Caffeine raises blood pressure at work.


OBJECTIVE:The study investigated the effects of moderate doses of caffeine on ambulatory blood pressure and heart rate during workday activities. METHODS:Healthy, nonsmoking, habitual coffee drinkers (N = 21) received daily doses of 100 mg and 500 mg of caffeine on 2 days in a crossover design. Treatment order was random and counterbalanced, and administration was double-blind. Ambulatory monitoring was conducted for 6 to 9 hours during normal workday activities and diary entries were completed at each measurement. Ambulatory data were analyzed for the effects of caffeine dose, controlling for variations in posture, physical activity, and perceived stress. RESULTS:The average workday blood pressure and heart rate were significantly higher when the higher dose of caffeine was consumed. Controlling for other factors, dose-related differences were 4 mm Hg for systolic and 3 mm Hg for diastolic blood pressure, and were 3 bpm for heart rate. CONCLUSIONS:Results support earlier evidence that caffeine raises blood pressure at work, and demonstrate that these pressor effects are independent of changes in posture, physical activity, or stress. Daily blood pressure increases associated with caffeine consumption could increase the risk of developing cardiovascular diseases. In addition, caffeine consumption effects might confound ambulatory investigations of the cardiovascular effects of other psychosocial, personality, or health-behavior factors.


Psychosom Med


Psychosomatic medicine


Lane JD,Phillips-Bute BG,Pieper CF




Has Abstract


1998-05-01 00:00:00












  • Role of monitoring and blunting coping styles in primary insomnia.

    abstract:OBJECTIVE:Primary insomnia is one of the most prevalent sleep disorders and assumed to be initiated and maintained, among other factors, by psychological variables such as coping strategies, sleep hygiene techniques, and arousability. Althouugh the number and kind of stressors seem to be important initiators of insomni...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Voss U,Kolling T,Heidenreich T

    更新日期:2006-01-01 00:00:00

  • Socioeconomic Position and Antidepressant Use as Predictors of Coronary Heart Disease Mortality: A Population-Based Registry Study of 362,271 Finns.

    abstract:OBJECTIVE:The interplay between depression and socioeconomic position (SEP) in predicting cardiovascular outcomes has rarely been examined. We investigated whether SEP modified the effect of antidepressant use on coronary heart disease (CHD) mortality. METHODS:The data consisted of an 11% random sample of the Finnish ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Konttinen H,Kilpi F,Moustgaard H,Martikainen P

    更新日期:2016-02-01 00:00:00

  • Telecommunications technology as an aid to family caregivers of persons with dementia.

    abstract:OBJECTIVE:The aging of the population implies that an increased number of people are going to need some form of care or assistance. Caregiving poses a range of physical, emotional, and financial demands and often causes burden and stress for family members. This article describes how technology can be used to provide s...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Czaja SJ,Rubert MP

    更新日期:2002-05-01 00:00:00

  • Effects of total sleep deprivation in major depression: overnight improvement of mood is accompanied by increased pain sensitivity and augmented pain complaints.

    abstract:OBJECTIVE:Major depressive disorder (MDD) is associated with more pain complaints and an altered pain perception. Studies regarding the longitudinal relationship between depressive symptoms and pain processing have rarely been performed and have produced inconsistent results. To clarify how short-term alleviation of de...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,随机对照试验


    authors: Kundermann B,Hemmeter-Spernal J,Huber MT,Krieg JC,Lautenbacher S

    更新日期:2008-01-01 00:00:00

  • Waist-to-hip ratio is positively associated with bioavailable testosterone but negatively associated with sexual desire in healthy premenopausal women.

    abstract:OBJECTIVE:We examined whether high waist-to-hip ratio (WHR) in women is a biomarker for increased testosterone (T) and higher levels of sexual desire. METHODS:Participants were 99 healthy nonobese premenopausal women. Trait levels of mean bioavailable T were estimated from three saliva samples collected at 8:00 am, 9:...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: van Anders SM,Hampson E

    更新日期:2005-03-01 00:00:00

  • Life events and acute cardiovascular reactions to mental stress: a cohort study.

