Abstract:
OBJECTIVE:Medically unexplained symptoms (MUS), which are highly prevalent in all fields of medicine, are considered difficult to treat. The primary objective of this systematic review and meta-analysis was to assess the efficacy of self-help for adults with MUS. METHODS:Four electronic databases were searched for relevant studies. Randomized controlled trials comparing self-help to usual care or waiting list in adults with MUS were selected. Studies were critically appraised using the Cochrane "risk of bias assessment tool." Standardized mean differences (Hedges g) were pooled using a random-effects model. Outcomes were symptom severity and quality of life (QoL) directly posttreatment and at follow-up. RESULTS:Of 582 studies identified, 18 studies met all inclusion criteria. Studies were heterogeneous with regard to patient populations, intervention characteristics, and outcome measures. Compared with usual care or waiting list, self-help was associated with lower symptom severity (17 studies, n = 1894, g = 0.58, 95% confidence interval = 0.32-0.84, p < .001) and higher QoL (16 studies, n = 1504, g = 0.66, 95% confidence interval = 0.34-0.99, p < .001) directly posttreatment. Similar effect sizes were found at follow-up. A high risk of bias was established in most of the included studies. However, sensitivity analyses suggested that this did not significantly influence study results. Funnel plot asymmetry indicated potential publication bias. CONCLUSIONS:Self-help is associated with a significant reduction in symptom severity and improvement of QoL. The methodological quality of included studies was suboptimal, and further research is needed to confirm the findings of this meta-analysis.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
van Gils A,Schoevers RA,Bonvanie IJ,Gelauff JM,Roest AM,Rosmalen JGdoi
10.1097/PSY.0000000000000325subject
Has Abstractpub_date
2016-07-01 00:00:00pages
728-39issue
6eissn
0033-3174issn
1534-7796journal_volume
78pub_type
杂志文章,meta分析,评审abstract:OBJECTIVE:To determine whether the relationship between interleukin (IL)-6 and depressive symptoms is moderated by participation in moderate-intensity physical activity in a sample of primary care patients. Elevated inflammation has been associated with a number of poor health outcomes. Depressive symptoms may be relat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182108412
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate whether individuals with somatic symptom disorder (SSD) display increased resting-state functional connectivity (FC) within and between the sensorimotor network (SMN), default mode network (DMN), salience network, and dorsal attention network (DAN). METHODS:Eighteen patie...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000681
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:The protective effects of female gender on the appearance and course of coronary heart disease (CHD) in nondiabetic subjects are diminished in the presence of diabetes. Depression predicts onset of and poor outcome from CHD in nondiabetic populations. We hypothesized that the doubled rates of depression in fe...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000041624.96580.1f
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:Macrophage migration inhibitory factor (MIF), a protein secreted by immune cells and the pituitary gland, may be associated with coronary artery disease (CAD) and the mental state of coronary patients. The first origin of MIF suggests positive, the second negative associations. The aim of this study was to ex...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/PSY.0b013e31802b8750
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVE:This study examines whether stressful negative life events and pessimism were associated with lower natural killer cell cytotoxicity (NKCC) and T cytotoxic/suppressor cell (CD8+CD3+) percentage in black women co-infected with human immunodeficiency virus Type 1 (HIV-1) and human papillomavirus (HPV), a viral ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199811000-00009
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP monitoring, and in the laboratory environment during behavioral st...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200203000-00007
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:Research suggests that individuals with posttraumatic stress disorder (PTSD) are more likely to develop medical conditions and other stress-related psychiatric disorders. Given these findings and others suggesting that PTSD victims may have altered neuroendocrine and immune systems, the hypothesis that Vietn...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章
doi:10.1097/00006842-199905000-00019
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:This investigation explored the relationship of coping responses and parental history of hypertension to task-induced blood pressure changes. MATERIALS AND METHODS:The sample consisted of 215 black college student volunteers (median age = 25.95 y). During the speaking task, participants responded to standard...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000097331.10458.f1
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVES:Asthma is a chronic condition affecting 300 million people worldwide. Management involves adherence to pharmacological treatments such as corticosteroids and β-agonists, but residual symptoms persist. As asthma symptoms are exacerbated by stress, one possible adjunct to pharmacological treatment is expressiv...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0000000000000166
更新日期:2015-05-01 00:00:00
abstract::An attempt was made to relate personality to premenstrual tension (PMT), using two groups of 40 parous and 40 mulliparous women, respectively composed of 20 single and 20 married subjects with an age range of 21 to 30 years. The menstrual instruction group had identical age range and means with the nonmenstrual group....
