Abstract:
OBJECTIVE:Although the association between major depressive disorder (MDD) and future cardiovascular disease (CVD) is established, less is known about the relationship between CVD risk factors and future depression, and no studies have examined MDD subtypes. Our objective was to determine whether hypertension, tobacco use, and body mass index (BMI) differentially predict atypical and typical MDD in a national sample of US adults. METHODS:We examined prospective data from 22,915 adults with no depressive disorder history at baseline who participated in Wave 1 (2001-2002) and Wave 2 (2004-2005) of the National Epidemiologic Survey on Alcohol and Related Conditions. CVD risk factors (Wave 1) and incident MDD subtypes (Wave 2) were determined by structured interviews. RESULTS:There were 252 patients with atypical MDD and 991 patients with typical MDD. In fully adjusted models, baseline hypertension (odds ratio [OR] = 0.57, 95% confidence interval [CI] = 0.43-0.76), former tobacco use (OR = 1.46, 95% CI = 1.20-1.78), and BMI (OR = 1.32, 95% CI = 1.25-1.40; all p < .001) predicted incident atypical MDD versus no MDD, whereas no CVD risk factor predicted incident typical MDD. Baseline hypertension (OR = 0.52, 95% CI = 0.39-0.70), former tobacco use (OR = 1.53, 95% CI = 1.22-1.93), and BMI (OR = 1.26, 95% CI = 1.18-1.36; all p < .001) also predicted incident atypical MDD versus typical MDD. CONCLUSIONS:Our study is the first to report that CVD risk factors differentially predict MDD subtypes, with hypertension (protective factor), former tobacco use (risk factor), and BMI (risk factor) being stronger predictors of incident atypical versus typical MDD. Such evidence could provide insights into the etiologies of MDD subtypes and inform interventions tailored to MDD subtype.
journal_name
Psychosom Medjournal_title
Psychosomatic medicineauthors
Patel JS,Berntson J,Polanka BM,Stewart JCdoi
10.1097/PSY.0000000000000583subject
Has Abstractpub_date
2018-07-01 00:00:00pages
508-514issue
6eissn
0033-3174issn
1534-7796journal_volume
80pub_type
杂志文章abstract:OBJECTIVE:This study investigated whether altruistic social interest behaviors such as engaging in helping others were associated with better physical and mental health in a stratified random sample of 2016 members of the Presbyterian Church throughout the United States. METHODS:Mailed questionnaires evaluated giving ...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/01.psy.0000079378.39062.d4
更新日期:2003-09-01 00:00:00
abstract::This study examines the effectiveness of an intervention for minor depression in primary care patients. One hundred fifty public care medical patients were randomly assigned to either an 8-week cognitive-behavioral course intended to help them use pleasant activities, constructive thinking, and interpersonal relations...
journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199403000-00009
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abstract::Aerobic fitness is associated with numerous physiological adaptations which permit physical stress to be coped with more efficiently. The present experiment examined whether aerobic fitness influences emotional response. Heart rate, biochemical measures (catecholamines, cortisol, prolactin, lactic acid), and self-repo...
journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198306000-00003
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-198102000-00002
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journal_title:Psychosomatic medicine
pub_type: 杂志文章
doi:10.1097/00006842-199809000-00011
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journal_title:Psychosomatic medicine
pub_type: 评论,社论
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journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00006842-199705000-00012
更新日期:1997-05-01 00:00:00
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journal_title:Psychosomatic medicine
pub_type: 杂志文章,评审
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abstract::Sleep disturbance was studied in relation to psychiatric and physical symptoms for 214 male psychiatric outpatients and 248 male nonpatients. Our self-report instrument required that subjects describe the frequency of symptoms precisely on a five-point scale from "every day" to "not at all." Percentages are based on t...
journal_title:Psychosomatic medicine
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journal_title:Psychosomatic medicine
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journal_title:Psychosomatic medicine
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-07-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2009-07-01 00:00:00
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journal_title:Psychosomatic medicine
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doi:10.1097/00006842-199905000-00009
更新日期:1999-05-01 00:00:00
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更新日期:2003-11-01 00:00:00
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更新日期:2009-11-01 00:00:00
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