    abstract:OBJECTIVE:This study addressed the issue of whether frequent exposure to life events is associated with aggravation or blunting of cardiovascular reactions to acute mental stress. METHODS:In a substantial cohort of 585 healthy young adults, systolic and diastolic blood pressure and pulse rate were recorded at rest and...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Phillips AC,Carroll D,Ring C,Sweeting H,West P

    更新日期:2005-05-01 00:00:00

  • Depression as an independent risk factor for mortality in critically ill patients.

    abstract:OBJECTIVE:Mortality on medical intensive care units (ICU) is approximately 25%. It is associated with age, severity of illness, and comorbidities. Preexisting depression is a risk factor for worse outcome in many diseases. The impact of depression on outcome of ICU patients has not been investigated. We assessed a poss...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Wewalka M,Warszawska J,Strunz V,Kitzberger R,Holzinger U,Fuhrmann V,Zauner C,Miehsler W,Moser G

    更新日期:2015-02-01 00:00:00

  • Daily Stress Processes as Contributors to and Targets for Promoting Cognitive Health in Later Life.

    abstract:OBJECTIVE:The aim of this study was to test the hypothesis that daily stress processes, including exposure and emotional reactivity to daily stressors, are associated with response time inconsistency (RTI), an indicator of processing efficiency and cognitive health. Furthermore, we considered daily stress-cognitive hea...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Stawski RS,Cerino ES,Witzel DD,MacDonald SWS

    更新日期:2019-01-01 00:00:00

  • Hyperventilation in anticipatory music performance anxiety.

    abstract:OBJECTIVES AND METHODS:Self-report studies have shown an association between music performance anxiety (MPA) and hyperventilation complaints. However, hyperventilation was never assessed physiologically in MPA. This study investigated the self-reported affective experience, self-reported physiological symptoms, and car...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Studer RK,Danuser B,Hildebrandt H,Arial M,Wild P,Gomez P

    更新日期:2012-09-01 00:00:00

  • Moderating effects of moderate-intensity physical activity in the relationship between depressive symptoms and interleukin-6 in primary care patients.

    abstract:OBJECTIVE:To determine whether the relationship between interleukin (IL)-6 and depressive symptoms is moderated by participation in moderate-intensity physical activity in a sample of primary care patients. Elevated inflammation has been associated with a number of poor health outcomes. Depressive symptoms may be relat...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Rethorst CD,Moynihan J,Lyness JM,Heffner KL,Chapman BP

    更新日期:2011-04-01 00:00:00

  • Mismatch in Spouses' Anger-Coping Response Styles and Risk of Early Mortality: A 32-Year Follow-Up Study.

    abstract:OBJECTIVE:Research in psychosomatic medicine includes a long history of studying how responses to anger-provoking situations are associated with health. In the context of a marriage, spouses may differ in their anger-coping response style. Where one person may express anger in response to unfair, aggressive interperson...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Bourassa KJ,Sbarra DA,Ruiz JM,Karciroti N,Harburg E

    更新日期:2019-01-01 00:00:00

  • Reverse causation in the association between C-reactive protein and fibrinogen levels and cognitive abilities in an aging sample.

    abstract:OBJECTIVE:To test the hypothesis that increased levels of inflammatory and hemostatic markers are associated with poorer cognitive performance and to assess the influence of childhood intelligence quotient (IQ) and current cardiovascular disease (CVD) risk factors on this relationship. Blood inflammatory markers have b...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Luciano M,Marioni RE,Gow AJ,Starr JM,Deary IJ

    更新日期:2009-05-01 00:00:00

  • Depressed mood, positive affect, and heart rate variability in patients with suspected coronary artery disease.

    abstract:OBJECTIVE:To test associations between heart rate variability (HRV), depressed mood, and positive affect in patients with suspected coronary artery disease (CAD). Depression is associated with impaired HRV post acute cardiac events, but evidence in patients with stable coronary artery disease (CAD) is inconsistent. ME...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究


    authors: Bhattacharyya MR,Whitehead DL,Rakhit R,Steptoe A

    更新日期:2008-11-01 00:00:00

  • Validation of the Women's Health Initiative Insomnia Rating Scale in a multicenter controlled clinical trial.

