Abstract:
OBJECTIVE:Despite a well-documented association between stress and depression with cardiac morbidity and mortality, there is no satisfactory explanation for the mechanisms linking affective and cardiac disorders. This study investigated cardiac electrophysiological properties in an animal model of depression. METHODS:Depression-relevant physiological and behavioral parameters were measured in adult male wild-type rats during and after a period of intermittent social defeat stress (n = 12) or empty cage exposure (control, n = 11). Nine days after the last defeat/empty cage exposure, high-definition epicardial mapping was performed under anesthesia. RESULTS:Stressed animals versus controls displayed a larger reduction in the circadian amplitude of heart rate (-32% [3%] versus -13 [2%]; p = .001) and body temperature (-33% [4%] versus -5% [2%]; p = .001) rhythms, had smaller body weight gain (+11% [1%] versus +17% [1%]; p < .001), and showed a larger reduction in sucrose solution intake (-19% [6%] versus -7% [4%]; p = .006). Epicardial mapping analysis revealed a decrease in the transversal conduction velocity of the wavefront (0.23 [0.0] versus 0.27 [0.1] m/s; p = .02) and a shortening of the effective refractory period (86.8 [2.1] versus 95.9 [3.0] milliseconds; p = .01) in stressed animals. Upon killing, moderate left ventricular fibrosis was observed in the stressed group. CONCLUSIONS:Intermittent social stress procedure is associated with depression-like symptoms and altered myocardial electrical stability in a potentially proarrhythmic manner. In particular, reduced myocardial refractoriness and impaired conduction, which are considered major determinants of arrhythmogenesis, represent possible mechanisms underlying cardiac vulnerability.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Carnevali L,Trombini M,Rossi S,Graiani G,Manghi M,Koolhaas JM,Quaini F,Macchi E,Nalivaiko E,Sgoifo Adoi
10.1097/PSY.0b013e318276cb0dsubject
Has Abstractpub_date
2013-01-01 00:00:00pages
42-51issue
1eissn
0033-3174issn
1534-7796pii
PSY.0b013e318276cb0djournal_volume
75pub_type
杂志文章abstract::Davidson and Schwartz (1) have proposed a psychobiological analysis of anxiety that emphasizes the patterning of multiple processes in the generation and self-regulation of this state. The present article specifically reviews recent research on cognitive and somatic components of anxiety. A dual component scale which ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-197806000-00004
更新日期:1978-06-01 00:00:00
abstract::The study of depression in cancer patients has been hampered by difficulty in establishing diagnostic criteria, since neurovegetative signs and symptoms may be attributable either to depression or physical illness. Confusion has also arisen in defining the boundary between "normal" grieving with illness, and "abnormal...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198405000-00002
更新日期:1984-05-01 00:00:00
abstract:OBJECTIVE:To determine if depression contributes to incident heart disease after accounting for genetic, behavioral, and medical factors associated with both conditions. METHODS:We used a prospective twin study with a 12-year follow-up. In 1992, lifetime diagnosis of depression was assessed in 1159 male-male twins and...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e3181d28125
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:Despite the abundant literature on the consequences of intimate partner violence (IPV) on mental health, psychological abuse has rarely been considered, and the separate effects of the different types of IPV have been understudied. The aim of this study was to analyze the association between physical, psychol...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000181269.11979.cd
更新日期:2005-09-01 00:00:00
abstract::Social interactions have long-term physiological, psychological, and behavioral consequences. Social isolation is a well-recognized but little understood risk factor and prognostic marker of disease; it can have profoundly detrimental effects on both mental and physical well-being, particularly during states of compro...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
doi:10.1097/PSY.0b013e3182002116
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to evaluate whether individuals with somatic symptom disorder (SSD) display increased resting-state functional connectivity (FC) within and between the sensorimotor network (SMN), default mode network (DMN), salience network, and dorsal attention network (DAN). METHODS:Eighteen patie...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000681
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To examine the cross-sectional associations among race, depressive symptoms, and aortic and coronary calcification in a sample of middle-aged women. Depressive symptoms have been associated with atherosclerotic indicators of coronary heart disease (CHD) in white women. Few studies have examined these associat...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究
doi:10.1097/PSY.0b013e31819080e5
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:This study examined pituitary-adrenocortical responses to dietary doses of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee), alone and combined with behavioral stress, in men at high risk versus low risk for hypertension. A randomized, double-blind, caffeine-placebo crossover design was used. METHOD...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199807000-00021
更新日期:1998-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181656a48
更新日期:2008-04-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198709000-00009
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:To assess whether a life-style physical activity intervention improved antibody response to a pneumococcal vaccination in sedentary middle-aged women. METHODS:Eighty-nine sedentary women completed a 16-week exercise (physical activity consultation, pedometer, telephone/e-mail prompts; n = 44) or control (adv...
