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Interactive effects of race and depressive symptoms on calcification in African American and white women.

Abstract：

OBJECTIVE:To examine the cross-sectional associations among race, depressive symptoms, and aortic and coronary calcification in a sample of middle-aged women. Depressive symptoms have been associated with atherosclerotic indicators of coronary heart disease (CHD) in white women. Few studies have examined these associations in samples including African American women, or explored whether any observed associations differ by race. METHODS:Participants were 508 (38% African American, 62% white) women. Aortic and coronary calcification were measured by electron beam tomography and depressive symptoms were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D). Multivariable linear and logistic regression models were conducted to test associations. RESULTS:In linear regression models adjusted for race, depressive symptoms were associated with a greater amount of aortic calcification (beta = 0.03, p = .01), and there was a significant race x depressive symptoms interaction (beta = 0.07, p = .006). Findings for depressive symptoms (odds ratio (OR) = 1.03, 95% Confidence Interval (CI) = 1.0-1.06, p = .07), and the race x depressive symptoms interaction (OR = 1.1, 95% CI = 1.01-1.18, p = .01) were similar in race-adjusted multinomial logistic regression models predicting high levels of aortic calcification. Race-specific models revealed a significant association between depressive symptoms and aortic calcification in African American, but not white women. Additional adjustments for education, study site, and CHD risk factors did not alter these results. Depressive symptoms were not associated with coronary calcification for women of either racial group. CONCLUSIONS:African American women may be particularly vulnerable to the effects of depressive symptoms on early atherosclerotic disease.

journal_name

Psychosom Med

journal_title

Psychosomatic medicine

authors

Lewis TT,Everson-Rose SA,Colvin A,Matthews K,Bromberger JT,Sutton-Tyrrell K

doi

10.1097/PSY.0b013e31819080e5

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

163-70

issue

eissn

0033-3174

issn

1534-7796

pii

PSY.0b013e31819080e5

journal_volume

pub_type

杂志文章,多中心研究

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Interactive effects of race and depressive symptoms on calcification in African American and white women.