Abstract:
OBJECTIVE:To understand the mechanisms underlying chronic interpersonal difficulties and their detrimental influence on mental and physical health. METHODS:A total of 103 healthy young women (mean age = 17 years) were administered a structured interview to assess the degree of chronic interpersonal stress in their lives. At the same time, blood was drawn to measure systemic inflammation, the expression of signaling molecules that regulate immune activation, and leukocyte production of the cytokine interleukin-6 after ex vivo stimulation with lipopolysaccharide. All of the immunologic assessments were repeated 6 months later. RESULTS:To the extent subjects were high in chronic interpersonal stress at baseline, their leukocytes displayed greater increases in messenger ribonucleic acid (mRNA) for the proinflammatory transcription factor nuclear factor-kappaB (NF-kappaB) over the next 6 months. They also showed larger increases in mRNA for inhibitor of kappaB, a molecule that sequesters NF-kappaB in the cytoplasm and minimizes its proinflammatory activities. Chronic interpersonal stress at baseline was unrelated to changes in biomarkers of systemic inflammation but was associated with increasingly pronounced interleukin-6 responses to lipopolysaccharide. These associations were independent of demographics, lifestyle variables, and depressive symptoms. CONCLUSIONS:These findings suggest that chronic interpersonal difficulties accentuate expression of pro- and anti-inflammatory signaling molecules. Although this process does not result in systemic inflammation under quiescent conditions, it does accentuate leukocytes' inflammatory response to microbial challenge. These dynamics may underlie the excess morbidity associated with social stress, particularly in inflammation-sensitive diseases like depression and atherosclerosis.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Miller GE,Rohleder N,Cole SWdoi
10.1097/PSY.0b013e318190d7desubject
Has Abstractpub_date
2009-01-01 00:00:00pages
57-62issue
1eissn
0033-3174issn
1534-7796pii
PSY.0b013e318190d7dejournal_volume
71pub_type
杂志文章abstract:BACKGROUND:This study examined the effect of synthetic oxytocin delivered intranasally on acute pain sensitivity using a placebo-controlled, double-blind, within-participant crossover design. METHODS:Thirty-seven (18 were male) pain-free young adults underwent two laboratory sessions separated by 1 week. Each session ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000068
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:Suboptimal self-care by individuals with diabetes mellitus (DM) is a significant public health concern. The common-sense model (CSM) proposes that illness representations are associated with coping and health outcomes across various conditions. The present study examined the efficacy of a CSM-based interventi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000883
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The natural course of elevated depressive symptoms or subthreshold depression in patients with an acute coronary syndrome (ACS) is presented, as is the prognostic impact. Safe and effective psychological treatment options are desirable for subthreshold depression in patients with ACS, should they prove tolera...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/01.psy.0000116716.19848.65
更新日期:2004-03-01 00:00:00
abstract:OBJECTIVE:This study examines whether stressful negative life events and pessimism were associated with lower natural killer cell cytotoxicity (NKCC) and T cytotoxic/suppressor cell (CD8+CD3+) percentage in black women co-infected with human immunodeficiency virus Type 1 (HIV-1) and human papillomavirus (HPV), a viral ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199811000-00009
更新日期:1998-11-01 00:00:00
abstract::In this industrial-based study we compared the blood pressure (BP)-lowering effectiveness of relaxation, a beta blocker, and the combined use of these two treatments in 47 untreated, mildly hypertensive blue collar steel workers. Using a randomized two by two factorial design, patients received either nadolol or place...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-198909000-00004
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVES:African Americans are characterized by higher heart rate variability (HRV), a finding ostensibly associated with beneficial health outcomes. However, these findings are at odds with other evidence that blacks have worse cardiovascular outcomes. Here, we examine associations in a large cohort from the ELSA-Br...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000359
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:Although the association between major depressive disorder (MDD) and future cardiovascular disease (CVD) is established, less is known about the relationship between CVD risk factors and future depression, and no studies have examined MDD subtypes. Our objective was to determine whether hypertension, tobacco ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000583
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To examine the role of self-efficacy and depression as potential pathways from physical activity to fatigue in two study samples: breast cancer survivors (BCS) (n = 192) and individuals with multiple sclerosis (MS) (n = 292). METHODS:We hypothesized that physical activity would be associated indirectly with ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181c68157
更新日期:2010-01-01 00:00:00
abstract:OBJECTIVE:This study examined how the perception of parental caring, obtained from undergraduates, relates to subsequent health over the ensuing 35 years. METHODS:In the early 1950s, initial ratings of parental caring were obtained from a sample of healthy, Harvard undergraduate men who participated in the Harvard Mas...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199703000-00005
更新日期:1997-03-01 00:00:00
abstract::This study examined the effects of Hurricane Andrew on physical symptoms and functional impairments in a sample of chronic fatigue syndrome (CFS) patients residing in South Florida. In the months after Hurricane Andrew (September 15-December 31, 1992), 49 CFS patients were assessed for psychosocial and physical functi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199507000-00002
更新日期:1995-07-01 00:00:00
abstract::The association of peripheral arterial disease (PAD) with hostility, a component of Type A behavior, has not been investigated. Previous studies have found an association between coronary arterial disease and hostility. We used Doppler tests to define PAD as consisting of a resting index less than 0.9, absence of post...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198905000-00003
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:Hostility is associated with adverse outcomes in patients with coronary heart disease (CHD). However, assessment tools used to evaluate hostility in epidemiological studies vary widely. METHODS:We administered nine subscales of the Cook-Medley Hostility Scale (CMHS) to 656 outpatients with stable CHD between...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000059
更新日期:2014-05-01 00:00:00
abstract::Twenty-two studies on the effects of psychological treatment on cancer patients are reviewed. Only studies that compared one or more experimental conditions with at least one control group have been considered. The studies were evaluated with respect to a) research methods, b) psychological interventions, and c) resul...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/00006842-199207000-00011