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198003000-00002
更新日期:1980-03-01 00:00:00
abstract::Sixty subjects classified as either Type A or Type B interacted in pairs by pressing buttons which transmitted messages through a television screen while the heart rate and digital blood volume pulse were computer-monitored. Partners could cooperate, compete, punish, reward, or withdraw on each interaction and could s...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197902000-00002
更新日期:1979-02-01 00:00:00
abstract:OBJECTIVES:Subtle alterations of the hypothalamic-pituitary-adrenal (HPA) axis in chronic fatigue syndrome (CFS) have been proposed as a shared pathway linking numerous etiological and perpetuating processes with symptoms and observed physiological abnormalities. Because the HPA axis is involved in the adaptive respons...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000038937.67401.61
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine the relationship of lifestyle factors and neurocognitive functioning in older adults with vascular risk factors and cognitive impairment, no dementia (CIND). METHODS:One hundred sixty adults (M [SD] = 65.4 [6.8] years) with CIND completed neurocognitive assessments of ex...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000474
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:Perceived discrimination has been associated with psychosocial distress and adverse health outcomes. We examined associations of perceived discrimination measures with changes in kidney function in a prospective cohort study, the Healthy Aging in Neighborhoods of Diversity across the Life Span. METHODS:Our s...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000478
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Bipolar disorder (BD) is associated with elevated cardiovascular mortality rates. We investigated the modulation of l-arginine-nitric oxide (NO) signaling in platelets from patients with BD at different phases. METHODS:Platelets obtained from 28 patients with BD and 10 healthy volunteers were analyzed for l-...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182689460
更新日期:2012-10-01 00:00:00
abstract::We studied 572 men and women who participated in a blood pressure screening program at a government unemployment office. Before having their blood pressures taken, the subjects completed a brief questionnaire that included two items measuring conflict over anger expression. Information was also obtained on obesity, ra...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198607000-00005
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVE:The main aims of this study were a) to investigate the relationship between lightheadedness and cerebral blood flow velocity (CBFv) during hyperventilation-induced hypocapnia, and b) to investigate whether and why the relationship between lightheadedness and CBFv may change after several episodes of this sens...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181e68e94
更新日期:2010-09-01 00:00:00
abstract::Two separate studies assessed the influence on menstrual distress and related inhibition of such variables as predictability of onset, dispositional susceptibility to cultural expectations, and the attentional focus provided by labels. Greater predictability of onset was associated with more positive feedlings about m...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197908000-00004
更新日期:1979-08-01 00:00:00
abstract:OBJECTIVES:Rumination has been linked to self-reported sleep quality. However, whether rumination is related to an objective sleep parameter has not been tested. This study examined whether rumination predicts sleep onset latency (SOL) on the night after an acute psychosocial stressor. We hypothesized that those who ru...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181ae58e8
更新日期:2009-09-01 00:00:00
abstract::Previous studies suggest that the ways in which parents respond to children's health complaints (reinforcement) and the ways in which they cope with their own illnesses (modeling) influence the frequency of symptoms, disability days, and health care visits made by these children when they grow up. However, previous st...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199411000-00010
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:This study investigates psychological and psychobiological processes in patients with somatization syndrome. METHOD:We compared physiological measures (heart rate, finger pulse volume, electrodermal activity, electromyography), cortisol levels, and subjective well-being during rest and during a mental stress...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199803000-00016
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:Posttraumatic stress disorder (PTSD) is associated with indicators of poor physical health and sleep disturbance. This study investigated the relationship between PTSD and metabolic risk factors and examined the role of sleep duration in medically healthy and medication-free adults. METHODS:Participants with...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000176
更新日期:2015-05-01 00:00:00
abstract::Semantics and history of psychosomatic medicine are not popular topics nowadays, if they ever were; yet both of them constitute indispensable facets of any discipline that lays claim to a separate identity, as psychosomatics does. The latter, being an inchoate and inherently complex field of study, is especially in ne...
journal_title:Psychosomatic medicine
pub_type: 历史文章,杂志文章
doi:10.1097/00006842-198403000-00007
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to describe perceived and polysomnograhic (PSG) sleep patterns and determine whether stress exposure, psychological distress, and physiological stress activation differed among midlife women with psychophysiologic-type (PP-type) or subjective only-type (SO-type) insomnia or no ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000024235.11538.9a
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVE:To examine the role of self-efficacy and depression as potential pathways from physical activity to fatigue in two study samples: breast cancer survivors (BCS) (n = 192) and individuals with multiple sclerosis (MS) (n = 292). METHODS:We hypothesized that physical activity would be associated indirectly with ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181c68157
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:To examine the relationship between cardiac self-efficacy and health status, including symptom burden, physical limitation, quality of life, and overall health among outpatients with stable coronary heart disease (CHD). We hypothesized that lower self-efficacy would predict worse health status, independent of...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3180514d57
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVE:Depression and coronary heart disease (CHD) are comorbid conditions, and it is thought that depression may increase the risk of CHD. However, the evidence for the latter relationship is sparse and difficult to collect. Cynomolgus monkeys (Macaca fascicularis) have been used effectively as animal models of CHD...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000021951.59258.c7
更新日期:2002-09-01 00:00:00
abstract::This study examined the effects of Hurricane Andrew on physical symptoms and functional impairments in a sample of chronic fatigue syndrome (CFS) patients residing in South Florida. In the months after Hurricane Andrew (September 15-December 31, 1992), 49 CFS patients were assessed for psychosocial and physical functi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199507000-00002
更新日期:1995-07-01 00:00:00
abstract::The study consisted of 1101 Caucasian, male outpatients, who were screened for depression and hypertension in order to test the hypothesis that there is a unique relationship between these two illnesses. Depression was assessed by the Zung Self-Rating Depression Scale (SDS) while diastolic blood pressure (BP) was acce...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197703000-00008
更新日期:1977-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare baseline levels of salivary cortisol, diurnal cortisol slopes, and cortisol reactivity to a mammogram in breast cancer survivors and women without a history of cancer. METHODS:Participants were 33 breast cancer survivors (3-5 years postdiagnosis) and 21 women with no ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000088595.91705.c5
更新日期:2003-09-01 00:00:00