    abstract:OBJECTIVE:The objective of this study was to evaluate the construct validity of the five-item Women's Health Initiative Insomnia Rating Scale (WHIIRS) by comparing women taking hormone therapy (HT) versus those taking a placebo and by comparing women known to differ in vasomotor symptoms. METHODS:The WHIIRS was includ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Levine DW,Dailey ME,Rockhill B,Tipping D,Naughton MJ,Shumaker SA

    更新日期:2005-01-01 00:00:00

  • Evidence of early retinal microvascular changes in patients with type 2 diabetes and depression.

    abstract:OBJECTIVE:To examine retinal vascular caliber, an indicator of early microvascular disease and depression in patients with Type 2 diabetes. METHODS:We conducted a clinic-based study, comparing participants with Type 2 diabetes with major depression (n = 43), without depression (n = 49), and healthy controls without di...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Nguyen TT,Wong TY,Islam FM,Hubbard L,Ajilore O,Haroon E,Darwin C,Esser B,Kumar A

    更新日期:2010-07-01 00:00:00

  • Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm).

    abstract:OBJECTIVE:Melissa officinalis (lemon balm) is contemporaneously used as a mild sedative and/or calming agent. Although recent research has demonstrated modulation of mood in keeping with these roles, no studies to date have directly investigated the effects of this herbal medication on laboratory-induced psychological ...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kennedy DO,Little W,Scholey AB

    更新日期:2004-07-01 00:00:00

  • Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.

    abstract:OBJECTIVES:Subtle alterations of the hypothalamic-pituitary-adrenal (HPA) axis in chronic fatigue syndrome (CFS) have been proposed as a shared pathway linking numerous etiological and perpetuating processes with symptoms and observed physiological abnormalities. Because the HPA axis is involved in the adaptive respons...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Gaab J,Hüster D,Peisen R,Engert V,Heitz V,Schad T,Schürmeyer TH,Ehlert U

    更新日期:2002-11-01 00:00:00

  • The effect of chronic conflict on the blood pressure of rats with a genetic susceptibility to experimental hypertension.

    abstract::Rats with a genetic susceptibility to experimental hypertension were exposed daily for 13 weeks to a conflict situation that resulted in food deprivation and the application of electric shock. Other subjects were either food deprived, shocked, both food deprived and shocked but without conflict, or not experimentally ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Friedman R,Dahl LK

    更新日期:1975-09-01 00:00:00

  • Effects of progressive relaxation on sleep disturbance: an electroencephalographic evaluation.

    abstract::Subjects with reported sleep-onset disturbance were given progressive relaxation training, placebo, or no-treatment. All three conditions showed significant improvement in daily reported sleep onset over the duration of the study. Between-condition effects were limited to relaxation superiority over no-treatment on St...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章


    authors: Borkovec TD,Weerts TC

    更新日期:1976-05-01 00:00:00

  • Psychiatric Disorders, Morbidity, and Mortality: Tracing Mechanistic Pathways to Accelerated Aging.

    abstract::A meta-analysis published in this issue of Psychosomatic Medicine provides convincing evidence that certain psychiatric populations have shorter telomeres than nonpsychiatric controls, in accord with the strong evidence linking psychiatric disorders with premature mortality. After addressing the clinical significance ...

    journal_title:Psychosomatic medicine

    pub_type: 评论,社论


    authors: Kiecolt-Glaser JK,Wilson SJ

    更新日期:2016-09-01 00:00:00

  • Cardiovascular and neuroendocrine responses to extended laboratory challenge.

    abstract::The purpose of this study was to examine the effects of a 2-hour laboratory challenge on heart rate, blood pressure, catecholamines, and cortisol; and investigate the contribution of the physical act of speaking on both neuroendocrine and cardiovascular measures. Using a within-subjects design, 14 subjects were tested...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: McCann BS,Carter J,Vaughan M,Raskind M,Wilkinson CW,Veith RC

    更新日期:1993-11-01 00:00:00

  • Tetrahydrocortisol/tetrahydrocortisone ratio (H4F/H4E) as an indicator of depressive feelings.

    abstract::Tetrahydrocortisol (H4F) and tetrahydrocortisone (H4E) were determined for a group of 15 depressed patients and 25 normal controls following the administration of cortisol-4-C14. The ratio, H4F/H4E, was significantly greater for the depressed patients than for the normal controls (P less than 0.001), although the sum ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Persky H

