History of modern psychopharmacology: a personal view with an emphasis on antidepressants.

Abstract:

OBJECTIVE:This article provides the chemical basis for the molecular modification of H1 antihistamines in the rational development of some antidepressant and antipsychotic drugs. METHODS:A review of the literature and personal experiences have been compiled. CONCLUSIONS:The contributions of many basic scientists, the crucial observations of clinicians, and the desire of the drug industry to make money have resulted in the currently available psychopharmacological treatments. The future development of psychopharmacology depends on better clinical research to generate new hypotheses of the chemical and behavioral pathology of mental disease. Psychosomatic medicine can make a unique contribution in its interdisciplinary role of stressing brain, body, and mind relationships.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Domino EF

doi

10.1097/00006842-199909000-00002

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

591-8

issue

5

eissn

0033-3174

issn

1534-7796

journal_volume

61

pub_type

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