acute standardized psychosocial stress task (Trier Social Stress Test). Perfe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318042589e
更新日期:2007-04-01 00:00:00
abstract::The peripheral decarboxylase inhibitor carbidopa (L-alphamethyl-dopa-hydrazine) allowed safe intravenous administration of L-DOPA in amounts sufficient to alter cortical average evoked response (AER) and learning function in 13 depressed patients. The apparently rapid conversion of L-DOPA to dopamine, as reported from...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197603000-00003
更新日期:1976-03-01 00:00:00