journal_title:Psychosomatic medicine
pub_type: 杂志文章,随机对照试验
doi:10.1097/PSY.0b013e3182a0b664
更新日期:2013-10-01 00:00:00
abstract::The plasma cholesterol levels of 279 students were measured and related to decision and movement times in choice reaction time tasks with one, two, four, and eight lamps. In female subjects, low plasma cholesterol levels were associated with slower movement times and, when responding to one or two lamps, slower decisi...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199501000-00008
更新日期:1995-01-01 00:00:00
abstract:OBJECTIVE:A role for the brain-derived neurotrophic factor (BDNF) in the regulation of eating behavior has been recently demonstrated. Therefore, the possibility exists that alterations in BDNF production and/or activity are involved in the pathophysiology of anorexia nervosa (AN) and obesity. METHODS:We measured morn...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000138119.12956.99
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:This case report describes the use of sacral neuromodulation to treat urinary retention after sexual abuse. METHODS:Sacral neuromodulation was added to therapeutic regimen of a 38-year-old woman in whom chronic, complete urinary retention developed after psychological and sexual abuse during childhood. RESU...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200105000-00022
更新日期:2001-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000059
更新日期:2014-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3182572599
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181990fff
更新日期:2009-04-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199609000-00011
更新日期:1996-09-01 00:00:00
abstract::Symptomatic individuals suspected of having myocardial ischemia often have no obstructive atherosclerotic narrowing of epicardial coronary arteries. Abnormal coronary vascular reactivity and, in particular, coronary artery vasospasm (CAS) may be an explanation in a subset of these patients. Psychological factors play ...
journal_title:Psychosomatic medicine
pub_type: 评论,杂志文章
doi:10.1097/PSY.0000000000000682
更新日期:2019-04-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000493
更新日期:2017-10-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e3181a6177c
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:Somatic symptom disorder (SSD) often co-occurs with major depressive disorder (MDD). Both conditions share common psychobiological and biobehavioral characteristics, but little is known about differential patterns in brain function. In this study, we compared resting-state functional brain connectivity betwee...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0000000000000490
更新日期:2017-11-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31828d3cb6
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:Little is known about how patients who seek medical help for benign palpitations can be distinguished from those with clinically significant arrhythmias. This study tested whether patients with arrhythmia can be distinguished from those who are aware of sinus rhythm or extrasystoles on the basis of sex, preva...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-200009000-00014
更新日期:2000-09-01 00:00:00
abstract:OBJECTIVE:Psychological factors such as depression affect recovery after whiplash-associated disorders. This study examined the prevalence of pain-related emotions, such as frustration, anger, and anxiety, and their predictive value for postcrash pain recovery during a 1-year follow-up. METHODS:A population-based pros...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31822f991a
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To explore whether primary school entry is associated with changes in immune system parameters in HIV-affected children. HIV-affected children are vulnerable to psychosocial stressors, regardless of their own HIV serological status. METHODS:Data from 38 HIV-positive and 29 HIV-negative children born to serop...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/PSY.0b013e31829807fb
更新日期:2013-07-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1097/01.psy.0000151743.58067.f0
更新日期:2005-01-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198605000-00001
更新日期:1986-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000088595.91705.c5
更新日期:2003-09-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-198909000-00004
更新日期:1989-09-01 00:00:00