Abstract:
OBJECTIVE:Previous research demonstrated that social environment can influence progression of atherosclerosis in the Watanabe Heritable Hyperlipidemic (WHHL) rabbit. This study examined the effect of social environment on markers of oxidative stress and inflammation to clarify the physiological pathways potentially responsible for the influence of social environment on disease. METHODS AND RESULTS:WHHL rabbits were assigned to 1 of 3 social groups: an unstable group, in which unfamiliar rabbits were paired daily, with the pairing switched each week; a stable group, in which littermates were paired daily; and an individually-caged group. The stable group engaged in more affiliative social behavior than the unstable group. The unstable group showed more agonistic behavior compared with the stable group and higher C-reactive protein levels than the individually caged group. The individually caged group was behaviorally sedentary, had higher 24-hour urinary catecholamine levels than the other groups, and exhibited higher NAD(P)H-oxidase activity in the aortic arch relative to the stable group. CONCLUSIONS:The results suggest that social environment creates distinct behavioral contexts that can affect markers of inflammation and oxidative stress early in the development of atherosclerosis. Specifically, physical inactivity associated with individual caging affects indices of oxidative stress and inflammation. These pathophysiological markers may help to explain behaviorally related differences in the extent of atherosclerosis observed in prior studies.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Nation DA,Gonzales JA,Mendez AJ,Zaias J,Szeto A,Brooks LG,Paredes J,D'Angola A,Schneiderman N,McCabe PMdoi
10.1097/PSY.0b013e3181646753subject
Has Abstractpub_date
2008-04-01 00:00:00pages
269-75issue
3eissn
0033-3174issn
1534-7796pii
PSY.0b013e3181646753journal_volume
70pub_type
杂志文章abstract:OBJECTIVE:The purpose of this study was to examine the association between psychobiological stress reactivity during healthy pregnancy and depressive symptoms in the early puerperium. METHODS:A sample of healthy nulliparous pregnant women (N = 57) between the ages of 21 and 35 years underwent a standardized psychosoci...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000244385.93141.3b
更新日期:2006-11-01 00:00:00
abstract::Thirty-five consecutive patients with Cushing's syndrome were studied prospectively prior to treatment. A consistent constellation of psychiatric disturbances was found, including impairments in affect (depressed mood and crying), cognitive functions (decreased concentration and memory), and vegetative functions (decr...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198102000-00002
更新日期:1981-02-01 00:00:00
abstract:OBJECTIVE:Activation of a psychological stress response increases autonomic activity and enhances immune function by inducing a significant increase in numbers of leukocytes at sites of inflammation. Chemotaxis and cellular adhesion are thought to mediate leukocyte trafficking. In this study, we examine the effects of ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000079377.86193.a8
更新日期:2003-07-01 00:00:00
abstract:OBJECTIVE:This study assessed the relation of stressful life events with survival after breast cancer. METHODS:This study was based on women with histologically confirmed, newly diagnosed, localized or regional stage breast cancer first treated in 1 of 11 Quebec City (Canada) hospitals from 1982 through 1984. Among 76...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200103000-00017
更新日期:2001-03-01 00:00:00
abstract::As increasing numbers of patients survive acute leukemia, it has become important to study the long-term psychological and social adjustment of patients who have successfully completed their leukemia treatment. An important aspect of this inquiry is comparing the long-term psychosocial impact of two treatments for acu...
journal_title:Psychosomatic medicine
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doi:10.1097/00006842-199201000-00006
更新日期:1992-01-01 00:00:00
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journal_title:Psychosomatic medicine
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doi:10.1097/PSY.0b013e318276cb0d
更新日期:2013-01-01 00:00:00
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journal_title:Psychosomatic medicine
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更新日期:2007-09-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000059
更新日期:2014-05-01 00:00:00
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journal_title:Psychosomatic medicine
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更新日期:2002-11-01 00:00:00
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更新日期:2011-02-01 00:00:00
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journal_title:Psychosomatic medicine
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更新日期:2020-04-01 00:00:00
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doi:10.1097/PSY.0b013e3182280016
更新日期:2011-09-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
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更新日期:2010-07-01 00:00:00
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更新日期:2012-10-01 00:00:00
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doi:10.1097/PSY.0b013e31816fd7d0
更新日期:2008-05-01 00:00:00
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doi:10.1097/00006842-200009000-00014
更新日期:2000-09-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198603000-00014
更新日期:1986-03-01 00:00:00
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doi:10.1097/PSY.0b013e31828d3cb6
更新日期:2013-05-01 00:00:00
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更新日期:1989-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-07-01 00:00:00
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doi:10.1097/PSY.0b013e3182108412
更新日期:2011-04-01 00:00:00
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doi:10.1097/00006842-199809000-00021
更新日期:1998-09-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200109000-00015
更新日期:2001-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1097/00006842-197507000-00004
更新日期:1975-07-01 00:00:00
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journal_title:Psychosomatic medicine
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doi:10.1097/PSY.0000000000000169
更新日期:2015-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199411000-00010
更新日期:1994-11-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
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更新日期:2017-09-01 00:00:00