    更新日期:1976-01-01 00:00:00

  • Respiratory airway changes in response to suggestion in normal individuals.

    abstract::Thirty normal individuals were told they were inhaling a substance that would either cause breathing difficulty (N = 15) or not affect breathing (N = 15). Total respiratory resistance was measured prior to and during inhalation. In reality, the subjects inhaled no substance; inhalation consisted of breathing normally ...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Kotses H,Rawson JC,Wigal JK,Creer TL

    更新日期:1987-09-01 00:00:00

  • Higher abnormal leukocyte and lymphocyte counts 20 years after exposure to severe stress: research and clinical implications.

    abstract:OBJECTIVES:Research suggests that individuals with posttraumatic stress disorder (PTSD) are more likely to develop medical conditions and other stress-related psychiatric disorders. Given these findings and others suggesting that PTSD victims may have altered neuroendocrine and immune systems, the hypothesis that Vietn...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章


    authors: Boscarino JA,Chang J

    更新日期:1999-05-01 00:00:00

  • Transforming Pain With Prosocial Meaning: A Functional Magnetic Resonance Imaging Study.

    abstract:OBJECTIVE:Contextual factors can transform how we experience pain, particularly if pain is associated with other positive outcomes. Here, we test a novel meaning-based intervention. Participants were given the opportunity to choose to receive pain on behalf of their romantic partners, situating pain experience in a pos...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: López-Solà M,Koban L,Wager TD

    更新日期:2018-11-01 00:00:00

  • Parental history of hypertension and coping responses predict blood pressure changes in black college volunteers undergoing a speaking task about perceptions of racism.

    abstract:OBJECTIVE:This investigation explored the relationship of coping responses and parental history of hypertension to task-induced blood pressure changes. MATERIALS AND METHODS:The sample consisted of 215 black college student volunteers (median age = 25.95 y). During the speaking task, participants responded to standard...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Clark R

    更新日期:2003-11-01 00:00:00

  • Smoking status and nicotine administration differentially modify hemodynamic stress reactivity in men and women.

    abstract:OBJECTIVES:To investigate the impact of cigarette smoking and oral contraceptive (OC) use on hemodynamic stress responses of women. Also, to examine gender differences in stress reactivity as a function of smoking status and acute nicotine administration. METHODS:Thirty men and 46 women, differing in smoking status an...

    journal_title:Psychosomatic medicine

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Girdler SS,Jamner LD,Jarvik M,Soles JR,Shapiro D

    更新日期:1997-05-01 00:00:00

  • Compliance with saliva sampling protocols: electronic monitoring reveals invalid cortisol daytime profiles in noncompliant subjects.

    abstract:OBJECTIVE:Ambulatory saliva collections for subsequent analysis of free cortisol levels are now frequently applied to measure adrenocortical activity in healthy subjects and patient populations. Despite the prime importance of accurate timing of saliva collection outside the laboratory, no data are available on the com...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Kudielka BM,Broderick JE,Kirschbaum C

    更新日期:2003-03-01 00:00:00

  • Asian-American deaths near the Harvest Moon Festival.

    abstract:OBJECTIVE:Reexamine the claim that elderly Chinese-American women are able to prolong their lives until after the celebration of the Harvest Moon Festival. METHODS:See if independent 1985 to 2000 data for Chinese-, Korean-, and Vietnamese-Americans replicate results that were reported using 1960 to 1984 data for Chine...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Smith G

    更新日期:2004-05-01 00:00:00

  • Brain Structure and Response to Emotional Stimuli as Related to Gut Microbial Profiles in Healthy Women.

    abstract:OBJECTIVE:Brain-gut-microbiota interactions may play an important role in human health and behavior. Although rodent models have demonstrated effects of the gut microbiota on emotional, nociceptive, and social behaviors, there is little translational human evidence to date. In this study, we identify brain and behavior...

    journal_title:Psychosomatic medicine

    pub_type: 杂志文章


    authors: Tillisch K,Mayer EA,Gupta A,Gill Z,Brazeilles R,Le Nevé B,van Hylckama Vlieg JET,Guyonnet D,Derrien M,Labus JS

    更新日期:2017-10-01 00:00:00