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVES:Our objectives were to test whether Conscientiousness, the other 4 domains of the Five-Factor Model, and their facets predicted mortality in older, frail individuals. METHODS:Controlling for demographic and health measures, we used Cox regression to test whether the NEO Five-Factor Inventory (NEO-FFI) Neuro...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000181272.58103.18
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:This case report describes the use of sacral neuromodulation to treat urinary retention after sexual abuse. METHODS:Sacral neuromodulation was added to therapeutic regimen of a 38-year-old woman in whom chronic, complete urinary retention developed after psychological and sexual abuse during childhood. RESU...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200105000-00022
更新日期:2001-05-01 00:00:00
abstract:OBJECTIVES:Somatic symptom ratings covary with neuroticism. Yet, people vary from one another in their ability to report their own emotions and differentiate them from bodily sensations. We hypothesized that stressed individuals with greater emotional awareness would experience somatic symptoms in a more differentiated...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318203b86a
更新日期:2011-02-01 00:00:00
abstract::The development of seven esophageal atresia infants is described. These children differed in the quality of maternal care received and the amount of oral experience permitted during the first year of life. Observation of these infants suggest differences between effects of maternal depression and effects of abnormal o...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198001001-00010
更新日期:1980-01-01 00:00:00
abstract::The authors recruited 229 treatment-seeking anorexic and bulimic women for a prospective, longitudinal study. Telephone interviews were arranged every 3 months for at least 1 year for 225 patients. At intake, 132 subjects were menstruating, 34 subjects were taking oral contraceptives, 5 subjects had an organic cause f...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199503000-00004
更新日期:1995-03-01 00:00:00
abstract::The Adolescent Structured Interview (ASI), adapted from the interview that assesses Type A behavior of adults, was administered to 204 adolescents. These adolescents also completed a battery of self-report questionnaires that measured the three major components of Pattern A: competitive achievement-striving, speed and...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198108000-00004
更新日期:1981-08-01 00:00:00
abstract:OBJECTIVES:Rumination has been linked to self-reported sleep quality. However, whether rumination is related to an objective sleep parameter has not been tested. This study examined whether rumination predicts sleep onset latency (SOL) on the night after an acute psychosocial stressor. We hypothesized that those who ru...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181ae58e8
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:The proportion of overweight and obese people has grown rapidly, and obesity has now been widely recognized as an important public health problem. At the same time, stress has increased in working life. The 2 problems could be connected if work stress promotes unhealthy eating habits and sedentary behavior an...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000170330.08704.62
更新日期:2005-07-01 00:00:00
abstract::Emotional characteristics and processes are robust predictors of the development and course of major medical illnesses and premature mortality, as are a variety of indicators of the presence and quality of personal relationships. Despite clear evidence of close interconnection between these two domains of risk and pro...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000739
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVE:This study assessed the relation of stressful life events with survival after breast cancer. METHODS:This study was based on women with histologically confirmed, newly diagnosed, localized or regional stage breast cancer first treated in 1 of 11 Quebec City (Canada) hospitals from 1982 through 1984. Among 76...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200103000-00017
更新日期:2001-03-01 00:00:00
abstract::Twenty young male coffee-drinkers consumed 150 mg of caffeine in decaffeinated coffee three times a day for 8 days. On days 3, 4, 7, and 8, caffeine or a placebo was administered in the laboratory at 11 A.M., 8 A.M., 11 A.M., and 8 A.M., respectively, in a randomized double-blind crossover design. There was a blood pr...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199005000-00007
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:Persons with elevated blood pressure (BP) show dampened emotional responses to affect-laden stimuli. We sought to further examine cardiovascular-emotional dampening by examination of the relationship between resting hemodynamic measures and recognition of emotion in an African American community-based sample....
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e318235ed55
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:This study examined pituitary-adrenocortical responses to dietary doses of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee), alone and combined with behavioral stress, in men at high risk versus low risk for hypertension. A randomized, double-blind, caffeine-placebo crossover design was used. METHOD...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199807000-00021
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that increased levels of inflammatory and hemostatic markers are associated with poorer cognitive performance and to assess the influence of childhood intelligence quotient (IQ) and current cardiovascular disease (CVD) risk factors on this relationship. Blood inflammatory markers have b...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181a24fb9
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:Biochemical host defenses at mucosal sites, such as the oral cavity, play a key role in the regulation of microbial ecology and the prevention of infectious disease. These biochemical factors have distinct features, some of which benefit the host and some that benefit bacteria. We investigated the effects of ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200001000-00006
更新日期:2000-01-01 00:00:00
abstract::Recent research with animals has indicated a central nervous system effect on the immune system. This report describes findings of a possible psychologically mediated effect on the delayed hypersensitivity reaction to tuberculin in humans. Seven tuberculin positive subjects evidenced a decreased response to tuberculin...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198303000-00009
更新日期:1983-03-01 00:00:00
abstract:OBJECTIVE:This study was designed to evaluate the relationship between left ventricular (LV) mass and blood pressure (BP) recorded in the following contexts: in the clinic, using standard auscultatory procedures, during a typical day using ambulatory BP monitoring, and in the laboratory environment during behavioral st...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200203000-00007
更新日期:2002-03-01 00:00:00